Detailed information for compound 411067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.422 | Formula: C22H21N3
  • H donors: 1 H acceptors: 2 LogP: 5.67 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cc1nc2c([nH]1)nc(cc2c1ccccc1)c1ccccc1)C
  • InChi: 1S/C22H21N3/c1-15(2)13-20-24-21-18(16-9-5-3-6-10-16)14-19(23-22(21)25-20)17-11-7-4-8-12-17/h3-12,14-15H,13H2,1-2H3,(H,23,24,25)
  • InChiKey: PPFWSQNEFCXMGP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References
Homo sapiens adenosine A2b receptor Starlite/ChEMBL References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0489 0.4903 0.4886
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0851 0.864 0.9069
Schistosoma mansoni opsin-like receptor 0.007 0.0587 0.0604
Schistosoma mansoni opsin-like receptor 0.007 0.0587 0.0604
Schistosoma mansoni neuronal calcium sensor 0.0043 0.0309 0.0312
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.044 0.4399 0.4381
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0043 0.0309 0.0278
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0587 0.0604
Brugia malayi calcium-binding protein 0.0043 0.0309 0.0312
Onchocerca volvulus Cathepsin L homolog 0.0937 0.9526 1
Echinococcus multilocularis dro:myosuppressin receptor 0.007 0.0587 0.0604
Trypanosoma brucei small myristoylated protein 1-1 0.0347 0.3445 0.3444
Plasmodium vivax unspecified product 0.019 0.1822 0.1902
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1075 0.4845
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.3228 0.3205
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0937 0.9526 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.019 0.1822 0.459
Toxoplasma gondii exonuclease III APE 0.0018 0.0058 0.0049
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0695 0.7028 0.7027
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0493 0.4945 0.4929
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0344 0.0348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0587 0.0604
Toxoplasma gondii centrin, putative 0.0043 0.0309 0.0313
Onchocerca volvulus Neuropeptide F receptor homolog 0.007 0.0587 0.0604
Echinococcus multilocularis tachykinin peptides receptor 99D 0.007 0.0587 0.0604
Echinococcus multilocularis neuropeptide receptor 0.007 0.0587 0.0604
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.019 0.1822 0.1902
Brugia malayi larval opioid receptor 0.007 0.0587 0.0604
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0587 0.0604
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Trypanosoma cruzi cruzipain precursor, putative 0.0303 0.2991 0.2968
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0029
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Entamoeba histolytica cysteine proteinase 2 0.0493 0.4945 0.5162
Trypanosoma cruzi unspecified product 0.0347 0.3445 0.3424
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0587 0.0604
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.023 0.0242
Mycobacterium tuberculosis Probable reductase 0.0105 0.0953 0.4282
Entamoeba histolytica protein kinase, putative 0.0206 0.1993 0.2043
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Toxoplasma gondii cathepsin CPC2 0.019 0.1822 0.1903
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Schistosoma mansoni calpain (C02 family) 0.044 0.4399 0.4611
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0294 0.2898 0.2875
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0609 0.0627
Mycobacterium tuberculosis Conserved protein 0.0035 0.023 0.0918
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0765 0.7745 0.7738
Entamoeba histolytica cysteine proteinase, putative 0.0493 0.4945 0.5162
Trypanosoma cruzi centrin, putative 0.0051 0.0391 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.023 0.0918
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.019 0.1822 0.1902
Loa Loa (eye worm) hypothetical protein 0.0303 0.2991 0.3131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0587 0.0604
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0037 0.0026
Brugia malayi G-protein coupled receptor 0.007 0.0587 0.0604
Schistosoma mansoni cathepsin B (C01 family) 0.019 0.1822 0.1902
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0318 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0587 0.0604
Leishmania major hypothetical protein, conserved 0.0201 0.1941 0.1915
Trichomonas vaginalis calmodulin-2, putative 0.0043 0.0309 0.0325
Echinococcus multilocularis cysteine protease 0.0937 0.9526 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0062 0.0029
Schistosoma mansoni cathepsin F (C01 family) 0.0937 0.9526 1
Schistosoma mansoni calpain-7 (C02 family) 0.044 0.4399 0.4611
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0082 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.019 0.1822 0.1913
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Onchocerca volvulus 0.007 0.0587 0.0604
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0765 0.7745 0.7738
Trypanosoma brucei centrin, putative 0.0043 0.0309 0.0308
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Echinococcus multilocularis neuropeptide FF receptor 2 0.007 0.0587 0.0604
Echinococcus multilocularis calmodulin 0.0043 0.0309 0.0312
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0234 0.2274 0.2387
Brugia malayi Uncoordinated protein 44 0.0014 0.0012 0.000000022051
Onchocerca volvulus Cathepsin L homolog 0.019 0.1822 0.1902
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0082 0.0087
Leishmania major hypothetical protein, conserved 0.0025 0.0121 0.0089
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0953 0.4282
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0937 0.9526 1
Trichomonas vaginalis calpain, putative 0.0234 0.2274 0.2387
Loa Loa (eye worm) hypothetical protein 0.0303 0.2991 0.3131
Trichomonas vaginalis centrin, putative 0.0043 0.0309 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0587 0.0604
Brugia malayi sulfakinin receptor protein 0.007 0.0587 0.0604
Trichomonas vaginalis calmodulin, putative 0.0043 0.0309 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0493 0.4945 0.4945
Schistosoma mansoni neuropeptide receptor 0.007 0.0587 0.0604
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0587 0.0604
Brugia malayi EF hand family protein 0.0044 0.0321 0.0325
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0937 0.9526 1
Entamoeba histolytica cysteine protease, putative 0.019 0.1822 0.1863
Onchocerca volvulus 0.0044 0.0321 0.0325
Entamoeba histolytica calmodulin, putative 0.0043 0.0309 0.0265
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0587 0.0604
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.023 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0634 0.6403 0.6721
Giardia lamblia Hypothetical protein 0.019 0.1822 0.459
Echinococcus granulosus cathepsin l cysteine peptidase 0.0937 0.9526 1
Toxoplasma gondii cathepsin CPC1 0.019 0.1822 0.1903
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0544 0.5468 0.5453
Echinococcus multilocularis serotonin receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.023 0.0229
Echinococcus granulosus peptide allatostatin:somatostatin 0.007 0.0587 0.0604
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0121 0.0094
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0043 0.0309 0.0308
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0851 0.864 0.9069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.019 0.1822 0.1902
Schistosoma mansoni thyroid hormone receptor 0.0133 0.1237 0.1287
Brugia malayi Thioredoxin reductase 0.0046 0.0344 0.0348
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0587 0.0604
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0624 0.6294 0.6282
Echinococcus multilocularis lamin 0.0026 0.0139 0.0133
Trypanosoma brucei I/6 autoantigen 0.0043 0.0309 0.0308
Trypanosoma brucei trypanothione reductase 0.0046 0.0344 0.0342
Trypanosoma brucei antigen, putative 0.044 0.4399 0.4398
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0294 0.2898 0.2875
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0587 0.0604
Trypanosoma cruzi kinesin, putative 0.0206 0.1993 0.1966
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.019 0.1822 0.1902
Echinococcus granulosus allatostatin A receptor 0.007 0.0587 0.0604
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0435 0.4348 0.4329
Echinococcus granulosus calbindin 32 0.0044 0.0321 0.0325
Echinococcus granulosus tachykinin peptides receptor 99D 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Schistosoma mansoni hypothetical protein 0.0402 0.4011 0.4203
Brugia malayi G protein-coupled receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.0025 0.0121 0.0115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0058 0.0026
