Detailed information for compound 40957

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 492.474 | Formula: C27H24O9
  • H donors: 2 H acceptors: 3 LogP: 3.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1O)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)Oc1ccc(cc1)O
  • InChi: 1S/C27H24O9/c1-31-21-7-13(8-22(32-2)25(21)29)23-16-9-19-20(35-12-34-19)10-17(16)26(18-11-33-27(30)24(18)23)36-15-5-3-14(28)4-6-15/h3-10,18,23-24,26,28-29H,11-12H2,1-2H3/t18-,23+,24-,26+/m0/s1
  • InChiKey: USZSVEZSUGAITN-DLTDCEFJSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.0085 0.0493
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0014 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0013 0.0062
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0012 0.1525
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0009 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0009 0.0009
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0014 0.007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0009 0.0009
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0076 0.177
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0006 0.168
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.0076 0.1778
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0103 0.0061 0.0061
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0002 0.0246
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0014 0.007
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0008 0.003
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0135 0.0083 0.0083
Schistosoma mansoni neuroligin 3 (S09 family) 0.2422 0.1681 0.168
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0014 0.007
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0014 0.0425
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0076 0.0076
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0135 0.0083 0.0482
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0009 0.0009
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0003 0.0002
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2422 0.1681 0.168
Schistosoma mansoni jumonji domain containing protein 0.006 0.0031 0.0031
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0008 0.0923
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0003 0.0296
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0023 0.0023
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0003 0.027
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0613 0.0417 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0068 0.0068
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0049 0.0049
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0004 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0014 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.2422 0.1681 0.1681
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0031 0.0031
Brugia malayi jmjC domain containing protein 0.006 0.0031 0.0031
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0012 0.1525
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0009 0.0009
Echinococcus multilocularis protein patched 0.0048 0.0023 0.0023
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 1.4334 1 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0031 0.0031
Onchocerca volvulus 0.0103 0.0061 0.0321
Loa Loa (eye worm) hypothetical protein 0.2422 0.1681 0.1681
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0004 0.0003
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0004 0.0003
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0076 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0417 0.2472
Loa Loa (eye worm) hypothetical protein 0.0036 0.0014 0.0014
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0013 0.025
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0003 0.0842
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0002 0.0002
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0013 0.025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0012 0.0012
Treponema pallidum fructose-bisphosphate aldolase 0.0613 0.0417 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0014 0.0014
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0014 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0158 0.01 0.0099
Brugia malayi hypothetical protein 0.0505 0.0342 0.0342
Echinococcus granulosus para nitrobenzyl esterase 0.2422 0.1681 0.168
Schistosoma mansoni hypothetical protein 0.0047 0.0022 0.0021
Loa Loa (eye worm) intermediate filament protein 0.0029 0.001 0.0009
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.2422 0.1681 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0014 0.1811
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0014 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0012 0.0012
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0004 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.0149 0.0871
Echinococcus granulosus acetylcholinesterase 1.4334 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0009 0.0009
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0225
Echinococcus granulosus expressed conserved protein 0.0106 0.0063 0.0063
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.0076 0.3611
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0012 0.0012
Onchocerca volvulus 0.0066 0.0036 0.0167
Mycobacterium leprae Possible regulatory protein 0.0026 0.0008 0.0076
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.0076 0.0076
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0009 0.0009
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.0085 0.4111
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0009 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0009 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0014 0.0014
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0008 0.0923
Leishmania major protein kinase, putative 0.0026 0.0008 0.0844
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0417 0.2472
Leishmania major protein kinase, putative 0.0026 0.0008 0.0844
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0003 0.0296
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0004 0.0003
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0004 0.0003
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0004 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0009 0.0009
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0023 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0417 0.2472
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0008 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0002 0.0702
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0034 0.0033
Mycobacterium tuberculosis Probable reductase 0.0123 0.0076 0.0435
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0004 0.0003
