TDR Targets

Basic information

Technical information

TDR Targets ID: 410537
Name: 5-methyl-2-[[(1S)-1-phenylethyl]amino]-5-prop an-2-yl-1,3-thiazol-4-one
MW: 276.397 | Formula: C15H20N2OS
H donors: 1 H acceptors: 1 LogP: 3.6 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: C[C@@H](c1ccccc1)NC1=NC(=O)C(S1)(C)C(C)C
InChi: 1S/C15H20N2OS/c1-10(2)15(4)13(18)17-14(19-15)16-11(3)12-8-6-5-7-9-12/h5-11H,1-4H3,(H,16,17,18)/t11-,15?/m0/s1
InChiKey: LESGKWOTXMFHMB-VPHXOMNUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-isopropyl-5-methyl-2-[[(1S)-1-phenylethyl]amino]thiazol-4-one
5-isopropyl-5-methyl-2-[[(1S)-1-phenylethyl]amino]-4-thiazolone
5-isopropyl-5-methyl-2-[[(1S)-1-phenylethyl]amino]-2-thiazolin-4-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	hydroxysteroid (11-beta) dehydrogenase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	short chain dehydrogenase	Get druggable targets OG5_132866	All targets in OG5_132866
Mycobacterium tuberculosis	Probable oxidoreductase	Get druggable targets OG5_132866	All targets in OG5_132866

