Detailed information for compound 409374

Basic information

Technical information
  • TDR Targets ID: 409374
  • Name: 5-methyl-1-(7-trityloxyheptyl)pyrimidine-2,4- dione
  • MW: 482.613 | Formula: C31H34N2O3
  • H donors: 1 H acceptors: 2 LogP: 6.08 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1[nH]c(=O)n(cc1C)CCCCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1
  • InChi: 1S/C31H34N2O3/c1-25-24-33(30(35)32-29(25)34)22-14-3-2-4-15-23-36-31(26-16-8-5-9-17-26,27-18-10-6-11-19-27)28-20-12-7-13-21-28/h5-13,16-21,24H,2-4,14-15,22-23H2,1H3,(H,32,34,35)
  • InChiKey: MYFJLJCVSVNEDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methyl-1-(7-trityloxyheptyl)pyrimidine-2,4-quinone
  • 5-methyl-1-[7-[tri(phenyl)methoxy]heptyl]pyrimidine-2,4-dione
  • 5-methyl-1-[7-[tri(phenyl)methoxy]heptyl]pyrimidine-2,4-quinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thymidine kinase 2, mitochondrial Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Thymidine kinase 2 mitochondrial Get druggable targets OG5_133103 All targets in OG5_133103
Schistosoma mansoni thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Echinococcus multilocularis transfer RNA-Ile Get druggable targets OG5_133103 All targets in OG5_133103
Echinococcus multilocularis thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Echinococcus granulosus thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Echinococcus granulosus thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Schistosoma japonicum ko:K00857 thymidine kinase [EC2.7.1.21], putative Get druggable targets OG5_133103 All targets in OG5_133103
Schistosoma japonicum similar to Centrosomal protein of 97 kDa, putative Get druggable targets OG5_133103 All targets in OG5_133103
Echinococcus multilocularis thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major mitochondrial DNA polymerase I protein A, putative thymidine kinase 2, mitochondrial 234 aa 232 aa 22.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0028 0.028 0.0992
Onchocerca volvulus 0.0022 0.0171 0.0886
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.006 0.091 0.0907
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0171 0.0886
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.006 0.091 0.091
Loa Loa (eye worm) PDE1B protein 0.006 0.091 0.091
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.091 0.0907
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0171 0.0171
Brugia malayi steroid hormone receptor 0.0022 0.0171 0.0171
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0085 0.1399 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0171 0.0886
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.1399 0.1494
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0017 0.0064 0.0064
Toxoplasma gondii hypothetical protein 0.0429 0.8157 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.091 0.091
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0085 0.1399 0.1395
Echinococcus multilocularis GPCR, family 2 0.0023 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0171
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0014 0.0004 0.0027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0171 0.0171
Plasmodium vivax hypothetical protein, conserved 0.0156 0.279 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.091 0.091
Leishmania major hypothetical protein, conserved 0.0026 0.0231 0.0227
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0171 0.0171
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0171 0.0886
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0315 0.5926 0.5926
Schistosoma mansoni hypothetical protein 0.0172 0.3103 0.3103
Plasmodium vivax phosphodiesterase gamma, putative 0.006 0.091 0.3262
Echinococcus multilocularis traf and tnf receptor associated protein 0.0359 0.6781 0.6781
Entamoeba histolytica hypothetical protein 0.0085 0.1399 0.1395
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0015 0.0032 0.0029
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.0907
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0085 0.1399 0.1399
Echinococcus multilocularis jumonji domain containing protein 0.0019 0.0106 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.091 0.0907
Entamoeba histolytica hypothetical protein 0.0085 0.1399 0.1395
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0064 0.0986 0.3526
Brugia malayi ecdysteroid receptor 0.0022 0.0171 0.0171
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0171 0.0171
Leishmania major hypothetical protein, conserved 0.0017 0.0064 0.006
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.006 0.091 0.091
Echinococcus granulosus flap endonuclease 1 0.0015 0.0032 0.0032
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0064 0.0986 0.3384
Loa Loa (eye worm) deoxynucleoside kinase 0.0085 0.1399 0.1399
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0445 0.0445
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0359 0.6781 0.6781
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0023 0.0178 0.0178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0171 0.0171
Echinococcus granulosus lysine specific demethylase 5A 0.0017 0.0057 0.0057
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Loa Loa (eye worm) flap endonuclease-1 0.0015 0.0032 0.0032
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0522 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0489 0.9339 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0489 0.9339 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.0971
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.006 0.091 0.091
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.091 0.0907
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.0971
Schistosoma mansoni hypothetical protein 0.0023 0.0178 0.0178
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.006 0.091 0.0907
Echinococcus multilocularis microtubule associated protein 2 0.0326 0.6149 0.6149
Mycobacterium ulcerans putative regulatory protein 0.0156 0.279 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0171 0.0171
Mycobacterium ulcerans esterase/lipase LipP 0.0017 0.0064 0.0215
Echinococcus multilocularis thymidine kinase 0.0379 0.7183 0.7183
Loa Loa (eye worm) glutathione reductase 0.0028 0.028 0.028
