Detailed information for compound 41098

Basic information

Technical information
  • TDR Targets ID: 41098
  • Name: 1-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)pip eridine
  • MW: 233.306 | Formula: C14H19NO2
  • H donors: 0 H acceptors: 0 LogP: 2.59 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN(CC1)CC1COc2c(O1)cccc2
  • InChi: 1S/C14H19NO2/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12/h2-3,6-7,12H,1,4-5,8-11H2
  • InChiKey: LYKMMUBOEFYJQG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Piperoxan
  • 59-39-2
  • 5-20-03-00452 (Beilstein Handbook Reference)
  • BRN 0222516
  • Benodaine
  • F933
  • Fourneau 933
  • Piperidine, 1-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)- (9CI)
  • Piperidine, 1-(1,4-benzodioxan-2-ylmethyl)-
  • Piperoxan [BAN:INN]
  • Piperoxane
  • Piperoxane [INN-French]
  • Piperoxano [INN-Spanish]
  • Piperoxanum [INN-Latin]
  • NCGC00160643-01
  • PDSP1_001101
  • 1,4-Benzodioxane, 2-(piperidinomethyl)-
  • PDSP2_001085
  • 1,4-BENZODIOXAN, 2-(PIPERIDINOMETHYL)-
  • 2-Piperidinomethyl-1,4-benzodioxan

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor alpha 2A References
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens adrenoceptor alpha 1A References
Homo sapiens adrenoceptor alpha 2B References
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 2C Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 1B References
Homo sapiens adrenoceptor alpha 1D References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni amine GPCR Adrenergic receptor alpha-2   450 aa 439 aa 29.2 %
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Echinococcus multilocularis neuropeptides capa receptor Adrenergic receptor alpha-2   450 aa 486 aa 20.6 %
Loa Loa (eye worm) TYRA-2 protein Adrenergic receptor alpha-2   450 aa 488 aa 23.8 %
Schistosoma mansoni biogenic amine (5HT) receptor Adrenergic receptor alpha-2   450 aa 433 aa 27.9 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 420 aa 19.8 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Adrenergic receptor alpha-2   450 aa 378 aa 20.9 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Echinococcus granulosus biogenic amine 5HT receptor Adrenergic receptor alpha-2   450 aa 423 aa 31.7 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Echinococcus granulosus alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 476 aa 21.0 %
Echinococcus multilocularis serotonin receptor Adrenergic receptor alpha-2   450 aa 426 aa 31.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0131 0.1746 0.2397
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0575 0.0575
Echinococcus multilocularis cathepsin b 0.0448 0.7284 0.7284
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.008 0.008
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.008 0.0109
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0098 0.0433
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.008 0.008
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.008 0.0109
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0124 0.1625 0.7224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1027 0.1027
Onchocerca volvulus 0.006 0.0498 0.2855
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1027 0.1411
Plasmodium vivax thioredoxin reductase, putative 0.0085 0.0943 0.4192
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0131 0.1746 0.1746
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0084 0.0372
Plasmodium falciparum serine repeat antigen 4 0.0032 0.0012 0.0054
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.008 0.008
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.008 0.008
Brugia malayi cathepsin Z-like cysteine proteinase 0.0032 0.0012 0.0017
Plasmodium vivax vivapain-3 0.0032 0.0012 0.0054
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.008 0.008
Trypanosoma cruzi 20S proteasome subunit 0.0077 0.0798 0.1095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0081 0.0234
Leishmania major proteasome beta 2 subunit, putative 0.0077 0.0798 0.3527
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0124 0.1625 0.2231
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Mycobacterium tuberculosis Conserved protein 0.0036 0.0081 0.0234
Echinococcus multilocularis cysteine protease 0.0083 0.0899 0.0899
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0077 0.0798 0.3527
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.008 0.008
Toxoplasma gondii thioredoxin reductase 0.0085 0.0943 0.417
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0012 0.0054
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.008 0.008
Giardia lamblia Cathepsin L precursor 0.0032 0.0012 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Echinococcus granulosus cysteine protease 0.0032 0.0012 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0083 0.0899 0.5147
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.008 0.0109
Schistosoma mansoni transient receptor potential channel 0.0097 0.1145 0.1572
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0899 0.1234
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0032 0.0012 0.0054
Plasmodium falciparum serine repeat antigen 8 0.0032 0.0012 0.0054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0448 0.7284 1
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0899 0.1234
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.008 0.0109
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.008 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.008 0.0109
Onchocerca volvulus 0.0036 0.008 0.0456
Loa Loa (eye worm) hypothetical protein 0.0448 0.7284 1
Mycobacterium tuberculosis Probable reductase 0.0195 0.2855 0.8194
Schistosoma mansoni neuropeptide receptor 0.0036 0.008 0.0109
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0081 0.036
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Echinococcus multilocularis cathepsin L cysteine protease 0.0083 0.0899 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0032 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0012 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Toxoplasma gondii preprocathepsin c precursor, putative 0.0032 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0032 0.0012 0.0054
Giardia lamblia Cysteine protease 0.0032 0.0012 0.0054
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0032 0.0012 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1027 0.1411
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0084 0.0084
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.008 0.008
Onchocerca volvulus 0.0034 0.0047 0.027
Leishmania major cathepsin L-like protease 0.0083 0.0899 0.3974
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0084 0.0372
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0081 0.0234
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0081 0.036
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0098 0.0435
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0498 0.0684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.008 0.0109
Giardia lamblia Cathepsin B precursor 0.0161 0.2261 1
Giardia lamblia Proteasome subunit beta type 2 0.0077 0.0798 0.3527
