Detailed information for compound 41079

Basic information

Technical information
  • TDR Targets ID: 41079
  • Name: N-[4-(3-chloro-4-fluoroanilino)-7-(2-methoxye thoxy)pyrido[3,2-d]pyrimidin-6-yl]prop-2-enam ide
  • MW: 417.821 | Formula: C19H17ClFN5O3
  • H donors: 2 H acceptors: 4 LogP: 3.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCOc1cc2ncnc(c2nc1NC(=O)C=C)Nc1ccc(c(c1)Cl)F
  • InChi: 1S/C19H17ClFN5O3/c1-3-16(27)25-18-15(29-7-6-28-2)9-14-17(26-18)19(23-10-22-14)24-11-4-5-13(21)12(20)8-11/h3-5,8-10H,1,6-7H2,2H3,(H,22,23,24)(H,25,26,27)
  • InChiKey: ITJFSLJZVPCUFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(3-chloro-4-fluoro-anilino)-7-(2-methoxyethoxy)pyrido[3,2-d]pyrimidin-6-yl]prop-2-enamide
  • N-[4-(3-chloro-4-fluoroanilino)-7-(2-methoxyethoxy)-6-pyrido[3,2-d]pyrimidinyl]-2-propenamide
  • N-[4-[(3-chloro-4-fluoro-phenyl)amino]-7-(2-methoxyethoxy)pyrido[3,2-d]pyrimidin-6-yl]prop-2-enamide
  • N-[4-(3-chloro-4-fluoro-anilino)-7-(2-methoxyethoxy)pyrido[3,2-d]pyrimidin-6-yl]acrylamide
  • N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)pyrido[6,5-e]pyrimidin-6-yl]prop-2-enamide
  • N-[4-[(3-chloro-4-fluoro-phenyl)amino]-7-(2-methoxyethoxy)pyrido[6,5-e]pyrimidin-6-yl]prop-2-enamide
  • N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)-6-pyrido[6,5-e]pyrimidinyl]prop-2-enamide
  • N-[4-[(3-chloro-4-fluoro-phenyl)amino]-7-(2-methoxyethoxy)pyrido[6,5-e]pyrimidin-6-yl]acrylamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0218 0.2295 0.2295
Onchocerca volvulus 0.0384 0.412 0.4537
Echinococcus granulosus death domain containing protein 0.0015 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0752 0.0752
Onchocerca volvulus 0.0076 0.0739 0.0754
Schistosoma mansoni hypothetical protein 0.0037 0.0303 0.0303
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0285 0.3027 0.3006
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0435 0.4677 0.5
Echinococcus granulosus solute carrier family 28 0.0169 0.1759 0.1759
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0238 0.0265
Trypanosoma cruzi nucleoside transporter 1, putative 0.0144 0.1479 0.1453
Mycobacterium tuberculosis Adenosine kinase 0.0105 0.1049 0.6608
Echinococcus multilocularis sex peptide receptor 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0066
Schistosoma mansoni adenosine kinase 0.0919 1 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0435 0.4677 0.4661
Loa Loa (eye worm) STAT protein 0.0139 0.1424 0.1424
Onchocerca volvulus Putative pyridoxal kinase 0.0105 0.1049 0.1101
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0828 0.9004 0.9004
Trypanosoma brucei unspecified product 0.0144 0.1479 0.1453
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.0063 0.0596 0.0596
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0787 0.1682
Trichomonas vaginalis ribokinase, putative 0.0105 0.1049 0.1135
Schistosoma mansoni tyrosine kinase 0.0058 0.0531 0.0531
Echinococcus multilocularis ribokinase 0.0105 0.1049 0.1049
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0435 0.4677 0.4661
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.03 0.3197 0.3197
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0182 0.0253
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0182 0.0152
Brugia malayi Protein kinase domain containing protein 0.0015 0.0065 0.0065
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0076 0.0046
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma brucei adenosine transporter 2 0.0144 0.1479 0.1453
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Onchocerca volvulus 0.008 0.0776 0.0796
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0063 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0051 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma cruzi nucleoside transporter 1, putative 0.0144 0.1479 0.1453
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Brugia malayi isocitrate dehydrogenase 0.0016 0.0076 0.0076
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) neuropeptide F receptor 0.0384 0.412 0.412
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0105 0.1049 0.1135
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.1159 0.1132
Echinococcus multilocularis GPCR, family 2 0.0016 0.0075 0.0075
Brugia malayi Ribokinase 0.0105 0.1049 0.1049
Trypanosoma brucei purine nucleoside transporter 0.0144 0.1479 0.1453
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Echinococcus multilocularis neuropeptide Y receptor 0.0384 0.412 0.412
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0435 0.4677 0.4661
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Brugia malayi putative neuropeptide receptor NPR1 0.0384 0.412 0.412
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0435 0.4677 0.5179
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0144 0.1479 0.1453
Brugia malayi AKH receptor 0.0384 0.412 0.412
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.1159 0.1258
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.1049 0.1022
Trypanosoma brucei adenosine transporter 2 0.0144 0.1479 0.1453
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0076 0.0076
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.0962 0.0962
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.412 0.412
Schistosoma mansoni hypothetical protein 0.0352 0.3772 0.3772