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0489 0.9339 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.091 0.091
Plasmodium falciparum thioredoxin reductase 0.0028 0.028 0.1004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0017 0.0064 0.0215
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0216 0.3972 0.3972
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0017 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0171 0.0171
Schistosoma mansoni survival motor neuron protein 0.0047 0.0654 0.0654
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Echinococcus granulosus thymidine kinase 0.0379 0.7183 0.7183
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0064 0.0986 0.3526
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0171 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0023 0.0178 0.0178
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.006 0.091 0.0907
Onchocerca volvulus 0.0112 0.1932 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0171 0.0171
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0171 0.0171
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.006 0.091 0.0907
Schistosoma mansoni jumonji/arid domain-containing protein 0.0017 0.0057 0.0057
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.3262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0171 0.0171
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Brugia malayi Pre-SET motif family protein 0.0014 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.006 0.091 0.0971
Plasmodium vivax glutathione reductase, putative 0.0028 0.028 0.1004
Entamoeba histolytica hypothetical protein 0.0036 0.0445 0.0442
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0045 0.0617 0.0617
Schistosoma mansoni coup transcription factor 0.0022 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0064
Brugia malayi glutathione reductase 0.0028 0.028 0.028
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0216 0.3972 0.4251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0171 0.0171
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0085 0.1399 0.1395
Onchocerca volvulus 0.0047 0.0654 0.3384
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0064 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0072 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0171
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0156 0.279 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Entamoeba histolytica hypothetical protein 0.0085 0.1399 0.1395
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Echinococcus granulosus jumonji domain containing protein 0.0019 0.0106 0.0106
Plasmodium falciparum GAF domain-related protein, putative 0.0156 0.279 1
Schistosoma mansoni thymidine kinase 0.0379 0.7183 0.7183
Echinococcus granulosus thymidine kinase 0.0379 0.7183 0.7183
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0064 0.006
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.006 0.091 0.6508
Trichomonas vaginalis D-aminoacylase, putative 0.0017 0.0064 0.0064
Brugia malayi Deoxynucleoside kinase family protein 0.0085 0.1399 0.1399
Brugia malayi hypothetical protein 0.0231 0.4264 0.4264
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0231 0.0827
Plasmodium vivax flap endonuclease 1, putative 0.0015 0.0032 0.0116
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0489 0.9339 0.9339
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0489 0.9339 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0064
Leishmania major trypanothione reductase 0.0028 0.028 0.0276
Loa Loa (eye worm) thioredoxin reductase 0.0028 0.028 0.028
Schistosoma mansoni hypothetical protein 0.0049 0.0699 0.0699
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.091 0.3262
Mycobacterium ulcerans hypothetical protein 0.0017 0.0064 0.0215
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0156 0.279 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.4264 0.4264
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0489 0.9339 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.006 0.091 0.0907
Schistosoma mansoni microtubule-associated protein tau 0.0326 0.6149 0.6149
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0171 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0171 0.0171
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0071 0.1127 0.403
Loa Loa (eye worm) hypothetical protein 0.0026 0.0231 0.0231
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.091 0.0971
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0171 0.0171
Trichomonas vaginalis flap endonuclease-1, putative 0.0015 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0064
Brugia malayi hypothetical protein 0.0026 0.0231 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.091 0.0907
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0171 0.0171
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.279 0.2985
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0171 0.0171
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0522 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.0971
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.006 0.091 0.091
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0171 0.0171
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0023 0.0178 0.0178
Toxoplasma gondii thioredoxin reductase 0.0028 0.028 0.0343
Trichomonas vaginalis penicillin-binding protein, putative 0.0017 0.0064 0.0064
Brugia malayi hypothetical protein 0.0036 0.0445 0.0445
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.006 0.091 0.091
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0171 0.0171
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.091 0.091
Mycobacterium tuberculosis Conserved protein 0.0017 0.0064 0.0215
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0171 0.0171
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.3262
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Mycobacterium tuberculosis Probable lipase LipE 0.0017 0.0064 0.0215
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0171 0.0171
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0064 0.006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0023 0.0178 0.0178
Brugia malayi beta-lactamase family protein 0.0017 0.0064 0.0064
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0023 0.0178 0.0178