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.008 0.008
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0047 0.0208
Onchocerca volvulus 0.0131 0.1746 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0081 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Onchocerca volvulus 0.0036 0.008 0.0456
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.016 0.2249 0.6455
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.008 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1027 0.1411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0084 0.0372
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.1145 0.1572
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0033 0.0024 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.008 0.008
Plasmodium falciparum cysteine proteinase falcipain 3 0.0083 0.0899 0.3995
Onchocerca volvulus 0.0036 0.008 0.0456
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0032 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0032 0.0012 0.0054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0448 0.7284 1
Plasmodium vivax vivapain-2 0.0083 0.0899 0.3995
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0112
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0084 0.0084
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.008 0.0109
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.008 0.0109
Schistosoma mansoni netrin receptor unc5 0.0062 0.0529 0.0726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.008 0.008
Onchocerca volvulus Cathepsin L homolog 0.0083 0.0899 0.5147
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.016 0.2249 0.3088
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Schistosoma mansoni adenoreceptor 0.0036 0.008 0.0109
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0032 0.0012 0.0017
Mycobacterium ulcerans beta-lactamase 0.0036 0.0081 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.008 0.0109
Brugia malayi Cathepsin L-like cysteine proteinase 0.0083 0.0899 0.1234
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0062 0.0533 0.0732
Giardia lamblia Cysteine protease 0.0032 0.0012 0.0054
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0032 0.0012 0.0054
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0498 0.2855
Brugia malayi Death domain containing protein 0.0062 0.0529 0.0726
Brugia malayi Cathepsin L-like precursor 0.0083 0.0899 0.1234
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0032 0.0012 0.0054
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0047 0.0208
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0032 0.0012 0.0017
Plasmodium falciparum serine repeat antigen 1 0.0032 0.0012 0.0054
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.008 0.008
Echinococcus granulosus sex peptide receptor 0.0036 0.008 0.008
Mycobacterium ulcerans lipase LipD 0.0036 0.0081 0.0362
Brugia malayi fibroinase precursor 0.0032 0.0012 0.0017
Echinococcus granulosus hypothetical protein 0.0036 0.008 0.008
Brugia malayi Dopamine receptor 0.0036 0.008 0.0109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0077 0.0798 0.1095
Schistosoma mansoni opsin-like receptor 0.0036 0.008 0.0109
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0012 0.0017
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0032 0.0012 0.0054
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0081 0.0362
Giardia lamblia Cathepsin L-like protease 0.0032 0.0012 0.0054
Onchocerca volvulus 0.0036 0.008 0.0456
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0515 0.229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0012 0.0054
Giardia lamblia Cysteine protease 0.0032 0.0012 0.0054
Schistosoma mansoni neuropeptide receptor 0.0036 0.008 0.0109
Brugia malayi glutathione reductase 0.0085 0.0943 0.1294
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0032 0.0012 0.0054
Plasmodium falciparum proteasome subunit beta type-5 0.016 0.2249 1
Echinococcus granulosus serotonin receptor 0.0036 0.008 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.008 0.0109
Onchocerca volvulus 0.0034 0.0047 0.027
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0084 0.0372
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0077 0.0798 0.1095
Schistosoma mansoni cathepsin F (C01 family) 0.0083 0.0899 0.1234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0012 0.0054
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0047 0.0065
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0098 0.0134
Onchocerca volvulus 0.0083 0.0899 0.5147
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0098 0.0134
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0012 0.0017
Schistosoma mansoni biogenic amine receptor 0.0036 0.008 0.0109
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0515 0.0515
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.0109
Brugia malayi hypothetical protein 0.0034 0.0047 0.0065
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0047 0.0208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus granulosus somatostatin receptor 0.0036 0.008 0.008
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0047 0.0208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0899 0.3974
Schistosoma mansoni neuropeptide receptor 0.0036 0.008 0.0109
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.008 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.008 0.008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0083 0.0899 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0083 0.0899 0.3974
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.008 0.0109
Loa Loa (eye worm) cathepsin B 0.0161 0.2261 0.3104
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0017
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0306
Mycobacterium ulcerans hypothetical protein 0.0036 0.0081 0.0362
Plasmodium vivax proteasome subunit beta type-1, putative 0.0124 0.1625 0.7224
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0032 0.0012 0.0054
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0032 0.0012 0.0054
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0124 0.1625 0.7186
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.008 0.0109
Onchocerca volvulus 0.0083 0.0899 0.5147
Echinococcus granulosus cathepsin L 0.0032 0.0012 0.0012
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0032 0.0012 0.0054
Schistosoma mansoni inhibitor of apoptosis protein 0.0131 0.1746 0.2397
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0084 0.0372
Echinococcus granulosus cathepsin l1 0.0083 0.0899 0.0899
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.0899 0.3995
Schistosoma mansoni inositol monophosphatase 0.0037 0.0098 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus granulosus Ankyrin 0.0062 0.0533 0.0533
Echinococcus multilocularis cathepsin b 0.0448 0.7284 0.7284
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Brugia malayi AKH receptor 0.0036 0.008 0.0109
Brugia malayi Uncoordinated protein 44 0.0062 0.0529 0.0726
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.008 0.008
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.008 0.008
