TDR Targets

Basic information

Technical information

TDR Targets ID: 409560
Name: 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-meth ylfuran-2-yl)ethyl]amino]-3,4-dioxocyclobuten -1-yl]amino]benzamide
MW: 383.398 | Formula: C20H21N3O5
H donors: 3 H acceptors: 4 LogP: 2.57 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(o1)[C@H](NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C)C
InChi: 1S/C20H21N3O5/c1-10-8-9-14(28-10)11(2)21-15-16(19(26)18(15)25)22-13-7-5-6-12(17(13)24)20(27)23(3)4/h5-9,11,21-22,24H,1-4H3/t11-/m1/s1
InChiKey: ACYREHAZQPOKBX-LLVKDONJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furyl)ethyl]amino]-3,4-dioxo-cyclobuten-1-yl]amino]benzamide
2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furyl)ethyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]benzamide
2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)ethyl]amino]-3,4-dioxo-cyclobuten-1-yl]amino]benzamide
3-[[3,4-diketo-2-[[(1R)-1-(5-methyl-2-furyl)ethyl]amino]cyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethyl-benzamide
2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)ethyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]benzamide
3-[[3,4-diketo-2-[[(1R)-1-(5-methyl-2-furyl)ethyl]amino]-1-cyclobutenyl]amino]-2-hydroxy-N,N-dimethyl-benzamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-X-C motif) receptor 2	Starlite/ChEMBL	References
Homo sapiens	chemokine (C-X-C motif) receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0224	0.0973	0.2785
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0224	0.0973	0.2785
Schistosoma mansoni	thyroid hormone receptor	0.0346	0.16	0.4725
Brugia malayi	hypothetical protein	0.007	0.0175	0.0338
Echinococcus granulosus	nuclear receptor nhr 48	0.0098	0.0323	0.0993
Brugia malayi	hypothetical protein	0.0098	0.0323	0.0791
Echinococcus multilocularis	nuclear receptor nhr 48	0.0098	0.0323	0.0993
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0224	0.0973	0.2785
Brugia malayi	hypothetical protein	0.0126	0.0467	0.1232
Brugia malayi	Nuclear hormone receptor-like 1	0.0126	0.0467	0.1232
Brugia malayi	Nuclear hormone receptor-like 1	0.0224	0.0973	0.2785
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0224	0.0973	0.2724
Loa Loa (eye worm)	gamma-secretase subunit pen-2	0.0186	0.0777	0.2184
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0224	0.0973	0.2785
Brugia malayi	Nuclear hormone receptor-like 1	0.0126	0.0467	0.1232
Brugia malayi	photoreceptor-specific nuclear receptor	0.0224	0.0973	0.2785
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0224	0.0973	0.2991
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0119	0.0366
Schistosoma mansoni	nuclear hormone receptor	0.0098	0.0323	0.0651
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0473	0.2256	0.6819
Brugia malayi	hypothetical protein	0.007	0.0175	0.0338
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0224	0.0973	0.2785
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0346	0.16	0.4918
Echinococcus multilocularis	microtubule associated protein 2	0.0667	0.3253	1
Brugia malayi	hypothetical protein	0.0097	0.0315	0.0768
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0126	0.0467	0.1434
Loa Loa (eye worm)	nuclear hormone receptor	0.0098	0.0323	0.0791
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0473	0.2256	0.6721
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0198	0.084	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0224	0.0973	0.2785
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.0444	0.1364
Echinococcus multilocularis	FTZ F1 alpha	0.0224	0.0973	0.2991
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0126	0.0467	0.1434
Brugia malayi	tailless protein	0.0098	0.0323	0.0791
Loa Loa (eye worm)	presenilin spe-4	0.007	0.0175	0.0338
Schistosoma mansoni	coup transcription factor	0.0224	0.0973	0.2724
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0224	0.0973	0.2785
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0973	0.2785
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0224	0.0973	0.2991
Brugia malayi	nuclear receptor RXR	0.0098	0.0323	0.0791
Brugia malayi	gamma-secretase subunit pen-2	0.0186	0.0777	0.2184
Echinococcus multilocularis	Nicastrin	0.0097	0.0315	0.097
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0467	0.1232
Echinococcus granulosus	presenilin enhancer 2	0.0186	0.0777	0.2389
Brugia malayi	hypothetical protein	0.0097	0.0315	0.0768
Mycobacterium ulcerans	short chain dehydrogenase	0.1975	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0098	0.0323	0.0993
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0098	0.0323	0.0791
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0193	0.0814	0.2502
Brugia malayi	hypothetical protein	0.0126	0.0467	0.1232
Onchocerca volvulus	Bile acid receptor homolog	0.0681	0.3326	1
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0973	0.2785
Echinococcus granulosus	thyroid hormone receptor alpha	0.0386	0.1806	0.555
Loa Loa (eye worm)	steroid hormone receptor	0.0512	0.2455	0.7331
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0224	0.0973	0.2724
Schistosoma mansoni	subfamily A22A unassigned peptidase (A22 family)	0.0198	0.084	0.23
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0098	0.0323	0.0993
Onchocerca volvulus	Protein ultraspiracle homolog	0.0224	0.0973	0.2165
Brugia malayi	Presenilin family protein	0.0198	0.084	0.2377
Loa Loa (eye worm)	DR-78	0.0098	0.0323	0.0791
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0119	0.0366
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0224	0.0973	0.2785
Schistosoma mansoni	zinc finger protein	0.0098	0.0323	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Schistosoma mansoni	retinoic acid receptor RXR	0.032	0.1464	0.4291
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0467	0.1232
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0098	0.0323	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0973	0.2785
Brugia malayi	conserved hypotetical protein	0.0098	0.0323	0.0791
Brugia malayi	gamma-secretase subunit aph-1	0.0473	0.2256	0.6721
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0467	0.1232
Echinococcus multilocularis	ecdysone induced protein 78C	0.0224	0.0973	0.2991
Brugia malayi	orphan nuclear receptor NR2E1	0.0098	0.0323	0.0791
Brugia malayi	hypothetical protein	0.007	0.0175	0.0338
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0224	0.0973	0.2724
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0224	0.0973	0.2991
Brugia malayi	ecdysteroid receptor	0.0681	0.3326	1
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0973	0.2785
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0467	0.1232
Echinococcus multilocularis	presenilin	0.0198	0.084	0.2582
Echinococcus granulosus	FTZ F1 alpha	0.0224	0.0973	0.2991
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0315	0.0768