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.0004 0.0004
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Schistosoma mansoni retinoic acid receptor RXR 0.0315 0.5926 0.5926
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0171
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0489 0.9339 0.9339
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.091 0.091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0017 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.1399 0.1494
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0489 0.9339 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0014 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0085 0.1399 0.1395
Loa Loa (eye worm) hypothetical protein 0.0024 0.0194 0.0194
Trichomonas vaginalis set domain proteins, putative 0.0112 0.1932 0.2066
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.006 0.091 0.0907
Schistosoma mansoni hypothetical protein 0.0172 0.3103 0.3103
Echinococcus multilocularis transfer RNA-Ile 0.0379 0.7183 0.7183
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0522 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Trichomonas vaginalis esterase, putative 0.0017 0.0064 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.0017 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0014 0.0006 0.0006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0171 0.0171
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0004 0.0013
Echinococcus granulosus beta LACTamase domain containing family member 0.0017 0.0064 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0171 0.0171
Echinococcus granulosus GPCR family 2 0.0023 0.0178 0.0178
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0171 0.0171
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0216 0.3972 0.3972
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.091 0.091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0171 0.0171
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Trichomonas vaginalis conserved hypothetical protein 0.0429 0.8157 0.8734
Trichomonas vaginalis D-aminoacylase, putative 0.0017 0.0064 0.0064
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0333 0.6277 0.6276
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0171 0.0171
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.006 0.091 0.091
Mycobacterium tuberculosis Probable oxidoreductase 0.0071 0.1127 0.403
Trypanosoma brucei hypothetical protein, conserved 0.006 0.091 0.0907
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0231 0.0283
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0171 0.0171
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.091 0.0907
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.0004 0.0004
Schistosoma mansoni ap endonuclease 0.0014 0.0004 0.0004
Mycobacterium ulcerans beta-lactamase 0.0017 0.0064 0.0215
Mycobacterium tuberculosis Probable hydrolase 0.0017 0.0064 0.0215
Schistosoma mansoni hypothetical protein 0.0023 0.0178 0.0178
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Giardia lamblia Hypothetical protein 0.0085 0.1399 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0098 0.1665 0.1665
Entamoeba histolytica hypothetical protein 0.0085 0.1399 0.1395
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0489 0.9339 1
Plasmodium falciparum flap endonuclease 1 0.0015 0.0032 0.0116
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0014 0.0006 0.0008
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0489 0.9339 0.9339
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0171
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.006 0.091 0.0907
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0171 0.0171
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.006 0.091 0.091
Entamoeba histolytica hypothetical protein 0.0085 0.1399 0.1395
Schistosoma mansoni hypothetical protein 0.0047 0.0654 0.0654
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0522 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0017 0.0064 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0171 0.0171
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0072 0.1149 0.1149
Loa Loa (eye worm) latrophilin receptor protein 2 0.0023 0.0178 0.0178
Brugia malayi latrophilin 2 splice variant baaae 0.0049 0.0699 0.0699
Treponema pallidum exodeoxyribonuclease (exoA) 0.0014 0.0004 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0171 0.0171
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0109 0.1869 0.6693
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.006 0.091 0.091
Plasmodium vivax SET domain protein, putative 0.0014 0.0006 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0231 0.0827
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0085 0.1399 0.1399
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0014 0.0006 0.0006
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.091 0.3262
Giardia lamblia Deoxynucleoside kinase 0.0085 0.1399 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0014 0.0004 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.006 0.091 0.091
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Trichomonas vaginalis conserved hypothetical protein 0.006 0.091 0.0971
Echinococcus multilocularis lysine specific demethylase 5A 0.0017 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0036 0.0445 0.0445
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0171 0.0171
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.006 0.091 0.0907
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0289 0.0289
Brugia malayi Latrophilin receptor protein 2 0.0023 0.0178 0.0178
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0333 0.6277 0.672
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0171 0.0171
Mycobacterium tuberculosis Probable esterase LipL 0.0017 0.0064 0.0215
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0303 0.5693 0.5693
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0085 0.1399 0.1395
Giardia lamblia Flap structure-specific endonuclease 0.0015 0.0032 0.0232
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0015 0.0032 0.004
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.006 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0023 0.0178 0.0178
