Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.1961 | 0.128 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0015 | 0.0781 | 0.0781 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4628 | 0.4172 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4628 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.5538 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.4628 | 0.4628 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.1961 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.1158 | 0.0408 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0015 | 0.0781 | 0.0781 |
Echinococcus granulosus | dna polymerase eta | 0.0015 | 0.0781 | 0.0781 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.1158 | 0.0408 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.5538 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0017 | 0.1158 | 0.0408 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4628 | 0.4172 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0012 | 0.0176 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.4628 | 0.4628 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0015 | 0.0781 | 0.0781 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0043 | 0.5538 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0015 | 0.0781 | 0.0781 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.5027 | 0.5027 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1961 | 0.128 |
Brugia malayi | hypothetical protein | 0.0038 | 0.4628 | 0.4628 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.3752 | 0.3223 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Brugia malayi | polk-prov protein | 0.0032 | 0.3752 | 0.3752 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0043 | 0.5538 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.1961 | 0.128 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0015 | 0.0781 | 0.0781 |
Schistosoma mansoni | DNA polymerase eta | 0.0015 | 0.0781 | 0.0781 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0015 | 0.0781 | 0.0781 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.4358 | 0.3879 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0781 | 0.0781 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Echinococcus granulosus | dna polymerase kappa | 0.0043 | 0.5538 | 0.5538 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.7443 | 0.7443 |
Echinococcus multilocularis | dna polymerase eta | 0.0015 | 0.0781 | 0.0781 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.5538 | 0.516 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.4628 | 0.4628 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.4358 | 0.3879 |
Echinococcus multilocularis | dna polymerase kappa | 0.0043 | 0.5538 | 0.5538 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.1961 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.3752 | 0.3223 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3752 | 0.3752 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4628 | 0.4172 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.5538 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.5538 | 0.516 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.5027 | 0.5027 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.4628 | 0.4628 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0015 | 0.0781 | 0.0781 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 16.5 | Antinociceptive activity in Swiss Albino mouse at 20 mg/kg, po by hot plate assay measured as licking latency | ChEMBL. | 17181165 |
Activity (functional) | = 28 | Antinociceptive activity in Swiss Albino mouse at 20 mg/kg, po by writhing test measured as number of writhes | ChEMBL. | 17181165 |
Activity (functional) | = 16.5 | Antinociceptive activity in Swiss Albino mouse at 20 mg/kg, po by hot plate assay measured as licking latency | ChEMBL. | 17181165 |
Activity (functional) | = 28 | Antinociceptive activity in Swiss Albino mouse at 20 mg/kg, po by writhing test measured as number of writhes | ChEMBL. | 17181165 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.