Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Alpha-tubulin | 0.0032 | 0.0109 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0032 | 0.0109 | 1 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0032 | 0.0109 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0032 | 0.0109 | 0.5 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0032 | 0.0109 | 0.0109 |
Brugia malayi | beta-tubulin, identical | 0.0032 | 0.0109 | 0.0109 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.1282 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0032 | 0.0109 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin, putative | 0.0032 | 0.0109 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.1282 | 1 | 1 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0032 | 0.0109 | 0.5 |
Entamoeba histolytica | tubulin gamma chain | 0.0032 | 0.0109 | 0.5 |
Brugia malayi | tubulin alpha chain - mouse | 0.0032 | 0.0109 | 0.0109 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0032 | 0.0109 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0032 | 0.0109 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0032 | 0.0109 | 1 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0477 | 0.363 | 0.363 |
Loa Loa (eye worm) | alpha-tubulin | 0.0032 | 0.0109 | 0.0109 |
Plasmodium falciparum | alpha tubulin 2 | 0.0032 | 0.0109 | 0.5 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma brucei | alpha tubulin | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma brucei | beta tubulin | 0.0032 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | BEN-1 protein | 0.0032 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0477 | 0.363 | 0.3559 |
Plasmodium falciparum | tubulin beta chain | 0.0032 | 0.0109 | 0.5 |
Brugia malayi | tubulin alpha-2 chain | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma brucei | beta tubulin | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma brucei | alpha tubulin | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0032 | 0.0109 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0477 | 0.363 | 0.3559 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0032 | 0.0109 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0032 | 0.0109 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0032 | 0.0109 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0032 | 0.0109 | 0.5 |
Plasmodium falciparum | alpha tubulin 1 | 0.0032 | 0.0109 | 0.5 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0032 | 0.0109 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0032 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0032 | 0.0109 | 0.0109 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.1282 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0032 | 0.0109 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0477 | 0.363 | 0.3559 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma brucei | alpha tubulin | 0.0032 | 0.0109 | 0.0109 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0032 | 0.0109 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.1282 | 1 | 1 |
Brugia malayi | Tubulin gamma chain | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma brucei | tubulin gamma chain | 0.0032 | 0.0109 | 0.0109 |
Leishmania major | 0.1282 | 1 | 1 | |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.1282 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0032 | 0.0109 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0032 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | beta-tubulin | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0032 | 0.0109 | 1 |
Trypanosoma brucei | epsilon tubulin | 0.0032 | 0.0109 | 0.0109 |
Brugia malayi | Tubulin alpha-2 chain | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0032 | 0.0109 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.1282 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0032 | 0.0109 | 0.0109 |
Brugia malayi | Tubulin alpha-2 chain | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0032 | 0.0109 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0032 | 0.0109 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0032 | 0.0109 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0032 | 0.0109 | 1 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0477 | 0.363 | 0.3559 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0032 | 0.0109 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0032 | 0.0109 | 0.5 |
Plasmodium falciparum | tubulin gamma chain | 0.0032 | 0.0109 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0032 | 0.0109 | 0.0109 |
Giardia lamblia | Gamma tubulin | 0.0032 | 0.0109 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma brucei | epsilon tubulin | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0032 | 0.0109 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0032 | 0.0109 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0032 | 0.0109 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0032 | 0.0109 | 1 |
Brugia malayi | alpha-tubulin | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1282 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0032 | 0.0109 | 0.0109 |
Brugia malayi | Tubulin alpha chain | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0032 | 0.0109 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1282 | 1 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0032 | 0.0109 | 0.0109 |
Trypanosoma brucei | alpha tubulin | 0.0032 | 0.0109 | 0.0109 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0032 | 0.0109 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 512 nM | Agonist activity at human D4.4 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPR | ChEMBL. | 17149874 |
EC50 (functional) | = 512 nM | Agonist activity at human D4.4 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPR | ChEMBL. | 17149874 |
Efficacy (functional) | = 40 % | Agonist activity at human D4.4 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPR with relative to dopamine | ChEMBL. | 17149874 |
Efficacy (functional) | = 40 % | Agonist activity at human D4.4 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPR with relative to dopamine | ChEMBL. | 17149874 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.