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0098	0.0323	0.0791
Entamoeba histolytica	presenilin 1 peptidase, putative	0.0198	0.084	1
Brugia malayi	N-terminal motif family protein	0.0174	0.0716	0.1996
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0098	0.0323	0.0651
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0224	0.0973	0.2724
Brugia malayi	Nuclear hormone receptor E75	0.0098	0.0323	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Echinococcus multilocularis	presenilin enhancer 2	0.0186	0.0777	0.2389
Echinococcus granulosus	Nicastrin	0.0097	0.0315	0.097
Loa Loa (eye worm)	hypothetical protein	0.0681	0.3326	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0224	0.0973	0.2785
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0224	0.0973	0.2785
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0098	0.0323	0.0651
Brugia malayi	Presenilin spe-4	0.007	0.0175	0.0338
Brugia malayi	steroid hormone receptor	0.0512	0.2455	0.7331
Brugia malayi	Presenilin-like protein At2g29900	0.007	0.0175	0.0338
Brugia malayi	hypothetical protein	0.0098	0.0323	0.0791
Schistosoma mansoni	nuclear receptor	0.0098	0.0323	0.0651
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0119	0.0183
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0224	0.0973	0.2724
Brugia malayi	nuclear hormone receptor	0.0224	0.0973	0.2785
Brugia malayi	Presenilin spe-4	0.007	0.0175	0.0338
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0224	0.0973	0.2785
Schistosoma mansoni	RAR-like nuclear receptor	0.0224	0.0973	0.2724
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0098	0.0323	0.0993
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0224	0.0973	0.2991
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0098	0.0323	0.0993
Trypanosoma brucei	Aph-1 protein, putative	0.0184	0.0767	0.9136
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Brugia malayi	nuclear receptor NHR-67	0.0098	0.0323	0.0791
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0224	0.0973	0.2991
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0098	0.0323	0.0993
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0473	0.2256	0.6935
Trypanosoma brucei	Presenilin enhancer-2 subunit of gamma secretase, putative	0.0056	0.0106	0.1259
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0098	0.0323	0.0791
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0224	0.0973	0.2785
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0224	0.0973	0.2785
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0224	0.0973	0.2165
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0224	0.0973	0.2785
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0224	0.0973	0.2991
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0224	0.0973	0.2991
Brugia malayi	nuclear receptor NHR-88	0.0098	0.0323	0.0791
Echinococcus granulosus	presenilin	0.0198	0.084	0.2582
Onchocerca volvulus		0.0224	0.0973	0.2165
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0198	0.084	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0098	0.0323	0.0791
Schistosoma mansoni	nuclear hormone receptor	0.0224	0.0973	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0174	0.0716	0.1996
Schistosoma mansoni	nuclear receptor nhr-48	0.0098	0.0323	0.0651
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0224	0.0973	0.2785
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0224	0.0973	0.2785
Trypanosoma cruzi	Aph-1 protein, putative	0.0184	0.0767	0.9136
Echinococcus granulosus	ecdysone induced protein 78C	0.0224	0.0973	0.2991
Brugia malayi	Presenilin spe-4	0.007	0.0175	0.0338
Schistosoma mansoni	hypothetical protein	0.0097	0.0315	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0973	0.2785
Trypanosoma cruzi	Aph-1 protein, putative	0.0184	0.0767	0.9136
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0224	0.0973	0.2785
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0126	0.0467	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0973	0.2785
Brugia malayi	nuclear hormone receptor	0.0098	0.0323	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Echinococcus granulosus	gamma secretase subunit aph 1	0.0473	0.2256	0.6935
Schistosoma mansoni	microtubule-associated protein tau	0.0667	0.3253	1
Schistosoma mansoni	nuclear hormone receptor	0.0098	0.0323	0.0651
Schistosoma mansoni	nuclear receptor	0.0098	0.0323	0.0651
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0198	0.084	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0098	0.0323	0.0993
Leishmania major	presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative	0.0198	0.084	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0126	0.0467	0.1109
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0224	0.0973	0.2991
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0098	0.0323	0.0993
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0467	0.1232
Toxoplasma gondii	hypothetical protein	0.007	0.0175	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0224	0.0973	0.2991
Schistosoma mansoni	hypothetical protein	0.0122	0.0444	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0224	0.0973	0.2991
Trypanosoma brucei	presenilin-like aspartic peptidase, putative	0.0198	0.084	1
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0174	0.0716	0.1308
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.032	0.1464	0.45
Brugia malayi	ecdysone receptor	0.0098	0.0323	0.0791
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0198	0.084	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0224	0.0973	0.2785
Echinococcus multilocularis	Nicastrin	0.0097	0.0315	0.097
Brugia malayi	Steroid receptor seven-up type 2	0.0224	0.0973	0.2785
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0119	0.1936
Schistosoma mansoni	thyroid hormone receptor	0.0346	0.16	0.4725
Brugia malayi	nuclear receptor RXR	0.0126	0.0467	0.1232
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0224	0.0973	0.2991
Brugia malayi	Nuclear hormone receptor E75	0.0098	0.0323	0.0791
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0224	0.0973	0.2991
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.0444	0.1364
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0098	0.0323	0.0993
Brugia malayi	nuclear receptor NHR-88	0.0224	0.0973	0.2785
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0224	0.0973	0.2724
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0224	0.0973	0.2785
Echinococcus granulosus	microtubule associated protein 2	0.0667	0.3253	1
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0198	0.084	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0323	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0973	0.2785
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0224	0.0973	0.2724
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0224	0.0973	0.2785
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0126	0.0467	0.1232

