TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 399.488 | Formula: C24H25N5O
H donors: 2 H acceptors: 2 LogP: 3.04 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC(Cn1c2c3CCc4c(c3c3c(c2c2c1ccc(c2)N)CNC3=O)cn(n4)C)C
InChi: 1S/C24H25N5O/c1-12(2)10-29-19-7-4-13(25)8-15(19)21-16-9-26-24(30)22(16)20-14(23(21)29)5-6-18-17(20)11-28(3)27-18/h4,7-8,11-12H,5-6,9-10,25H2,1-3H3,(H,26,30)
InChiKey: NTSCVTQLXOMFGW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	TEK tyrosine kinase, endothelial	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0061	0.0061
Echinococcus granulosus	fmrfamide receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0091	0.0091
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0068	0.0618	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0011	0.0019	0.0019
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	somatostatin receptor	0.0041	0.0336	0.0336
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.0019	0.0019
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0041	0.0336	0.0336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.0336	0.0336
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	nephrin	0.0018	0.0098	0.0098
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0041	0.0336	0.0336
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0013	0.0038	0.0038
Onchocerca volvulus		0.0041	0.0336	0.1985
Schistosoma mansoni	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0336	0.0336
Brugia malayi	Protein kinase domain containing protein	0.0672	0.6905	0.6905
Schistosoma mansoni	amine GPCR	0.0041	0.0336	0.0336
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0041	0.0336	0.0336
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0041	0.0336	0.1985
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0041	0.0336	0.0336
Onchocerca volvulus		0.0041	0.0336	0.1985
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Schistosoma mansoni	cell adhesion molecule	0.0011	0.0019	0.0019
Schistosoma mansoni	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	neuroglian	0.0014	0.0052	0.0052
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.0336	0.0336
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0336	0.0336
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0023	0.0023
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	7tm_1 domain containing protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0336	0.0336
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.097	1	1
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.097	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	opsin-like receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.0336	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Brugia malayi	putative neuropeptide receptor NPR1	0.0041	0.0336	0.0336
Echinococcus multilocularis	orexin receptor type 2	0.0041	0.0336	0.0336
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	somatostatin receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0336	0.0336
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0061	0.0061
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Brugia malayi	Fibronectin type III domain containing protein	0.0016	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0011	0.0019	0.0019
Onchocerca volvulus		0.0041	0.0336	0.1985
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	neuropeptide receptor A26	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	twitchin	0.0016	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0011	0.0019	0.0019
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	serotonin receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	allatostatin A receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	roundabout 2	0.0011	0.0019	0.0019
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.0336	0.0336
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0068	0.0618	0.5
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0361	0.366	0.3242
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Brugia malayi	neuropeptide F receptor	0.0041	0.0336	0.0336
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0041	0.0336	0.0336
Onchocerca volvulus		0.0041	0.0336	0.1985
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0336	0.0336
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0041	0.0336	0.0336
Echinococcus multilocularis	G protein coupled receptor 139	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0011	0.0019	0.0019
Onchocerca volvulus		0.0167	0.1641	0.9683
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0041	0.0336	0.0336
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0041	0.0336	0.0336
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0041	0.0336	0.1985
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0336	0.0336
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0068	0.0068
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.0336	0.0336
Echinococcus multilocularis	neuroglian	0.0011	0.0019	0.0019
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.0336	0.0336
Echinococcus granulosus	neuropeptide FF receptor 2	0.0041	0.0336	0.0336
Schistosoma mansoni	myosin xvIII	0.0041	0.0336	0.0336
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	amine GPCR	0.0041	0.0336	0.0336
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0041	0.0336	0.0336
Brugia malayi	G-protein coupled receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	amine GPCR	0.0041	0.0336	0.0336
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0041	0.0336	0.0336
Echinococcus granulosus	neuropeptide receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	neuropeptide s receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0336	0.0336
Echinococcus multilocularis	roundabout 2	0.0022	0.0136	0.0136
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0041	0.0336	0.0336
Onchocerca volvulus		0.0041	0.0336	0.1985
Echinococcus granulosus	contactin	0.0011	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Brugia malayi	ORL1-like opioid receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0041	0.0336	0.0336
Schistosoma mansoni	histamine h1 receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Onchocerca volvulus		0.0041	0.0336	0.1985
Onchocerca volvulus		0.0041	0.0336	0.1985
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0361	0.366	0.3242
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0041	0.0336	0.0336
Onchocerca volvulus		0.0041	0.0336	0.1985
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	dihydrofolate reductase	0.0179	0.1768	0.1768
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	serotonin receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	adenoreceptor	0.0041	0.0336	0.0336
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0179	0.1768	0.5
Onchocerca volvulus		0.0041	0.0336	0.1985
Schistosoma mansoni	neuroglian	0.0011	0.0019	0.0019
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0179	0.1768	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.0019	0.0019
Loa Loa (eye worm)	TYRA-2 protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Echinococcus multilocularis	roundabout 2	0.0011	0.0019	0.0019
Brugia malayi	sulfakinin receptor protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Onchocerca volvulus		0.0041	0.0336	0.1985
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	serotonin receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	sex peptide receptor	0.0041	0.0336	0.0336
Brugia malayi	Dopamine receptor	0.0041	0.0336	0.0336
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.097	1	1
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.097	1	1
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0179	0.1768	0.5
