TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 429.425 | Formula: C25H30Cl2N2
H donors: 1 H acceptors: 0 LogP: 6 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C1CC2(CCNC1C(C2)c1ccc(cc1)Cl)N1CCCCC1
InChi: 1S/C25H30Cl2N2/c26-20-8-4-18(5-9-20)22-16-25(29-14-2-1-3-15-29)12-13-28-24(22)23(17-25)19-6-10-21(27)11-7-19/h4-11,22-24,28H,1-3,12-17H2
InChiKey: PZCDMBQLEQDGIC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0377027	0.318447	0.476303
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.00418402	0.0115198	0.00871853
Echinococcus multilocularis	nervana 2	0.0723178	0.635414	0.959183
Echinococcus granulosus	protein kinase C gamma type	0.0377027	0.318447	0.476303
Brugia malayi	protein kinase C II.	0.0377027	0.318447	0.314473
Entamoeba histolytica	protein kinase, putative	0.112133	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0193704	0.15058	0.145627
Trypanosoma cruzi	Protein kinase B	0.0752438	0.662207	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0377027	0.318447	0.476303
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.00434681	0.0130105	0.0072557
Loa Loa (eye worm)	hypothetical protein	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.00418402	0.0115198	0.0057563
Brugia malayi	p70 ribosomal S6 kinase beta	0.11002	0.980654	0.980542
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.00434681	0.0130105	0.0072557
Loa Loa (eye worm)	hypothetical protein	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0377027	0.318447	0.314473
Plasmodium falciparum	cGMP-dependent protein kinase	0.00355903	0.00579688	0.00901731
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.00418402	0.0115198	0.00871853
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.00418402	0.0115198	0.00871853
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0377027	0.318447	0.476303
Echinococcus multilocularis	voltage gated potassium channel	0.00633262	0.0311944	0.0386915
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.00418402	0.0115198	0.0057563
Echinococcus multilocularis	rac serine:threonine kinase	0.0752438	0.662207	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0752438	0.662207	0.662207
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.00418402	0.0115198	0.00871853
Loa Loa (eye worm)	hypothetical protein	0.0898127	0.795614	0.794422
Schistosoma mansoni	nuclear hormone receptor	0.00418402	0.0115198	0.00871853
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0377027	0.318447	0.476303
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0354885	0.298172	0.45027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.00418402	0.0115198	0.0057563
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.00418402	0.0115198	0.00871853
Schistosoma mansoni	retinoic acid receptor RXR	0.00418402	0.0115198	0.00871853
Schistosoma mansoni	serine/threonine protein kinase	0.0377027	0.318447	0.476303
Echinococcus granulosus	protein kinase c epsilon type	0.0377027	0.318447	0.476303
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.00418402	0.0115198	0.00871853
Echinococcus granulosus	hyperpolarization activated cyclic	0.00434681	0.0130105	0.0109895
Echinococcus granulosus	zinc finger protein	0.0249131	0.201334	0.297888
Brugia malayi	nuclear receptor NHR-88	0.00418402	0.0115198	0.0057563
Entamoeba histolytica	protein kinase, putative	0.11002	0.980654	0.980654
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.00418402	0.0115198	0.00871853
Trichomonas vaginalis	AGC family protein kinase	0.112133	1	1
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0377027	0.318447	0.476303
Brugia malayi	Nuclear hormone receptor-like 1	0.00418402	0.0115198	0.0057563
Schistosoma mansoni	thyroid hormone receptor	0.00418402	0.0115198	0.00871853
Leishmania major	malonyl-coa decarboxylase-like protein	0.0354885	0.298172	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0377027	0.318447	0.476303
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.00418402	0.0115198	0.5
Loa Loa (eye worm)	hypothetical protein	0.0377027	0.318447	0.314473
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0752438	0.662207	0.662207
Trichomonas vaginalis	AGC family protein kinase	0.112133	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0213562	0.168764	0.24827
Brugia malayi	Protein kinase domain containing protein	0.0377027	0.318447	0.314473
Echinococcus multilocularis	ecdysone induced protein 78C	0.00418402	0.0115198	0.00871853
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0377027	0.318447	0.476303
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.00418402	0.0115198	0.0057563
