Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0065 | 0.0219 | 1 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.2444 | 0.9995 | 1 |
Echinococcus multilocularis | activin receptor type | 0.1107 | 0.45 | 0.449 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.1104 | 0.4491 | 0.448 |
Echinococcus granulosus | activin receptor type | 0.1107 | 0.45 | 0.449 |
Schistosoma mansoni | protein kinase | 0.1103 | 0.4485 | 0.4475 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0081 | 0.0285 | 0.0267 |
Schistosoma mansoni | tyrosine kinase | 0.0081 | 0.0285 | 0.0267 |
Echinococcus granulosus | bone morphogenetic protein 2 | 0.0017 | 0.0024 | 0.0005 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0018 | 0.0028 | 0.0009 |
Echinococcus multilocularis | bone morphogenetic protein 2 | 0.0017 | 0.0024 | 0.0005 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0063 | 0.0099 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0071 | 0.0243 | 0.0225 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0942 | 0.3825 | 0.3816 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0063 | 0.0085 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0065 | 0.0219 | 0.0201 |
Loa Loa (eye worm) | LjBmp2/4b | 0.0017 | 0.0024 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0035 | 0.0017 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0018 | 0.0028 | 0.0009 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0063 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0063 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.0063 | 0.2838 |
Echinococcus granulosus | tgf beta family | 0.0017 | 0.0024 | 0.0005 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0081 | 0.0285 | 0.0267 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0018 | 0.0028 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0035 | 0.0017 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0017 | 0.0024 | 0.0005 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0081 | 0.0285 | 0.0267 |
Echinococcus granulosus | tyrosine kinase | 0.0073 | 0.0252 | 0.0234 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0073 | 0.0252 | 0.0234 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0081 | 0.0285 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0035 | 0.0017 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0063 | 0.0044 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.2445 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0063 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0063 | 0.0044 |
Schistosoma mansoni | tgf-beta family | 0.0017 | 0.0024 | 0.0005 |
Mycobacterium ulcerans | haloalkane dehalogenase | 0.0814 | 0.3296 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0063 | 0.0085 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0081 | 0.0285 | 0.0267 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0084 | 0.0299 | 0.0281 |
Echinococcus multilocularis | tgf beta family | 0.0017 | 0.0024 | 0.0005 |
Schistosoma mansoni | tgf-beta family | 0.0017 | 0.0024 | 0.0005 |
Echinococcus granulosus | c src tyrosine kinase | 0.0018 | 0.0028 | 0.0009 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0018 | 0.0028 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0024 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0035 | 0.0017 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0028 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0024 | 0.0005 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0063 | 0.0099 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0081 | 0.0285 | 0.0267 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0081 | 0.0285 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0024 | 0.0005 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0063 | 0.0085 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0028 | 0.0009 |
Schistosoma mansoni | protein kinase | 0.2445 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0063 | 0.0085 |
Brugia malayi | protein-tyrosine kinase | 0.0073 | 0.0252 | 0.0234 |
Loa Loa (eye worm) | TK protein kinase | 0.0065 | 0.0219 | 0.0201 |
Onchocerca volvulus | 0.0017 | 0.0024 | 0.3752 | |
Brugia malayi | SRC-1 | 0.0081 | 0.0285 | 0.0267 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0065 | 0.0219 | 0.0201 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0067 | 0.0229 | 0.0211 |
Onchocerca volvulus | 0.0017 | 0.0024 | 0.3752 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0073 | 0.0252 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0035 | 0.0017 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.2444 | 0.9995 | 1 |
Onchocerca volvulus | 0.0027 | 0.0063 | 1 | |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0073 | 0.0252 | 0.0234 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0035 | 0.5 |
Loa Loa (eye worm) | growth/differentiation factor 10 | 0.0017 | 0.0024 | 0.0005 |
Loa Loa (eye worm) | SRC-1 | 0.0081 | 0.0285 | 0.0267 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0063 | 0.0085 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0073 | 0.0252 | 0.0234 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0024 | 0.0005 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0942 | 0.3825 | 0.3816 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.2445 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0035 | 0.0014 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0081 | 0.0285 | 0.0267 |
Brugia malayi | Protein kinase domain containing protein | 0.0942 | 0.3825 | 0.3816 |
Brugia malayi | hypothetical protein | 0.0939 | 0.3811 | 0.3801 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0081 | 0.0285 | 0.0267 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0063 | 0.0044 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0063 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0063 | 0.0085 |
Mycobacterium tuberculosis | Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) | 0.0814 | 0.3296 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0035 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0081 | 0.0285 | 0.0267 |
Loa Loa (eye worm) | TK protein kinase | 0.0073 | 0.0252 | 0.0234 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0063 | 0.2838 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0063 | 0.0085 |
Brugia malayi | protein C17H12.11 | 0.0939 | 0.3811 | 0.3801 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0063 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0071 | 0.0243 | 0.0225 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0035 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0081 | 0.0285 | 0.0267 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0063 | 0.2838 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0018 | 0.0028 | 0.0009 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0081 | 0.0285 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0063 | 0.0044 |
Echinococcus granulosus | anti dorsalizing morphogenetic protein 1a | 0.0067 | 0.0229 | 0.021 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0063 | 0.0085 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0081 | 0.0285 | 0.0267 |
Brugia malayi | Transforming growth factor beta like domain containing protein | 0.0017 | 0.0024 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0063 | 0.0044 |
Schistosoma mansoni | tyrosine kinase | 0.0081 | 0.0285 | 0.0267 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0081 | 0.0285 | 0.0267 |
Loa Loa (eye worm) | bone morphogenic protein 6 | 0.0067 | 0.0229 | 0.0211 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0081 | 0.0285 | 0.0267 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0081 | 0.0285 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0939 | 0.3811 | 0.3801 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0063 | 0.0044 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0073 | 0.0252 | 0.0234 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0018 | 0.0028 | 0.0009 |
Echinococcus multilocularis | anti dorsalizing morphogenetic protein 1a | 0.0067 | 0.0229 | 0.021 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of CSK at 25 uM in presence of 12 mM MgCl2 | ChEMBL. | 17149882 |
Inhibition (binding) | = 0 % | Inhibition of CSK at 25 uM in presence of 12 mM MgCl2 | ChEMBL. | 17149882 |
Inhibition (binding) | = 2 % | Inhibition of CSK at 25 uM in presence of 12 mM MgCl2 and 0.2 mM CoCl2 | ChEMBL. | 17149882 |
Inhibition (binding) | = 2 % | Inhibition of CSK at 25 uM in presence of 12 mM MgCl2 and 0.2 mM CoCl2 | ChEMBL. | 17149882 |
Inhibition (binding) | = 14 % | Inhibition of histidine decarboxylase in Sprague-Dawley rat stomach assessed as decrease in 14CO2 production using L-histidine-carboxyl-14C as substrate at 0.10 mM by scintillation counting analysis | ChEMBL. | 850236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.