Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glutaminase, putative | 0.0302 | 0.3815 | 1 |
Schistosoma mansoni | glutaminase | 0.0302 | 0.3815 | 0.379 |
Brugia malayi | glutaminase DH11.1 | 0.0302 | 0.3815 | 0.5882 |
Loa Loa (eye worm) | glutaminase 2 | 0.0302 | 0.3815 | 0.5856 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.6486 | 1 |
Brugia malayi | DnaJ domain containing protein | 0.0068 | 0.0668 | 0.1029 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0474 | 0.0434 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0042 | 0.0064 |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.3409 | 0.3381 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.018 | 0.2176 | 0.3355 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0474 | 0.0434 |
Schistosoma mansoni | alpha glucosidase | 0.004 | 0.0295 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0264 | 0.0345 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0042 | 0.0064 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.066 | 0.062 |
Trichomonas vaginalis | protein kinase inhibitor, putative | 0.0068 | 0.0668 | 0.1058 |
Loa Loa (eye worm) | glutaminase | 0.0302 | 0.3815 | 0.5856 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.1064 | 0.1586 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0042 | 0.0064 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0133 | 0.5 |
Echinococcus multilocularis | geminin | 0.0188 | 0.2273 | 0.2241 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0133 | 0.0141 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0042 | 0.0064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0295 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0764 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.004 | 0.0295 | 0.5 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.004 | 0.0295 | 0.0254 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.018 | 0.2176 | 0.3312 |
Schistosoma mansoni | alpha-glucosidase | 0.0155 | 0.184 | 0.1806 |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.3409 | 0.3381 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.1064 | 0.1026 |
Brugia malayi | TAR-binding protein | 0.0272 | 0.3409 | 0.5255 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0272 | 0.3409 | 0.5255 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.066 | 0.062 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | RNA binding protein | 0.0272 | 0.3409 | 0.5255 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.066 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0498 | 0.0708 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.004 | 0.0295 | 0.3082 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0042 | 0.0064 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0133 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0264 | 0.0223 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0498 | 0.0768 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0042 | 0.0064 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0272 | 0.3409 | 0.5224 |
Echinococcus granulosus | geminin | 0.0188 | 0.2273 | 0.2241 |
Loa Loa (eye worm) | DnaJ domain-containing protein | 0.0068 | 0.0668 | 0.0971 |
Schistosoma mansoni | alpha-glucosidase | 0.0155 | 0.184 | 0.1806 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0042 | 0.0064 |
Echinococcus granulosus | dnaJ subfamily C 6 | 0.0068 | 0.0668 | 0.0628 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.066 | 0.062 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.1064 | 0.1026 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0764 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0498 | 0.0768 |
Leishmania major | alpha glucosidase II subunit, putative | 0.004 | 0.0295 | 0.3082 |
Onchocerca volvulus | 0.0502 | 0.6486 | 1 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.153 | 0.231 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0042 | 0.0064 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.1064 | 0.164 |
Brugia malayi | hypothetical protein | 0.0262 | 0.3268 | 0.5038 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0264 | 0.0407 |
Brugia malayi | hypothetical protein | 0.0502 | 0.6486 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0302 | 0.3815 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0042 | 0.0064 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.066 | 0.062 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.1064 | 0.1026 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.018 | 0.2176 | 0.2144 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0042 | 0.0064 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.004 | 0.0295 | 0.0393 |
Onchocerca volvulus | 0.0104 | 0.1157 | 0.173 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0272 | 0.3409 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0498 | 0.0708 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.004 | 0.0295 | 0.5 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.004 | 0.0295 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.3268 | 0.5006 |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.3409 | 0.3381 |
Echinococcus granulosus | tar DNA binding protein | 0.0272 | 0.3409 | 0.3381 |
Loa Loa (eye worm) | TAR-binding protein | 0.0272 | 0.3409 | 0.5224 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.066 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.066 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.153 | 0.2359 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0262 | 0.3268 | 0.324 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0133 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0295 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.3409 | 0.3381 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.1064 | 0.1026 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.018 | 0.2176 | 0.2144 |
Echinococcus multilocularis | dnaJ subfamily C 6 | 0.0068 | 0.0668 | 0.0628 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0668 | 0.0628 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.2273 | 0.2241 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0262 | 0.3268 | 0.324 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0474 | 0.0731 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0042 | 0.0064 |
Trypanosoma brucei | glucosidase, putative | 0.004 | 0.0295 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.1064 | 0.1026 |
Onchocerca volvulus | 0.0053 | 0.0474 | 0.0671 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.1064 | 0.1026 |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.3409 | 0.3381 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0133 | 0.0204 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.1064 | 0.1026 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.153 | 0.231 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.004 | 0.0295 | 0.0455 |
Loa Loa (eye worm) | RNA binding protein | 0.0272 | 0.3409 | 0.5224 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.018 | 0.2176 | 0.2144 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.2273 | 0.2241 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.