Detailed information for compound 409776

Basic information

Technical information
  • TDR Targets ID: 409776
  • Name: (2S)-2-amino-3-(3,4-difluorophenyl)-N-hydroxy propanamide
  • MW: 216.185 | Formula: C9H10F2N2O2
  • H donors: 3 H acceptors: 2 LogP: 0.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)[C@H](Cc1ccc(c(c1)F)F)N
  • InChi: 1S/C9H10F2N2O2/c10-6-2-1-5(3-7(6)11)4-8(12)9(14)13-15/h1-3,8,15H,4,12H2,(H,13,14)/t8-/m0/s1
  • InChiKey: YDIDRLKDMSKUDO-QMMMGPOBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-amino-3-(3,4-difluorophenyl)propanehydroxamic acid
  • (2S)-2-azanyl-3-(3,4-difluorophenyl)-N-hydroxy-propanamide
  • (2S)-2-amino-3-(3,4-difluorophenyl)-N-hydroxy-propanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens c-src tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi SH2 domain containing protein Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus multilocularis tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus multilocularis c src tyrosine kinase Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus granulosus tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus granulosus c src tyrosine kinase Get druggable targets OG5_133402 All targets in OG5_133402
Loa Loa (eye worm) TK/CSK protein kinase Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus multilocularis tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus multilocularis tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus granulosus tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus granulosus tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Onchocerca volvulus Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus multilocularis tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Schistosoma japonicum Tyrosine-protein kinase CSK, putative Get druggable targets OG5_133402 All targets in OG5_133402
Loa Loa (eye worm) SH2 domain-containing protein Get druggable targets OG5_133402 All targets in OG5_133402
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0219 0.0219
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0219 0.0219
Giardia lamblia Cathepsin L-like protease 0.0012 0.0589 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0219 0.0219
Plasmodium vivax unspecified product 0.0035 0.4404 0.4054
Giardia lamblia Cathepsin B precursor 0.0012 0.0589 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0012 0.0589 0.5
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.4404 0.4404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Brugia malayi Cathepsin L-like precursor 0.0067 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0067 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0067 1 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.2275 0.2275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0589 0.0589
Schistosoma mansoni tyrosine kinase 0.001 0.0219 0.0219
Schistosoma mansoni cathepsin B (C01 family) 0.0012 0.0589 0.0589
Leishmania major cathepsin L-like protease 0.0067 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.6185 0.6185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Brugia malayi Cathepsin L-like precursor 0.0067 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0012 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0012 0.0589 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0067 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.2275 0.2275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 1 1
Onchocerca volvulus 0.0067 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0589 0.0589
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0012 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0035 0.4404 0.4054
Onchocerca volvulus 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0589 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Giardia lamblia Cathepsin L precursor 0.0012 0.0589 0.5
Brugia malayi Cathepsin L-like cysteine proteinase 0.0045 0.6185 0.6185
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0022 0.2275 0.2275
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0012 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0045 0.6185 0.6185
Leishmania major cathepsin L-like protease 0.0067 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0219 0.0219
Brugia malayi cathepsin L-like precursor 0.0045 0.6185 0.6185
Loa Loa (eye worm) hypothetical protein 0.0012 0.0589 0.0589
Brugia malayi Cathepsin L-like precursor 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0067 1 1
Leishmania major cathepsin L-like protease 0.0067 1 1
Entamoeba histolytica cysteine proteinase 2 0.0035 0.4404 0.4054
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0219 0.0219
Giardia lamblia Hypothetical protein 0.0012 0.0589 0.5
Echinococcus multilocularis cathepsin L 0.0035 0.4404 0.4404
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0067 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0012 0.0589 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0219 0.0219
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0219 0.0219
Echinococcus granulosus tyrosine protein kinase csk 0.004 0.5241 0.5241
Echinococcus multilocularis cysteine protease 0.0067 1 1
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0067 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0035 0.4404 0.4404
Giardia lamblia Cathepsin B precursor 0.0012 0.0589 0.5
