Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Cathepsin B precursor | 0.0621 | 0.1663 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0783 | 0.3036 | 0.3036 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0783 | 0.3036 | 0.3036 |
Echinococcus granulosus | cathepsin l1 | 0.0783 | 0.3036 | 0.3036 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0539 | 0.0966 | 0.0966 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0621 | 0.1663 | 0.5478 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0783 | 0.3036 | 0.3036 |
Plasmodium vivax | vivapain-2 | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0783 | 0.3036 | 0.3036 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0621 | 0.1663 | 0.1663 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0783 | 0.3036 | 0.3036 |
Echinococcus multilocularis | cysteine protease | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Onchocerca volvulus | 0.0783 | 0.3036 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0539 | 0.0966 | 0.3182 |
Echinococcus multilocularis | cathepsin b | 0.1606 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0783 | 0.3036 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0539 | 0.0966 | 0.0966 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0783 | 0.3036 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0783 | 0.3036 | 1 |
Leishmania major | cathepsin L-like protease | 0.0783 | 0.3036 | 1 |
Leishmania major | cathepsin L-like protease | 0.0783 | 0.3036 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0783 | 0.3036 | 0.2291 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0783 | 0.3036 | 0.3036 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0783 | 0.3036 | 0.3036 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0783 | 0.3036 | 0.3036 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0539 | 0.0966 | 0.3182 |
Toxoplasma gondii | cathepsin CPL | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0783 | 0.3036 | 0.3036 |
Giardia lamblia | Cathepsin B precursor | 0.0621 | 0.1663 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0783 | 0.3036 | 0.2291 |
Echinococcus multilocularis | cathepsin b | 0.1606 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1606 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0539 | 0.0966 | 0.0966 |
Echinococcus granulosus | cathepsin b | 0.1606 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1606 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1606 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0621 | 0.1663 | 0.0772 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Onchocerca volvulus | 0.0783 | 0.3036 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0783 | 0.3036 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0621 | 0.1663 | 0.1663 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Onchocerca volvulus | 0.0783 | 0.3036 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0783 | 0.3036 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Onchocerca volvulus | 0.0783 | 0.3036 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0783 | 0.3036 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0539 | 0.0966 | 0.0966 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Leishmania major | cathepsin L-like protease | 0.0783 | 0.3036 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0539 | 0.0966 | 0.0966 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0783 | 0.3036 | 0.3036 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0539 | 0.0966 | 0.3182 |
Loa Loa (eye worm) | fibroinase | 0.0783 | 0.3036 | 0.2291 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0783 | 0.3036 | 0.3036 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0783 | 0.3036 | 0.2291 |
Onchocerca volvulus | 0.0783 | 0.3036 | 1 | |
Onchocerca volvulus | 0.0783 | 0.3036 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0783 | 0.3036 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1606 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0783 | 0.3036 | 0.3036 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1606 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0539 | 0.0966 | 0.0966 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0783 | 0.3036 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Leishmania major | cathepsin L-like protease | 0.0783 | 0.3036 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0621 | 0.1663 | 0.5478 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0783 | 0.3036 | 0.2291 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0783 | 0.3036 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0783 | 0.3036 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1606 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0783 | 0.3036 | 0.3036 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0783 | 0.3036 | 0.2291 |
Onchocerca volvulus | 0.0783 | 0.3036 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0621 | 0.1663 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0783 | 0.3036 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0783 | 0.3036 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0539 | 0.0966 | 0.0966 |
Leishmania major | cathepsin L-like protease | 0.0783 | 0.3036 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1606 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0783 | 0.3036 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 55.8 % | Cytotoxicity against HCT116 cell line xenografted in NMRI nu/nu mouse at 10 umol/kg relative to control | ChEMBL. | 17154520 |
Activity (functional) | = 55.8 % | Cytotoxicity against HCT116 cell line xenografted in NMRI nu/nu mouse at 10 umol/kg relative to control | ChEMBL. | 17154520 |
IC50 (functional) | = 37 uM | Cytotoxicity against doxorubicin-sensitive MCF7/6 cell line by WST1 assay | ChEMBL. | 17154520 |
IC50 (functional) | = 37 uM | Cytotoxicity against doxorubicin-sensitive MCF7/6 cell line by WST1 assay | ChEMBL. | 17154520 |
IC50 (functional) | = 121 uM | Cytotoxicity against doxorubicin-resistant MCF7/Adr cell line by WST1 assay | ChEMBL. | 17154520 |
IC50 (functional) | = 121 uM | Cytotoxicity against doxorubicin-resistant MCF7/Adr cell line by WST1 assay | ChEMBL. | 17154520 |
IC50 (functional) | = 153 uM | Cytotoxicity against doxorubicin-sensitive HCT116 cell line by WST1 assay | ChEMBL. | 17154520 |
IC50 (functional) | = 153 uM | Cytotoxicity against doxorubicin-sensitive HCT116 cell line by WST1 assay | ChEMBL. | 17154520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.