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0121 0.0116
Echinococcus multilocularis cathepsin L cysteine protease 0.0937 0.9526 1
Plasmodium falciparum serine repeat antigen 7 0.019 0.1822 0.1885
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Leishmania major small myristoylated protein-1 0.0347 0.3445 0.3424
Echinococcus multilocularis geminin 0.0166 0.1574 0.1641
Schistosoma mansoni hypothetical protein 0.0234 0.2274 0.2377
Leishmania major hypothetical protein, conserved 0.0043 0.0309 0.0278
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0587 0.0604
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0058 0.0048
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.023 0.0918
Loa Loa (eye worm) calpain family protein 1 0.0632 0.6379 0.6692
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0059 0.0049
Schistosoma mansoni reticulocalbin 0.0043 0.0309 0.0312
Echinococcus granulosus EF hand domain containing family member A2 0.0044 0.0321 0.0325
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0417 0.4169 0.415
Onchocerca volvulus 0.0937 0.9526 1
Echinococcus multilocularis neuropeptide s receptor 0.007 0.0587 0.0604
Entamoeba histolytica cysteine proteinase, putative 0.0937 0.9526 1
Trypanosoma brucei centrin-3 0.0051 0.0391 0.0389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0937 0.9526 1
Echinococcus granulosus dnaJ subfamily B 0.0402 0.4011 0.4203
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.019 0.1822 0.1902
Trypanosoma brucei calpain-like protein, putative 0.044 0.4399 0.4398
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0587 0.0604
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0255 0.2496 0.2472
Onchocerca volvulus Cathepsin L homolog 0.0937 0.9526 1
Trypanosoma brucei calpain, putative 0.0489 0.4903 0.4902
Onchocerca volvulus 0.007 0.0587 0.0604
Echinococcus granulosus sex peptide receptor 0.007 0.0587 0.0604
Entamoeba histolytica calpain family cysteine protease, putative 0.0234 0.2274 0.234
Echinococcus granulosus intermediate filament protein 0.0026 0.0139 0.0133
Leishmania major hypothetical protein, conserved 0.0201 0.1941 0.1915
Brugia malayi beta-lactamase family protein 0.0035 0.023 0.0229
Brugia malayi calpain D 0.0234 0.2274 0.2377
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0033 0.0031
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0057 0.0047
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0417 0.4169 0.415
Schistosoma mansoni myosin xvIII 0.007 0.0587 0.0604
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0953 0.4282
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Loa Loa (eye worm) calpain D 0.0234 0.2274 0.2377
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0058 0.1294
Echinococcus multilocularis neuronal calcium sensor 0.0043 0.0309 0.0312
Giardia lamblia Cathepsin L precursor 0.019 0.1822 0.459
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0043 0.0309 0.0325
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0121 0.0089
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0058 0.0048
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0765 0.7745 0.7738
Trichomonas vaginalis calcineurin B subunit, putative 0.0044 0.0321 0.0337
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0587 0.0604
Brugia malayi Serotonin receptor 0.007 0.0587 0.0604
Leishmania major centrin, putative 0.0043 0.0309 0.0278
Echinococcus multilocularis cathepsin L 0.0493 0.4945 0.5185
Echinococcus multilocularis programmed cell death protein 0.0051 0.0391 0.0398
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.019 0.1822 0.1885
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0587 0.0604
Brugia malayi G-protein coupled receptor 0.007 0.0587 0.0604
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Plasmodium vivax unspecified product 0.0493 0.4945 0.5185
Echinococcus granulosus 7TM GPCR rhodopsin 0.007 0.0587 0.0604
Schistosoma mansoni intermediate filament proteins 0.0026 0.0139 0.0133
Echinococcus granulosus neuropeptide receptor 0.007 0.0587 0.0604
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0394 0.3931 0.3911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.4945 0.5191
Leishmania major hypothetical protein, conserved 0.0326 0.3228 0.3205
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0937 0.9526 1
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.1941 0.1915
Echinococcus granulosus serotonin receptor 0.007 0.0587 0.0604
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0587 0.0604
Brugia malayi Cathepsin L-like precursor 0.0634 0.6403 0.6717
Giardia lamblia Cysteine protease 0.019 0.1822 0.459
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0121 0.0089
Trypanosoma cruzi cysteine peptidase, putative 0.0983 1 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0024 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.023 0.0229
Giardia lamblia Cathepsin B precursor 0.0394 0.3931 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0765 0.7745 0.7738
Echinococcus granulosus g protein coupled receptor 0.007 0.0587 0.0604
Echinococcus multilocularis cathepsin b 0.0851 0.864 0.9069
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.007 0.0587 0.0604
Brugia malayi cathepsin F-like cysteine proteinase 0.0303 0.2991 0.3131
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0043 0.0309 0.0325
Leishmania major centrin, putative 0.0043 0.0309 0.0278
Loa Loa (eye worm) hypothetical protein 0.0234 0.2274 0.2377
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0044 0.0321 0.0325
Loa Loa (eye worm) follicle stimulating hormone receptor 0.007 0.0587 0.0604
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0255 0.2496 0.2495
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0303 0.2991 0.3131
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Brugia malayi Cathepsin L-like cysteine proteinase 0.0634 0.6403 0.6717
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.019 0.1822 0.1902
Echinococcus multilocularis calpain 7 (C02 family) 0.044 0.4399 0.4611
Brugia malayi Tachykinin-like peptides receptor 99D 0.007 0.0587 0.0604
Entamoeba histolytica cysteine proteinase 1, putative 0.0493 0.4945 0.5162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Leishmania major hypothetical protein, unknown function 0.0234 0.2274 0.2249
Echinococcus multilocularis g-protein coupled receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) calmodulin-like protein 0.0043 0.0309 0.0312
Trypanosoma brucei cysteine peptidase, putative 0.0435 0.4348 0.4347
Onchocerca volvulus 0.0035 0.023 0.0229
Schistosoma mansoni amine GPCR 0.007 0.0587 0.0604
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1822 0.1913
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1822 0.1913
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.9526 0.9525
Plasmodium vivax vivapain-3 0.0493 0.4945 0.5185
Brugia malayi gonadotropin-releasing hormone receptor 2 0.007 0.0587 0.0604
Echinococcus granulosus neuropeptide receptor A26 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1822 0.1913
Brugia malayi Cathepsin L-like precursor 0.0937 0.9526 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Toxoplasma gondii ABC1 family protein 0.0035 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0229
Giardia lamblia Cysteine protease 0.019 0.1822 0.459
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.068 0.6877 0.6866
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.007 0.0587 0.0604
Trypanosoma cruzi major cysteine proteinase, putative 0.019 0.1822 0.1795
Loa Loa (eye worm) cysteine protease 0.0937 0.9526 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.044 0.4399 0.4381
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.019 0.1822 0.1902
Schistosoma mansoni amine GPCR 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0937 0.9526 1
Trypanosoma brucei calpain-like protein, putative 0.0695 0.7028 0.7027
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.0044 0.0318 0.0322
Trichomonas vaginalis calcineurin B subunit, putative 0.0043 0.0309 0.0325
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0013 0.0001
Echinococcus multilocularis musashi 0.0026 0.0139 0.0133
Plasmodium vivax vivapain-1 0.0493 0.4945 0.5185
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.3228 0.3205
Loa Loa (eye worm) hypothetical protein 0.019 0.1822 0.1902
Trypanosoma cruzi cysteine proteinase, putative 0.0493 0.4945 0.4929
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0531 0.5339 0.5323
Loa Loa (eye worm) papain family cysteine protease containing protein 0.019 0.1822 0.1902
Trichomonas vaginalis conserved hypothetical protein 0.019 0.1822 0.1913
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0058 0.0048