Schistosoma mansoni tyrosine kinase 0.001 0.0219 0.0219
Brugia malayi Cathepsin L-like precursor 0.0067 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.004 0.5241 0.5241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0589 0.0589
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0219 0.0219
Brugia malayi Cathepsin L-like precursor 0.0067 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0589 0.0589
Echinococcus granulosus cysteine protease 0.0035 0.4404 0.4404
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0589 0.0589
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0589 0.0589
Trypanosoma cruzi cysteine proteinase, putative 0.0035 0.4404 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Giardia lamblia Cathepsin B precursor 0.0012 0.0589 0.5
Echinococcus multilocularis cathepsin b 0.0012 0.0589 0.0589
Echinococcus granulosus cathepsin l1 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 1 1
Echinococcus multilocularis cathepsin b 0.0012 0.0589 0.0589
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0045 0.6185 0.5946
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0035 0.4404 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0012 0.0589 0.0589
Giardia lamblia Cathepsin L-like protease 0.0012 0.0589 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0067 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0022 0.2275 0.2275
Giardia lamblia Cathepsin B precursor 0.0012 0.0589 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.2275 0.2275
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0012 0.0589 0.0589
Brugia malayi Cathepsin L-like precursor 0.0045 0.6185 0.6185
Toxoplasma gondii cathepsin CPL 0.0067 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0035 0.4404 0.4404
Onchocerca volvulus 0.0067 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0219 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Echinococcus multilocularis cathepsin L 0.0012 0.0589 0.0589
Plasmodium falciparum cysteine proteinase falcipain 3 0.0067 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0219 0.0219
Onchocerca volvulus 0.0067 1 1
Echinococcus granulosus cathepsin b 0.0012 0.0589 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0012 0.0589 0.0589
Loa Loa (eye worm) ctsf protein 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.4404 0.4054
Brugia malayi SRC-1 0.001 0.0219 0.0219
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0219 0.0219
Leishmania major cathepsin L-like protease 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0067 1 1
Schistosoma mansoni tyrosine kinase 0.0049 0.6782 0.6782
Leishmania major cathepsin L-like protease 0.0067 1 1
Loa Loa (eye worm) TK/CSK protein kinase 0.004 0.5241 0.5241
Giardia lamblia Cathepsin L precursor 0.0012 0.0589 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.004 0.5241 0.5241
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0067 1 1
Onchocerca volvulus Cathepsin L homolog 0.0067 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0012 0.0589 0.0589
Echinococcus granulosus tyrosine protein kinase Lyn 0.001 0.0219 0.0219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0589 0.0589
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0012 0.0589 0.0589
Entamoeba histolytica cysteine proteinase, putative 0.0067 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.4404 0.4054
Onchocerca volvulus Cathepsin F homolog 0.0067 1 1
Plasmodium vivax unspecified product 0.0022 0.2275 0.1791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Giardia lamblia Cysteine protease 0.0012 0.0589 0.5
Giardia lamblia Hypothetical protein 0.0012 0.0589 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0049 0.6782 0.6782
Giardia lamblia Cysteine protease 0.0012 0.0589 0.5
Giardia lamblia Cathepsin L precursor 0.0012 0.0589 0.5
Loa Loa (eye worm) cathepsin B 0.0012 0.0589 0.0589
Schistosoma mansoni cathepsin s 0.0022 0.2275 0.2275
Echinococcus granulosus cathepsin L 0.0012 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.4404 0.4054
Onchocerca volvulus 0.0044 0.6021 0.5772
Brugia malayi SH2 domain containing protein 0.0044 0.6021 0.6021
Echinococcus multilocularis tyrosine protein kinase csk 0.004 0.5241 0.5241
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.2275 0.2275
Echinococcus granulosus cathepsin L 0.0035 0.4404 0.4404
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0219 0.0219
Giardia lamblia Cathepsin B precursor 0.0012 0.0589 0.5
Trypanosoma cruzi cysteine protease, putative 0.0035 0.4404 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0067 1 1
Loa Loa (eye worm) fibroinase 0.0067 1 1
Brugia malayi Cathepsin L-like precursor 0.0045 0.6185 0.6185
Loa Loa (eye worm) SRC-1 0.001 0.0219 0.0219
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 1 1
Leishmania major cathepsin L-like protease 0.0067 1 1
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0067 1 1
Onchocerca volvulus Cathepsin L homolog 0.0067 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.2275 0.2275
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0012 0.0589 0.0589
Giardia lamblia Cathepsin B precursor 0.0012 0.0589 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.4404 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0012 0.0589 0.0589
Onchocerca volvulus 0.0067 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0067 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0035 0.4404 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0589 0.0589
