Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0058 | 0.0042 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0018 | 0.0025 | 0.0009 |
Echinococcus multilocularis | anti dorsalizing morphogenetic protein 1a | 0.0067 | 0.0213 | 0.0197 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0072 | 0.0235 | 0.0219 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.008 | 0.0266 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0994 | 0.3812 | 0.3804 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.008 | 0.0266 | 0.025 |
Loa Loa (eye worm) | bone morphogenic protein 6 | 0.0067 | 0.0213 | 0.0197 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.008 | 0.0266 | 0.025 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.008 | 0.0266 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0058 | 0.0042 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0058 | 0.0085 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0017 | 0.0021 | 0.0005 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0266 | 0.025 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.008 | 0.0266 | 0.025 |
Echinococcus granulosus | anti dorsalizing morphogenetic protein 1a | 0.0067 | 0.0213 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0058 | 0.0042 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.007 | 0.0227 | 0.0211 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0058 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0058 | 0.2804 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.008 | 0.0266 | 0.025 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0018 | 0.0025 | 0.0009 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0032 | 0.5 |
Brugia malayi | protein C17H12.11 | 0.0994 | 0.3812 | 0.3804 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0058 | 0.0085 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0032 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0058 | 0.2804 |
Loa Loa (eye worm) | TK protein kinase | 0.0072 | 0.0235 | 0.0219 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.008 | 0.0266 | 0.025 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0058 | 0.0085 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0058 | 0.5 |
Mycobacterium tuberculosis | Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) | 0.0807 | 0.3087 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0998 | 0.3827 | 0.3819 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0058 | 0.0042 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.008 | 0.0266 | 0.025 |
Brugia malayi | hypothetical protein | 0.0994 | 0.3812 | 0.3804 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0021 | 0.0005 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0998 | 0.3827 | 0.3819 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0032 | 0.0014 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.008 | 0.0266 | 0.025 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.2589 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0032 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0072 | 0.0235 | 0.0219 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0058 | 0.0085 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0072 | 0.0235 | 0.0219 |
Loa Loa (eye worm) | SRC-1 | 0.008 | 0.0266 | 0.025 |
Loa Loa (eye worm) | growth/differentiation factor 10 | 0.0017 | 0.0021 | 0.0005 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.2587 | 0.9994 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0032 | 0.0015 |
Onchocerca volvulus | 0.0026 | 0.0058 | 1 | |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0067 | 0.0213 | 0.0197 |
Onchocerca volvulus | 0.0017 | 0.0021 | 0.3657 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0072 | 0.0235 | 0.0219 |
Brugia malayi | SRC-1 | 0.008 | 0.0266 | 0.025 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0064 | 0.0204 | 0.0188 |
Schistosoma mansoni | protein kinase | 0.2589 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0025 | 0.0009 |
Onchocerca volvulus | 0.0017 | 0.0021 | 0.3657 | |
Loa Loa (eye worm) | TK protein kinase | 0.0064 | 0.0204 | 0.0188 |
Brugia malayi | protein-tyrosine kinase | 0.0072 | 0.0235 | 0.0219 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0058 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0021 | 0.0005 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0058 | 0.0085 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.008 | 0.0266 | 0.025 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.008 | 0.0266 | 0.025 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0025 | 0.0009 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0058 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0021 | 0.0005 |
Schistosoma mansoni | tgf-beta family | 0.0017 | 0.0021 | 0.0005 |
Echinococcus multilocularis | tgf beta family | 0.0017 | 0.0021 | 0.0005 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0018 | 0.0025 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0021 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0032 | 0.0015 |
Echinococcus granulosus | c src tyrosine kinase | 0.0018 | 0.0025 | 0.0009 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0058 | 0.0085 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0084 | 0.028 | 0.0264 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.008 | 0.0266 | 0.025 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0058 | 0.5 |
Mycobacterium ulcerans | haloalkane dehalogenase | 0.0807 | 0.3087 | 1 |
Schistosoma mansoni | tgf-beta family | 0.0017 | 0.0021 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0058 | 0.0042 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0058 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0032 | 0.0015 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.2589 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0072 | 0.0235 | 0.0219 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.008 | 0.0266 | 0.025 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0072 | 0.0235 | 0.0219 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.008 | 0.0266 | 0.025 |
Echinococcus granulosus | tgf beta family | 0.0017 | 0.0021 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0032 | 0.0015 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0017 | 0.0021 | 0.0005 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0018 | 0.0025 | 0.0009 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.008 | 0.0266 | 0.025 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0058 | 0.2804 |
Loa Loa (eye worm) | LjBmp2/4b | 0.0017 | 0.0021 | 0.0005 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0058 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0058 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0018 | 0.0025 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0032 | 0.0015 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.007 | 0.0227 | 0.0211 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0998 | 0.3827 | 0.3819 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0058 | 0.0085 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0064 | 0.0204 | 0.0188 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0018 | 0.0025 | 0.0009 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0058 | 0.0099 |
Echinococcus multilocularis | bone morphogenetic protein 2 | 0.0017 | 0.0021 | 0.0005 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0266 | 0.025 |
Echinococcus granulosus | bone morphogenetic protein 2 | 0.0017 | 0.0021 | 0.0005 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.008 | 0.0266 | 0.025 |
Echinococcus multilocularis | activin receptor type | 0.1171 | 0.45 | 0.4491 |
Echinococcus granulosus | activin receptor type | 0.1171 | 0.45 | 0.4491 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.1169 | 0.4492 | 0.4483 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.2587 | 0.9994 | 1 |
Schistosoma mansoni | protein kinase | 0.1168 | 0.4486 | 0.4477 |
Entamoeba histolytica | protein kinase, putative | 0.0064 | 0.0204 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I/IC50 (binding) | = -1.855 | log(I/IC50) against estrogen receptor alpha | ChEMBL. | 14592514 |
IC50 (binding) | = 71.6 nM | Binding affinity for estrogen receptor alpha | ChEMBL. | 14592514 |
logP (ADMET) | = 5.16 | Partition coefficient (logP) | ChEMBL. | 14592514 |
pKa | = 9.61 | pKa value of the compound was determined | ChEMBL. | 14592514 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.