Brugia malayi glutathione reductase 0.0054 0.0027 0.0027
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0012 0.1394
Brugia malayi beta-lactamase family protein 0.0036 0.0014 0.0014
Leishmania major hypothetical protein, conserved 0.0036 0.0014 0.1655
Loa Loa (eye worm) hypothetical protein 0.2422 0.1681 0.1681
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0009 0.0009
Plasmodium vivax glutathione reductase, putative 0.0054 0.0027 0.7624
Mycobacterium ulcerans beta-lactamase 0.0036 0.0014 0.007
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.0068 0.0067
Brugia malayi beta-lactamase family protein 0.0036 0.0014 0.0014
Brugia malayi steroid hormone receptor 0.0029 0.0009 0.0009
Mycobacterium tuberculosis Carboxylesterase LipT 0.2422 0.1681 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.003
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.0076 0.0439
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0004 0.0004
Echinococcus granulosus bloom syndrome protein 0.0023 0.0005 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0013 0.0062
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0002 0.0002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0135 0.0083 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0012 0.1525
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.2422 0.1681 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0004 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.001 0.0009
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0004 0.0003
Plasmodium vivax SET domain protein, putative 0.0066 0.0036 1
Entamoeba histolytica hypothetical protein 0.0021 0.0004 0.0021
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0012 0.0012
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0005 0.0017
Onchocerca volvulus 0.0074 0.0041 0.0201
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0004 0.0003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0012 0.4342
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0006 0.3519
Onchocerca volvulus 0.0036 0.0014 0.004
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0013 0.3579
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0417 0.2472
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0004 0.0003
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0002 0.0702
Loa Loa (eye worm) RecQ helicase 0.0023 0.0005 0.0005
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0004 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0009 0.0009
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0008 0.003
Mycobacterium ulcerans carboxylesterase, LipT 0.2422 0.1681 1
Brugia malayi jmjC domain containing protein 0.006 0.0031 0.0031
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0021 0.0004 0.0021
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0076 0.177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0246
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0013 0.4608
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0027 0.3511
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0004 0.0003
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0004 0.0003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0135 0.0083 0.0083
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0076 0.177
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0004 0.0003
Loa Loa (eye worm) carboxylesterase 0.2422 0.1681 0.1681
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0246
Mycobacterium leprae Probable lipase LipE 0.0036 0.0014 0.0425
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0009 0.0009
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0031 0.0031
Echinococcus multilocularis neuroligin 0.2422 0.1681 0.168
Schistosoma mansoni hypothetical protein 0.0047 0.0022 0.0021
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0008 0.0923
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0023 0.0123
Brugia malayi phosphofructokinase 0.0124 0.0076 0.0076
Toxoplasma gondii thioredoxin reductase 0.0054 0.0027 0.3255
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0012 0.0012
Onchocerca volvulus 0.0029 0.001 0.0012
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0012 0.1452
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0004 0.0003
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0006 0.0729
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0013 0.1536
Schistosoma mansoni aldehyde dehydrogenase 0.0135 0.0083 0.0083
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0299 0.0198 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0009 0.0009
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.0068 0.0067
Mycobacterium tuberculosis Conserved protein 0.0036 0.0014 0.007
Schistosoma mansoni lamin 0.0029 0.001 0.0009
Echinococcus granulosus expressed protein 0.04 0.0269 0.0268
Loa Loa (eye worm) beta-lactamase 0.0036 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0009 0.0009
Onchocerca volvulus 0.2422 0.1681 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.0076 0.3645
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2422 0.1681 0.168
Schistosoma mansoni aldehyde dehydrogenase 0.0135 0.0083 0.0083
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0014 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0009 0.0009
Schistosoma mansoni BC026374 protein (S09 family) 0.2422 0.1681 0.168
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0012 0.0012
Loa Loa (eye worm) phosphofructokinase 0.0124 0.0076 0.0076
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.0076 0.0076
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0001 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0014 0.1811
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0066 0.0036 0.0035
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0031 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0036 0.0035
Schistosoma mansoni glutaminase 0.0564 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.0076 0.9142
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0003
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0006 0.0022
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0003
Echinococcus multilocularis acetylcholinesterase 1.4334 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0003 0.0003
Echinococcus granulosus lamin dm0 0.0029 0.001 0.0009
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0013 1
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0003
Echinococcus multilocularis BC026374 protein (S09 family) 0.2422 0.1681 0.168
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0009 0.0009
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.2422 0.1681 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0002 0.0246
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.0076 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0036 0.0035