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0081 0.0787 0.4829
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0238 0.0238
Trypanosoma brucei adenosine kinase, putative 0.0919 1 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0144 0.1479 0.1615
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0682 0.0654
Echinococcus granulosus bloom syndrome protein 0.0023 0.0145 0.0145
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0435 0.4677 0.4677
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.1049 0.1049
Echinococcus granulosus Ankyrin 0.0015 0.0066 0.0066
Onchocerca volvulus 0.0814 0.8849 0.9826
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0144 0.1479 0.1453
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0752 0.0752
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0076 0.0023
Leishmania major ubiquitin activating enzyme, putative 0.002 0.0114 0.0084
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.03 0.3197 0.3197
Echinococcus granulosus g-protein coupled receptor 0.0384 0.412 0.412
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0285 0.3029 0.3342
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0384 0.412 0.412
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0384 0.412 0.412
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0627 0.6789 0.6789
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0435 0.4677 0.5179
Onchocerca volvulus 0.0384 0.412 0.4537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.412 0.412
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0828 0.9004 0.9004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0285 0.3029 0.3029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.412 0.412
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0076 0.0046
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0352 0.0352
Echinococcus multilocularis neuropeptide Y receptor 0.0384 0.412 0.412
Brugia malayi G protein-coupled receptor F59B2.13 0.0384 0.412 0.412
Loa Loa (eye worm) G-protein coupled receptor 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Echinococcus granulosus neuropeptide receptor 0.0384 0.412 0.412
Trypanosoma cruzi nucleobase transporter, putative 0.0144 0.1479 0.1453
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0435 0.4677 0.4677
Schistosoma mansoni neuropeptide receptor 0.0384 0.412 0.412
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0025 0.0025
Leishmania major tagatose-6-phosphate kinase-like protein 0.0105 0.1049 0.1022
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.1159 0.1159
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.412 0.412
Loa Loa (eye worm) RecQ helicase 0.0023 0.0145 0.0145
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0238 0.0232
Brugia malayi Nucleoside transporter family protein 0.0828 0.9004 0.9004
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0135 0.1378 0.1353
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.412 0.412
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0144 0.1479 0.1453
Echinococcus multilocularis serotonin receptor 0.0384 0.412 0.412
Echinococcus granulosus alpha 1A adrenergic receptor 0.0384 0.412 0.412
Echinococcus granulosus biogenic amine 5HT receptor 0.0384 0.412 0.412
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0238 0.0232
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0384 0.412 0.412
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0144 0.1479 0.1453
Onchocerca volvulus Neuropeptide F receptor homolog 0.0384 0.412 0.4537
Schistosoma mansoni ribokinase 0.0105 0.1049 0.1049
Leishmania major hypothetical protein, conserved 0.0026 0.0182 0.0152
Brugia malayi phosphofructokinase 0.0115 0.1159 0.1159
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0384 0.412 0.412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.412 0.412
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0384 0.412 0.412
Echinococcus multilocularis g-protein coupled receptor 0.0384 0.412 0.412
Brugia malayi ORL1-like opioid receptor 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma brucei nucleoside transporter 1, putative 0.0144 0.1479 0.1453
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1049 0.1135
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0238 0.0232
Brugia malayi hypothetical protein 0.0144 0.1479 0.1479
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.1159 0.1159
Echinococcus multilocularis allatostatin A receptor 0.0384 0.412 0.412
Entamoeba histolytica nucleoside transporter, putative 0.0828 0.9004 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0075
Mycobacterium tuberculosis Ribokinase RbsK 0.0105 0.1049 0.6608
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0573 0.0573
Schistosoma mansoni biogenic amine receptor 0.0384 0.412 0.412
Echinococcus granulosus insulin receptor 0.0058 0.0531 0.0531
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Giardia lamblia Ribokinase 0.0105 0.1049 0.1165
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.1159 0.1258
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0384 0.412 0.412
Onchocerca volvulus Ribokinase homolog 0.0105 0.1049 0.1101
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0384 0.412 0.412
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0828 0.9004 0.9004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0132
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0384 0.412 0.412