Trypanosoma brucei Calpain-like protein 1.2 0.0575 0.579 0.5789
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0344 0.0348
Giardia lamblia Cathepsin B precursor 0.019 0.1822 0.459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Trypanosoma cruzi centrin-3 0.0051 0.0391 0.0359
Echinococcus granulosus calmodulin 0.0043 0.0309 0.0312
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0575 0.579 0.5776
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0587 0.0604
Loa Loa (eye worm) fibroinase 0.0937 0.9526 1
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Trypanosoma cruzi cysteine peptidase, putative 0.0983 1 1
Echinococcus multilocularis fmrfamide receptor 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0937 0.9526 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0452 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Schistosoma mansoni calmodulin related calcium binding protein 0.0043 0.0309 0.0312
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0881 0.8946 0.939
Entamoeba histolytica papain family cysteine protease domain containing protein 0.019 0.1822 0.1863
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0575 0.579 0.5776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0587 0.0604
Trypanosoma brucei unspecified product 0.0201 0.1941 0.194
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.007 0.0587 0.0604
Toxoplasma gondii hypothetical protein 0.0234 0.2274 0.2378
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0587 0.0604
Schistosoma mansoni hypothetical protein 0.0051 0.0388 0.0395
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0435 0.4348 0.4329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0587 0.0604
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0201 0.1941 0.194
Schistosoma mansoni cathepsin S (C01 family) 0.019 0.1822 0.1902
Leishmania major programmed cell death 6 protein-like protein 0.0043 0.0309 0.0278
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Schistosoma mansoni mitochondrial solute carrier 0.0043 0.0309 0.0312
Plasmodium falciparum glutathione reductase 0.0046 0.0344 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.019 0.1822 0.1913
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0937 0.9526 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.019 0.1822 0.1902
Echinococcus multilocularis calmodulin 0.0043 0.0309 0.0312
Leishmania major receptor-type adenylate cyclase a-like protein 0.0201 0.1941 0.1915
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0881 0.8946 0.939
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0229
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0229
Schistosoma mansoni calpain-7 (C02 family) 0.044 0.4399 0.4611
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0121 0.0094
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0033 0.0021
Trypanosoma brucei Calpain-like protein CALP1.3 0.0435 0.4348 0.4347
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.006
Trypanosoma brucei cysteine peptidase C (CPC) 0.0394 0.3931 0.393
Echinococcus granulosus hypothetical protein 0.007 0.0587 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0309 0.0325
Loa Loa (eye worm) hypothetical protein 0.0632 0.6379 0.6692
Trichomonas vaginalis conserved hypothetical protein 0.0234 0.2274 0.2387
Echinococcus granulosus calpain A 0.0882 0.8958 0.9402
Trypanosoma brucei conserved protein 0.021 0.203 0.2029
Onchocerca volvulus 0.007 0.0587 0.0604
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1075 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0587 0.0604
Entamoeba histolytica cysteine proteinase, putative 0.0634 0.6403 0.6701
Echinococcus granulosus cpg binding protein 0.006 0.0485 0.0497
Plasmodium falciparum serine repeat antigen 6 0.019 0.1822 0.1885
Leishmania major cathepsin L-like protease 0.0937 0.9526 0.9525
Schistosoma mansoni hypothetical protein 0.0166 0.1574 0.1641
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0394 0.3931 0.4119
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0435 0.4348 0.4329
Echinococcus multilocularis calpain family protein 1, d 0.0632 0.6379 0.6692
Trypanosoma brucei hypothetical protein 0.0489 0.4903 0.4902
Giardia lamblia Cathepsin B precursor 0.019 0.1822 0.459
Trypanosoma cruzi cysteine peptidase, putative 0.0303 0.2991 0.2968
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0062 0.0029
Echinococcus granulosus alpha 1A adrenergic receptor 0.007 0.0587 0.0604
Leishmania major cathepsin L-like protease 0.0983 1 1
Echinococcus granulosus G protein coupled receptor 139 0.007 0.0587 0.0604
Schistosoma mansoni calpain-2 (C02 family) 0.0234 0.2274 0.2377
Schistosoma mansoni cathepsin F (C01 family) 0.0937 0.9526 1
Trypanosoma brucei unspecified product 0.0019 0.0062 0.006
Trypanosoma brucei Component of motile flagella 41 0.0043 0.0309 0.0308
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0058 0.0026
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.023 0.0242
Onchocerca volvulus 0.0026 0.0139 0.0133
Brugia malayi Dopamine receptor protein 1 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Echinococcus granulosus cathepsin l1 0.0634 0.6403 0.6717
Trypanosoma brucei calmodulin, putative 0.0043 0.0309 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0181 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0587 0.0604
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.0177
Loa Loa (eye worm) hypothetical protein 0.0605 0.6097 0.6396
Schistosoma mansoni neuropeptide receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Leishmania major calpain protease-like protein 0.0234 0.2274 0.2249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0587 0.0604
Schistosoma mansoni biogenic amine receptor 0.007 0.0587 0.0604
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0318 0.0322
Brugia malayi follicle stimulating hormone receptor 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0838 0.8504 0.8925
Schistosoma mansoni centrin-related 0.0043 0.0309 0.0312
Echinococcus multilocularis programmed cell death protein 0.0051 0.0391 0.0398
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0722 0.7311 0.7303
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0062 0.1485
Toxoplasma gondii calcium-dependent protein kinase 0.0044 0.0321 0.0326
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0255 0.2496 0.2495
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Echinococcus granulosus lamin 0.0026 0.0139 0.0133
Brugia malayi cathepsin B-like cysteine proteinase 0.0851 0.864 0.9069
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0234 0.2274 0.2387
Brugia malayi beta-lactamase 0.0035 0.023 0.0229
Echinococcus multilocularis calumenin 0.0044 0.0321 0.0325
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0201 0.1941 0.194
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.019 0.1822 0.1885
Echinococcus granulosus calpain 7 C02 family 0.044 0.4399 0.4611
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0234 0.2274 0.2273
Echinococcus granulosus g protein coupled receptor 0.007 0.0587 0.0604
Leishmania major calmodulin, putative 0.0043 0.0309 0.0278
Schistosoma mansoni amine GPCR 0.007 0.0587 0.0604
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0665 0.6719 0.6709
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1135 0.118
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0575 0.579 0.5776
Leishmania major calmodulin-like protein 0.0043 0.0309 0.0278
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0033 0.5
Onchocerca volvulus 0.0043 0.0309 0.0312
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Trypanosoma cruzi calmodulin, putative 0.0043 0.0309 0.0278
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0695 0.7028 0.7018
Echinococcus granulosus dna polymerase kappa 0.0019 0.0062 0.0052
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0058 0.0066
Brugia malayi Dopamine receptor 0.007 0.0587 0.0604
Schistosoma mansoni hypothetical protein 0.007 0.0587 0.0604
Trypanosoma brucei small myristoylated protein 1-2 0.0347 0.3445 0.3444
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0587 0.0604
Plasmodium vivax unspecified product 0.0303 0.2991 0.313
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.023 0.0229
Echinococcus granulosus cathepsin b 0.0851 0.864 0.9069
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0062 0.0065
Brugia malayi AKH receptor 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1976 0.2063
Onchocerca volvulus 0.0398 0.3973 0.4163
Giardia lamblia Cathepsin L-like protease 0.019 0.1822 0.459
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0544 0.5468 0.5453
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Echinococcus granulosus centrin 2 0.0043 0.0309 0.0312
Echinococcus granulosus fmrfamide receptor 0.007 0.0587 0.0604