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxysteroid (11-beta) dehydrogenase 1	292 aa	250 aa	24.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0253	0.6928	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0253	0.6928	1
Echinococcus granulosus	geminin	0.0165	0.3968	0.5728
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0253	0.6928	1
Echinococcus multilocularis	geminin	0.0165	0.3968	0.5728
Brugia malayi	ecdysteroid receptor	0.0253	0.6928	1
Schistosoma mansoni	zinc finger protein	0.012	0.2457	0.2924
Onchocerca volvulus		0.012	0.2457	0.0297
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0083	0.012
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.007	0.0799	1
Onchocerca volvulus		0.012	0.2457	0.0297
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0253	0.6928	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.007	0.0799	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.007	0.0799	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.012	0.2457	0.3546
Loa Loa (eye worm)	hypothetical protein	0.0253	0.6928	1
Brugia malayi	nuclear receptor NHR-88	0.012	0.2457	0.3546
Brugia malayi	nuclear receptor RXR	0.012	0.2457	0.3546
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2935	0.4237
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.1967	0.1967
Mycobacterium ulcerans	short chain dehydrogenase	0.0346	1	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.012	0.2457	0.3546
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0083	0.012
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.012	0.2457	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2935	0.4237
Brugia malayi	calpain 7	0.007	0.0799	0.1154
Loa Loa (eye worm)	hypothetical protein	0.0253	0.6928	1
Loa Loa (eye worm)	hypothetical protein	0.0253	0.6928	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.012	0.2457	0.3546
Brugia malayi	hypothetical protein	0.0134	0.2935	0.4237
Schistosoma mansoni	calpain C (C02 family)	0.007	0.0799	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0137	0.3022	0.4362
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0253	0.6928	1
Loa Loa (eye worm)	hypothetical protein	0.0253	0.6928	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.1967	0.1967
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0253	0.6928	1
Schistosoma mansoni	nuclear receptor nhr-48	0.012	0.2457	0.2924
Schistosoma mansoni	hypothetical protein	0.0165	0.3968	0.5316
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0064	0.0609	0.0609
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0134	0.2935	0.3682
Trypanosoma cruzi	kinesin, putative	0.0049	0.0097	0.1219
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0253	0.6928	1
Loa Loa (eye worm)	DR-78	0.012	0.2457	0.3546
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.007	0.0799	1
Schistosoma mansoni	nuclear receptor	0.012	0.2457	0.2924
Echinococcus multilocularis	hypothetical protein	0.007	0.0799	0.1154
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0134	0.2935	0.4237
Loa Loa (eye worm)	hypothetical protein	0.0253	0.6928	1
Mycobacterium tuberculosis	Probable reductase	0.0105	0.1967	0.1967
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0202	0.0292
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.012	0.2457	0.3546
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0083	0.012
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.007	0.0799	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.007	0.0799	0.0302
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0064	0.0609	0.0879
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.007	0.0799	1
Brugia malayi	nuclear receptor NHR-88	0.0253	0.6928	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0134	0.2935	0.4237
Plasmodium vivax	calpain, putative	0.007	0.0799	1
Loa Loa (eye worm)	calpain	0.007	0.0799	0.1154
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0253	0.6928	1
Schistosoma mansoni	nuclear receptor	0.012	0.2457	0.2924
Brugia malayi	steroid hormone receptor	0.0253	0.6928	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0253	0.6928	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0253	0.6928	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0253	0.6928	1
Brugia malayi	nuclear receptor NHR-67	0.012	0.2457	0.3546
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2935	0.4237
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0253	0.6928	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0253	0.6928	1
Schistosoma mansoni	nuclear hormone receptor	0.012	0.2457	0.2924
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.012	0.2457	0.0297
Trypanosoma brucei	calpain-like protein, putative	0.007	0.0799	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0253	0.6928	1
Loa Loa (eye worm)	calpain 5	0.0049	0.0097	0.0141
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0064	0.0609	0.7613
Echinococcus multilocularis	calpain	0.007	0.0799	0.1154
Echinococcus granulosus	calpain A	0.007	0.0799	0.1154
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0253	0.6928	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0253	0.6928	1
Schistosoma mansoni	nuclear hormone receptor	0.012	0.2457	0.2924
Trypanosoma brucei	calpain-like protein, putative	0.007	0.0799	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0253	0.6928	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0205	0.5309	0.7438
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0253	0.6928	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.012	0.2457	0.3546
Echinococcus granulosus	Nuclear hormone receptor HR96	0.012	0.2457	0.3546
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.007	0.0799	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0205	0.5309	0.7438
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Loa Loa (eye worm)	calpain family protein 1	0.0185	0.4655	0.6719
Brugia malayi	nuclear hormone receptor	0.012	0.2457	0.3546
Brugia malayi	hypothetical protein	0.012	0.2457	0.3546
Schistosoma mansoni	calpain-7 (C02 family)	0.007	0.0799	0.0302
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0253	0.6928	1
Loa Loa (eye worm)	hypothetical protein	0.0253	0.6928	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0205	0.5309	0.7663
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.2358	0.2358
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2935	0.4237
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0253	0.6928	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.012	0.2457	0.3546
Echinococcus multilocularis	calpain 5	0.007	0.0799	0.1154
Trypanosoma brucei	calpain-like protein, putative	0.007	0.0799	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.007	0.0799	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0253	0.6928	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.1967	0.1967
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Trypanosoma brucei	calpain-like protein, putative	0.007	0.0799	1
Plasmodium falciparum	thioredoxin reductase	0.0046	0	0.5
Toxoplasma gondii	thioredoxin reductase	0.0046	0	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0253	0.6928	1
Brugia malayi	calpain family protein 1	0.0185	0.4655	0.6719
Brugia malayi	nuclear hormone receptor	0.0253	0.6928	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.012	0.2457	0.3546
Brugia malayi	conserved hypotetical protein	0.012	0.2457	0.3546
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0253	0.6928	1
Leishmania major	kinesin, putative	0.0049	0.0097	0.1219