Echinococcus multilocularis insulin receptor 0.0058 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0144 0.1479 0.1479
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.011 0.1112 0.1112
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0384 0.412 0.412
Schistosoma mansoni neuropeptide F-like receptor 0.0384 0.412 0.412
Schistosoma mansoni tyrosine kinase 0.0096 0.0951 0.0951
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.1159 0.1159
Echinococcus multilocularis G-protein coupled receptor, putative 0.0384 0.412 0.412
Loa Loa (eye worm) adenylyl cyclase 3 0.008 0.0776 0.0776
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.1159 0.2259
Echinococcus multilocularis orexin receptor type 2 0.0384 0.412 0.412
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0435 0.4677 0.4661
Echinococcus multilocularis g protein coupled receptor 0.0384 0.412 0.412
Schistosoma mansoni netrin receptor unc5 0.0015 0.0065 0.0065
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0025 0.0025
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0682 0.0654
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0787 0.1565
Brugia malayi Tachykinin-like peptides receptor 99D 0.0384 0.412 0.412
Schistosoma mansoni tyrosine kinase 0.0097 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0828 0.9004 0.9004
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0144 0.1479 0.1615
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0285 0.3029 0.3029
Loa Loa (eye worm) G-protein coupled receptor 0.0384 0.412 0.412
Schistosoma mansoni hypothetical protein 0.0352 0.3772 0.3772
Loa Loa (eye worm) TYRA-2 protein 0.0384 0.412 0.412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.412 0.412
Onchocerca volvulus 0.0384 0.412 0.4537
Brugia malayi STAT protein, DNA binding domain containing protein 0.0139 0.1424 0.1424
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0384 0.412 0.412
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0828 0.9004 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0076 0.0076
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0182 0.0182
Schistosoma mansoni amine GPCR 0.0384 0.412 0.412
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0459 0.0459
Entamoeba histolytica kinase, PfkB family 0.0105 0.1049 0.1135
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.1159 0.1159
Schistosoma mansoni hypothetical protein 0.0384 0.412 0.412
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0282
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0435 0.4677 0.5179
Echinococcus multilocularis Ankyrin 0.0015 0.0066 0.0066
Trypanosoma brucei ribokinase, putative 0.0105 0.1049 0.1022
Echinococcus multilocularis serotonin receptor 0.0384 0.412 0.412
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0076 0.0076
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0105 0.1049 0.6608
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0144 0.1479 0.1615
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0303 0.0303
Echinococcus granulosus neuropeptide Y receptor 0.0384 0.412 0.412
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0435 0.4677 0.4677
Entamoeba histolytica nucleoside transporter, putative 0.0144 0.1479 0.1615
Loa Loa (eye worm) hypothetical protein 0.0105 0.1049 0.1049
Echinococcus granulosus biogenic amine 5HT receptor 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0065 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0573 0.0573
Echinococcus granulosus neuropeptide FF receptor 2 0.0384 0.412 0.412
Schistosoma mansoni neuropeptide receptor 0.0384 0.412 0.412
Brugia malayi neuropeptide F receptor 0.0384 0.412 0.412
Schistosoma mansoni amine GPCR 0.0384 0.412 0.412
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.002 0.0114 0.0084
Echinococcus multilocularis fmrfamide receptor 0.0384 0.412 0.412
Onchocerca volvulus 0.0384 0.412 0.4537
Leishmania major nucleoside transporter 1, putative 0.0144 0.1479 0.1453
Loa Loa (eye worm) hypothetical protein 0.0053 0.0486 0.0486
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0169 0.1759 0.1759
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0238 0.051
Brugia malayi MH2 domain containing protein 0.0122 0.1242 0.1242
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Brugia malayi Uncoordinated protein 44 0.0015 0.0065 0.0065
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0135 0.1378 0.1353
Brugia malayi hypothetical protein 0.0128 0.131 0.131
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0435 0.4677 0.4661
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0682 0.0682
Toxoplasma gondii endonuclease IV APN 0.0081 0.0787 0.0787
Mycobacterium ulcerans fructokinase, PfkB 0.0105 0.1049 0.2018
Brugia malayi Serotonin receptor 0.0384 0.412 0.412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.412 0.412
Echinococcus multilocularis somatostatin receptor 0.0384 0.412 0.412
Echinococcus granulosus neuropeptide receptor 0.0384 0.412 0.412
Echinococcus multilocularis solute carrier family 28 0.0169 0.1759 0.1759
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0435 0.4677 0.4677
Echinococcus granulosus G protein coupled receptor 139 0.0384 0.412 0.412
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0435 0.4677 0.4677
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0076 0.0076
Onchocerca volvulus 0.0384 0.412 0.4537
