TDR Targets

Basic information

Technical information

TDR Targets ID: 410542
Name: 4-(2-anilinopyridin-3-yl)-N-(3,4,5-trimethoxy phenyl)-1,3,5-triazin-2-amine
MW: 430.459 | Formula: C23H22N6O3
H donors: 2 H acceptors: 4 LogP: 4.23 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(OC)cc(cc1OC)Nc1ncnc(n1)c1cccnc1Nc1ccccc1
InChi: 1S/C23H22N6O3/c1-30-18-12-16(13-19(31-2)20(18)32-3)28-23-26-14-25-22(29-23)17-10-7-11-24-21(17)27-15-8-5-4-6-9-15/h4-14H,1-3H3,(H,24,27)(H,25,26,28,29)
InChiKey: YRSYWYSGZPRSOP-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

4-(2-anilino-3-pyridyl)-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine
4-(2-phenylazanylpyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine
[4-(2-anilino-3-pyridyl)-s-triazin-2-yl]-(3,4,5-trimethoxyphenyl)amine
4-[2-(phenylamino)pyridin-3-yl]-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine
4-[2-(phenylamino)-3-pyridyl]-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine
[4-[2-(phenylamino)-3-pyridyl]-s-triazin-2-yl]-(3,4,5-trimethoxyphenyl)amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TEK tyrosine kinase, endothelial	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1143	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0145	0.6176	0.7758
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0068	0.2649	0.4289
Echinococcus granulosus	FTZ F1 alpha	0.0145	0.6176	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.1143	0.1436
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0017	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0145	0.6176	0.7758
Brugia malayi	tailless protein	0.0068	0.2649	0.3328
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0057	0.2118	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0068	0.2649	0.3328
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0145	0.6176	0.7758
Brugia malayi	hypothetical protein	0.0016	0.0216	0.0272
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0068	0.2649	0.3328
Onchocerca volvulus		0.0145	0.6176	0.8035
Schistosoma mansoni	nuclear hormone receptor	0.0068	0.2649	0.4289
Brugia malayi	nuclear receptor RXR	0.0077	0.3027	0.3802
Brugia malayi	Nuclear hormone receptor-like 1	0.0077	0.3027	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Brugia malayi	photoreceptor-specific nuclear receptor	0.0145	0.6176	0.7758
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0145	0.6176	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0145	0.6176	0.8035
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0185	0.03
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3027	0.3802
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0145	0.6176	0.7758
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0068	0.2649	0.4289
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0068	0.2649	0.4289
Brugia malayi	Nuclear hormone receptor-like 1	0.0077	0.3027	0.3802
Echinococcus multilocularis	neuroglian	0.0014	0.0149	0.0241
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.1143	0.5
Brugia malayi	ecdysteroid receptor	0.0145	0.6176	0.7758
Echinococcus granulosus	thyroid hormone receptor alpha	0.0068	0.2649	0.4289
Onchocerca volvulus		0.0068	0.2649	0.2404
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0145	0.6176	0.7758
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0068	0.2649	0.4289
Schistosoma mansoni	RAR-like nuclear receptor	0.0145	0.6176	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0068	0.2649	0.2404
Brugia malayi	Nuclear hormone receptor E75	0.0068	0.2649	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0145	0.6176	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0145	0.6176	0.8035
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0068	0.2649	0.4289
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0145	0.6176	0.7758
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0053	0.1942	0.244
Brugia malayi	hypothetical protein	0.0068	0.2649	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0317	0.0399
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0057	0.2118	0.2661
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0317	0.0399
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0057	0.2118	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0145	0.6176	0.7758
Loa Loa (eye worm)	hypothetical protein	0.0145	0.6176	0.7758
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0216	0.0272
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0077	0.3027	0.4901
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0068	0.2649	0.2404
Loa Loa (eye worm)	steroid hormone receptor	0.0145	0.6176	0.7758
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0145	0.6176	1
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1143	0.1436
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.1143	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0216	0.0272
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.1143	0.1851
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0057	0.2118	0.343
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.1143	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0068	0.2649	0.3328
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0077	0.3027	0.3802
Brugia malayi	Nuclear hormone receptor E75	0.0068	0.2649	0.3328
Brugia malayi	nuclear receptor NHR-67	0.0068	0.2649	0.3328
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0145	0.6176	0.7758
Brugia malayi	hypothetical protein	0.0077	0.3027	0.3802
Schistosoma mansoni	zinc finger protein	0.0068	0.2649	0.4289
Schistosoma mansoni	nephrin	0.0018	0.0348	0.0564
Brugia malayi	nuclear receptor NHR-88	0.0145	0.6176	0.7758
Mycobacterium leprae	Probable lipase LipE	0.0036	0.1143	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1143	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0145	0.6176	0.7758
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0184	0.7961	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.6176	0.7758
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0145	0.6176	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0145	0.6176	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3027	0.3802
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0145	0.6176	1
Brugia malayi	ecdysone receptor	0.0068	0.2649	0.3328
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0068	0.2649	0.4289
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Brugia malayi	hypothetical protein	0.0077	0.3027	0.3802
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0057	0.2118	0.343
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Loa Loa (eye worm)	nuclear hormone receptor	0.0068	0.2649	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1143	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0145	0.6176	0.7758
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0216	0.0272
Brugia malayi	Fibronectin type III domain containing protein	0.0016	0.0216	0.0272
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0145	0.6176	0.7758
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0068	0.2649	0.4289
Brugia malayi	Steroid receptor seven-up type 2	0.0145	0.6176	0.7758
Brugia malayi	conserved hypotetical protein	0.0068	0.2649	0.3328
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0145	0.6176	0.7758
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1143	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0145	0.6176	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0145	0.6176	0.7758