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0004 0.0003
Brugia malayi PXA domain containing protein 0.0021 0.0004 0.0004
Mycobacterium ulcerans putative regulatory protein 0.0074 0.0041 0.0231
Onchocerca volvulus 0.0085 0.0049 0.0247
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0004 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0009 0.0009
Toxoplasma gondii ABC1 family protein 0.0036 0.0014 0.1711
Echinococcus multilocularis para nitrobenzyl esterase 0.2422 0.1681 0.168
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0014 0.1811
Loa Loa (eye worm) hypothetical protein 0.2422 0.1681 0.1681
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.0076 0.0435
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0009 0.0009
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0008 0.0923
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0014 0.007
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0004 0.0003
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0008 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0009 0.0009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.0085 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0007
Onchocerca volvulus 0.2422 0.1681 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0004 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0009 0.0009
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0225
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Giardia lamblia Fructose-bisphosphate aldolase 0.0613 0.0417 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0246
Brugia malayi hypothetical protein 0.0021 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0004 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0009 0.0009
Brugia malayi Pre-SET motif family protein 0.0066 0.0036 0.0035
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.0076 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0009 0.0009
Onchocerca volvulus 0.0036 0.0014 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0007
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0002 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0085 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0036 0.0014 0.0014
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0009 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0002 0.0246
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0002 0.0246
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0049 0.0048
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.2422 0.1681 0.1681
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0009 0.0009
Onchocerca volvulus 0.0029 0.001 0.0012
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0004 0.0003
Onchocerca volvulus 0.0036 0.0014 0.004
Echinococcus multilocularis acetylcholinesterase 1.4334 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0417 0.2472
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0008 0.003
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0009 0.0009
Onchocerca volvulus 0.0525 0.0356 0.2082
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0003 0.0002
Brugia malayi hypoxia-induced factor 1 0.0311 0.0206 0.0206
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0012 0.0058
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0009 0.0012
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0004 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0129 0.0079 0.0079
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.0076 0.0435
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0004 0.0003
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0001 0.0067
Loa Loa (eye worm) glutathione reductase 0.0054 0.0027 0.0027
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0002 0.0291
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0417 0.2472
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0014 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0047 0.0022 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0036 0.0035
Loa Loa (eye worm) carboxylesterase 0.2422 0.1681 0.1681
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0004 0.0003
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0012 0.1452
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.001 0.0009
Echinococcus multilocularis lamin 0.0029 0.001 0.0009
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0003 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0076 0.0439
Echinococcus granulosus lamin 0.0029 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0009 0.0009
Echinococcus granulosus BC026374 protein S09 family 0.2422 0.1681 0.168
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0012 0.338
Brugia malayi beta-lactamase 0.0036 0.0014 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0337 0.0224 0.0224
Trichomonas vaginalis esterase, putative 0.0036 0.0014 0.007
Schistosoma mansoni lamin 0.0029 0.001 0.0009
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0012 0.0012
Mycobacterium ulcerans lipase LipD 0.0036 0.0014 0.007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0002 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0014 0.0014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0003 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0009 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0246
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0024 0.0006 0.0079
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0002 0.0246
Trichomonas vaginalis spcc417.12 protein, putative 0.2422 0.1681 1
Brugia malayi Carboxylesterase family protein 1.4334 1 1
Plasmodium falciparum glutathione reductase 0.0054 0.0027 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0006 0.2076
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.0076 0.0435
Onchocerca volvulus 0.2422 0.1681 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0049 0.0048
Plasmodium falciparum glutathione reductase 0.0019 0.0002 0.0702
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.2422 0.1681 0.1681
Schistosoma mansoni survival motor neuron protein 0.0103 0.0061 0.0061
Mycobacterium tuberculosis Conserved protein 0.0036 0.0014 0.007
Loa Loa (eye worm) glutaminase 2 0.0564 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0083 0.0482
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0008 0.0923
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0009 0.0009
Plasmodium falciparum thioredoxin reductase 0.0019 0.0002 0.0702
Mycobacterium ulcerans glutaminase 0.0564 0.0383 0.2268
Brugia malayi nuclear receptor NHR-88 0.0029 0.0009 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0002 0.0649
Loa Loa (eye worm) hypothetical protein 1.4334 1 1
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0008 0.0007