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0081 0.0787 0.4625
Leishmania major adenosine kinase-like protein 0.0105 0.1049 0.1022
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0384 0.412 0.412
Echinococcus multilocularis adenosine kinase 0.0919 1 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0285 0.3027 0.3361
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.0063 0.0596 0.0596
Schistosoma mansoni biogenic amine receptor 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0075
Echinococcus multilocularis geminin 0.0352 0.3772 0.3772
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0135 0.1378 0.1353
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0573 0.0573
Schistosoma mansoni growth hormone secretagogue receptor 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0144 0.1479 0.1453
Echinococcus granulosus tm gpcr rhodopsin 0.0384 0.412 0.412
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0435 0.4677 0.4661
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0141 0.0141
Trypanosoma cruzi adenosine kinase, putative 0.0919 1 1
Mycobacterium ulcerans endonuclease IV 0.0081 0.0787 0.1442
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0238 0.0232
Echinococcus granulosus ribokinase 0.0105 0.1049 0.1049
Schistosoma mansoni histamine h1 receptor 0.0384 0.412 0.412
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0435 0.4677 1
Onchocerca volvulus 0.0384 0.412 0.4537
Brugia malayi putative neuropeptide receptor 0.0384 0.412 0.412
Brugia malayi Ectopic membrane ruffles in embryo protein 1 0.0063 0.0596 0.0596
Brugia malayi hypothetical protein 0.0037 0.0303 0.0303
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0182 0.0388
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0573 0.0573
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0459 0.0459
Brugia malayi Death domain containing protein 0.0015 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0384 0.412 0.412
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0076 0.0076
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0435 0.4677 1
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0169 0.1759 0.1759
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.412 0.412
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0573 0.0573
Echinococcus granulosus epidermal growth factor receptor 0.018 0.1878 0.1878
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.1159 0.1258
Echinococcus granulosus peptide allatostatin:somatostatin 0.0384 0.412 0.412
Echinococcus granulosus equilibrative nucleoside transporter 0.0828 0.9004 0.9004
Schistosoma mansoni tyrosine kinase 0.018 0.1878 0.1878
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0435 0.4677 0.5195
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0065 0.0065
Schistosoma mansoni tyrosine kinase 0.0058 0.0531 0.0531
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0384 0.412 0.412
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.0063 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0105 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0384 0.412 0.4537
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0285 0.3027 0.3006
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0238 0.0232
Brugia malayi follicle stimulating hormone receptor 0.0627 0.6789 0.6789
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0384 0.412 0.412
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.002 0.0114 0.0243
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0384 0.412 0.412
Entamoeba histolytica hypothetical protein 0.0037 0.0303 0.0304
Entamoeba histolytica hypothetical protein 0.0037 0.0303 0.0304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0238 0.0376
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.0063 0.0596 0.0596
Brugia malayi G-protein coupled receptor 0.0384 0.412 0.412
Trypanosoma brucei adenosine transporter, putative 0.0144 0.1479 0.1453
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0384 0.412 0.412
Echinococcus multilocularis neuropeptide FF receptor 2 0.0384 0.412 0.412
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0435 0.4677 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0238 0.0376
Brugia malayi Dopamine receptor 0.0384 0.412 0.412
Schistosoma mansoni hypothetical protein 0.0384 0.412 0.412
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Echinococcus granulosus neuropeptide s receptor 0.0384 0.412 0.412
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0076 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0384 0.412 0.412
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0384 0.412 0.412
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0285 0.3029 0.3029
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0076 0.0046
Entamoeba histolytica hypothetical protein 0.0037 0.0303 0.0304
Echinococcus multilocularis neuropeptides capa receptor 0.0384 0.412 0.412
Echinococcus multilocularis neuropeptide receptor A26 0.0384 0.412 0.412
Leishmania major nucleobase transporter 0.0144 0.1479 0.1453
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.1878 0.1878
Brugia malayi 6-phosphofructokinase 0.0115 0.1159 0.1159
Schistosoma mansoni amine GPCR 0.0384 0.412 0.412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0026 0.0182 0.0182
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0828 0.9004 1
