Detailed information for compound 409497

Basic information

Technical information
  • TDR Targets ID: 409497
  • Name: 2-decyl-3,4-dihydro-1H-isoquinoline-6,7-diol
  • MW: 305.455 | Formula: C19H31NO2
  • H donors: 2 H acceptors: 2 LogP: 5.58 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCN1CCc2c(C1)cc(c(c2)O)O
  • InChi: 1S/C19H31NO2/c1-2-3-4-5-6-7-8-9-11-20-12-10-16-13-18(21)19(22)14-17(16)15-20/h13-14,21-22H,2-12,15H2,1H3
  • InChiKey: KPGIJVPFAJCNNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,7-Isoquinolinediol, 2-decyl-1,2,3,4-tetrahydro-
  • AIDS-418165
  • AIDS418165

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Cathepsin L homolog 0.0156 0.0502 0.1875
Plasmodium falciparum plasmepsin VII 0.0045 0.0051 0.0611
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0261 0.0337
Echinococcus granulosus sodium:myo inositol cotransporter 0.25 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.0078 0.0101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0283 0.0365
Plasmodium falciparum cysteine proteinase falcipain 3 0.0156 0.0502 1
Echinococcus multilocularis high affinity choline transporter 1 0.0638 0.2454 0.2454
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Plasmodium vivax plasmepsin V, putative 0.0045 0.0051 0.0611
Loa Loa (eye worm) hypothetical protein 0.007 0.0152 0.0196
Brugia malayi Papain family cysteine protease containing protein 0.008 0.0195 0.0252
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0378
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0045 0.0051 0.0038
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0156 0.0502 1
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0347 0.0448
Echinococcus granulosus cathepsin l1 0.0104 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Plasmodium vivax aspartyl protease, putative 0.0045 0.0051 0.0611
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0073 0.0073
Schistosoma mansoni cathepsin s 0.0052 0.0078 0.0078
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0043 0.0043
Leishmania major 0.1944 0.7746 1
Toxoplasma gondii fructose-bisphospatase II 0.1944 0.7746 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0078 0.0101
Echinococcus granulosus cysteine protease 0.008 0.0195 0.0195
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.0502 0.0502
Brugia malayi Cathepsin L-like precursor 0.0104 0.0293 0.0378
Trypanosoma cruzi cysteine proteinase, putative 0.008 0.0195 0.0224
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.0502 0.0502
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1944 0.7746 1
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0152 0.0196
Schistosoma mansoni sodium/solute symporter 0.0638 0.2454 0.2454
Plasmodium falciparum plasmepsin X 0.0124 0.0372 0.7304
Loa Loa (eye worm) hypothetical protein 0.0053 0.0084 0.0108
Plasmodium vivax unspecified product 0.0052 0.0078 0.1177
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0078 0.0073
Loa Loa (eye worm) hypothetical protein 0.0154 0.0492 0.0635
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0078 0.0073
Brugia malayi aspartic protease BmAsp-1, identical 0.0045 0.0051 0.0066
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0154 0.0492 0.0635
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Trypanosoma cruzi cruzipain precursor, putative 0.0156 0.0502 0.0621
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Schistosoma mansoni inositol transporter 0.25 1 1
Schistosoma mansoni eyes absent homolog 0.0097 0.0261 0.0261
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0723 0.2798 0.3595
Onchocerca volvulus 0.0156 0.0502 0.1875
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Schistosoma mansoni inositol transporter 0.25 1 1
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Schistosoma mansoni hypothetical protein 0.007 0.0152 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Onchocerca volvulus 0.0156 0.0502 0.1875
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0021 0.0021
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1944 0.7746 1
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1944 0.7746 1
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Entamoeba histolytica cysteine protease, putative 0.0156 0.0502 1
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0638 0.2454 0.2454
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Onchocerca volvulus Cathepsin L homolog 0.0156 0.0502 0.1875
Onchocerca volvulus 0.0156 0.0502 0.1875
Toxoplasma gondii cathepsin CPL 0.0156 0.0502 0.0621
Onchocerca volvulus 0.0156 0.0502 0.1875
Leishmania major cysteine peptidase A (CPA) 0.0156 0.0502 0.0621
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0045 0.0051 0.0066
Plasmodium vivax plasmepsin IV, putative 0.0154 0.0492 0.9793
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.008 0.0195 0.0195
Schistosoma mansoni cathepsin D (A01 family) 0.0524 0.1991 0.1991
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0293 0.3182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.25 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.008 0.0195 0.0224
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Onchocerca volvulus 0.0104 0.0293 0.1005
Plasmodium vivax vivapain-3 0.008 0.0195 0.361
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Trypanosoma cruzi cysteine protease, putative 0.008 0.0195 0.0224
Toxoplasma gondii aspartyl protease ASP3 0.0124 0.0372 0.0454
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1944 0.7746 0.7746
Echinococcus granulosus cathepsin L 0.008 0.0195 0.0195
Schistosoma mansoni cathepsin D (A01 family) 0.0524 0.1991 0.1991
Plasmodium falciparum plasmepsin VI 0.0154 0.0492 0.9793
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Plasmodium vivax aspartyl protease, putative 0.0124 0.0372 0.7304
Plasmodium falciparum cysteine proteinase falcipain 1 0.008 0.0195 0.361
Plasmodium vivax aspartyl protease, putative 0.0124 0.0372 0.7304
Loa Loa (eye worm) hepatopoietin HPO2 0.0038 0.0022 0.0028
Brugia malayi cathepsin L-like precursor 0.0104 0.0293 0.0378
Loa Loa (eye worm) fibroinase 0.0156 0.0502 0.0648
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0723 0.2798 0.3595
Echinococcus granulosus cathepsin l cysteine peptidase 0.0156 0.0502 0.0502
Toxoplasma gondii aspartyl protease ASP1 0.0154 0.0492 0.0609
Loa Loa (eye worm) hypothetical protein 0.0638 0.2454 0.3168
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0043 0.0043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0638 0.2454 0.3168
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0283 0.0365
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Loa Loa (eye worm) hypothetical protein 0.0156 0.0502 0.0648
Plasmodium vivax vivapain-2 0.0156 0.0502 1
Onchocerca volvulus 0.0156 0.0502 0.1875
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0073 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0073 0.0073
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.0502 0.0648
Brugia malayi Cathepsin L-like cysteine proteinase 0.0104 0.0293 0.0378
Brugia malayi Pepsin A precursor 0.0045 0.0051 0.0066
Brugia malayi Papain family cysteine protease containing protein 0.008 0.0195 0.0252
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0073 0.0073