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0027 0.0027
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0005 0.0005
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0031 0.0031
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0013 0.0062
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0006 0.0729
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0013 0.0062
Loa Loa (eye worm) hypothetical protein 0.0048 0.0023 0.0023
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0076 0.0439
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0027 0.0027
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.0085 0.0493
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0003 0.0009
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0008 0.4936
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0013 0.0241
Brugia malayi hypothetical protein 0.0337 0.0224 0.0224
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0083 0.0482
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0003 0.1054
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0076 1
Brugia malayi Pre-SET motif family protein 0.0461 0.0311 0.0311
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0013 0.1536
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0006 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0613 0.0417 1
Brugia malayi bHLH-PAS transcription factor 0.0074 0.0041 0.0041
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0008 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0009 0.0009
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0004 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0002 0.0225
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0009 0.0009
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0002 0.0246
Trypanosoma brucei trypanothione reductase 0.0054 0.0027 0.3511
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0299 0.0198 0.1168
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0004 0.0004
Loa Loa (eye worm) acetylcholinesterase 1 1.4334 1 1
Plasmodium vivax JmjC domain containing protein 0.0016 0.0001 0.0122
Schistosoma mansoni gliotactin 0.2422 0.1681 0.168
Echinococcus granulosus intermediate filament protein 0.0029 0.001 0.0009
Brugia malayi glutaminase DH11.1 0.0564 0.0383 0.0383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0009 0.0009
Echinococcus multilocularis expressed protein 0.04 0.0269 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.2422 0.1681 0.1681
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0003 0.1022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0003 0.0296
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0003 0.0754
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0012 0.0012
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0047 0.0022 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0246
Onchocerca volvulus 0.0029 0.0009 0.0012
Echinococcus multilocularis protein dispatched 1 0.0055 0.0028 0.0027
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.2422 0.1681 0.168
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0076 0.0439
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0003 0.0002
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0008 0.003
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0012 0.1525
Trichomonas vaginalis glutaminase, putative 0.0564 0.0383 0.2268
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0036 0.4265
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0004 0.0003
Brugia malayi PXA domain containing protein 0.0021 0.0004 0.0004
Schistosoma mansoni coup transcription factor 0.0029 0.0009 0.0009
Mycobacterium tuberculosis Conserved protein 0.0036 0.0014 0.007
Echinococcus granulosus family S9 non peptidase ue S09 family 0.2422 0.1681 0.168
Brugia malayi CHE-14 protein 0.0048 0.0023 0.0023
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0014 0.007
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0004 0.0003
Echinococcus granulosus neuroligin 0.2422 0.1681 0.168
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0036 0.0035
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0002 0.0291
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0079 0.0079
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0006 0.0729
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0083 0.0482
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0009 0.0009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0009 0.0012
Trichomonas vaginalis set domain proteins, putative 0.0525 0.0356 0.2106
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0076 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0013 0.0062
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0076 0.0076
Toxoplasma gondii aldehyde dehydrogenase 0.0135 0.0083 1
Onchocerca volvulus 0.2422 0.1681 1
Brugia malayi hypothetical protein 0.0021 0.0004 0.0004
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0006 0.0022
Echinococcus multilocularis lamin dm0 0.0029 0.001 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0014 0.007
Brugia malayi 6-phosphofructokinase 0.0124 0.0076 0.0076
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0013 0.3579
Loa Loa (eye worm) hypothetical protein 0.0036 0.0014 0.0014
Brugia malayi isocitrate dehydrogenase 0.0033 0.0012 0.0012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0036 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0013 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0009 0.0009
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0014 0.007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0009 0.0009
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0014 0.0014
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 1.4334 1 1
Plasmodium falciparum thioredoxin reductase 0.0054 0.0027 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0008 0.0007
Schistosoma mansoni aryl hydrocarbon receptor 0.01 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0505 0.0342 0.0342
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0005 0.0017
Echinococcus granulosus carboxylesterase 5A 1.4334 1 1
Entamoeba histolytica hypothetical protein 0.0021 0.0004 0.0021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0061 0.0061
Onchocerca volvulus 0.2422 0.1681 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0004 0.0004
Echinococcus granulosus survival motor neuron protein 1 0.0505 0.0342 0.0341
Echinococcus multilocularis carboxylesterase 5A 1.4334 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0031 0.0031
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2422 0.1681 0.168
Brugia malayi hypothetical protein 0.2422 0.1681 0.1681
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0031 0.0031
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0008 0.003