Schistosoma mansoni hypothetical protein 0.0015 0.0065 0.0065
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0076 0.0162
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0285 0.3027 0.3006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0065 0.0065
Echinococcus multilocularis neuropeptides capa receptor 0.0384 0.412 0.412
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0435 0.4677 0.4677
Brugia malayi G-protein coupled receptor 0.0384 0.412 0.412
Onchocerca volvulus 0.0105 0.1049 0.1101
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) neuropeptide F receptor 0.0384 0.412 0.412
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0303 0.0303
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0384 0.412 0.412
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.0531 0.0531
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.002 0.0114 0.0093
Echinococcus multilocularis G protein coupled receptor 139 0.0384 0.412 0.412
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0285 0.3029 0.3342
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0384 0.412 0.412
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0682 0.0682
Trypanosoma brucei nucleoside transporter 1, putative 0.0144 0.1479 0.1453
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0238 0.0232
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Brugia malayi 6-phosphofructokinase 0.0115 0.1159 0.1159
Echinococcus granulosus adenosine kinase 0.0919 1 1
Onchocerca volvulus 0.0384 0.412 0.4537
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0132 0.0075
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0435 0.4677 1
Onchocerca volvulus 0.0384 0.412 0.4537
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0075 0.0075
Echinococcus granulosus hypothetical protein 0.0384 0.412 0.412
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0828 0.9004 1
Leishmania major adenosine kinase-like protein 0.0105 0.1049 0.1022
Echinococcus granulosus tm gpcr rhodopsin 0.0384 0.412 0.412
Schistosoma mansoni opsin-like receptor 0.0384 0.412 0.412
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.002 0.0114 0.0105
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0132 0.038
Trypanosoma brucei adenosine transporter 2, putative 0.0144 0.1479 0.1453
Entamoeba histolytica ribokinase, putative 0.0105 0.1049 0.1135
Brugia malayi sulfakinin receptor protein 0.0384 0.412 0.412
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.1159 0.1159
Echinococcus granulosus g protein coupled receptor 0.0384 0.412 0.412
Trypanosoma brucei adenosine transporter 2, putative 0.0144 0.1479 0.1453
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0076 0.0076
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0144 0.1479 0.1453
Echinococcus granulosus tar DNA binding protein 0.0061 0.0573 0.0573
Echinococcus granulosus 7tm_1 domain containing protein 0.0384 0.412 0.412
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0435 0.4677 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0384 0.412 0.412
Schistosoma mansoni tyrosine kinase 0.0096 0.0951 0.0951
Brugia malayi neuropeptide F receptor 0.0384 0.412 0.412
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0384 0.412 0.412
Onchocerca volvulus 0.0384 0.412 0.4537
Trypanosoma cruzi ribokinase, putative 0.0105 0.1049 0.1022
Echinococcus multilocularis fmrfamide receptor 0.0384 0.412 0.412
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0144 0.1479 0.1615
Loa Loa (eye worm) hypothetical protein 0.0081 0.0787 0.0787
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0145 0.0145
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0384 0.412 0.412
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0384 0.412 0.412
Echinococcus granulosus 7TM GPCR rhodopsin 0.0384 0.412 0.412
Onchocerca volvulus 0.0384 0.412 0.4537
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0384 0.412 0.412
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0435 0.4677 0.4661
Trypanosoma cruzi nucleoside transporter-like, putative 0.0144 0.1479 0.1453
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0435 0.4677 0.5179
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0384 0.412 0.412
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0384 0.412 0.412
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.412 0.412
Echinococcus granulosus fmrfamide receptor 0.0384 0.412 0.412
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0145 0.0145
Brugia malayi Dopamine receptor protein 2 0.0384 0.412 0.412
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0135 0.1378 0.1378
Schistosoma mansoni protein kinase 0.0144 0.1479 0.1479
Toxoplasma gondii nucleoside transporter protein 0.0144 0.1479 0.1479
Onchocerca volvulus 0.0384 0.412 0.4537
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.015 0.1546 0.1546
Echinococcus granulosus tumor protein p63 0.0365 0.3914 0.3914
Schistosoma mansoni hypothetical protein 0.0384 0.412 0.412
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0145 0.0128
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0182 0.0388
Echinococcus granulosus adenylate cyclase 9 0.008 0.0776 0.0776
Entamoeba histolytica hypothetical protein 0.0037 0.0303 0.0304
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0384 0.412 0.412
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.1159 0.7249
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0238 0.0238
