Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0083 | 0.0353 | 0.0353 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0329 | 0.1874 | 0.1577 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0494 | 0.29 | 0.29 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0494 | 0.29 | 0.264 |
Leishmania major | vacuolar-type proton translocating pyrophosphatase 1, putative | 0.0329 | 0.1874 | 0.1577 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1639 | 1 | 0.5 |
Brugia malayi | hexokinase | 0.0083 | 0.0353 | 0.0353 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0494 | 0.29 | 0.5 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0329 | 0.1874 | 0.1577 |
Loa Loa (eye worm) | hexokinase type II | 0.0083 | 0.0353 | 0.0353 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1639 | 1 | 1 |
Leishmania major | polyprenyl synthase, putative | 0.0826 | 0.4955 | 0.4771 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1639 | 1 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1639 | 1 | 0.5 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0494 | 0.29 | 0.264 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0494 | 0.29 | 0.5 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0494 | 0.29 | 1 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0329 | 0.1874 | 0.1577 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0494 | 0.29 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0329 | 0.1874 | 0.1577 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0329 | 0.1874 | 0.1577 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0826 | 0.4955 | 0.4771 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0329 | 0.1874 | 0.1577 |
Brugia malayi | Hexokinase family protein | 0.0052 | 0.016 | 0.016 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0494 | 0.29 | 0.29 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0826 | 0.4955 | 0.4771 |
Loa Loa (eye worm) | hexokinase | 0.0052 | 0.016 | 0.016 |
Onchocerca volvulus | 0.0083 | 0.0353 | 1 | |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0826 | 0.4955 | 0.4771 |
Schistosoma mansoni | glutathione synthetase | 0.0494 | 0.29 | 0.264 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0329 | 0.1874 | 0.1577 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0494 | 0.29 | 0.264 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0494 | 0.29 | 0.264 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0494 | 0.29 | 0.264 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0826 | 0.4955 | 0.4771 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0494 | 0.29 | 0.5 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0494 | 0.29 | 0.5 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0826 | 0.4955 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1639 | 1 | 0.5 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1639 | 1 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1639 | 1 | 1 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0329 | 0.1874 | 0.1577 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0494 | 0.29 | 1 |
Plasmodium vivax | octaprenyl pyrophosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1639 | 1 | 1 |
Onchocerca volvulus | 0.0083 | 0.0353 | 1 | |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0329 | 0.1874 | 0.1577 |
Brugia malayi | Hexokinase family protein | 0.0083 | 0.0353 | 0.0353 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0826 | 0.4955 | 0.4771 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0188 | 0.0188 |
Onchocerca volvulus | 0.0083 | 0.0353 | 1 | |
Leishmania major | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1639 | 1 | 1 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0494 | 0.29 | 0.264 |
Schistosoma mansoni | trans-prenyltransferase | 0.0494 | 0.29 | 0.264 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0826 | 0.4955 | 0.4955 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Loa Loa (eye worm) | hexokinase | 0.0083 | 0.0353 | 0.0353 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0494 | 0.29 | 0.264 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.0826 | 0.4955 | 0.4955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.