Entamoeba histolytica cysteine proteinase, putative 0.0493 0.4945 0.5162
Brugia malayi Cathepsin L-like precursor 0.0937 0.9526 1
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0059 0.0049
Schistosoma mansoni opsin-like receptor 0.007 0.0587 0.0604
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0044 0.0321 0.029
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0587 0.0604
Brugia malayi EF hand family protein 0.0043 0.0309 0.0312
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.007 0.0587 0.0604
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0435 0.4348 0.4329
Leishmania major DNA polymerase eta, putative 0.0044 0.0318 0.0287
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0557 0.5611 0.5597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1822 0.1913
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1822 0.1913
Trypanosoma cruzi cysteine proteinase, putative 0.0493 0.4945 0.4929
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.1941 0.1915
Toxoplasma gondii cathepsin CPL 0.0937 0.9526 1
Trichomonas vaginalis hypothetical protein 0.0234 0.2274 0.2387
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0851 0.864 0.9069
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.019 0.1822 0.1913
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.007 0.0587 0.0604
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0435 0.4348 0.4329
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.007 0.0587 0.0604
Brugia malayi hypothetical protein 0.0119 0.1093 0.1136
Schistosoma mansoni hypothetical protein 0.007 0.0587 0.0604
Brugia malayi Papain family cysteine protease containing protein 0.019 0.1822 0.1902
Brugia malayi Cathepsin L-like precursor 0.0937 0.9526 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0012 0.000000022051
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Giardia lamblia Cathepsin L-like protease 0.019 0.1822 0.459
Trichomonas vaginalis calmodulin, putative 0.0043 0.0309 0.0325
Trypanosoma cruzi small myristoylated protein 1-1 0.0347 0.3445 0.3424
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0587 0.0604
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0587 0.0604
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0033 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.0177
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0609 0.0627
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Entamoeba histolytica calpain large subunit domain III containing protein 0.0206 0.1993 0.2043
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0587 0.0604
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0201 0.1941 0.194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0937 0.9526 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Schistosoma mansoni alpha-1 adrenergic receptor 0.007 0.0587 0.0604
Trypanosoma cruzi I/6 autoantigen, putative 0.0043 0.0309 0.0278
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0043 0.0309 0.0308
Echinococcus multilocularis neuropeptide receptor 0.007 0.0587 0.0604
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0052
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0435 0.4348 0.4329
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0062 0.0052
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.019 0.1822 0.1902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0937 0.9526 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0029
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.019 0.1822 0.1902
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1822 0.1913
Plasmodium falciparum serine repeat antigen 9 0.019 0.1822 0.1885
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Leishmania major cathepsin L-like protease 0.0937 0.9526 0.9525
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.019 0.1822 0.1913
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0234 0.2274 0.2387
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.023 1
Leishmania major calcineurin B subunit, putative 0.0043 0.0309 0.0278
Loa Loa (eye worm) hypothetical protein 0.0634 0.6403 0.6717
Trypanosoma cruzi centrin, putative 0.0051 0.0391 0.0359
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0587 0.0604
Schistosoma mansoni histamine h1 receptor 0.007 0.0587 0.0604
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0544 0.5468 0.5453
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0587 0.0604
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1075 0.4845
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0695 0.7028 0.7018
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0587 0.0604
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0062 0.0004
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.023 0.0918
Echinococcus granulosus g protein coupled receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0937 0.9526 1
Brugia malayi cathepsin F-like cysteine proteinase 0.019 0.1822 0.1902
Trypanosoma cruzi small myristoylated protein 1-2 0.0347 0.3445 0.3424
Onchocerca volvulus 0.007 0.0587 0.0604
Giardia lamblia Cathepsin L precursor 0.019 0.1822 0.459
Echinococcus granulosus calcium uptake protein 1 0.0044 0.0321 0.0325
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.019 0.1822 0.1902
Onchocerca volvulus 0.007 0.0587 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Plasmodium falciparum cysteine proteinase falcipain 3 0.0937 0.9526 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0255 0.2496 0.2495
Schistosoma mansoni thyroid hormone receptor 0.0133 0.1237 0.1287
Trichomonas vaginalis calcium binding protein, putative 0.0043 0.0309 0.0325
Giardia lamblia Cathepsin L precursor 0.019 0.1822 0.459
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0033 0.0023
Trypanosoma brucei calmodulin, putative 0.0044 0.0321 0.032
Giardia lamblia Cathepsin B precursor 0.019 0.1822 0.459
Echinococcus multilocularis somatostatin receptor 0.007 0.0587 0.0604
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0953 0.4282
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0294 0.2898 0.2897
Echinococcus multilocularis calbindin 32 0.0044 0.0321 0.0325
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0937 0.9526 1
Echinococcus multilocularis cathepsin b 0.0851 0.864 0.9069
Loa Loa (eye worm) calpain 0.044 0.4399 0.4611
Brugia malayi Papain family cysteine protease containing protein 0.0937 0.9526 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0722 0.7311 0.7303
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0394 0.3931 0.4126
Loa Loa (eye worm) cathepsin B 0.0394 0.3931 0.4119
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0695 0.7028 0.7018
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.007 0.0587 0.0604
Echinococcus granulosus thyrotropin releasing hormone receptor 0.007 0.0587 0.0604
Onchocerca volvulus 0.0233 0.2266 0.2369
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.023 0.0242
Brugia malayi Cathepsin L-like precursor 0.0937 0.9526 1
Schistosoma mansoni hypothetical protein 0.0043 0.0309 0.0312
Echinococcus multilocularis g protein coupled receptor 0.007 0.0587 0.0604
Schistosoma mansoni neuronal calcium sensor 0.0043 0.0309 0.0312
Schistosoma mansoni ap endonuclease 0.0018 0.0058 0.0048
Giardia lamblia Cathepsin L precursor 0.019 0.1822 0.459
Giardia lamblia Cathepsin B precursor 0.019 0.1822 0.459
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0695 0.7028 0.7018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Brugia malayi Papain family cysteine protease containing protein 0.0493 0.4945 0.5185
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0201 0.1941 0.1915
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0587 0.0604
Brugia malayi cathepsin Z-like cysteine proteinase 0.019 0.1822 0.1902
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0056 0.0025
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0043 0.0309 0.0312
Brugia malayi Protein kinase domain containing protein 0.0014 0.0012 0.000000022051
Schistosoma mansoni Mername-AA248 (C02 family) 0.044 0.4399 0.4611
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0587 0.0604
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.019 0.1822 0.1902
Schistosoma mansoni biogenic amine receptor 0.007 0.0587 0.0604
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0139 0.0133
Brugia malayi Papain family cysteine protease containing protein 0.019 0.1822 0.1902
Plasmodium falciparum calpain 0.0234 0.2274 0.2361
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.0043 0.0309 0.0312
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.007 0.0587 0.0604
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.006
Brugia malayi calpain 7 0.044 0.4399 0.4611
Onchocerca volvulus 0.0026 0.0139 0.0133