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.008 0.0109
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.008 0.008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.008 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.0899 0.3995
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0084 0.0374
Plasmodium falciparum serine repeat antigen 6 0.0032 0.0012 0.0054
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.016 0.2249 0.3088
Schistosoma mansoni opsin-like receptor 0.0036 0.008 0.0109
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0047 0.0047
Echinococcus multilocularis neuropeptide receptor 0.0036 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.008 0.008
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0012 0.0054
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0081 0.036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0017
Echinococcus multilocularis apoptotic protease activating factor 1 0.006 0.0498 0.0498
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.016 0.2249 0.3088
Brugia malayi larval opioid receptor 0.0036 0.008 0.0109
Entamoeba histolytica cysteine proteinase 1, putative 0.0032 0.0012 0.0054
Giardia lamblia Encystation-specific protease 0.0032 0.0012 0.0054
Loa Loa (eye worm) inositol-1 0.0037 0.0098 0.0134
Trypanosoma cruzi trypanothione reductase, putative 0.0085 0.0943 0.1294
Giardia lamblia Cathepsin L-like protease 0.0032 0.0012 0.0054
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0012 0.007
Leishmania major cathepsin L-like protease 0.0083 0.0899 0.3974
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.2308 0.2308
Loa Loa (eye worm) hypothetical protein 0.0083 0.0899 0.1234
Echinococcus granulosus cathepsin b 0.0448 0.7284 0.7284
Schistosoma mansoni neuropeptide receptor 0.0036 0.008 0.0109
Echinococcus multilocularis Ankyrin 0.0062 0.0533 0.0533
Schistosoma mansoni cathepsin B (C01 family) 0.0032 0.0012 0.0017
Brugia malayi Cathepsin L-like precursor 0.0083 0.0899 0.1234
Onchocerca volvulus 0.0083 0.0899 0.5147
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.008 0.008
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.008 0.0109
Leishmania major cathepsin L-like protease 0.0083 0.0899 0.3974
Schistosoma mansoni alpha-glucosidase 0.0141 0.191 0.2622
Leishmania major cysteine peptidase A (CPA) 0.0083 0.0899 0.3974
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Brugia malayi G-protein coupled receptor 0.0036 0.008 0.0109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0012 0.0017
Brugia malayi Dopamine receptor protein 2 0.0036 0.008 0.0109
Echinococcus multilocularis aminopeptidase N 0.0034 0.0047 0.0047
Mycobacterium ulcerans aminopeptidase N PepN 0.0034 0.0047 0.0209
Giardia lamblia Cysteine protease 0.0032 0.0012 0.0054
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.0109
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.008 0.008
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0047 0.0208
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.008 0.0456
Loa Loa (eye worm) proteasome subunit beta type 2 0.0077 0.0798 0.1095
Brugia malayi Cell death protein 3 precursor 0.006 0.0498 0.0684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0012 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Schistosoma mansoni hypothetical protein 0.006 0.0498 0.0684
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0077 0.0798 0.0798
Echinococcus multilocularis fmrfamide receptor 0.0036 0.008 0.008
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0083 0.0899 0.1234
Schistosoma mansoni biogenic amine receptor 0.0036 0.008 0.0109
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0012 0.0054
Loa Loa (eye worm) hypothetical protein 0.006 0.0498 0.0684
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0098 0.0433
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0195 0.2855 0.8194
Schistosoma mansoni opsin-like receptor 0.0036 0.008 0.0109
Giardia lamblia Cathepsin L precursor 0.0032 0.0012 0.0054
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.008 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.008 0.008
Brugia malayi cathepsin L precursor 0.0032 0.0012 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.008 0.0109
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0012 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0012 0.0054
Onchocerca volvulus 0.0036 0.0081 0.0467
Echinococcus multilocularis serotonin receptor 0.0036 0.008 0.008
Brugia malayi hypothetical protein 0.0035 0.0069 0.0094
Leishmania major hypothetical protein, conserved 0.0036 0.0081 0.036
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Onchocerca volvulus Cathepsin F homolog 0.0083 0.0899 0.5147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0112
Onchocerca volvulus 0.0036 0.008 0.0456
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.008 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Brugia malayi cathepsin L-like precursor 0.0083 0.0899 0.1234
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0012 0.0017
Plasmodium vivax unspecified product 0.0032 0.0012 0.0054
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Loa Loa (eye worm) aminopeptidase N 0.0034 0.0047 0.0065
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.011
Echinococcus granulosus neuropeptide receptor 0.0036 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0062 0.0529 0.0726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Schistosoma mansoni histamine h1 receptor 0.0036 0.008 0.0109
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Onchocerca volvulus 0.0083 0.0899 0.5147
Echinococcus multilocularis cathepsin L 0.0032 0.0012 0.0012
Entamoeba histolytica aminopeptidase, putative 0.0034 0.0047 0.0209
Mycobacterium leprae proteasome (beta subunit) PrcB 0.016 0.2249 0.6952
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Brugia malayi Proteasome A-type and B-type family protein 0.016 0.2249 0.3088
Onchocerca volvulus 0.0036 0.008 0.0456
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.008 0.008
Giardia lamblia Cathepsin B precursor 0.0032 0.0012 0.0054
Brugia malayi Cathepsin L-like precursor 0.0083 0.0899 0.1234
Echinococcus granulosus proteasome prosome macropain 0.016 0.2249 0.2249
Echinococcus granulosus orexin receptor type 2 0.0036 0.008 0.008
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Echinococcus multilocularis caspase 2 0.006 0.0498 0.0498
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0131 0.1746 0.2397
Schistosoma mansoni cathepsin F (C01 family) 0.0083 0.0899 0.1234
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1027 0.1027
Brugia malayi Inositol-1 0.0037 0.0098 0.0134
Loa Loa (eye worm) hypothetical protein 0.0062 0.0529 0.0726
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0081 0.036
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0032 0.0012 0.0017
Onchocerca volvulus 0.0036 0.008 0.0456
Schistosoma mansoni amine GPCR 0.0036 0.008 0.0109
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0081 0.0081
Schistosoma mansoni transient receptor potential channel 0.0064 0.0575 0.079
Onchocerca volvulus 0.0036 0.008 0.0456