Echinococcus multilocularis	calpain family protein 1, d	0.0137	0.3022	0.4362
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0253	0.6928	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.012	0.2457	0.3546
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.012	0.2457	0.3546
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.007	0.0799	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0253	0.6928	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.2358	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0253	0.6928	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2935	0.4237
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.007	0.0799	1
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0049	0.0097	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0064	0.0609	0.0879
Brugia malayi	calpain 5	0.0049	0.0097	0.0141
Loa Loa (eye worm)	steroid hormone receptor	0.0253	0.6928	1
Echinococcus granulosus	calpain 7 C02 family	0.007	0.0799	0.1154
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Trypanosoma brucei	kinesin, putative	0.0049	0.0097	0.1219
Brugia malayi	Nuclear hormone receptor E75	0.012	0.2457	0.3546
Schistosoma mansoni	hypothetical protein	0.0165	0.3968	0.5316
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0253	0.6928	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0253	0.6928	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0064	0.0609	0.0879
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Loa Loa (eye worm)	hypothetical protein	0.0115	0.232	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0253	0.6928	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.012	0.2457	0.3546
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0253	0.6928	1
Schistosoma mansoni	nuclear hormone receptor	0.0253	0.6928	1
Loa Loa (eye worm)	hypothetical protein	0.0164	0.3953	0.5706
Onchocerca volvulus		0.0253	0.6928	1
Brugia malayi	Steroid receptor seven-up type 2	0.0253	0.6928	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0134	0.2935	0.3682
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0253	0.6928	1
Echinococcus granulosus	FTZ F1 alpha	0.0253	0.6928	1
Brugia malayi	nuclear receptor RXR	0.0134	0.2935	0.4237
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0185	0.4655	0.6403
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.1967	0.1967
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0205	0.5309	0.7663
Onchocerca volvulus	Bile acid receptor homolog	0.0253	0.6928	1
Schistosoma mansoni	calpain (C02 family)	0.007	0.0799	0.0302
Echinococcus granulosus	calpain	0.007	0.0799	0.1154
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0253	0.6928	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.012	0.2457	0.3546
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0253	0.6928	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.2358	0.2358
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.2358	0.2358
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.012	0.2457	0.3546
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0134	0.2935	0.4237
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.007	0.0799	1
Brugia malayi	hypothetical protein	0.012	0.2457	0.3546
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0253	0.6928	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0253	0.6928	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.012	0.2457	0.3546
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0253	0.6928	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0083	0.012
Schistosoma mansoni	thyroid hormone receptor	0.0253	0.6928	1
Schistosoma mansoni	thyroid hormone receptor	0.0253	0.6928	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0253	0.6928	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.012	0.2457	0.2924
Echinococcus granulosus	calpain 5	0.007	0.0799	0.1154
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0253	0.6928	1
Schistosoma mansoni	coup transcription factor	0.0253	0.6928	1
Echinococcus granulosus	nuclear receptor nhr 48	0.012	0.2457	0.3546
Echinococcus multilocularis	calpain A	0.0206	0.5336	0.7702
Echinococcus granulosus	calpain A	0.0206	0.5336	0.7702
Trypanosoma brucei	antigen, putative	0.007	0.0799	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0253	0.6928	1
Echinococcus multilocularis	calpain 7 (C02 family)	0.007	0.0799	0.1154
Echinococcus granulosus	thyroid hormone receptor alpha	0.012	0.2457	0.3546
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.007	0.0799	1
Plasmodium falciparum	glutathione reductase	0.0046	0	0.5
Brugia malayi	orphan nuclear receptor NR2E1	0.012	0.2457	0.3546
Loa Loa (eye worm)	hypothetical protein	0.0253	0.6928	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.007	0.0799	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0253	0.6928	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.1967	0.1967
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0253	0.6928	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.5935	0.5935
Loa Loa (eye worm)	nuclear hormone receptor	0.012	0.2457	0.3546
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0253	0.6928	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0253	0.6928	1
Brugia malayi	ecdysone receptor	0.012	0.2457	0.3546
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.012	0.2457	0.2924
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.007	0.0799	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Entamoeba histolytica	protein kinase, putative	0.0049	0.0097	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0253	0.6928	1
Echinococcus multilocularis	FTZ F1 alpha	0.0253	0.6928	1
Brugia malayi	calpain family protein 1	0.0185	0.4655	0.6719
Loa Loa (eye worm)	hypothetical protein	0.012	0.2457	0.3546
Echinococcus multilocularis	ecdysone induced protein 78C	0.0253	0.6928	1
Trypanosoma cruzi	kinesin, putative	0.0049	0.0097	0.1219
Echinococcus multilocularis	nuclear receptor nhr 48	0.012	0.2457	0.3546
Loa Loa (eye worm)	calpain family protein 1	0.0137	0.3022	0.4362
Brugia malayi	tailless protein	0.012	0.2457	0.3546
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0253	0.6928	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.4655	0.6719
Brugia malayi	Nuclear hormone receptor-like 1	0.0134	0.2935	0.4237
Brugia malayi	Nuclear hormone receptor E75	0.012	0.2457	0.3546
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0253	0.6928	1
Brugia malayi	hypothetical protein	0.0134	0.2935	0.4237
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.007	0.0799	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0253	0.6928	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0134	0.2935	0.4237
Schistosoma mansoni	calpain-7 (C02 family)	0.007	0.0799	0.0302
Onchocerca volvulus	Protein ultraspiracle homolog	0.0253	0.6928	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0253	0.6928	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 20 nM	Inhibition of human 11beta-HSD1 over expressed in CHO cells by whole cell assay	ChEMBL.	17266194
IC50 (binding)	= 20 nM	Inhibition of human 11beta-HSD1 over expressed in CHO cells by whole cell assay	ChEMBL.	17266194
Ki (binding)	= 50 nM	Displacement of [3H]cortisone from human recombinant 11beta-HSD1 by SPA	ChEMBL.	17266194
Ki (binding)	= 50 nM	Displacement of [3H]cortisone from human recombinant 11beta-HSD1 by SPA	ChEMBL.	17266194

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL376470
PubChem: 16105485

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 410537