Entamoeba histolytica cysteine protease, putative 0.019 0.1822 0.1863
Schistosoma mansoni adenoreceptor 0.007 0.0587 0.0604
Entamoeba histolytica calcium binding family protein 0.0043 0.0309 0.0265
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.019 0.1822 0.459
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.007 0.0587 0.0604
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0181 0.0177
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0417 0.4169 0.415
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0765 0.7745 0.7738
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Loa Loa (eye worm) calpain family protein 1 0.0838 0.8504 0.8925
Loa Loa (eye worm) melatonin receptor type 1A 0.007 0.0587 0.0604
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0953 0.4282
Onchocerca volvulus 0.007 0.0587 0.0604
Echinococcus multilocularis centrin 2 0.0043 0.0309 0.0312
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0082 0.0074
Brugia malayi beta-lactamase family protein 0.0035 0.023 0.0229
Schistosoma mansoni lamin 0.0026 0.0139 0.0133
Echinococcus granulosus neuropeptide FF receptor 2 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Leishmania major hypothetical protein, conserved 0.0201 0.1941 0.1915
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0043 0.0309 0.0312
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0033 0.0034
Plasmodium falciparum serine repeat antigen 4 0.019 0.1822 0.1885
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0033 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.023 0.0198
Giardia lamblia Dipeptidyl-peptidase I precursor 0.019 0.1822 0.459
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0043 0.0309 0.0312
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Entamoeba histolytica cysteine protease, putative 0.019 0.1822 0.1863
Echinococcus multilocularis allatostatin A receptor 0.007 0.0587 0.0604
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0058 0.0048
Trichomonas vaginalis calmodulin, putative 0.0044 0.0321 0.0337
Brugia malayi Serotonin receptor 0.007 0.0587 0.0604
Brugia malayi cahepsin L-like non-peptiedase homolog 0.019 0.1822 0.1902
Echinococcus multilocularis biogenic amine (5HT) receptor 0.007 0.0587 0.0604
Trypanosoma brucei centrin, putative 0.0043 0.0309 0.0308
Entamoeba histolytica grainin, putative 0.0044 0.0321 0.0278
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.019 0.1822 0.1902
Schistosoma mansoni cpg binding protein 0.0057 0.0452 0.0462
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0001
Plasmodium falciparum thioredoxin reductase 0.0046 0.0344 0.0328
Trichomonas vaginalis calcium binding protein, putative 0.0051 0.0391 0.041
Loa Loa (eye worm) glutathione reductase 0.0046 0.0344 0.0348
Schistosoma mansoni neuropeptide receptor 0.007 0.0587 0.0604
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0058 0.0027
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Leishmania major cathepsin L-like protease 0.0937 0.9526 0.9525
Schistosoma mansoni cpg binding protein 0.006 0.0485 0.0497
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0062 0.0052
Brugia malayi cathepsin L precursor 0.019 0.1822 0.1902
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0028
Leishmania major hypothetical protein, conserved 0.0201 0.1941 0.1915
Giardia lamblia Dipeptidyl-peptidase I precursor 0.019 0.1822 0.459
Echinococcus granulosus bloom syndrome protein 0.0021 0.0082 0.0074
Toxoplasma gondii preprocathepsin c precursor, putative 0.019 0.1822 0.1903
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0139 0.0133
Onchocerca volvulus 0.0937 0.9526 1
Entamoeba histolytica cysteine proteinase, putative 0.0493 0.4945 0.5162
Schistosoma mansoni hypothetical protein 0.0043 0.0309 0.0312
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.019 0.1822 0.1913
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0344 0.0348
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0937 0.9526 1
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0201 0.1941 0.1915
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0587 0.0604
Trypanosoma cruzi cysteine peptidase, putative 0.0983 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0318 0.0287
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0587 0.0604
Brugia malayi calpain 5 0.0206 0.1993 0.2081
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0043 0.0309 0.0278
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0493 0.4945 0.5185
Trypanosoma cruzi calmodulin, putative 0.0043 0.0309 0.0278
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0587 0.0604
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0234 0.2274 0.2273
Onchocerca volvulus 0.007 0.0587 0.0604
Onchocerca volvulus 0.019 0.1822 0.1902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Plasmodium falciparum serine repeat antigen 3 0.019 0.1822 0.1885
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0294 0.2898 0.2875
Plasmodium vivax vivapain-2 0.0937 0.9526 1
Trypanosoma cruzi kinesin, putative 0.0206 0.1993 0.1966
Leishmania major hypothetical protein, conserved 0.0201 0.1941 0.1915
Onchocerca volvulus 0.0937 0.9526 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1118 0.1162
Plasmodium falciparum serine repeat antigen 8 0.019 0.1822 0.1885
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Loa Loa (eye worm) calpain 5 0.0206 0.1993 0.2081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.023 0.0229
Onchocerca volvulus 0.0035 0.023 0.0229
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0985 0.1024
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0058 0.0048
Trypanosoma brucei Calpain-like protein 1.1 0.0765 0.7745 0.7745
Loa Loa (eye worm) hypothetical protein 0.0634 0.6403 0.6717
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Echinococcus multilocularis neuropeptide receptor A26 0.007 0.0587 0.0604
Giardia lamblia Encystation-specific protease 0.019 0.1822 0.459
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0201 0.1941 0.194
Trypanosoma brucei calpain-like protein, putative 0.044 0.4399 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0012 0.000000022051
Plasmodium vivax centrin-1, putative 0.0043 0.0309 0.0312
Brugia malayi G protein-coupled receptor F59B2.13 0.007 0.0587 0.0604
Leishmania major cathepsin L-like protease 0.0983 1 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.023 0.0229
Leishmania major kinesin, putative 0.0206 0.1993 0.1966
Echinococcus granulosus orexin receptor type 2 0.007 0.0587 0.0604
Mycobacterium tuberculosis Conserved protein 0.0035 0.023 0.0918
Schistosoma mansoni centrin 0.0043 0.0309 0.0312
Schistosoma mansoni growth hormone secretagogue receptor 0.007 0.0587 0.0604
Trypanosoma cruzi cruzipain precursor, putative 0.0983 1 1
Trichomonas vaginalis calmodulin, putative 0.0043 0.0309 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0229
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0058 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Echinococcus granulosus neurocalcin 0.0043 0.0309 0.0312
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0435 0.4348 0.4347
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0587 0.0604
Schistosoma mansoni calmodulin 0.0043 0.0309 0.0312
Leishmania major DNA polymerase eta, putative 0.0031 0.0184 0.0152
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0234 0.2274 0.2378
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0587 0.0604
Plasmodium vivax SET domain protein, putative 0.003 0.0181 0.0177
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0587 0.0604
Onchocerca volvulus 0.0937 0.9526 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0435 0.4348 0.4329
Schistosoma mansoni neuronal calcium sensor 0.0043 0.0309 0.0312
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Schistosoma mansoni amine GPCR 0.007 0.0587 0.0604
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0201 0.1941 0.194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0029
Trypanosoma cruzi calmodulin, putative 0.0043 0.0309 0.0278
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0229
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Trichomonas vaginalis centrin, putative 0.0043 0.0309 0.0325
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0043 0.0309 0.0278
Brugia malayi hypothetical protein 0.0025 0.0121 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0937 0.9526 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.1237 0.1287
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.044 0.4399 0.4381
Plasmodium vivax serine-repeat antigen (SERA), putative 0.019 0.1822 0.1902
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0587 0.0604
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0881 0.8946 0.939