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.008 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0012 0.0054
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Schistosoma mansoni amine GPCR 0.0436 0.7069 0.9705
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0195 0.2855 0.8194
Plasmodium vivax glutathione reductase, putative 0.0085 0.0943 0.4192
Giardia lamblia Cathepsin L precursor 0.0032 0.0012 0.0054
Entamoeba histolytica cysteine protease, putative 0.0083 0.0899 0.3995
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0899 0.3974
Loa Loa (eye worm) hypothetical protein 0.0131 0.1746 0.2397
Giardia lamblia Cathepsin B precursor 0.0032 0.0012 0.0054
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.2308 0.3168
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.008 0.008
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.008 0.008
Trypanosoma cruzi cruzipain precursor, putative 0.0083 0.0899 0.1234
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0306
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0098 0.0098
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0081 0.0234
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0032 0.0012 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0217 0.3236 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1027 0.1027
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0062 0.0529 0.0529
Onchocerca volvulus 0.0036 0.008 0.0456
Plasmodium vivax vivapain-2 0.0083 0.0899 0.3995
Onchocerca volvulus 0.0036 0.008 0.0456
Trypanosoma brucei trypanothione reductase 0.0085 0.0943 0.417
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.008 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.008 0.0109
Trypanosoma brucei proteasome subunit beta type-5, putative 0.016 0.2249 0.9948
Schistosoma mansoni hypothetical protein 0.0035 0.0069 0.0094
Loa Loa (eye worm) glutathione reductase 0.0085 0.0943 0.1294
Plasmodium falciparum thioredoxin reductase 0.0085 0.0943 0.4192
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0081 0.0234
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0084 0.0372
Echinococcus multilocularis somatostatin receptor 0.0036 0.008 0.008
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0952 0.0952
Brugia malayi Dopamine receptor protein 1 0.0036 0.008 0.0109
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.008 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.008 0.008
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0084 0.0372
Brugia malayi cathepsin F-like cysteine proteinase 0.0032 0.0012 0.0017
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0012 0.0054
Schistosoma mansoni alpha-glucosidase 0.0141 0.191 0.2622
Leishmania major cathepsin L-like protease 0.0083 0.0899 0.3974
Giardia lamblia Cathepsin B precursor 0.0161 0.2261 1
Onchocerca volvulus 0.0083 0.0899 0.5147
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0012 0.0017
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.003 0.0086
Brugia malayi cathepsin Z-like cysteine proteinase 0.0032 0.0012 0.0017
Brugia malayi G-protein coupled receptor 0.0036 0.008 0.0109
Brugia malayi beta-lactamase 0.0036 0.0081 0.0112
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Schistosoma mansoni cathepsin C 0.0032 0.0012 0.0017
Echinococcus granulosus g protein coupled receptor 0.0036 0.008 0.008
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0047 0.0065
Giardia lamblia Cathepsin L precursor 0.0032 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0124 0.1625 0.2231
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0012 0.0017
Mycobacterium ulcerans proteasome PrcB 0.016 0.2249 1
Schistosoma mansoni transient receptor potential channel 0.0064 0.0571 0.0784
Echinococcus multilocularis fmrfamide receptor 0.0036 0.008 0.008
Leishmania major cathepsin L-like protease 0.0083 0.0899 0.3974
Echinococcus multilocularis neuropeptide receptor 0.0036 0.008 0.008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0899 0.3974
Onchocerca volvulus Deterin homolog 0.0131 0.1746 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1027 0.1027
Brugia malayi proteasome subunit beta type 1 0.0124 0.1625 0.2231
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.008 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.008 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1027 0.1411
Plasmodium falciparum serine repeat antigen 5 0.0032 0.0012 0.0054
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0798 0.3527
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0084 0.0372
Loa Loa (eye worm) hypothetical protein 0.0083 0.0899 0.1234
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0012 0.0054
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.008 0.008
Plasmodium vivax proteasome subunit beta type-5, putative 0.016 0.2249 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0098 0.0433
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0069 0.0069
Brugia malayi Thioredoxin reductase 0.0085 0.0943 0.1294
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0124 0.1625 0.7186
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0041 0.017 0.0234
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0112
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0077 0.0798 0.0798
Brugia malayi Cathepsin L-like precursor 0.0083 0.0899 0.1234
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.0529 0.0726
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0047 0.0047
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0098 0.0433
Schistosoma mansoni amine GPCR 0.0036 0.008 0.0109
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Mycobacterium tuberculosis Probable oxidoreductase 0.0217 0.3236 0.9285
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.008 0.0109
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.008 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.008 0.008
Echinococcus multilocularis inhibitor of apoptosis protein 0.0131 0.1746 0.1746
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0084 0.0372
Toxoplasma gondii cathepsin CPC1 0.0032 0.0012 0.0054
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.0109
Brugia malayi Cathepsin L-like precursor 0.0083 0.0899 0.1234
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.008 0.0109
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.008 0.008
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.016 0.2249 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0098 0.0435
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0515 0.1478
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0098 0.0433
Mycobacterium tuberculosis Probable dehydrogenase 0.0195 0.2855 0.8194
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0077 0.0798 0.3546
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0899 0.1234
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0267 0.4114 0.5649
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.016 0.2249 0.9948
Echinococcus granulosus caspase 2 0.006 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0097 0.1145 0.1572
Plasmodium vivax serine-repeat antigen (SERA) 0.0032 0.0012 0.0054
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.1088 0.1088