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.1143	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.7961	1
Brugia malayi	nuclear receptor RXR	0.0068	0.2649	0.3328
Echinococcus granulosus	roundabout 2	0.0022	0.0517	0.0837
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0068	0.2649	0.4289
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0145	0.6176	0.7758
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0068	0.2649	0.4289
Schistosoma mansoni	coup transcription factor	0.0145	0.6176	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.1143	0.5
Brugia malayi	nuclear receptor NHR-88	0.0068	0.2649	0.3328
Brugia malayi	beta-lactamase family protein	0.0036	0.1143	0.1436
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0145	0.6176	1
Schistosoma mansoni	nuclear receptor	0.0068	0.2649	0.4289
Brugia malayi	beta-lactamase family protein	0.0036	0.1143	0.1436
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0077	0.3027	0.4901
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0145	0.6176	0.7758
Loa Loa (eye worm)	hypothetical protein	0.0145	0.6176	0.7758
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0077	0.3027	0.4901
Schistosoma mansoni	nuclear receptor	0.0068	0.2649	0.4289
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Schistosoma mansoni	nuclear hormone receptor	0.0068	0.2649	0.4289
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0145	0.6176	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3027	0.3802
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0145	0.6176	0.7758
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0216	0.0272
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0145	0.6176	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0145	0.6176	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0057	0.2118	0.343
Schistosoma mansoni	thyroid hormone receptor	0.0145	0.6176	1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.1143	0.5
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0017	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0145	0.6176	0.7758
Brugia malayi	beta-lactamase	0.0036	0.1143	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0021
Brugia malayi	nuclear hormone receptor	0.0068	0.2649	0.3328
Schistosoma mansoni	retinoic acid receptor RXR	0.0145	0.6176	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.6176	0.7758
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1143	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0145	0.6176	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0185	0.0233
Schistosoma mansoni	nuclear hormone receptor	0.0145	0.6176	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0172	0.7407	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0068	0.2649	0.3328
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0145	0.6176	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0068	0.2649	0.3328
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0145	0.6176	0.7758
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0145	0.6176	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3027	0.3802
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0145	0.6176	0.7758
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0145	0.6176	0.7758
Brugia malayi	nuclear hormone receptor	0.0145	0.6176	0.7758
Schistosoma mansoni	nuclear receptor nhr-48	0.0068	0.2649	0.4289
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.1143	0.5
Loa Loa (eye worm)	DR-78	0.0068	0.2649	0.3328
Onchocerca volvulus		0.0068	0.2649	0.2404
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0145	0.6176	0.7758
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0145	0.6176	1
Echinococcus multilocularis	roundabout 2	0.0022	0.0517	0.0837
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0017	0.0027
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.1143	0.5
Echinococcus granulosus	nuclear receptor nhr 48	0.0068	0.2649	0.4289
Echinococcus granulosus	twitchin	0.0014	0.0149	0.0241
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0145	0.6176	1
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0017	0.0027
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0068	0.2649	0.3328
Echinococcus granulosus	defective proboscis extension response	0.0011	0.0017	0.0027
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0145	0.6176	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0011	0.0017	0.0027
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0077	0.3027	0.4901
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.1143	0.1851
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0068	0.2649	0.4289
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.1143	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0145	0.6176	0.7758
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.1143	0.5
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0385	0.0623
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0145	0.6176	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.1143	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0145	0.6176	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.1143	0.1851
Echinococcus multilocularis	FTZ F1 alpha	0.0145	0.6176	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2649	0.3328
Echinococcus multilocularis	ecdysone induced protein 78C	0.0145	0.6176	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0145	0.6176	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1143	0.1436
Echinococcus multilocularis	nuclear receptor nhr 48	0.0068	0.2649	0.4289
Trichomonas vaginalis	esterase, putative	0.0036	0.1143	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0145	0.6176	0.7758
Loa Loa (eye worm)	beta-lactamase	0.0036	0.1143	0.1436
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0145	0.6176	0.7758
Brugia malayi	steroid hormone receptor	0.0145	0.6176	0.7758
Onchocerca volvulus		0.0167	0.7169	0.962
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0145	0.6176	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0021
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0057	0.2118	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0057	0.2118	0.1101
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0145	0.6176	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0145	0.6176	0.7758
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0145	0.6176	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0068	0.2649	0.4289
Loa Loa (eye worm)	hypothetical protein	0.0077	0.3027	0.3802
Echinococcus granulosus	neuroglian	0.0014	0.0149	0.0241
Onchocerca volvulus	Bile acid receptor homolog	0.0145	0.6176	0.8035
Brugia malayi	hypothetical protein	0.0068	0.2649	0.3328
Echinococcus granulosus	Immunoglobulin	0.0011	0.0017	0.0027
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1143	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 68 nM	Inhibition of Tie2 by HTRF assay	ChEMBL.	17253678
IC50 (binding)	= 68 nM	Inhibition of Tie2 by HTRF assay	ChEMBL.	17253678
IC50 (binding)	>= 5000 nM	Inhibition of KDR by HTRF assay	ChEMBL.	17253678
IC50 (binding)	>= 5000 nM	Inhibition of KDR by HTRF assay	ChEMBL.	17253678

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL218057
PubChem: 16040288

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 410542