Schistosoma mansoni cathepsin s 0.0303 0.2991 0.3131
Echinococcus multilocularis cathepsin L 0.019 0.1822 0.1902
Onchocerca volvulus 0.0937 0.9526 1
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0201 0.1941 0.1915
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0031
Leishmania major i/6 autoantigen-like protein 0.0043 0.0309 0.0278
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0881 0.8946 0.939
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.019 0.1822 0.1902
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0012 0.000000022051
Entamoeba histolytica calcium-binding protein, putative 0.0043 0.0309 0.0265
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0062 0.0052
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0722 0.7311 0.7303
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0587 0.0604
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.019 0.1822 0.1902
Entamoeba histolytica cysteine protease, putative 0.019 0.1822 0.1863
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0029
Trypanosoma brucei caltractin, putative 0.0051 0.0391 0.0389
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0024 0.0012
Echinococcus multilocularis neurocalcin 0.0043 0.0309 0.0312
Loa Loa (eye worm) RecQ helicase 0.0021 0.0082 0.0074
Entamoeba histolytica grainin 2 0.0051 0.0391 0.0351
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0587 0.0604
Toxoplasma gondii EFHC1, putative 0.0043 0.0309 0.0313
Leishmania major cathepsin L-like protease 0.0937 0.9526 0.9525
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.007 0.0587 0.0604
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0043 0.0309 0.0312
Trypanosoma brucei calpain-like protein, putative 0.044 0.4399 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.4945 0.5191
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0417 0.4169 0.415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Echinococcus multilocularis cpg binding protein 0.006 0.0485 0.0497
Trichomonas vaginalis calpain, putative 0.0234 0.2274 0.2387
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0024 0.0012
Onchocerca volvulus 0.0937 0.9526 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0624 0.6294 0.6282
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.023 0.0918
Loa Loa (eye worm) hypothetical protein 0.0937 0.9526 1
Onchocerca volvulus 0.007 0.0587 0.0604
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0184 0.0182
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0033 0.0031
Entamoeba histolytica hypothetical protein 0.019 0.1822 0.1863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0587 0.0604
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0013 0.0001
Trypanosoma brucei Calpain-like protein 2 0.0557 0.5611 0.561
Loa Loa (eye worm) hypothetical protein 0.0634 0.6403 0.6717
Echinococcus granulosus Ankyrin 0.0014 0.0014 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.019 0.1822 0.1913
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0851 0.864 0.8636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0493 0.4945 0.4945
Toxoplasma gondii calmodulin CAM1 0.0044 0.0321 0.0326
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0043 0.0309 0.0312
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.019 0.1822 0.1902
Onchocerca volvulus Cathepsin F homolog 0.0937 0.9526 1
Echinococcus granulosus EF HAND 1 calcium binding site 0.0043 0.0309 0.0312
Giardia lamblia Hypothetical protein 0.019 0.1822 0.459
Brugia malayi Cathepsin L-like precursor 0.0937 0.9526 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.019 0.1822 0.1863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1822 0.1913
Echinococcus granulosus programmed cell death protein 0.0051 0.0391 0.0398
Onchocerca volvulus 0.007 0.0587 0.0604
Echinococcus multilocularis hypothetical protein 0.044 0.4399 0.4611
Trichomonas vaginalis calmodulin, putative 0.0051 0.0391 0.041
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.007 0.0587 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.3228 0.3388
Echinococcus multilocularis G protein coupled receptor 139 0.007 0.0587 0.0604
Echinococcus granulosus cathepsin L 0.0493 0.4945 0.5185
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0435 0.4348 0.4329
Trichomonas vaginalis calpain, putative 0.0234 0.2274 0.2387
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0765 0.7745 0.7745
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.044 0.4399 0.4381
Toxoplasma gondii troponin c, isotype gamma, putative 0.0043 0.0309 0.0313
Loa Loa (eye worm) hypothetical protein 0.0398 0.3973 0.4163
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0417 0.4169 0.4168
Plasmodium falciparum serine repeat antigen 1 0.019 0.1822 0.1885
Echinococcus multilocularis g protein coupled receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.0838 0.8504 0.8925
Brugia malayi hypothetical protein 0.0016 0.0031 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0493 0.4945 0.4929
Schistosoma mansoni hypothetical protein 0.007 0.0587 0.0604
Brugia malayi calpain family protein 1 0.0838 0.8504 0.8925
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0033 0.0034
Leishmania major hypothetical protein, conserved 0.0201 0.1941 0.1915
Brugia malayi neuropeptide F receptor 0.007 0.0587 0.0604
Leishmania major phospholipase c-like protein 0.0043 0.0309 0.0278
Toxoplasma gondii cathepsin B 0.0394 0.3931 0.4119
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0937 0.9526 1
Echinococcus granulosus neuronal calcium sensor 0.0043 0.0309 0.0312
Echinococcus multilocularis cathepsin L cysteine protease 0.0937 0.9526 1
Trichomonas vaginalis calmodulin, putative 0.0043 0.0309 0.0325
Echinococcus multilocularis dna polymerase eta 0.0044 0.0318 0.0322
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0344 0.0348
Onchocerca volvulus 0.003 0.0181 0.0177
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.023 0.0229
Brugia malayi cathepsin L-like cysteine proteinase 0.019 0.1822 0.1902
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.007 0.0587 0.0604
Echinococcus multilocularis calpain A 0.0882 0.8958 0.9402
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.007 0.0587 0.0604
Brugia malayi Papain family cysteine protease containing protein 0.019 0.1822 0.1902
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0234 0.2274 0.2387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Onchocerca volvulus 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.019 0.1822 0.1913
Loa Loa (eye worm) hypothetical protein 0.0043 0.0309 0.0312
Leishmania major cysteine peptidase A (CPA) 0.0937 0.9526 0.9525
Loa Loa (eye worm) papain family cysteine protease containing protein 0.019 0.1822 0.1902
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Echinococcus multilocularis orexin receptor type 2 0.007 0.0587 0.0604
Onchocerca volvulus 0.007 0.0587 0.0604
Brugia malayi Death domain containing protein 0.0014 0.0012 0.000000022051
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0181 0.0178
Onchocerca volvulus 0.007 0.0587 0.0604
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0587 0.0604
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0587 0.0604
Giardia lamblia Cathepsin L precursor 0.019 0.1822 0.459
Echinococcus multilocularis alpha 1A adrenergic receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.0026 0.0139 0.0133
Trichomonas vaginalis calcium binding proteins, putative 0.0043 0.0309 0.0325
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0082 0.0087
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0851 0.864 0.9069
Brugia malayi cathepsin L-like precursor 0.0634 0.6403 0.6717
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.023 0.0918
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.019 0.1822 0.1902
Trichomonas vaginalis myosin light chain 1, putative 0.0043 0.0309 0.0325
Leishmania major centrin, putative,caltractin, putative 0.0043 0.0309 0.0278
Brugia malayi intermediate filament protein 0.0026 0.0139 0.0133
Leishmania major protein kinase, putative 0.0043 0.0309 0.0278
Mycobacterium ulcerans lipase LipD 0.0035 0.023 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1075 0.4845
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0181 0.0177
Echinococcus multilocularis EF hand domain containing family member A2 0.0043 0.0309 0.0312
Schistosoma mansoni rab 0.0043 0.0309 0.0312
Entamoeba histolytica cysteine protease, putative 0.0937 0.9526 1
Plasmodium vivax calpain, putative 0.044 0.4399 0.461
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0344 0.0312
Loa Loa (eye worm) ctsf protein 0.0937 0.9526 1
Leishmania major calmodulin, putative 0.0043 0.0309 0.0278
Brugia malayi programmed cell death protein 6 0.0043 0.0309 0.0312