Toxoplasma gondii proteasome subunit beta type, putative 0.016 0.2249 0.9948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0047 0.0047
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.008 0.008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0081 0.0081
Plasmodium vivax unspecified product 0.0032 0.0012 0.0054
Giardia lamblia Proteasome subunit beta type 1 0.0124 0.1625 0.7186
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0515 0.0515
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0571 0.0571
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0032 0.0012 0.0017
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0047 0.0047
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.008 0.0109
Trypanosoma brucei proteasome beta 6 subunit 0.0124 0.1625 0.7186
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.003 0.0092
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0195 0.2855 0.8825
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0032 0.0012 0.0054
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0077 0.0798 0.1095
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0131 0.1746 0.1746
Plasmodium falciparum serine repeat antigen 2 0.0032 0.0012 0.0054
Schistosoma mansoni cathepsin S (C01 family) 0.0032 0.0012 0.0017
Leishmania major cathepsin L-like protease 0.0083 0.0899 0.3974
Echinococcus granulosus death domain containing protein 0.0062 0.0529 0.0529
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0083 0.0899 0.1234
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0081 0.0362
Brugia malayi Cathepsin L-like precursor 0.0083 0.0899 0.1234
Plasmodium falciparum serine repeat antigen 3 0.0032 0.0012 0.0054
Schistosoma mansoni amine GPCR 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.008 0.0109
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0061 0.0514 0.0706
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0124 0.1625 0.1625
Giardia lamblia Cathepsin B precursor 0.0032 0.0012 0.0054
Onchocerca volvulus 0.0036 0.008 0.0456
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.008 0.008
Brugia malayi Protein kinase domain containing protein 0.0062 0.0529 0.0726
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.1145 0.1145
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0032 0.0012 0.0054
Onchocerca volvulus 0.0083 0.0899 0.5147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0112
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.3485 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Mycobacterium tuberculosis Conserved protein 0.0036 0.0081 0.0234
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.008 0.0109
Echinococcus multilocularis g protein coupled receptor 0.0036 0.008 0.008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0217 0.3236 0.9285
Echinococcus granulosus cathepsin L cysteine protease 0.0032 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.2308 0.3168
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0899 0.1234
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.008 0.0109
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0515 0.0707
Brugia malayi neuropeptide F receptor 0.0036 0.008 0.0109
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0084 0.0374
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.008 0.0109
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0604 1 1
Echinococcus granulosus cathepsin L 0.0032 0.0012 0.0012
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0032 0.0012 0.0054
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.008 0.008
Loa Loa (eye worm) thioredoxin reductase 0.0085 0.0943 0.1294
Echinococcus granulosus inhibitor of apoptosis protein 0.0131 0.1746 0.1746
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0131 0.1746 0.2397
Onchocerca volvulus 0.0083 0.0899 0.5147
Onchocerca volvulus 0.0036 0.008 0.0456
Echinococcus granulosus cathepsin L cysteine proteinase 0.0083 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.008 0.0109
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.008 0.008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0081 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0084 0.0115
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0032 0.0012 0.0017
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Giardia lamblia Cathepsin B precursor 0.0161 0.2261 1
Brugia malayi Cathepsin L-like precursor 0.0083 0.0899 0.1234
Schistosoma mansoni cathepsin F (C01 family) 0.0083 0.0899 0.1234
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0124 0.1625 0.2231
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0047 0.0208
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0083 0.0899 0.0899
Schistosoma mansoni hypothetical protein 0.0131 0.1746 0.2397
Echinococcus multilocularis sex peptide receptor 0.0036 0.008 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.008 0.0109
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0571 0.0571
Toxoplasma gondii cathepsin CPC2 0.0032 0.0012 0.0054
Trypanosoma brucei glucosidase, putative 0.0036 0.0084 0.0372
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.016 0.2249 0.3088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0012 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Echinococcus multilocularis g protein coupled receptor 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.006 0.0498 0.0684
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0124 0.1625 0.7186
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0195 0.2855 0.8194
Schistosoma mansoni ankyrin 23/unc44 0.0062 0.0529 0.0726
Plasmodium vivax proteasome subunit beta type-2, putative 0.0077 0.0798 0.3546
Plasmodium falciparum cysteine proteinase falcipain 1 0.0032 0.0012 0.0054
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0084 0.0372
Schistosoma mansoni biogenic amine receptor 0.0036 0.008 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.008 0.008
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0083 0.0899 0.3995
Echinococcus granulosus cathepsin l1 0.0083 0.0899 0.0899
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0098 0.0433
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.008 0.008
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.008 0.008
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0047 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Echinococcus granulosus g protein coupled receptor 0.0036 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0062 0.0529 0.0529
Giardia lamblia Proteasome subunit beta type 5 precursor 0.016 0.2249 0.9948
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0047 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.008 0.008
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.008 0.0109
Giardia lamblia Hypothetical protein 0.0032 0.0012 0.0054
Loa Loa (eye worm) beta-lactamase 0.0036 0.0081 0.0112
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.2308 0.2308
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0161 0.2261 0.3104
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Toxoplasma gondii cathepsin CPL 0.0083 0.0899 0.3974
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0112