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0573 0.0573
Trypanosoma brucei adenosine transporter 2, putative 0.0144 0.1479 0.1453
Echinococcus granulosus neuropeptide receptor A26 0.0384 0.412 0.412
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0025
Schistosoma mansoni neuropeptide receptor 0.0384 0.412 0.412
Echinococcus granulosus neuropeptides capa receptor 0.0384 0.412 0.412
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0384 0.412 0.412
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0435 0.4677 0.4677
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0682 0.0727
Onchocerca volvulus 0.0384 0.412 0.4537
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma brucei unspecified product 0.0144 0.1479 0.1453
Leishmania major putative PfkB family sugar kinase 0.0105 0.1049 0.1022
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trichomonas vaginalis ribokinase, putative 0.0105 0.1049 0.1135
Toxoplasma gondii kinase, pfkB family protein 0.0919 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0384 0.412 0.412
Echinococcus granulosus geminin 0.0352 0.3772 0.3772
Brugia malayi hypothetical protein 0.0105 0.1049 0.1049
Leishmania major nucleoside transporter 1, putative 0.0144 0.1479 0.1453
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0182 0.0152
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.412 0.412
Echinococcus granulosus g protein coupled receptor 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) phosphofructokinase 0.0115 0.1159 0.1159
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0066 0.0066
Leishmania major adenosine kinase, putative 0.0919 1 1
Trypanosoma brucei ribokinase, putative 0.0105 0.1049 0.1022
Brugia malayi hypothetical protein 0.0828 0.9004 0.9004
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0105 0.1049 0.1135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.412 0.412
Schistosoma mansoni neuropeptide F-like receptor 0.0384 0.412 0.412
Trypanosoma cruzi adenosine kinase, putative 0.0919 1 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0435 0.4677 0.5179
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0828 0.9004 1
Echinococcus granulosus neuropeptides capa receptor 0.0384 0.412 0.412
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.1159 0.1132
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.412 0.412
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0093 0.0093
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.1159 0.1258
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Echinococcus granulosus GPCR family 2 0.0016 0.0075 0.0075
Schistosoma mansoni amine GPCR 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.002 0.0114 0.0084
Schistosoma mansoni neuropeptide receptor 0.0384 0.412 0.412
Schistosoma mansoni amine GPCR 0.0384 0.412 0.412
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.1159 0.1132
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.1049 0.1022
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0684 0.7423 0.7423
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0285 0.3029 0.3029
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0115 0.0246
Brugia malayi larval opioid receptor 0.0384 0.412 0.412
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0384 0.412 0.412
Brugia malayi Serotonin receptor 0.0384 0.412 0.412
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0384 0.412 0.412
Echinococcus granulosus somatostatin receptor 0.0384 0.412 0.412
Onchocerca volvulus 0.0384 0.412 0.4537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.412 0.412
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0303 0.0303
Brugia malayi G protein-coupled receptor 0.0384 0.412 0.412
Echinococcus multilocularis neuropeptide s receptor 0.0384 0.412 0.412
Schistosoma mansoni adenoreceptor 0.0384 0.412 0.412
Echinococcus granulosus dro:myosuppressin receptor 0.0384 0.412 0.412
Trypanosoma brucei adenosine kinase, putative 0.0919 1 1
Onchocerca volvulus 0.0384 0.412 0.4537
Brugia malayi TAR-binding protein 0.0061 0.0573 0.0573
Echinococcus multilocularis tumor protein p63 0.0365 0.3914 0.3914
Schistosoma mansoni equilibrative nucleoside transporter 0.0144 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0828 0.9004 1
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Trypanosoma brucei adenosine transporter 2, putative 0.0144 0.1479 0.1453
Trichomonas vaginalis ribokinase, putative 0.0105 0.1049 0.1135
Entamoeba histolytica fructokinase, putative 0.0105 0.1049 0.1135
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0384 0.412 0.412
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0435 0.4677 0.5179
Leishmania major tagatose-6-phosphate kinase-like protein 0.0105 0.1049 0.1022
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0384 0.412 0.412
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0075 0.0075
Brugia malayi RNA binding protein 0.0061 0.0573 0.0573
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.1159 0.2073
Schistosoma mansoni opsin-like receptor 0.0384 0.412 0.412
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0238 0.0232
Leishmania major nucleobase transporter 0.0144 0.1479 0.1453
Schistosoma mansoni biogenic amine receptor 0.0384 0.412 0.412
Trypanosoma brucei purine nucleoside transporter 0.0144 0.1479 0.1453
Schistosoma mansoni biogenic amine (5HT) receptor 0.0384 0.412 0.412
