TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 547.65 | Formula: C32H33N7O2
H donors: 3 H acceptors: 3 LogP: 3.97 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: CCCn1c2ccc(cc2c2c1c1CCc3c(c1c1c2CNC1=O)cn(n3)C)NC(=O)Nc1ccc(cc1)N(C)C
InChi: 1S/C32H33N7O2/c1-5-14-39-26-13-8-19(35-32(41)34-18-6-9-20(10-7-18)37(2)3)15-22(26)28-23-16-33-31(40)29(23)27-21(30(28)39)11-12-25-24(27)17-38(4)36-25/h6-10,13,15,17H,5,11-12,14,16H2,1-4H3,(H,33,40)(H2,34,35,41)
InChiKey: VSIVBIKXDHFNBD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TEK tyrosine kinase, endothelial	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	steroid hormone receptor	0.0104	0.5387	0.5387
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1951	0.2185
Echinococcus granulosus	FTZ F1 alpha	0.0104	0.5387	0.6035
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0399	0.0399
Onchocerca volvulus		0.0167	0.9006	0.9645
Loa Loa (eye worm)	DR-78	0.0049	0.2209	0.2209
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.7544	0.8452
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0104	0.5387	0.6035
Echinococcus granulosus	nuclear receptor nhr 48	0.0049	0.2209	0.2475
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0104	0.5387	0.5387
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0104	0.5387	0.5387
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0049	0.2209	0.2475
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0104	0.5387	0.5387
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5387	0.5387
Schistosoma mansoni	nuclear hormone receptor	0.0104	0.5387	0.6035
Loa Loa (eye worm)	hypothetical protein	0.0055	0.2549	0.2549
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0104	0.5387	0.5387
Onchocerca volvulus		0.0049	0.2209	0.1566
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.1775	0.1988
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Brugia malayi	nuclear receptor RXR	0.0055	0.2549	0.2549
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0049	0.2209	0.2475
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0104	0.5387	0.6035
Brugia malayi	Steroid receptor seven-up type 2	0.0104	0.5387	0.5387
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0055	0.2549	0.2856
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0049	0.2209	0.2475
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0049	0.2209	0.1566
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0104	0.5387	0.6035
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0432	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0055	0.2549	0.2549
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0104	0.5387	0.5387
Schistosoma mansoni	nuclear receptor nhr-48	0.0049	0.2209	0.2475
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.7544	0.8452
Echinococcus granulosus	ecdysone induced protein 78C	0.0104	0.5387	0.6035
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0432	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1951	0.2185
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0021
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0432	0.0432
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0104	0.5387	0.5387
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1951	0.2185
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0105	0.0118
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0184	1	1
Echinococcus multilocularis	lamin	0.0026	0.0892	0.0999
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0233	0.0261
Echinococcus granulosus	lamin	0.0026	0.0892	0.0999
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0049	0.2209	0.2475
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0049	0.2209	0.2209
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0049	0.2209	0.2475
Schistosoma mansoni	hypothetical protein	0.0165	0.8926	1
Brugia malayi	nuclear receptor NHR-88	0.0104	0.5387	0.5387
Schistosoma mansoni	thyroid hormone receptor	0.0104	0.5387	0.6035
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1951	0.2185
Brugia malayi	nuclear receptor RXR	0.0049	0.2209	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5387	0.5387
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0892	0.0892
Brugia malayi	tailless protein	0.0049	0.2209	0.2209
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0104	0.5387	0.5387
Brugia malayi	nuclear receptor NHR-88	0.0049	0.2209	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5387	0.5387
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0104	0.5387	0.5387
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.1775	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0892	0.0892
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0104	0.5387	0.5387
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0432	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0432	0.0484
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0104	0.5387	0.6035
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0055	0.2549	0.2856
Brugia malayi	Nuclear hormone receptor E75	0.0049	0.2209	0.2209
Echinococcus granulosus	defective proboscis extension response	0.0011	0.0021	0.0024
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0021	0.0024
Brugia malayi	photoreceptor-specific nuclear receptor	0.0104	0.5387	0.5387