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0073 0.0094
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Echinococcus multilocularis cysteine protease 0.0156 0.0502 0.0502
Plasmodium falciparum plasmepsin I 0.0154 0.0492 0.9793
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1944 0.7746 0.7746
Loa Loa (eye worm) ctsf protein 0.0156 0.0502 0.0648
Echinococcus multilocularis cysteine protease 0.0156 0.0502 0.0502
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0073 0.0073
Loa Loa (eye worm) aspartyl protease 6 0.0045 0.0051 0.0066
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0038 0.0022 0.0022
Plasmodium falciparum plasmepsin VIII, putative 0.0045 0.0051 0.0611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0195 0.0224
Plasmodium vivax aspartyl proteinase, putative 0.0045 0.0051 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0283 0.0365
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0154 0.0492 0.0492
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.0502 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0638 0.2454 0.3149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Plasmodium falciparum plasmepsin IV 0.0154 0.0492 0.9793
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.008 0.0195 0.0195
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1944 0.7746 0.7746
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.008 0.0195 0.0195
Brugia malayi hypothetical protein 0.0045 0.0051 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Brugia malayi Sodium:solute symporter family protein 0.0638 0.2454 0.3168
Loa Loa (eye worm) cysteine protease 0.0156 0.0502 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Plasmodium vivax unspecified product 0.008 0.0195 0.361
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0347 0.0448
Brugia malayi Cathepsin L-like precursor 0.0156 0.0502 0.0648
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0127 0.0165
Brugia malayi GH02984p 0.0638 0.2454 0.3168
Brugia malayi aspartic protease BmAsp-2, identical 0.0045 0.0051 0.0066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0283 0.0365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0073 0.0094
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0723 0.2798 0.3595
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.008 0.0195 0.0224
Schistosoma mansoni cathepsin F (C01 family) 0.0104 0.0293 0.0293
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0195 0.0224
Echinococcus granulosus cathepsin l1 0.0156 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0045 0.0051 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0154 0.0492 0.0492
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0154 0.0492 0.9675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0038 0.0022 0.0022
Plasmodium falciparum plasmepsin III 0.0045 0.0051 0.0611
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0156 0.0502 1
Echinococcus granulosus solute carrier family 5 0.25 1 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.0078 0.0101
Onchocerca volvulus 0.0156 0.0502 0.1875
Schistosoma mansoni jumonji domain containing protein 0.008 0.0195 0.0195
Plasmodium vivax aspartyl proteinase, putative 0.0154 0.0492 0.9793
Toxoplasma gondii aspartyl protease 0.0045 0.0051 0.0038
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0723 0.2798 0.3595
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Echinococcus granulosus cathepsin L cysteine protease 0.008 0.0195 0.0195
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Onchocerca volvulus 0.0156 0.0502 0.1875
Brugia malayi Cathepsin L-like precursor 0.0104 0.0293 0.0378
Plasmodium vivax vivapain-1 0.008 0.0195 0.361
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Brugia malayi jmjC domain containing protein 0.0037 0.0021 0.0027
Echinococcus granulosus cathepsin L cysteine proteinase 0.0156 0.0502 0.0502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Loa Loa (eye worm) hypothetical protein 0.0097 0.0261 0.0337
Plasmodium falciparum plasmepsin II 0.0154 0.0492 0.9793
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0073 0.0073
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0021 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0293 0.3182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0638 0.2454 0.2454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Brugia malayi fructose-1,6-bisphosphatase 0.1944 0.7746 1
Plasmodium falciparum plasmepsin IX 0.0124 0.0372 0.7304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0502 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0021 0.0027
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.0502 0.0502
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0073 0.0073
Echinococcus multilocularis cathepsin L 0.008 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Toxoplasma gondii fructose-bisphospatase I 0.0723 0.2798 0.3595
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0279 0.0279
Schistosoma mansoni high-affinity choline transporter 0.0638 0.2454 0.2454
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.0502 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Brugia malayi MH2 domain containing protein 0.0118 0.0347 0.0448
Echinococcus multilocularis sodium:myo inositol cotransporter 0.25 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.008 0.0195 0.0224
Brugia malayi hypothetical protein 0.0045 0.0051 0.0066
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0156 0.0502 0.0648
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0104 0.0293 0.0351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0502 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Onchocerca volvulus 0.0638 0.2454 1
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1944 0.7746 1
Plasmodium falciparum plasmepsin V 0.0045 0.0051 0.0611
Schistosoma mansoni memapsin-2 (A01 family) 0.0045 0.0051 0.0051
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.0502 0.0502
Brugia malayi hypothetical protein 0.0097 0.0261 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621
Brugia malayi jmjC domain containing protein 0.0101 0.0279 0.036
Leishmania major cathepsin L-like protease 0.0156 0.0502 0.0621
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0101
Echinococcus granulosus high affinity choline transporter 1 0.0638 0.2454 0.2454
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0045 0.0051 0.0066
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.0502 0.0621
Echinococcus granulosus sodium:glucose cotransporter 2 0.25 1 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.0045 0.0051 0.0066
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0293 0.3182
Echinococcus multilocularis solute carrier family 5 0.25 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0101
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0154 0.0492 0.0609
Brugia malayi Augmenter of liver regeneration 0.0038 0.0022 0.0028
Onchocerca volvulus Cathepsin F homolog 0.0156 0.0502 0.1875
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.0502 0.0648
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0078 0.0101
Plasmodium vivax vivapain-2 0.0156 0.0502 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0154 0.0492 0.0492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0156 0.0502 0.0621