Entamoeba histolytica hypothetical protein 0.0085 0.1399 0.1395
Brugia malayi jmjC domain containing protein 0.0045 0.0617 0.0617
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0015 0.0032 0.0029
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0171 0.0171
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Schistosoma mansoni hypothetical protein 0.0023 0.0178 0.0178
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0085 0.1399 0.1399
Entamoeba histolytica hypothetical protein 0.0085 0.1399 0.1395
Giardia lamblia Hypothetical protein 0.0085 0.1399 1
Trypanosoma brucei trypanothione reductase 0.0028 0.028 0.0276
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0216 0.3972 0.3972
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.028 0.0276
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0353 0.6676 0.6676
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0216 0.3972 0.4251
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0216 0.3972 0.3972
Echinococcus multilocularis thioredoxin glutathione reductase 0.0028 0.028 0.028
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0171 0.0171
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0489 0.9339 0.9339
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.1399 0.1494
Brugia malayi Pre-SET motif family protein 0.0098 0.1665 0.1665
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Brugia malayi jmjC domain containing protein 0.0017 0.0057 0.0057
Plasmodium falciparum phosphodiesterase delta, putative 0.006 0.091 0.3262
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.006 0.091 0.091
Echinococcus granulosus microtubule associated protein 2 0.0326 0.6149 0.6149
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.006 0.091 0.091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0171 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0171 0.0171
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0522 1 1
Giardia lamblia Hypothetical protein 0.006 0.091 0.6508
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.1399 0.1494
Echinococcus granulosus histone lysine methyltransferase setb 0.0014 0.0006 0.0006
Onchocerca volvulus 0.0017 0.0064 0.033
Entamoeba histolytica Flap nuclease, putative 0.0015 0.0032 0.0029
Toxoplasma gondii GAF domain-containing protein 0.0156 0.279 0.3421
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.006 0.091 0.091
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.006 0.091 0.0971
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0231 0.0227
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0017 0.0064 0.0215
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.006 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.006 0.091 0.091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0522 1 1
Echinococcus granulosus transcription factor Dp 1 0.0302 0.5674 0.5674
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0072 0.1149 0.1149
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.3262
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0396 0.7513 0.7513
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.091 0.091
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0171 0.0171
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0489 0.9339 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.006 0.091 0.091
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0171 0.0171
Echinococcus multilocularis beta LACTamase domain containing family member 0.0017 0.0064 0.0064
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.006 0.091 0.091
Leishmania major hypothetical protein, conserved 0.006 0.091 0.0907
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.4264 0.4264
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0489 0.9339 1
Trichomonas vaginalis conserved hypothetical protein 0.0489 0.9339 1
Onchocerca volvulus 0.0014 0.0006 0.0034
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.0907
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0489 0.9339 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.0971
Brugia malayi beta-lactamase family protein 0.0017 0.0064 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0017 0.0064 0.0215
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0014 0.0006 0.0006
Mycobacterium tuberculosis Probable reductase 0.0064 0.0986 0.3526
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.091 0.091
Entamoeba histolytica hypothetical protein 0.0036 0.0445 0.0442
Toxoplasma gondii ABC1 family protein 0.0017 0.0064 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0014 0.0006 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0231 0.0827
Brugia malayi hypothetical protein 0.0016 0.0053 0.0053
Toxoplasma gondii hypothetical protein 0.0156 0.279 0.3421
Entamoeba histolytica hypothetical protein 0.0085 0.1399 0.1395
Toxoplasma gondii hypothetical protein 0.0156 0.279 0.3421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0171 0.0171
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0171 0.0171
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0346 0.654 0.8018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0004 0.0013
Schistosoma mansoni flap endonuclease-1 0.0014 0.0003 0.0003
Giardia lamblia hypothetical protein 0.006 0.091 0.6508
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0064 0.0228
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.091 0.0971
Plasmodium vivax thioredoxin reductase, putative 0.0028 0.028 0.1004
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0445 0.0445
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0071 0.1127 0.403
Mycobacterium tuberculosis Probable lipase LipD 0.0017 0.0064 0.0215
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.4264 0.4264
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.3262
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.091 0.091
Loa Loa (eye worm) beta-lactamase 0.0017 0.0064 0.0064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0045 0.0617 0.0617
Mycobacterium tuberculosis Probable dehydrogenase 0.0064 0.0986 0.3526
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0064
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0171 0.0171
Mycobacterium ulcerans putative regulatory protein 0.0156 0.279 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0216 0.3972 0.4251