Echinococcus granulosus	Immunoglobulin	0.0011	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0041	0.0336	0.0336
Brugia malayi	Serotonin receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0184	0.182	0.182
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	defective proboscis extension response	0.0011	0.0023	0.0023
Schistosoma mansoni	opsin-like receptor	0.0041	0.0336	0.0336
Brugia malayi	dihydrofolate reductase family protein	0.0179	0.1768	0.1768
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0336	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Brugia malayi	AKH receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0336	0.0336
Brugia malayi	G protein-coupled receptor F59B2.13	0.0041	0.0336	0.0336
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0041	0.0336	0.0336
Onchocerca volvulus	Tyrosine kinase homolog	0.0172	0.1694	1
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.097	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0041	0.0336	0.0336
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0041	0.0336	0.0336
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0336	0.0336
Brugia malayi	Dihydrofolate reductase	0.0179	0.1768	0.1768
Brugia malayi	Dopamine receptor protein 2	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0472	0.4823	0.4823
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	dihydrofolate reductase	0.0179	0.1768	0.1768
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.0019	0.0019
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0041	0.0336	0.0336
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0041	0.0336	0.0336
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0041	0.0336	0.0336
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0011	0.0019	0.0019
Echinococcus granulosus	neuroglian	0.0014	0.0052	0.0052
Brugia malayi	hypothetical protein	0.0016	0.0068	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0011	0.0019	0.0019
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0023
Echinococcus granulosus	neuropeptide receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	dro:myosuppressin receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	sex peptide receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0472	0.4823	0.4823
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0041	0.0336	0.0336
Onchocerca volvulus		0.0041	0.0336	0.1985
Schistosoma mansoni	cell adhesion molecule	0.0011	0.0019	0.0019
Onchocerca volvulus		0.0041	0.0336	0.1985
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0023	0.0023
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	g-protein coupled receptor	0.0041	0.0336	0.0336
Leishmania major		0.097	1	1
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	melatonin receptor type 1A	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Toxoplasma gondii	fructose-bisphospatase II	0.097	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0336	0.0336
Echinococcus granulosus	dro:myosuppressin receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0041	0.0336	0.0336
Schistosoma mansoni	amine GPCR	0.0041	0.0336	0.0336
Schistosoma mansoni	nephrin	0.0011	0.0019	0.0019
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0361	0.366	0.3242
Brugia malayi	follicle stimulating hormone receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0068	0.0068
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0041	0.0336	0.0336
Echinococcus multilocularis	g-protein coupled receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	neuropeptide receptor A26	0.0041	0.0336	0.0336
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0336	0.0336
Loa Loa (eye worm)	dihydrofolate reductase	0.0179	0.1768	0.1768
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0068	0.0068
Schistosoma mansoni	dihydrofolate reductase	0.0179	0.1768	0.1768
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0023	0.0023
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	7TM GPCR rhodopsin	0.0041	0.0336	0.0336
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0011	0.0023	0.0023
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0361	0.366	0.3242
Brugia malayi	neuropeptide F receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	roundabout 2	0.0011	0.0019	0.0019
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus granulosus	neuroglian	0.0011	0.0019	0.0019
Brugia malayi	RE15519p	0.0041	0.0336	0.0336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	neuropeptide f receptor 76f	0.0041	0.0336	0.0336
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0106	0.0106
Brugia malayi	putative neuropeptide receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	amine GPCR	0.0041	0.0336	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0336	0.0336
Schistosoma mansoni	serine/threonine protein kinase	0.0672	0.6905	0.6905
Onchocerca volvulus		0.0041	0.0336	0.1985
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0336	0.0336
Onchocerca volvulus		0.0041	0.0336	0.1985
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Echinococcus granulosus	roundabout 2	0.0022	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Toxoplasma gondii	fructose-bisphospatase I	0.0361	0.366	0.3242
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.0336	0.0336
Brugia malayi	G-protein coupled receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.097	1	1
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	opsin-like receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	allatostatin A receptor	0.0041	0.0336	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0672	0.6905	0.6905
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.182	0.182
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.0336	0.0336
Onchocerca volvulus		0.0041	0.0336	0.1985
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0336	0.0336
Echinococcus granulosus	roundabout 2	0.0011	0.0019	0.0019
Onchocerca volvulus		0.0041	0.0336	0.1985
Onchocerca volvulus		0.0041	0.0336	0.1985
Brugia malayi	larval opioid receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0023
Brugia malayi	GnHR receptor homolog	0.0041	0.0336	0.0336
Brugia malayi	Melatonin receptor type 1A	0.0041	0.0336	0.0336
Echinococcus granulosus	orexin receptor type 2	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Chlamydia trachomatis	dihydrofolate reductase	0.0179	0.1768	0.5
Brugia malayi	Serotonin receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0041	0.0336	0.0336
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0336	0.0336
Brugia malayi	hypothetical protein	0.0041	0.0336	0.0336
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0011	0.0019	0.0019
Echinococcus granulosus	G protein coupled receptor 139	0.0041	0.0336	0.0336
Brugia malayi	G protein-coupled receptor	0.0041	0.0336	0.0336
Brugia malayi	Dopamine receptor protein 1	0.0041	0.0336	0.0336
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0336	0.0336
Schistosoma mansoni	growth hormone secretagogue receptor	0.0041	0.0336	0.0336
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0041	0.0336	0.0336

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Activity at VEGFR2 by autophosphorylation assay relative to control	ChEMBL.	16890434
Activity (functional)	0	Activity at VEGFR2 by autophosphorylation assay relative to control	ChEMBL.	16890434
IC50 (binding)	= 11 nM	Inhibition of VEGFR2	ChEMBL.	16890434
IC50 (binding)	= 11 nM	Inhibition of VEGFR2	ChEMBL.	16890434
IC50 (binding)	= 48 nM	Inhibition of Tie2	ChEMBL.	16890434
IC50 (binding)	= 48 nM	Inhibition of Tie2	ChEMBL.	16890434

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL218799

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 410157