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.5 umol/L Antifungal activity against Candida parapsilosis after 24 hrs ChEMBL. 17900179
MIC (functional) = 1 umol/L Antifungal activity against Cryptococcus neoformans after 72 hrs ChEMBL. 17900179
MIC (functional) = 1 umol/L Antifungal activity against Trichophyton rubrum ChEMBL. 17900179
MIC (functional) = 1 umol/L Antifungal activity against Cryptococcus neoformans after 72 hrs ChEMBL. 17900179
MIC (functional) = 16 umol/L Antifungal activity against Fonsecaea compacta ChEMBL. 17900179
MIC (functional) = 16 umol/L Antifungal activity against Aspergillus fumigatus ChEMBL. 17900179
MIC (functional) > 64 umol/L Antifungal activity against Candida albicans after 24 hrs ChEMBL. 17900179
MIC (functional) > 64 umol/L Antifungal activity against Microsporum gypseum ChEMBL. 17900179
MIC (functional) > 64 umol/L Antifungal activity against Candida albicans after 24 hrs ChEMBL. 17900179
MIC80 (functional) = 3.125 ug ml-1 Antifungal activity against Trichophyton rubrum after 7 days ChEMBL. 16905318
MIC80 (functional) = 3.125 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs ChEMBL. 16905318
MIC80 (functional) = 3.125 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs ChEMBL. 16905318
MIC80 (functional) = 12.5 ug ml-1 Antifungal activity against Microsporum canis after 7 days ChEMBL. 16905318
MIC80 (functional) = 12.5 ug ml-1 Antifungal activity against Candida parapsilosis after 24 hrs ChEMBL. 16905318
MIC80 (functional) = 16 ug ml-1 Antifungal activity against Cryptococcus neoformans by serial dilution method ChEMBL. 20036534
MIC80 (functional) = 50 ug ml-1 Antifungal activity against Aspergillus fumigatus after 7 days ChEMBL. 16905318
MIC80 (functional) = 64 ug ml-1 Antifungal activity against Candida albicans by serial dilution method ChEMBL. 20036534
MIC80 (functional) = 100 ug ml-1 Antifungal activity against Candida albicans after 24 hrs ChEMBL. 16905318
MIC80 (functional) = 100 ug ml-1 Antifungal activity against Candida albicans after 24 hrs ChEMBL. 16905318

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.