Echinococcus granulosus apoptotic protease activating factor 1 0.006 0.0498 0.0498
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0032 0.0012 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Trypanosoma cruzi major cysteine proteinase, putative 0.0032 0.0012 0.0017
Brugia malayi beta-lactamase family protein 0.0036 0.0081 0.0112
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0032 0.0012 0.0054
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0131 0.1746 0.2397
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0077 0.0798 0.3546
Brugia malayi Serotonin receptor 0.0036 0.008 0.0109
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0047 0.0065
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0083 0.0899 0.1234
Echinococcus granulosus neuropeptide receptor 0.0036 0.008 0.008
Onchocerca volvulus 0.0036 0.0081 0.0467
Loa Loa (eye worm) fibroinase 0.0083 0.0899 0.1234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0083 0.0899 0.3995
Plasmodium falciparum glutathione reductase 0.0085 0.0943 0.4192
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.008 0.0109
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.008 0.0109
Echinococcus multilocularis proteasome (prosome, macropain) 0.016 0.2249 0.2249
Brugia malayi Transient-receptor-potential like protein 0.0036 0.008 0.011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.008 0.0456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Brugia malayi ORL1-like opioid receptor 0.0036 0.008 0.0109
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Echinococcus multilocularis serotonin receptor 0.0036 0.008 0.008
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.008 0.008
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0012 0.0017
Echinococcus granulosus cathepsin b 0.0448 0.7284 0.7284
Leishmania major cathepsin L-like protease 0.0083 0.0899 0.3974
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0217 0.3236 0.9285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1027 0.1411
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0161 0.2261 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0448 0.7284 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0012 0.0017
Brugia malayi hypothetical protein 0.006 0.0498 0.0684
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.0529 0.0726
Loa Loa (eye worm) hypothetical protein 0.0062 0.0533 0.0732
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.008 0.008
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0081 0.0362
Trypanosoma cruzi cysteine protease, putative 0.0032 0.0012 0.0017
Onchocerca volvulus 0.0083 0.0899 0.5147
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.008 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0899 0.3974
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0032 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus granulosus fmrfamide receptor 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0083 0.0899 0.1234
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.008 0.008
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0012 0.0017
Onchocerca volvulus 0.0036 0.008 0.0456
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0084 0.0115
Loa Loa (eye worm) cysteine protease 0.0083 0.0899 0.1234
Toxoplasma gondii cathepsin B 0.0161 0.2261 1
Loa Loa (eye worm) ctsf protein 0.0083 0.0899 0.1234
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0798 0.3527
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Echinococcus granulosus allatostatin A receptor 0.0036 0.008 0.008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.008 0.008
Plasmodium vivax serine-repeat antigen (SERA) 0.0032 0.0012 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0515 0.0707
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0077 0.0798 0.3527
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0448 0.7284 1
Entamoeba histolytica cysteine proteinase 2 0.0032 0.0012 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.008 0.0109
Giardia lamblia Cathepsin B precursor 0.0032 0.0012 0.0054
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0047 0.0047
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0081 0.0252
Echinococcus multilocularis g protein coupled receptor 0.0036 0.008 0.008
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0085 0.0943 0.2706
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0081 0.0234
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.008 0.0109
Toxoplasma gondii ABC1 family protein 0.0036 0.0081 0.036
Brugia malayi sulfakinin receptor protein 0.0036 0.008 0.0109
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0069 0.0069
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Brugia malayi cathepsin L-like cysteine proteinase 0.0032 0.0012 0.0017
Schistosoma mansoni amine GPCR 0.0036 0.008 0.0109
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.008 0.0109
Echinococcus multilocularis cathepsin L 0.0032 0.0012 0.0012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.008 0.0109
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0081 0.036
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0047 0.0047
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0047 0.0047
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.008 0.0109
Giardia lamblia Cathepsin L precursor 0.0032 0.0012 0.0054
Echinococcus multilocularis cathepsin L cysteine protease 0.0083 0.0899 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0012 0.0054
Entamoeba histolytica hypothetical protein 0.0032 0.0012 0.0054
Brugia malayi proteasome subunit beta type 2 0.0077 0.0798 0.1095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0081 0.0112
Echinococcus granulosus g-protein coupled receptor 0.0036 0.008 0.008
Echinococcus granulosus netrin receptor unc 5 0.0062 0.0529 0.0529
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0032 0.0012 0.0054
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Giardia lamblia Cathepsin L precursor 0.0032 0.0012 0.0054
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0084 0.0115
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.008 0.0109
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0032 0.0012 0.0017
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.008 0.008
Schistosoma mansoni inositol monophosphatase 0.0037 0.0098 0.0134
Echinococcus granulosus g protein coupled receptor 0.0036 0.008 0.008
Brugia malayi beta-lactamase family protein 0.0036 0.0081 0.0112
Trypanosoma brucei cysteine peptidase C (CPC) 0.0161 0.2261 1
Brugia malayi neuropeptide F receptor 0.0036 0.008 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0515 0.2278
Onchocerca volvulus 0.0036 0.008 0.0456
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.008 0.008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0515 0.229
Leishmania major cathepsin L-like protease 0.0083 0.0899 0.3974
Trichomonas vaginalis esterase, putative 0.0036 0.0081 0.036
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0032 0.0012 0.0054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0012 0.0017
Onchocerca volvulus 0.0036 0.008 0.0456
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0081 0.0112