Trichomonas vaginalis	AGC family protein kinase	0.0377027	0.318447	0.318447
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0377027	0.318447	0.314473
Echinococcus granulosus	nervana 2	0.0723178	0.635414	0.959183
Echinococcus multilocularis	thyroid hormone receptor alpha	0.00418402	0.0115198	0.00871853
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.00434681	0.0130105	0.0109895
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0731311	0.642862	0.970528
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.026278	0.213832	0.316929
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.00418402	0.0115198	0.0057563
Schistosoma mansoni	voltage-gated potassium channel	0.00633262	0.0311944	0.0386915
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0377027	0.318447	0.314473
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.00418402	0.0115198	0.00871853
Echinococcus granulosus	protein kinase c iota type	0.0377027	0.318447	0.476303
Schistosoma mansoni	60S ribosomal protein L21	0.00358687	0.00605182	0.000388371
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0193704	0.15058	0.220568
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.00418402	0.0115198	0.0057563
Brugia malayi	Cyclic-nucleotide gated cation channel	0.00434681	0.0130105	0.0072557
Trichomonas vaginalis	AGC family protein kinase	0.0377027	0.318447	0.318447
Schistosoma mansoni	voltage-gated potassium channel	0.0213562	0.168764	0.24827
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.00418402	0.0115198	0.00871853
Echinococcus granulosus	hyperpolarization activated cyclic	0.00434681	0.0130105	0.0109895
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.00418402	0.0115198	0.0057563
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.00418402	0.0115198	0.00871853
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.00434681	0.0130105	0.0109895
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.00418402	0.0115198	0.00871853
Loa Loa (eye worm)	hypothetical protein	0.00418402	0.0115198	0.0057563
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0731311	0.642862	1
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0354885	0.298172	0.45027
Entamoeba histolytica	protein kinase, putative	0.112133	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0377027	0.318447	0.476303
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.00418402	0.0115198	0.00871853
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0368894	0.311	0.311
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.00355903	0.00579688	0.00591124
Trypanosoma brucei	rac serine-threonine kinase, putative	0.112133	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0398154	0.337793	0.337793
Loa Loa (eye worm)	AGC/AKT protein kinase	0.112133	1	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0429447	0.366448	0.549429
Schistosoma mansoni	serine/threonine protein kinase	0.0377027	0.318447	0.476303
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.026278	0.213832	0.316929
Brugia malayi	Protein kinase domain containing protein	0.0377027	0.318447	0.314473
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0377027	0.318447	0.476303
Echinococcus granulosus	Glutaredoxin protein 5	0.0723178	0.635414	0.959183
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0377027	0.318447	0.314473
Schistosoma mansoni	zinc finger protein	0.026278	0.213832	0.316929
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0193704	0.15058	0.220568
Loa Loa (eye worm)	MBOAT family protein	0.026278	0.213832	0.209249
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0377027	0.318447	0.476303
Schistosoma mansoni	atypical protein kinase C	0.0377027	0.318447	0.476303
Trichomonas vaginalis	AGC family protein kinase	0.112133	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.00418402	0.0115198	0.0057563
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.00434681	0.0130105	0.0109895
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	hypothetical protein	0.00418402	0.0115198	0.0057563
Trichomonas vaginalis	AGC family protein kinase	0.0377027	0.318447	0.318447
Schistosoma mansoni	RAR-like nuclear receptor	0.00418402	0.0115198	0.00871853
Echinococcus multilocularis	Glutaredoxin protein 5	0.0723178	0.635414	0.959183
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.11002	0.980654	0.980542
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.00418402	0.0115198	0.0057563
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.00418402	0.0115198	0.00871853
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.00418402	0.0115198	0.0057563