Activities

Activity type	Activity value	Assay description	Source	Reference
AUC (ADMET)	= 34 uM.hr	AUC (0-6h) in rat at 10 mg/kg, po	ChEMBL.	17181143
IC50 (functional)	= 2.4 nM	Inhibition of CXCL1-induced human neutrophil chemotaxis	ChEMBL.	17181143
IC50 (functional)	= 2.4 nM	Inhibition of CXCL1-induced human neutrophil chemotaxis	ChEMBL.	17181143
IC50 (binding)	= 5.4 nM	Displacement of [125I]hCXCL8 from human CXCR2 receptor expressed in BaF3 cells	ChEMBL.	17181143
IC50 (binding)	= 5.4 nM	Displacement of [125I]hCXCL8 from human CXCR2 receptor expressed in BaF3 cells	ChEMBL.	17181143
IC50 (functional)	= 251 nM	Inhibition of CXCL8-induced human neutrophil chemotaxis	ChEMBL.	17181143
IC50 (functional)	= 251 nM	Inhibition of CXCL8-induced human neutrophil chemotaxis	ChEMBL.	17181143
IC50 (binding)	= 775 nM	Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cells	ChEMBL.	17181143
IC50 (binding)	= 775 nM	Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cells	ChEMBL.	17181143
Ratio IC50 (binding)	> 100	Selectivity for CXCR2 over CXCR1	ChEMBL.	17181143
Ratio IC50 (binding)	> 100	Selectivity for CXCR2 over CXCR1	ChEMBL.	17181143

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL216602
PubChem: 16098481

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 409560