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.008 0.008
Brugia malayi G protein-coupled receptor 0.0036 0.008 0.0109
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0081 0.036
Brugia malayi follicle stimulating hormone receptor 0.0267 0.4114 0.5649
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0017
Mycobacterium leprae Probable lipase LipE 0.0036 0.0081 0.0252
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0012 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0069 0.0094
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0032 0.0012 0.0054
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.008 0.0109
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0195 0.2855 0.8194
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0306
Plasmodium vivax vivapain-1 0.0032 0.0012 0.0054
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.0899 0.3995
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Onchocerca volvulus 0.0036 0.008 0.0456
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0047 0.0047
Onchocerca volvulus 0.0036 0.008 0.0456
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0047 0.0065
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Brugia malayi GnHR receptor homolog 0.0036 0.008 0.0109
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0012 0.0017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0032 0.0012 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.008 0.008
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0081 0.0234
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0017
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0124 0.1625 0.1625
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.008 0.008
Brugia malayi Melatonin receptor type 1A 0.0036 0.008 0.0109
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0084 0.0372
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.2308 0.2308
Schistosoma mansoni myosin xvIII 0.0036 0.008 0.0109
Onchocerca volvulus 0.0036 0.0081 0.0467
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.008 0.0109
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0012 0.0054
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0032 0.0012 0.0054
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.008 0.008
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0098 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0083 0.0899 0.0899
Loa Loa (eye worm) proteasome subunit beta type 1 0.0124 0.1625 0.2231
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0124 0.1625 0.7224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0012 0.0054
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.008 0.008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0081 0.0112
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.2261 0.3104
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0032 0.0012 0.0054
Echinococcus multilocularis cysteine protease 0.0083 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0575 0.0575
Mycobacterium tuberculosis Conserved protein 0.0036 0.0081 0.0234
Plasmodium falciparum serine repeat antigen 9 0.0032 0.0012 0.0054
Brugia malayi Serotonin receptor 0.0036 0.008 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.008 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0012 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0899 0.3974
Schistosoma mansoni alpha glucosidase 0.0036 0.0084 0.0115
Leishmania major proteasome beta 5 subunit, putative 0.016 0.2249 0.9948
Brugia malayi hypothetical protein 0.0036 0.008 0.0109
Onchocerca volvulus 0.0032 0.0012 0.007
Loa Loa (eye worm) hypothetical protein 0.0083 0.0899 0.1234
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0515 0.229
Giardia lamblia Cathepsin B precursor 0.0032 0.0012 0.0054
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Giardia lamblia Hypothetical protein 0.0032 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0899 0.3974
Entamoeba histolytica cysteine protease, putative 0.0032 0.0012 0.0054
Plasmodium falciparum serine repeat antigen 7 0.0032 0.0012 0.0054
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0084 0.0115
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0032 0.0012 0.0054
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0899 0.1234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.008 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0081 0.0112
Brugia malayi Cathepsin L-like precursor 0.0083 0.0899 0.1234
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0032 0.0012 0.0054
Onchocerca volvulus Netrin receptor homolog 0.0062 0.0529 0.3029
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Brugia malayi RE15519p 0.0036 0.008 0.0109
Entamoeba histolytica hypothetical protein 0.0035 0.0069 0.0306
Loa Loa (eye worm) hypothetical protein 0.0036 0.008 0.0109
Leishmania major trypanothione reductase 0.0085 0.0943 0.417
Echinococcus granulosus aminopeptidase N 0.0034 0.0047 0.0047
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0047 0.0065
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0515 0.2278
Echinococcus multilocularis allatostatin A receptor 0.0036 0.008 0.008
Trypanosoma cruzi major cysteine proteinase, putative 0.0032 0.0012 0.0017
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.008 0.0109
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0952 0.0952
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0448 0.7284 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0161 0.2261 1
Brugia malayi putative neuropeptide receptor 0.0036 0.008 0.0109
Brugia malayi cathepsin B-like cysteine proteinase 0.0448 0.7284 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0012 0.0054
Onchocerca volvulus 0.0095 0.1103 0.6317
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0012 0.0017
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.008 0.008
Echinococcus multilocularis orexin receptor type 2 0.0036 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0899 0.3974
Echinococcus granulosus neuropeptide s receptor 0.0036 0.008 0.008
Echinococcus multilocularis netrin receptor unc 5 0.0062 0.0529 0.0529
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0081 0.0234
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.1145 0.1145
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0032 0.0012 0.0054

Activities

Activity type Activity value Assay description Source Reference
Binding energy (ADMET) = 10.7 kCal mol-1 Binding energy of the compound was determined by using the equation deltaG obsd = -RT ln KD ChEMBL. 6094812
IC50 (binding) = 0.00000014 M Inhibition of specific [3H]-clonidine binding (0.4 nM) to rat brain membranes alpha2 adrenoreceptor ChEMBL. 6142954
IC50 (binding) = 0.00000014 M Inhibition of specific [3H]-clonidine binding (0.4 nM) to rat brain membranes alpha2 adrenoreceptor ChEMBL. 6142954
IC50 (binding) = 0.00000072 M Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha1 adrenoreceptor. ChEMBL. 6142954
IC50 (binding) = 0.00000072 M Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha1 adrenoreceptor. ChEMBL. 6142954
IC50 (binding) = 61 uM Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex ChEMBL. 2579237