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.1775	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0104	0.5387	0.6035
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0233	0.0233
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0049	0.2209	0.2475
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0105	0.0105
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Onchocerca volvulus	Protein ultraspiracle homolog	0.0104	0.5387	0.5343
Echinococcus granulosus	geminin	0.0165	0.8926	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0104	0.5387	0.6035
Brugia malayi	Nuclear hormone receptor-like 1	0.0055	0.2549	0.2549
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1951	0.2185
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0272	0.0272
Brugia malayi	nuclear hormone receptor	0.0049	0.2209	0.2209
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0104	0.5387	0.5387
Schistosoma mansoni	coup transcription factor	0.0104	0.5387	0.6035
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0104	0.5387	0.6035
Brugia malayi	nuclear hormone receptor	0.0104	0.5387	0.5387
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.1775	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0892	0.0892
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0049	0.2209	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5387	0.5387
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5387	0.5387
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0892	0.0892
Echinococcus granulosus	twitchin	0.0014	0.0187	0.0209
Schistosoma mansoni	hypothetical protein	0.0165	0.8926	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0104	0.5387	0.6035
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0104	0.5387	0.5387
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0272	0.0272
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1951	0.1951
Schistosoma mansoni	thyroid hormone receptor	0.0104	0.5387	0.6035
Echinococcus multilocularis	lamin dm0	0.0026	0.0892	0.0999
Echinococcus multilocularis	nuclear receptor nhr 48	0.0049	0.2209	0.2475
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.1574	1
Schistosoma mansoni	lamin	0.0026	0.0892	0.0999
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0104	0.5387	0.6035
Brugia malayi	intermediate filament protein	0.0026	0.0892	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0104	0.5387	0.6035
Loa Loa (eye worm)	acetyltransferase	0.0141	0.7544	0.7544
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.1775	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0104	0.5387	0.5343
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0104	0.5387	0.6035
Echinococcus granulosus	lamin dm0	0.0026	0.0892	0.0999
Schistosoma mansoni	nephrin	0.0018	0.0438	0.049
Schistosoma mansoni	zinc finger protein	0.0049	0.2209	0.2475
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1951	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0055	0.2549	0.2549
Brugia malayi	Nuclear hormone receptor-like 1	0.0104	0.5387	0.5387
Brugia malayi	hypothetical protein	0.0016	0.0272	0.0272
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0104	0.5387	0.5387
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0432	0.5
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0432	0.5
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.7544	0.7544
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0021	0.0024
Echinococcus granulosus	Immunoglobulin	0.0011	0.0021	0.0024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1951	0.2185
Echinococcus multilocularis	roundabout 2	0.0022	0.065	0.0728
Schistosoma mansoni	retinoic acid receptor RXR	0.0104	0.5387	0.6035
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0104	0.5387	0.6035
Schistosoma mansoni	nuclear hormone receptor	0.0049	0.2209	0.2475
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0049	0.2209	0.2209
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0484	0.0542
Schistosoma mansoni	nuclear hormone receptor	0.0049	0.2209	0.2475
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0104	0.5387	0.5387
Brugia malayi	conserved hypotetical protein	0.0049	0.2209	0.2209
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0892	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0399	0.0399
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0104	0.5387	0.6035
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0049	0.2209	0.2209
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0049	0.2209	0.2475
Brugia malayi	Nuclear hormone receptor E75	0.0049	0.2209	0.2209
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0049	0.2209	0.2475
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5387	0.5387
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0104	0.5387	0.6035
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0055	0.2549	0.2856
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0272	0.0272
Brugia malayi	Nuclear hormone receptor-like 1	0.0055	0.2549	0.2549
Onchocerca volvulus	Bile acid receptor homolog	0.0104	0.5387	0.5343
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0049	0.2209	0.2475
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0186	0.0186
Brugia malayi	ecdysteroid receptor	0.0104	0.5387	0.5387