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0377027	0.318447	0.314473
Entamoeba histolytica	protein kinase, putative	0.0377027	0.318447	0.318447
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0377027	0.318447	0.476303
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0377027	0.318447	0.314473
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.00434681	0.0130105	0.0109895
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.00434681	0.0130105	0.0109895
Echinococcus multilocularis	FTZ F1 alpha	0.00418402	0.0115198	0.00871853
Schistosoma mansoni	voltage-gated potassium channel	0.00434681	0.0130105	0.0109895
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.00434681	0.0130105	0.0109895
Entamoeba histolytica	protein kinase 2, putative	0.0731311	0.642862	0.642862
Loa Loa (eye worm)	hypothetical protein	0.0166246	0.125437	0.120338
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.00418402	0.0115198	0.00871853
Echinococcus granulosus	nervana 2	0.0723178	0.635414	0.959183
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.0898127	0.795614	0.5
Trichomonas vaginalis	AGC family protein kinase	0.112133	1	1
Trichomonas vaginalis	AGC family protein kinase	0.112133	1	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0731311	0.642862	0.970786
Echinococcus multilocularis	nervana 2	0.0723178	0.635414	0.959183
Onchocerca volvulus	Protein ultraspiracle homolog	0.00418402	0.0115198	0.5
Echinococcus multilocularis	hyperpolarization activated cyclic	0.00434681	0.0130105	0.0109895
Loa Loa (eye worm)	steroid hormone receptor	0.00418402	0.0115198	0.0057563
Leishmania major	protein kinase, putative	0.00355903	0.00579688	0.0194414
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0377027	0.318447	0.476303
Schistosoma mansoni	coup transcription factor	0.00418402	0.0115198	0.00871853
Brugia malayi	steroid hormone receptor	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.00418402	0.0115198	0.0057563
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.00418402	0.0115198	0.0057563
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0731311	0.642862	1
Brugia malayi	MBOAT family protein	0.026278	0.213832	0.209249
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0354885	0.298172	0.298172
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.00633262	0.0311944	0.0386915
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.00418402	0.0115198	0.00871853
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.00418402	0.0115198	0.00871853
Toxoplasma gondii	AGC kinase	0.11002	0.980654	1
Onchocerca volvulus	Bile acid receptor homolog	0.00418402	0.0115198	0.5
Echinococcus granulosus	NDR protein kinase	0.0377027	0.318447	0.476303
Leishmania major	protein kinase, putative	0.00355903	0.00579688	0.0194414
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.00418402	0.0115198	0.00871853
Schistosoma mansoni	serine/threonine protein kinase	0.0377027	0.318447	0.476303
Trichomonas vaginalis	AGC family protein kinase	0.112133	1	1
Schistosoma mansoni	serine/threonine kinase	0.0377027	0.318447	0.476303
Echinococcus multilocularis	protein kinase c iota type	0.0377027	0.318447	0.476303
Loa Loa (eye worm)	hypothetical protein	0.00418402	0.0115198	0.0057563
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.00434681	0.0130105	0.0109895
Schistosoma mansoni	serine/threonine-protein kinase	0.0752438	0.662207	1
Loa Loa (eye worm)	hypothetical protein	0.00418402	0.0115198	0.0057563
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.00418402	0.0115198	0.00871853
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0752438	0.662207	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0731311	0.642862	0.970528
Trichomonas vaginalis	AGC family protein kinase	0.112133	1	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.00418402	0.0115198	0.00871853
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0193704	0.15058	0.145627
Loa Loa (eye worm)	hypothetical protein	0.00418402	0.0115198	0.0057563
Schistosoma mansoni	serine/threonine protein kinase	0.0377027	0.318447	0.476303
Loa Loa (eye worm)	hypothetical protein	0.00633262	0.0311944	0.0255456
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.00434681	0.0130105	0.0109895
Echinococcus granulosus	ecdysone induced protein 78C	0.00418402	0.0115198	0.00871853
Brugia malayi	Protein kinase domain containing protein	0.112133	1	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0723178	0.635414	0.959183
Brugia malayi	putative malonyl-CoA decarboxylase	0.0898127	0.795614	0.794422