Schistosoma mansoni thyroid hormone receptor 0.0158 0.01 0.0099
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0005 0.0005
Schistosoma mansoni single-minded 0.01 0.0059 0.0059
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0002 0.0649
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0023 0.0023
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.0008 0.003
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.0076 0.0439
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0014 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0417 0.2472
Loa Loa (eye worm) hypothetical protein 0.0363 0.0243 0.0243
Echinococcus multilocularis geminin 0.0349 0.0233 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0036 0.0035
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0013 0.4608
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0003 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0004 0.0004
Echinococcus granulosus single minded 2 0.0074 0.0041 0.0041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0009 0.0009
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0004 0.0004
Loa Loa (eye worm) carboxylesterase 1.4334 1 1
Echinococcus multilocularis transfer RNA-Lys 0.0074 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0029 0.001 0.0009
Echinococcus multilocularis Niemann Pick C1 protein 0.0161 0.0102 0.0101
Echinococcus multilocularis thyroid hormone receptor alpha 0.0158 0.01 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0014 0.0014
Brugia malayi ecdysteroid receptor 0.0029 0.0009 0.0009
Brugia malayi Carboxylesterase family protein 0.2422 0.1681 0.1681
Loa Loa (eye worm) glutaminase 0.0564 0.0383 0.0383
Mycobacterium ulcerans hypothetical protein 0.0036 0.0014 0.007
Schistosoma mansoni hypothetical protein 0.0349 0.0233 0.0233
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0027 0.7624
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0014 0.007
Loa Loa (eye worm) hypoxia-induced factor 1 0.0311 0.0206 0.0206
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0012 0.0012
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.0008 0.0007
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0009 0.0009
Brugia malayi nuclear hormone receptor 0.0029 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0009 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0076 0.0439
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0004 0.0004
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0006 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0014 0.007
Toxoplasma gondii exonuclease III APE 0.0019 0.0003 0.0336
Echinococcus multilocularis musashi 0.0029 0.001 0.0009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0461 0.0311 0.0311
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0009 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0417 0.2472
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0004 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0013 0.0062
Echinococcus granulosus Niemann Pick C1 protein 0.0161 0.0102 0.0101
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0013 0.1536
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.003
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0055 0.0028 0.0027
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.0068 0.1573
Schistosoma mansoni hypothetical protein 0.0349 0.0233 0.0233
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0006 0.0088
Echinococcus granulosus acetylcholinesterase 1.4334 1 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0014 0.3991
Brugia malayi Carboxylesterase family protein 0.2422 0.1681 0.1681
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0114 0.0069 0.0069
Brugia malayi PAS domain containing protein 0.01 0.0059 0.0059
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0013 1
Brugia malayi Thioredoxin reductase 0.0054 0.0027 0.0027
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0003
Brugia malayi hypothetical protein 0.0139 0.0087 0.0086
Brugia malayi Carboxylesterase family protein 0.2422 0.1681 0.1681
Brugia malayi 6-phosphofructokinase 0.0124 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0009 0.0009
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0008 0.0923
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0299 0.0198 0.1168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0014 0.0014
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0006 0.0666
Leishmania major trypanothione reductase 0.0054 0.0027 0.321
Schistosoma mansoni acetylcholinesterase 0.2422 0.1681 0.168
Schistosoma mansoni intermediate filament proteins 0.0029 0.001 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0014 0.007
Brugia malayi Carboxylesterase family protein 0.2422 0.1681 0.1681
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0076 0.0076
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0027 0.0147
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0004 0.0003
Schistosoma mansoni patched 1 0.0048 0.0023 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0003 0.0002
Echinococcus multilocularis expressed conserved protein 0.0106 0.0063 0.0063
Echinococcus granulosus geminin 0.0349 0.0233 0.0233
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0009 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0036 0.0035
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0002 0.0246
Echinococcus multilocularis survival motor neuron protein 1 0.0505 0.0342 0.0341
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0002 0.0225
Brugia malayi intermediate filament protein 0.0029 0.001 0.0009
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0027 0.0027

Activities

Activity type Activity value Assay description Source Reference
Complex formation (binding) = 34 % Percentage of intracellular covalent DNA-topoisomerase II complexes formed ChEMBL. 12014968
Complex formation (binding) = 34 % Percentage of intracellular covalent DNA-topoisomerase II complexes formed ChEMBL. 12014968
Formation (functional) = 34 % Inhibition of cellular protein-DNA complex formation at 10 microM ChEMBL. 2167985
ID50 (functional) < 1 uM Concentration for 50% reduction in cell number after 3-day incubation ChEMBL. 2167985
ID50 (binding) = 50 uM Inhibitory activity against human DNA topoisomerase II ChEMBL. 2167985
ID50 (binding) = 50 uM Inhibitory activity against human DNA topoisomerase II ChEMBL. 2167985
Protein-DNA complex formation (functional) = 34 % Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. ChEMBL. 8691468
Protein-DNA complex formation (functional) = 34 % Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. ChEMBL. 8691468

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

3 literature references were collected for this gene.

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