Loa Loa (eye worm) hypothetical protein 0.0156 0.279 0.279
Schistosoma mansoni hypothetical protein 0.0023 0.0178 0.0178
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0489 0.9339 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Trichomonas vaginalis penicillin-binding protein, putative 0.0017 0.0064 0.0064
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0071 0.1127 0.3899
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0654 0.0654
Brugia malayi nuclear hormone receptor 0.0022 0.0171 0.0171
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0522 1 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.006 0.091 0.3262
Echinococcus granulosus geminin 0.0172 0.3103 0.3103
Brugia malayi nuclear receptor NHR-88 0.0022 0.0171 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0171 0.0171
Brugia malayi beta-lactamase 0.0017 0.0064 0.0064
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0017 0.0064 0.0064
Mycobacterium leprae conserved hypothetical protein 0.0156 0.279 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0445 0.0445
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0489 0.9339 0.9339
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0171 0.0171
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0333 0.6277 0.672
Schistosoma mansoni jumonji domain containing protein 0.0036 0.0435 0.0435
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0216 0.3972 0.3972
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0015 0.0032 0.0029
Entamoeba histolytica hypothetical protein 0.0036 0.0445 0.0442
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0231 0.0227
Mycobacterium ulcerans lipase LipD 0.0017 0.0064 0.0215
Schistosoma mansoni ap endonuclease 0.0014 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0429 0.8157 0.8734
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0171 0.0171
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0171 0.0171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0171 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.1399 0.1494
Schistosoma mansoni jumonji/arid domain-containing protein 0.0017 0.0057 0.0057
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Entamoeba histolytica hypothetical protein 0.0036 0.0445 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0171 0.0171
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0489 0.9339 0.9339
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0085 0.1399 0.1395
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.091 0.3262
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.0004 0.0004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0379 0.7183 0.7183
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0171 0.0171
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0489 0.9339 0.9339
Brugia malayi Thioredoxin reductase 0.0028 0.028 0.028
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0171 0.0171
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0171 0.0171
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.091 0.0971
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.006 0.091 0.091
Echinococcus multilocularis transcription factor Dp 1 0.0302 0.5674 0.5674
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0522 1 1
Echinococcus granulosus traf and tnf receptor associated protein 0.0359 0.6781 0.6781
Onchocerca volvulus 0.0017 0.0064 0.033
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0057 0.0057
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Mycobacterium tuberculosis Conserved protein 0.0017 0.0064 0.0215
Loa Loa (eye worm) hypothetical protein 0.006 0.091 0.091
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0216 0.3972 0.3972
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0049 0.0699 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.0429 0.8157 0.8734
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0064 0.0986 0.3526
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.091 0.0971
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0231 0.0227
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0171
Leishmania major hypothetical protein, conserved 0.006 0.091 0.0907
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0489 0.9339 1
Brugia malayi Flap endonuclease-1 0.0015 0.0032 0.0032
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0522 1 1
Onchocerca volvulus 0.0017 0.0064 0.033
Echinococcus granulosus thioredoxin glutathione reductase 0.0028 0.028 0.028
Echinococcus multilocularis thymidine kinase 0.0379 0.7183 0.7183
Echinococcus multilocularis geminin 0.0172 0.3103 0.3103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0064
Echinococcus multilocularis flap endonuclease 1 0.0015 0.0032 0.0032
Plasmodium falciparum glutathione reductase 0.0028 0.028 0.1004
Mycobacterium tuberculosis Conserved protein 0.0017 0.0064 0.0215
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.091 0.0971
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.091 0.1116
Loa Loa (eye worm) hypothetical protein 0.006 0.091 0.091
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0489 0.9339 0.9339
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0156 0.279 1
Toxoplasma gondii exonuclease III APE 0.0014 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0072 0.1149 0.1149
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0064 0.0986 0.3526
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0171 0.0171
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.091 0.0907
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0171 0.0171

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.7 uM Inhibition of [3H]methyl dThd phosphorylation by TK2 ChEMBL. 17181158
IC50 (binding) = 4.7 uM Inhibition of [3H]methyl dThd phosphorylation by TK2 ChEMBL. 17181158
IC50 (binding) = 32 uM Inhibition of [3H]methyl dThd phosphorylation by Drosophila melanogaster dNK ChEMBL. 17181158
IC50 (binding) = 32 uM Inhibition of [3H]methyl dThd phosphorylation by Drosophila melanogaster dNK ChEMBL. 17181158
IC50 (binding) >= 50 uM Inhibition of [3H]methyl dThd phosphorylation by HSV1 TK ChEMBL. 17181158
IC50 (binding) >= 50 uM Inhibition of [3H]methyl dThd phosphorylation by HSV1 TK ChEMBL. 17181158

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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