Loa Loa (eye worm)	hypothetical protein	0.00434681	0.0130105	0.0072557
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.00434681	0.0130105	0.0109895
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0177693	0.135919	0.135919
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0377027	0.318447	0.476303
Schistosoma mansoni	thyroid hormone receptor	0.00418402	0.0115198	0.00871853
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.00633262	0.0311944	0.0255456
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.00434681	0.0130105	0.0109895
Schistosoma mansoni	voltage-gated potassium channel	0.00358687	0.00605182	0.000388371
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.00418402	0.0115198	0.00871853
Echinococcus granulosus	serine threonine protein kinase nrc	0.0731311	0.642862	0.970528
Echinococcus multilocularis	hyperpolarization activated cyclic	0.00434681	0.0130105	0.0109895
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0723178	0.635414	0.959183
Brugia malayi	nuclear hormone receptor	0.00418402	0.0115198	0.0057563
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.00434681	0.0130105	0.0130105
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0177693	0.135919	0.135919
Schistosoma mansoni	serine/threonine-protein kinase	0.0752438	0.662207	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.00418402	0.0115198	0.0057563
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.00434681	0.0130105	0.0109895
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.00434681	0.0130105	0.0130105
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.00434681	0.0130105	0.0109895
Echinococcus granulosus	serine:threonine protein kinase N2	0.0377027	0.318447	0.476303
Echinococcus multilocularis	serine threonine protein kinase	0.0377027	0.318447	0.476303
Echinococcus granulosus	FTZ F1 alpha	0.00418402	0.0115198	0.00871853
Echinococcus granulosus	Protein kinase C brain isozyme	0.0377027	0.318447	0.476303
Echinococcus granulosus	voltage gated potassium channel	0.00633262	0.0311944	0.0386915
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.00633262	0.0311944	0.0386915
Brugia malayi	Steroid receptor seven-up type 2	0.00418402	0.0115198	0.0057563
Onchocerca volvulus		0.00418402	0.0115198	0.5
Loa Loa (eye worm)	hypothetical protein	0.00418402	0.0115198	0.0057563
Schistosoma mansoni	voltage-gated potassium channel	0.00633262	0.0311944	0.0386915
Giardia lamblia	Kinase, AGC PKA	0.0731311	0.642862	0.5
Brugia malayi	ecdysteroid receptor	0.00418402	0.0115198	0.0057563
Schistosoma mansoni	serine/threonine protein kinase	0.0377027	0.318447	0.476303
Brugia malayi	Hr1 repeat family protein	0.0377027	0.318447	0.314473
Echinococcus granulosus	serine/threonine protein kinase	0.0752438	0.662207	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.00418402	0.0115198	0.0057563
Echinococcus multilocularis	zinc finger protein	0.0249131	0.201334	0.297888
Brugia malayi	photoreceptor-specific nuclear receptor	0.00418402	0.0115198	0.0057563

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.065 microM	Antiplasmodial activity against Trypanosoma brucei rhodesiense STIB 900 by microplate assay	ChEMBL.	19879671
IC50 (functional)	= 0.46 microM	Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by microplate assay	ChEMBL.	19879671
IC50 (functional)	= 0.065 uM	Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900	ChEMBL.	16889962
IC50 (functional)	= 0.065 uM	Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900	ChEMBL.	16889962
IC50 (functional)	= 0.46 uM	Antiprotozoal activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1	ChEMBL.	16889962
IC50 (functional)	= 0.46 uM	Antiprotozoal activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1	ChEMBL.	16889962
IC50 (ADMET)	= 8.1 uM	Cytotoxicity against L6 cells	ChEMBL.	16889962
Mean survival days (functional)	= 10.25 day	Survival of NMRI mouse infected with Trypanosoma brucei brucei at 50 mg/kg, ip	ChEMBL.	16889962
Mean survival days (functional)	= 10.25 day	Survival of NMRI mouse infected with Trypanosoma brucei brucei at 50 mg/kg, ip	ChEMBL.	16889962
Ratio IC50 (functional)	= 17.61	Selectivity index, IC50 for L6 cells/IC50 for Plasmodium falciparum K1	ChEMBL.	16889962
Ratio IC50 (functional)	= 124.6	Selectivity index, IC50 for L6 cells/ IC50 for Trypanosoma brucei rhodesience	ChEMBL.	16889962

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei gambiense		16889962
Plasmodium falciparum	ChEMBL23	16889962

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL216966

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 410068