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0075 0.0075
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0221 0.2332 0.2536
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.008 0.0776 0.0796
Brugia malayi Protein kinase domain containing protein 0.0058 0.0531 0.0531
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0144 0.1479 0.1615
Loa Loa (eye worm) RNA binding protein 0.0061 0.0573 0.0573
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0238 0.0232
Schistosoma mansoni opsin-like receptor 0.0384 0.412 0.412
Schistosoma mansoni myosin xvIII 0.0384 0.412 0.412
Toxoplasma gondii nucleoside transporter protein 0.0144 0.1479 0.1479
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0144 0.1479 0.1453
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0075 0.0075
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0682 0.0682
Echinococcus granulosus orexin receptor type 2 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Schistosoma mansoni biogenic amine (5HT) receptor 0.0384 0.412 0.412
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0828 0.9004 0.9004
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0065 0.0065
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0682 0.0682
Entamoeba histolytica nucleoside transporter, putative 0.0144 0.1479 0.1615
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0384 0.412 0.412
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0435 0.4677 0.4661
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1242 0.1242
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0135 0.1378 0.1353
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0682 0.0682
Leishmania major ribokinase, putative 0.0105 0.1049 0.1022
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.015 0.1549 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0682 0.0654
Trypanosoma cruzi nucleoside transporter 1, putative 0.0144 0.1479 0.1453
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0238 0.0238
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0105 0.1049 0.2018
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.412 0.412
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0919 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0076 0.0076
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0352 0.0352
Trypanosoma cruzi nucleobase transporter, putative 0.0144 0.1479 0.1453
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0435 0.4677 0.4661
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0435 0.4677 0.4677
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0384 0.412 0.412
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0076 0.0046
Onchocerca volvulus 0.0246 0.2608 0.2845
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0828 0.9004 1
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.015 0.1549 1
Schistosoma mansoni hypothetical protein 0.0035 0.0282 0.0282
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0384 0.412 0.412
Brugia malayi hypothetical protein 0.0026 0.0182 0.0182
Echinococcus multilocularis g protein coupled receptor 0.0384 0.412 0.412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.412 0.412
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Brugia malayi RE15519p 0.0384 0.412 0.412
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0063 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1242 0.1242
Echinococcus granulosus serotonin receptor 0.0384 0.412 0.412
Echinococcus multilocularis dro:myosuppressin receptor 0.0384 0.412 0.412
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.000000000046535 0.000000000046535
Brugia malayi Adenylyl cyclase protein 0.008 0.0776 0.0776
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0384 0.412 0.412
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.1159 0.7353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.412 0.412
Echinococcus granulosus sex peptide receptor 0.0384 0.412 0.412
Chlamydia trachomatis endonuclease IV 0.0081 0.0787 0.1236
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0435 0.4677 0.5179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma cruzi nucleobase transporter, putative 0.0144 0.1479 0.1453
Onchocerca volvulus 0.0053 0.0486 0.0471
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.015 0.1546 0.1689
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0435 0.4677 0.4677
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0573 0.0573
Schistosoma mansoni adenosine kinase 0.0919 1 1
Toxoplasma gondii nucleoside transporter protein 0.0144 0.1479 0.1479
Echinococcus granulosus neuropeptide Y receptor 0.0384 0.412 0.412
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.1159 0.1258
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0076 0.0076
Echinococcus granulosus tm gpcr rhodopsin 0.0384 0.412 0.412
Onchocerca volvulus 0.0384 0.412 0.4537
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.1159 0.1258
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0075
Brugia malayi Melatonin receptor type 1A 0.0384 0.412 0.412
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0285 0.3027 0.3006
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.1159 0.1258
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.9304 0.9304
Giardia lamblia Hypothetical protein 0.0828 0.9004 1
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0063 0.0596 0.063