Leishmania major cysteine peptidase A (CPA) 0.0067 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.2275 0.1791
Entamoeba histolytica cysteine protease, putative 0.0067 1 1
Plasmodium vivax vivapain-1 0.0035 0.4404 0.4054
Leishmania major cathepsin L-like protease 0.0067 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.4404 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0067 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.4404 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 1 1
Brugia malayi fibroinase precursor 0.0012 0.0589 0.0589
Trypanosoma cruzi cysteine peptidase, putative 0.0067 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0067 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.6185 0.6185
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.4404 0.4054
Echinococcus multilocularis cysteine protease 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 1 1
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Schistosoma mansoni tyrosine kinase 0.001 0.0219 0.0219
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0219 0.0219
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.4404 0.4404
Loa Loa (eye worm) hypothetical protein 0.0012 0.0589 0.0589
Brugia malayi cathepsin Z-like cysteine proteinase 0.0012 0.0589 0.0589
Echinococcus granulosus c src tyrosine kinase 0.0049 0.6782 0.6782
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0067 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.004 0.5241 0.5241
Entamoeba histolytica cysteine proteinase 1, putative 0.0035 0.4404 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0589 0.0589
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.6185 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.6185 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0067 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0219 0.0219
Onchocerca volvulus 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0067 1 1
Brugia malayi cathepsin L precursor 0.0012 0.0589 0.0589
Plasmodium vivax vivapain-2 0.0067 1 1
Giardia lamblia Cysteine protease 0.0012 0.0589 0.5
Giardia lamblia Encystation-specific protease 0.0012 0.0589 0.5
Brugia malayi cathepsin B-like cysteine proteinase 0.0012 0.0589 0.0589
Plasmodium vivax vivapain-3 0.0035 0.4404 0.4054
Echinococcus granulosus cathepsin l1 0.0045 0.6185 0.6185
Giardia lamblia Cysteine protease 0.0012 0.0589 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0035 0.4404 0.4404
Giardia lamblia Cathepsin B precursor 0.0012 0.0589 0.5
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0012 0.0589 0.5
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Plasmodium vivax vivapain-2 0.0067 1 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0219 0.0219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0589 0.0589
Loa Loa (eye worm) cysteine protease 0.0067 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.6185 0.6185
Onchocerca volvulus 0.0067 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.004 0.5241 0.5241
Onchocerca volvulus 0.0045 0.6185 0.5946
Echinococcus granulosus cathepsin b 0.0012 0.0589 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0035 0.4404 0.4404
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Leishmania major cathepsin L-like protease 0.0067 1 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0012 0.0589 0.0589
Giardia lamblia Cathepsin L precursor 0.0012 0.0589 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0067 1 1
Giardia lamblia Cathepsin B precursor 0.0012 0.0589 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0219 0.0219
Giardia lamblia Cathepsin L precursor 0.0012 0.0589 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.4404 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0589 0.0589
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.4404 0.4054
Loa Loa (eye worm) SH2 domain-containing protein 0.0043 0.5802 0.5802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0219 0.0219
Giardia lamblia Cathepsin L precursor 0.0012 0.0589 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0067 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0589 0.0589
Echinococcus multilocularis tyrosine protein kinase csk 0.004 0.5241 0.5241
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.2275 0.1791
Schistosoma mansoni cathepsin C 0.0012 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0589 0.0589
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0589 0.0589
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0219 0.0219
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.6185 0.5946
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0589 0.0589
Entamoeba histolytica cysteine protease, putative 0.0035 0.4404 0.4054
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0589 0.0589
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0219 0.0219

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 18 uM Inhibition of CSK measured as poly-E4Y phosphorylation by acid precipitation assay in presence of 0.2 mM CoCl2 ChEMBL. 17149882
IC50 (functional) = 18 uM Inhibition of CSK measured as poly-E4Y phosphorylation by acid precipitation assay in presence of 0.2 mM CoCl2 ChEMBL. 17149882

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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