Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor delta | 441 aa | 369 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Echinococcus granulosus | FTZ F1 alpha | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0167 | 0.0167 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0105 | 0.0398 | 0.0435 |
Brugia malayi | steroid hormone receptor | 0.0105 | 0.0398 | 0.0398 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0167 | 0.0182 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0105 | 0.0398 | 0.0435 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0302 | 0.1972 | 0.5 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0302 | 0.1972 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0105 | 0.0398 | 0.0398 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0105 | 0.0398 | 0.0457 |
Loa Loa (eye worm) | 4-hydroxyphenylpyruvate dioxygenase | 0.0302 | 0.1972 | 0.1972 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0105 | 0.0398 | 0.0457 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0105 | 0.0398 | 0.0435 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0105 | 0.0398 | 0.0398 |
Plasmodium falciparum | glyoxalase I | 0.1306 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium ulcerans | biphenyl-2,3-diol 1,2-dioxygenase | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0105 | 0.0398 | 0.0398 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Onchocerca volvulus | Putative protein | 0.0302 | 0.1972 | 0.1639 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0105 | 0.0398 | 0.0457 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1142 | 0.8692 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0105 | 0.0398 | 0.0398 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0105 | 0.0398 | 0.0457 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0167 | 0.0192 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0105 | 0.0398 | 0.0435 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0105 | 0.0398 | 0.0435 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | nuclear hormone receptor | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0167 | 0.0167 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0105 | 0.0398 | 0.0435 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.1306 | 1 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.1306 | 1 | 0.5 |
Leishmania major | glyoxalase I,trypanothione-dependent glyoxalase I | 0.1306 | 1 | 0.5 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.1306 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1198 | 0.9137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0167 | 0.0167 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0105 | 0.0398 | 0.0435 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0105 | 0.0398 | 0.0398 |
Schistosoma mansoni | 4-hydroxyphenylpyruvate dioxygenase | 0.0302 | 0.1972 | 0.2158 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0105 | 0.0398 | 0.0457 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0105 | 0.0398 | 0.0398 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0105 | 0.0398 | 0.0435 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium tuberculosis | Conserved protein | 0.0302 | 0.1972 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0105 | 0.0398 | 0.0398 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0105 | 0.0398 | 0.0457 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0105 | 0.0398 | 0.0398 |
Schistosoma mansoni | nuclear hormone receptor | 0.0105 | 0.0398 | 0.0435 |
Brugia malayi | 4-hydroxyphenylpyruvate dioxygenase family protein | 0.0302 | 0.1972 | 0.1972 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium leprae | conserved hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0105 | 0.0398 | 0.0398 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0105 | 0.0398 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0105 | 0.0398 | 0.0398 |
Schistosoma mansoni | thyroid hormone receptor | 0.0105 | 0.0398 | 0.0435 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0167 | 0.0182 |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0302 | 0.1972 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0105 | 0.0398 | 0.0398 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0105 | 0.0398 | 0.0435 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1198 | 0.9137 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0167 | 0.0167 |
Plasmodium vivax | glyoxalase I, putative | 0.1306 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium tuberculosis | Conserved protein | 0.0302 | 0.1972 | 0.5 |
Schistosoma mansoni | gynecophoral canal protein | 0.0302 | 0.1972 | 0.2158 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0105 | 0.0398 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0105 | 0.0398 | 0.0398 |
Mycobacterium ulcerans | hypothetical protein | 0.0302 | 0.1972 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0105 | 0.0398 | 0.0435 |
Toxoplasma gondii | glyoxalase I, putative | 0.1306 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0105 | 0.0398 | 0.0435 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0167 | 0.0167 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0105 | 0.0398 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0398 | 0.0398 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0105 | 0.0398 | 0.0457 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0167 | 0.0167 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0105 | 0.0398 | 0.0435 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0105 | 0.0398 | 0.0398 |
Schistosoma mansoni | coup transcription factor | 0.0105 | 0.0398 | 0.0435 |
Onchocerca volvulus | Lactoylglutathione lyase homolog | 0.1306 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Activity against human androgen receptor expressed in HepG2 cells assessed as renilla reporter gene activation in presence of 1 nM DHT at 1 uM after 40 hrs | ChEMBL. | 17149866 | |
Activity (binding) | Displacement of androgen fluormone from androgen receptor at 100 uM | ChEMBL. | 17149866 | |
Activity (binding) | 0 | Displacement of androgen fluormone from androgen receptor at 100 uM | ChEMBL. | 17149866 |
Activity (binding) | 0 | Activity against human androgen receptor expressed in HepG2 cells assessed as renilla reporter gene activation in presence of 1 nM DHT at 1 uM after 40 hrs | ChEMBL. | 17149866 |
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of androgen receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.5686 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.7076 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.77 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.9589 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.3553 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (ADMET) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (ADMET) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (functional) | 17.4121 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.3705 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 42.1632 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of farnesoid X receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 54.4827 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 55.062 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 61.1306 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway measured by Nrf2-dependant transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 74.978 uM | PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.