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0049	0.2209	0.2475
Loa Loa (eye worm)	hypothetical protein	0.0055	0.2549	0.2549
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0104	0.5387	0.5387
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0104	0.5387	0.6035
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0104	0.5387	0.5387
Echinococcus granulosus	neuroglian	0.0014	0.0187	0.0209
Schistosoma mansoni	ap endonuclease	0.0018	0.0432	0.0484
Schistosoma mansoni	ap endonuclease	0.0018	0.0432	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5387	0.5387
Echinococcus multilocularis	ecdysone induced protein 78C	0.0104	0.5387	0.6035
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0104	0.5387	0.6035
Echinococcus multilocularis	FTZ F1 alpha	0.0104	0.5387	0.6035
Loa Loa (eye worm)	nuclear hormone receptor	0.0049	0.2209	0.2209
Onchocerca volvulus		0.0104	0.5387	0.5343
Onchocerca volvulus		0.0049	0.2209	0.1566
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.1574	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0104	0.5387	0.5387
Brugia malayi	steroid hormone receptor	0.0104	0.5387	0.5387
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5387	0.5387
Schistosoma mansoni	nuclear receptor	0.0049	0.2209	0.2475
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.1775	1
Brugia malayi	Fibronectin type III domain containing protein	0.0016	0.0272	0.0272
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0021	0.0024
Schistosoma mansoni	nuclear receptor	0.0049	0.2209	0.2475
Brugia malayi	nuclear receptor NHR-67	0.0049	0.2209	0.2209
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0432	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0104	0.5387	0.6035
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0104	0.5387	0.5387
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0104	0.5387	0.5387
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.7314	0.8195
Onchocerca volvulus	Tyrosine kinase homolog	0.0172	0.9305	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0104	0.5387	0.6035
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0055	0.2549	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0055	0.2549	0.2856
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Brugia malayi	ecdysone receptor	0.0049	0.2209	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0021	0.0024
Brugia malayi	hypothetical protein	0.0055	0.2549	0.2549
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0104	0.5387	0.6035
Echinococcus multilocularis	neuroglian	0.0014	0.0187	0.0209
Brugia malayi	hypothetical protein	0.0049	0.2209	0.2209
Echinococcus granulosus	thyroid hormone receptor alpha	0.0049	0.2209	0.2475
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0104	0.5387	0.5387
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0021
Echinococcus granulosus	roundabout 2	0.0022	0.065	0.0728
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.1574	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1951	0.2185
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2209	0.2209
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0049	0.2209	0.1566
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0077	0.0077
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0432	0.0484
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0011	0.0021	0.0024
Echinococcus granulosus	intermediate filament protein	0.0026	0.0892	0.0999
Echinococcus multilocularis	musashi	0.0026	0.0892	0.0999
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0021	0.0024
Brugia malayi	hypothetical protein	0.0049	0.2209	0.2209
Schistosoma mansoni	lamin	0.0026	0.0892	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0077	0.0077
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0104	0.5387	0.6035
Brugia malayi	orphan nuclear receptor NR2E1	0.0049	0.2209	0.2209
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0104	0.5387	0.6035
Loa Loa (eye worm)	hypothetical protein	0.0055	0.2549	0.2549
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0049	0.2209	0.2475
Brugia malayi	nuclear hormone receptor family member odr-7	0.0049	0.2209	0.2209
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0104	0.5387	0.6035
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0432	0.5
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0105	0.0118
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0104	0.5387	0.5387
Echinococcus multilocularis	geminin	0.0165	0.8926	1
Brugia malayi	hypothetical protein	0.0055	0.2549	0.2549
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0432	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0864	0.0864

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 26 %	Activity at VEGFR2 by autophosphorylation assay relative to control	ChEMBL.	16890434
Activity (functional)	= 26 %	Activity at VEGFR2 by autophosphorylation assay relative to control	ChEMBL.	16890434
IC50 (binding)	= 6 nM	Inhibition of Tie2	ChEMBL.	16890434
IC50 (binding)	= 6 nM	Inhibition of Tie2	ChEMBL.	16890434
IC50 (binding)	= 24 nM	Inhibition of VEGFR2	ChEMBL.	16890434
IC50 (binding)	= 24 nM	Inhibition of VEGFR2	ChEMBL.	16890434

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL375311

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 409832