IC50 (binding) = 61 uM Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex ChEMBL. 2579237
Inhibition (binding) = 58.8 % Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high-affinity sites on voltage-dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 100 microM ChEMBL. 2579237
Inhibition (binding) = 58.8 % Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high-affinity sites on voltage-dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 100 microM ChEMBL. 2579237
Kd (functional) = 5.71 Antagonist activity against phenylephrine-induced alpha1- adrenoreceptor mediated vasoconstriction in pithed normotensive rats . ChEMBL. 6142954
Kd (binding) = 6.06 Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor ChEMBL. 6142954
Kd (functional) = 6.23 Antagonist activity against B-HT 933-induced alpha2-adrenoreceptor-mediated vasoconstriction in pithed normotensive rats ChEMBL. 6142954
Kd (functional) = 6.4 Antagonistic activity against Alpha-1 adrenergic receptor in the epidermal portion of the rat vas deferens ChEMBL. 6124635
Kd (binding) = 6.5 In vitro relative blocking action (pA2) of the post-synaptic Alpha adrenergic receptor from rat and rabbit aorta. ChEMBL. 6124636
Kd (binding) = 6.61 Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus. ChEMBL. 6133953
Kd (functional) = 7.16 Antagonist potency towards alpha-1 adrenergic receptor in the rat electrically stimulated vas deferens with reference to phenylephrine ChEMBL. 2875186
Kd (functional) = 7.4 Antagonistic activity against Alpha-2 adrenergic receptor in the prostatic portion of the rat vas deferens ChEMBL. 6124635
Kd (functional) = 7.54 Antagonist potency towards alpha-2 adrenergic receptor in the rat electrically stimulated vas deferens with reference to P-aminoclonidine ChEMBL. 2875186
Kd (binding) = 7.6 In vitro for relative blocking action (pA2) of Presynaptic Alpha-2 adrenergic receptor from guinea pig ileum. ChEMBL. 6124636
Kd (binding) = 7.72 Alpha-2 adrenergic receptor pA2 value against clonidine in vitro experiment in rat vas deferens ChEMBL. 6133953
Ki (binding) = 95 nM Displacement of [3H]-clonidine from Alpha-2 adrenergic receptor of rat brain membranes ChEMBL. 6296387
Ki (binding) = 95 nM Displacement of [3H]-clonidine from Alpha-2 adrenergic receptor of rat brain membranes ChEMBL. 6296387
pA2 (functional) = 5.71 Antagonist activity against phenylephrine-induced alpha1- adrenoreceptor mediated vasoconstriction in pithed normotensive rats . ChEMBL. 6142954
pA2 (binding) = 6.06 Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor ChEMBL. 6142954
pA2 (functional) = 6.23 Antagonist activity against B-HT 933-induced alpha2-adrenoreceptor-mediated vasoconstriction in pithed normotensive rats ChEMBL. 6142954
pA2 (functional) = 6.4 Antagonistic activity against Alpha-1 adrenergic receptor in the epidermal portion of the rat vas deferens ChEMBL. 6124635
pA2 (binding) = 6.5 In vitro relative blocking action (pA2) of the post-synaptic Alpha adrenergic receptor from rat and rabbit aorta. ChEMBL. 6124636
pA2 (binding) = 6.61 Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus. ChEMBL. 6133953
pA2 (functional) = 7.16 Antagonist potency towards alpha-1 adrenergic receptor in the rat electrically stimulated vas deferens with reference to phenylephrine ChEMBL. 2875186
pA2 (functional) = 7.4 Antagonistic activity against Alpha-2 adrenergic receptor in the prostatic portion of the rat vas deferens ChEMBL. 6124635
pA2 (functional) = 7.54 Antagonist potency towards alpha-2 adrenergic receptor in the rat electrically stimulated vas deferens with reference to P-aminoclonidine ChEMBL. 2875186
pA2 (binding) = 7.6 In vitro for relative blocking action (pA2) of Presynaptic Alpha-2 adrenergic receptor from guinea pig ileum. ChEMBL. 6124636
pA2 (binding) = 7.72 Alpha-2 adrenergic receptor pA2 value against clonidine in vitro experiment in rat vas deferens ChEMBL. 6133953
pC30 (binding) = 6.22 Inhibition of specific [3H]-clonidine binding (0.4 nM) to rat brain membranes Alpha-2 adrenergic receptor ChEMBL. 6142954
pC30 (binding) = 6.22 Inhibition of specific [3H]-clonidine binding (0.4 nM) to rat brain membranes Alpha-2 adrenergic receptor ChEMBL. 6142954
Potency (functional) = 0 Agonist potency towards alpha-2 adrenergic receptor in the mouse isolated electrically stimulated vas deferens with reference to clonidine (prejunctional) ChEMBL. 2875186
Potency (functional) = 0 Agonist potency towards alpha-1 adrenergic receptor in the rat isolated electrically stimulated vas deferens with reference to phenylephrine (postjunctional) ChEMBL. 2875186
Potency (functional) = 0.29 Antagonist potency towards alpha-2 adrenergic receptor in the mouse isolated electrically stimulated vas deferens with reference to idazoxan (prejunctional) ChEMBL. 2875186
Potency (functional) = 4.8 Antagonist potency towards alpha-1 adrenergic receptor in the rat isolated electrically stimulated vas deferens with reference to pA2 idazoxan (postjunctional) ChEMBL. 2875186
Potency (functional) = 0 Agonist potency towards alpha-2 adrenergic receptor in the mouse isolated electrically stimulated vas deferens with reference to clonidine (prejunctional) ChEMBL. 2875186
Potency (functional) = 0 Agonist potency towards alpha-1 adrenergic receptor in the rat isolated electrically stimulated vas deferens with reference to phenylephrine (postjunctional) ChEMBL. 2875186
Potency (functional) = 0.29 Antagonist potency towards alpha-2 adrenergic receptor in the mouse isolated electrically stimulated vas deferens with reference to idazoxan (prejunctional) ChEMBL. 2875186
Potency (functional) = 4.8 Antagonist potency towards alpha-1 adrenergic receptor in the rat isolated electrically stimulated vas deferens with reference to pA2 idazoxan (postjunctional) ChEMBL. 2875186
Potency (functional) 0.0849 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.0691 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Selectivity (binding) = 13 Ratio of pA2 value against alpha2 to alpha1 adrenoreceptor ChEMBL. 6133953
Selectivity index (binding) = -0.7 Index of alpha1/alpha2 adrenoceptor binding selectivity. ChEMBL. 6142954
Selectivity index (functional) = -0.52 Index of alpha1/alpha2 adrenoceptor antagonist selectivity at post junctional vascular sites in vivo. ChEMBL. 6142954
Selectivity index (binding) = -0.7 Index of alpha1/alpha2 adrenoceptor binding selectivity. ChEMBL. 6142954
Selectivity index (functional) = -0.52 Index of alpha1/alpha2 adrenoceptor antagonist selectivity at post junctional vascular sites in vivo. ChEMBL. 6142954
Selectivity index (functional) = -0.16 Index of alpha1/alpha2 adrenoceptor antagonist selectivity at pre and postsynaptic sites in vitro. ChEMBL. 6142954
Selectivity ratio (binding) = 10 Selectivity ratio is the ratio between pA2 values of alfa2 and alfa1 adrenoceptors ChEMBL. 6124635
Selectivity ratio (binding) = 10 Selectivity ratio is the ratio between pA2 values of alfa2 and alfa1 adrenoceptors ChEMBL. 6124635

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

8 literature references were collected for this gene.

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