Echinococcus granulosus g protein coupled receptor 0.0384 0.412 0.412
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.1159 0.1159
Loa Loa (eye worm) melatonin receptor type 1A 0.0384 0.412 0.412
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0076 0.0076
Brugia malayi hypothetical protein 0.0017 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0828 0.9004 0.9004
Trypanosoma brucei adenosine transporter, putative 0.0144 0.1479 0.1453
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0459 0.0459
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0435 0.4677 0.4661
Brugia malayi Dopamine receptor protein 1 0.0384 0.412 0.412
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0145 0.0128
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0435 0.4677 0.4661
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0075 0.0075
Schistosoma mansoni tyrosine kinase 0.0096 0.0951 0.0951
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0238 0.051
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0135 0.1378 0.1353
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0384 0.412 0.412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.412 0.412
Echinococcus multilocularis neuropeptide receptor 0.0384 0.412 0.412
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0076 0.0076
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.002 0.0114 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.412 0.412
Trypanosoma brucei adenosine transporter 2, putative 0.0144 0.1479 0.1453
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0075 0.0075
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0384 0.412 0.412
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0065 0.0065
Brugia malayi Pax transcription factor protein 2 0.0246 0.2608 0.2608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.412 0.412
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.0531 0.0531
Onchocerca volvulus 0.0384 0.412 0.4537
Brugia malayi hypothetical protein 0.0384 0.412 0.412
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.1878 0.1878
Echinococcus multilocularis 0.0056 0.0511 0.0511
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0682 0.0654
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0435 0.4677 0.4661
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0182 0.0152
Schistosoma mansoni tyrosine kinase 0.0097 0.0962 0.0962
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0105 0.1049 0.1049
Schistosoma mansoni neuropeptide f receptor 76f 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0335 0.3578 0.3578
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0144 0.1479 0.1453
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.0531 0.0531
Echinococcus multilocularis neuropeptide receptor 0.0384 0.412 0.412
Loa Loa (eye worm) pax transcription factor protein 2 0.0246 0.2608 0.2608
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0169 0.1759 0.1759
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.0962 0.0962
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0435 0.4677 0.5179
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0384 0.412 0.412
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0081 0.0787 0.0787
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0285 0.3029 0.3029
Echinococcus granulosus tachykinin peptides receptor 99D 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.008 0.0776 0.0776
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0435 0.4677 0.4677
Onchocerca volvulus 0.0384 0.412 0.4537
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.1878 0.1878
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0105 0.1049 0.1049
Echinococcus granulosus allatostatin A receptor 0.0384 0.412 0.412
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Echinococcus multilocularis g protein coupled receptor 0.0384 0.412 0.412
Echinococcus multilocularis adenylate cyclase 9 0.008 0.0776 0.0776
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0384 0.412 0.412
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0046 0.0401 0.0413
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0435 0.4677 0.4677
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0573 0.0573
Trypanosoma cruzi nucleoside transporter-like, putative 0.0144 0.1479 0.1453
Brugia malayi GnHR receptor homolog 0.0384 0.412 0.412
Mycobacterium leprae Probable adenosine kinase adk 0.0105 0.1049 0.6474

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.97 nM Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by immunoaffinity chromatography ChEMBL. 10753475
IC50 (binding) = 0.97 nM Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by immunoaffinity chromatography ChEMBL. 10753475
IC50 (binding) = 377 nM Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblotting ChEMBL. 10753475
IC50 (binding) = 377 nM Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblotting ChEMBL. 10753475
Inhibition (functional) > 80 % Irreversible inhibition of formation of phosphorylated EGFR enzyme in A431 cells 8 h after washing cells free of the inhibitor ChEMBL. 10753475
Inhibition (functional) > 80 % Irreversible inhibition of formation of phosphorylated EGFR enzyme in A431 cells 8 h after washing cells free of the inhibitor ChEMBL. 10753475

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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