Giardia lamblia Cathepsin B precursor 0.0394 0.3931 1
Loa Loa (eye worm) programmed cell death protein 6 0.0044 0.0321 0.0325
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0229
Mycobacterium ulcerans beta-lactamase 0.0035 0.023 1
Schistosoma mansoni DNA polymerase eta 0.0044 0.0318 0.0322
Entamoeba histolytica cysteine proteinase, putative 0.0937 0.9526 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0624 0.6294 0.6293
Echinococcus multilocularis Ankyrin 0.0014 0.0014 0.0001
Echinococcus granulosus somatostatin receptor 0.007 0.0587 0.0604
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Brugia malayi neuropeptide F receptor 0.007 0.0587 0.0604
Trypanosoma cruzi major cysteine proteinase, putative 0.0236 0.2296 0.227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1822 0.1913
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0493 0.4945 0.5185
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0255 0.2496 0.2495
Schistosoma mansoni cathepsin C 0.019 0.1822 0.1902
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0309 0.0325
Trypanosoma brucei calpain, putative 0.0234 0.2274 0.2273
Echinococcus granulosus calpain 0.044 0.4399 0.4611
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0234 0.2274 0.2387
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.0321 0.0278
Brugia malayi CXXC zinc finger family protein 0.0057 0.0452 0.0462
Echinococcus granulosus cathepsin b 0.0851 0.864 0.9069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1822 0.1913
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0062 0.0136
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0587 0.0604
Schistosoma mansoni amine GPCR 0.007 0.0587 0.0604
Trichomonas vaginalis esterase, putative 0.0035 0.023 0.0242
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0134 0.0128
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.019 0.1822 0.1902
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0665 0.6719 0.6709
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.019 0.1822 0.1885
Schistosoma mansoni biogenic amine receptor 0.007 0.0587 0.0604
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.0303 0.2991 0.3131
Leishmania major META domain containing protein 0.0201 0.1941 0.1915
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.019 0.1822 0.1913
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0062 0.1485
Trichomonas vaginalis calmodulin, putative 0.0043 0.0309 0.0325
Schistosoma mansoni reticulocalbin 0.0044 0.0321 0.0325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0024 0.0012
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.044 0.4399 0.4381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0344 0.1446
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.007 0.0587 0.0604
Trypanosoma cruzi caltractin, putative 0.0043 0.0309 0.0278
Echinococcus granulosus cathepsin L cysteine protease 0.0493 0.4945 0.5185
Loa Loa (eye worm) hypothetical protein 0.019 0.1822 0.1902
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Plasmodium vivax serine-repeat antigen (SERA) 0.019 0.1822 0.1902
Trichomonas vaginalis calcium binding protein, putative 0.0043 0.0309 0.0325
Leishmania major hypothetical protein, conserved 0.0044 0.0321 0.029
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.023 0.0229
Trichomonas vaginalis calmodulin, putative 0.0043 0.0309 0.0325
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0062 0.0065
Echinococcus multilocularis EF hand domain containing family member A2 0.0044 0.0321 0.0325
Echinococcus multilocularis serotonin receptor 0.007 0.0587 0.0604
Echinococcus multilocularis calpain 5 0.044 0.4399 0.4611
Leishmania major small myristoylated protein-3, putative 0.0294 0.2898 0.2875
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0139 0.0133
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0587 0.0604
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0394 0.3931 0.3911
Schistosoma mansoni hypothetical protein 0.007 0.0587 0.0604
Schistosoma mansoni calpain C (C02 family) 0.044 0.4399 0.4611
Plasmodium vivax serine-repeat antigen (SERA) 0.019 0.1822 0.1902
Onchocerca volvulus 0.007 0.0587 0.0604
Onchocerca volvulus 0.007 0.0587 0.0604
Echinococcus granulosus calpain A 0.044 0.4399 0.4611
Loa Loa (eye worm) hypothetical protein 0.031 0.3061 0.3205
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0587 0.0604
Echinococcus granulosus calpain 5 0.044 0.4399 0.4611
Echinococcus multilocularis calcium uptake protein 1 0.0044 0.0321 0.0325
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0309 0.0308
Giardia lamblia DINP protein human, muc B family 0.0019 0.0062 0.0075
Echinococcus granulosus dna polymerase eta 0.0044 0.0318 0.0322
Schistosoma mansoni neuropeptide f receptor 76f 0.007 0.0587 0.0604
Onchocerca volvulus 0.007 0.0587 0.0604
Plasmodium vivax hypothetical protein, conserved 0.0035 0.023 0.0228
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0695 0.7028 0.7018
Entamoeba histolytica cysteine protease, putative 0.019 0.1822 0.1863
Echinococcus granulosus EF hand domain containing family member A2 0.0043 0.0309 0.0312
Mycobacterium tuberculosis Conserved protein 0.0035 0.023 0.0918
Schistosoma mansoni ap endonuclease 0.0018 0.0058 0.0048
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0157 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.007 0.0587 0.0604
Echinococcus granulosus cathepsin L cysteine proteinase 0.0937 0.9526 1
Plasmodium falciparum serine repeat antigen 2 0.019 0.1822 0.1885
Giardia lamblia Hypothetical protein 0.0044 0.0321 0.0741
Trypanosoma cruzi conserved protein 0.0443 0.4437 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0294 0.2898 0.2897
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0121 0.012
Brugia malayi GnHR receptor homolog 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.4011 0.4203
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0062 0.0052
Onchocerca volvulus 0.0057 0.0452 0.0462
Loa Loa (eye worm) hypothetical protein 0.019 0.1822 0.1902
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0587 0.0604
Onchocerca volvulus 0.0035 0.023 0.0229
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0356 0.3537 0.3516
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0587 0.0604
Brugia malayi RE15519p 0.007 0.0587 0.0604
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0201 0.1941 0.194
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0058 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0937 0.9526 1
Echinococcus granulosus dro:myosuppressin receptor 0.007 0.0587 0.0604
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Leishmania major cathepsin L-like protease 0.0937 0.9526 0.9525
Entamoeba histolytica cysteine protease, putative 0.019 0.1822 0.1863
Plasmodium falciparum centrin-1 0.0043 0.0309 0.0292
Brugia malayi Pre-SET motif family protein 0.0205 0.1976 0.2063
Brugia malayi Dopamine receptor protein 2 0.007 0.0587 0.0604
Echinococcus granulosus neuropeptide receptor 0.007 0.0587 0.0604
Leishmania major small myristoylated protein-2 0.0633 0.6387 0.6375
Brugia malayi hypothetical protein 0.007 0.0587 0.0604
Leishmania major hypothetical protein, conserved 0.0443 0.4437 0.4419
Toxoplasma gondii EF hand domain-containing protein 0.0043 0.0309 0.0313
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2265 0.2378
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0181 0.0177
Onchocerca volvulus 0.007 0.0587 0.0604
Plasmodium vivax glutathione reductase, putative 0.0046 0.0344 0.0348
Leishmania major trypanothione reductase 0.0046 0.0344 0.0312
Trypanosoma cruzi cysteine protease, putative 0.0493 0.4945 0.4929
Schistosoma mansoni hypothetical protein 0.0166 0.1574 0.1641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0634 0.6403 0.6721
Plasmodium falciparum serine repeat antigen 5 0.019 0.1822 0.1885
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.007 0.0587 0.0604
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.007 0.0587 0.0604
Giardia lamblia Cysteine protease 0.019 0.1822 0.459
Schistosoma mansoni cathepsin F (C01 family) 0.0634 0.6403 0.6717
Leishmania major calpain family cysteine protease-like protein 0.0435 0.4348 0.4329
Echinococcus granulosus cathepsin l1 0.0937 0.9526 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Echinococcus granulosus geminin 0.0166 0.1574 0.1641
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.019 0.1822 0.1902
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0058 0.0061
Schistosoma mansoni ef hand domain family member A2 0.0043 0.0309 0.0312
Echinococcus granulosus cathepsin L 0.019 0.1822 0.1902
Echinococcus granulosus calumenin 0.0044 0.0321 0.0325
Brugia malayi Pre-SET motif family protein 0.003 0.0181 0.0177
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0033 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.023 0.0198
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0062 0.0136
Loa Loa (eye worm) TYRA-2 protein 0.007 0.0587 0.0604
Brugia malayi ORL1-like opioid receptor 0.007 0.0587 0.0604
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.1941 0.1915
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0983 1 1
Echinococcus multilocularis g protein coupled receptor 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0937 0.9526 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.0177
Leishmania major hypothetical protein, conserved 0.0035 0.023 0.0198
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Trypanosoma cruzi I/6 autoantigen, putative 0.0043 0.0309 0.0278
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0953 0.4282
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0953 0.8565
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0547 0.5506 0.5491
Trichomonas vaginalis calcium binding protein, putative 0.0043 0.0309 0.0325
Giardia lamblia Cathepsin B precursor 0.0394 0.3931 1
Schistosoma mansoni neuropeptide receptor 0.007 0.0587 0.0604
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.023 0.0918
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2183 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.019 0.1822 0.1902
Brugia malayi cathepsin Z-like cysteine proteinase 0.019 0.1822 0.1902
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0043 0.0309 0.0278
Brugia malayi Melatonin receptor type 1A 0.007 0.0587 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0937 0.9526 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1135 0.118
Trichomonas vaginalis calmodulin, putative 0.0043 0.0309 0.0325
Trypanosoma brucei protein I/6 0.0043 0.0309 0.0308
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0043 0.0309 0.0265
Echinococcus multilocularis calpain 0.044 0.4399 0.4611
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.1941 0.1915
Brugia malayi glutathione reductase 0.0046 0.0344 0.0348
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0043 0.0309 0.0278
Schistosoma mansoni lamin 0.0026 0.0139 0.0133
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0493 0.4945 0.5185
Echinococcus multilocularis G-protein coupled receptor, putative 0.007 0.0587 0.0604
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0587 0.0604
Schistosoma mansoni calmodulin 0.0043 0.0309 0.0312
Brugia malayi fibroinase precursor 0.019 0.1822 0.1902
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0043 0.0309 0.0265
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0058 0.0061
Brugia malayi putative neuropeptide receptor 0.007 0.0587 0.0604
Brugia malayi Serotonin/octopamine receptor family protein 7 0.007 0.0587 0.0604
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0184 0.0152
Loa Loa (eye worm) hypothetical protein 0.019 0.1822 0.1902
Entamoeba histolytica cysteine proteinase, putative 0.0493 0.4945 0.5162
Trichomonas vaginalis conserved hypothetical protein 0.019 0.1822 0.1913
Plasmodium vivax serine-repeat antigen (SERA), putative 0.019 0.1822 0.1902
Schistosoma mansoni peptide (allatostatin)-like receptor 0.007 0.0587 0.0604
Giardia lamblia Cathepsin B precursor 0.019 0.1822 0.459
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0062 0.0052
Echinococcus multilocularis fmrfamide receptor 0.007 0.0587 0.0604
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0489 0.4903 0.4902
Leishmania major calmodulin-like protein 0.0043 0.0309 0.0278
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0121 0.0114
Giardia lamblia Cysteine protease 0.019 0.1822 0.459
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0695 0.7028 0.7018
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0014 0.0001
Loa Loa (eye worm) hypothetical protein 0.0851 0.864 0.9069
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0321 0.0324
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.1941 0.1915
Brugia malayi putative neuropeptide receptor NPR1 0.007 0.0587 0.0604
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0435 0.4348 0.4329
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.007 0.0587 0.0604
Echinococcus granulosus neuropeptide s receptor 0.007 0.0587 0.0604
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.023 0.0229
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Mycobacterium ulcerans hypothetical protein 0.0035 0.023 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.023 0.0918
Echinococcus granulosus cysteine protease 0.0493 0.4945 0.5185
Echinococcus multilocularis sex peptide receptor 0.007 0.0587 0.0604
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0435 0.4348 0.4329
Onchocerca volvulus 0.0043 0.0309 0.0312
Plasmodium falciparum cysteine proteinase falcipain 1 0.0493 0.4945 0.5175
Giardia lamblia Cathepsin L precursor 0.019 0.1822 0.459
Schistosoma mansoni cpg binding protein 0.006 0.0485 0.0497
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0059 0.0049
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0058 0.0057
Schistosoma mansoni hypothetical protein 0.0123 0.1135 0.118
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.007 0.0587 0.0604
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.023 0.0242
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0587 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Brugia malayi Cathepsin L-like precursor 0.0303 0.2991 0.3131
Plasmodium vivax vivapain-2 0.0937 0.9526 1
Trypanosoma brucei kinesin, putative 0.0206 0.1993 0.1991
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0234 0.2274 0.2387
Echinococcus multilocularis cysteine protease 0.0937 0.9526 1
Echinococcus multilocularis lamin dm0 0.0026 0.0139 0.0133
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0765 0.7745 0.7738
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0303 0.2991 0.3131
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Brugia malayi Papain family cysteine protease containing protein 0.0493 0.4945 0.5185
Leishmania major small myristoylated protein 4, putative 0.0547 0.5506 0.5491
Entamoeba histolytica calmodulin, putative 0.0043 0.0309 0.0265
Loa Loa (eye worm) hypothetical protein 0.007 0.0587 0.0604
Loa Loa (eye worm) EF hand family protein 0.0043 0.0309 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.007 0.0587 0.0604
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0058 0.0026
Schistosoma mansoni neuronal calcium sensor 0.0043 0.0309 0.0312
Brugia malayi Cathepsin L-like precursor 0.0937 0.9526 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0052
Echinococcus granulosus g-protein coupled receptor 0.007 0.0587 0.0604
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0255 0.2496 0.2495
Trypanosoma brucei mitochondrial calcium uptake 1 0.0043 0.0309 0.0308
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0033 0.0021
Entamoeba histolytica cysteine protease, putative 0.0493 0.4945 0.5162
Toxoplasma gondii thioredoxin reductase 0.0046 0.0344 0.0349
Brugia malayi Cathepsin L-like precursor 0.0634 0.6403 0.6717
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0587 0.0604
Brugia malayi calpain 5 0.0234 0.2274 0.2377
Onchocerca volvulus 0.0937 0.9526 1
Brugia malayi calpain family protein 1 0.0838 0.8504 0.8925
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0024 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0326 0.3228 0.3226
Echinococcus granulosus lamin dm0 0.0026 0.0139 0.0133
Onchocerca volvulus 0.0634 0.6403 0.6717
Toxoplasma gondii centrin 0.0043 0.0309 0.0313
Brugia malayi Calmodulin-like protein 0.0043 0.0309 0.0312
Onchocerca volvulus 0.007 0.0587 0.0604

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Activity at human adenosine A1 receptor expressed in CHO cells assessed as effect on forskolin-stimulated cAMP production at 100 nM ChEMBL. 17300165
Activity (functional) Activity at human adenosine A1 receptor in CHO cells assessed as effect on CPA induced inhibition of forskolin-stimulated cAMP production at 1 uM ChEMBL. 17300165
Activity (functional) 0 Activity at human adenosine A1 receptor expressed in CHO cells assessed as effect on forskolin-stimulated cAMP production at 100 nM ChEMBL. 17300165
Activity (functional) 0 Activity at human adenosine A1 receptor in CHO cells assessed as effect on CPA induced inhibition of forskolin-stimulated cAMP production at 1 uM ChEMBL. 17300165
Ki (binding) = 0.55 nM Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells ChEMBL. 17300165
Ki (binding) = 25 nM Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 17300165
Ki (binding) = 189 nM Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells ChEMBL. 17300165
Ki (binding) = 300 nM Displacement of [3H]MRS1754 from human adenosine A2B receptor ChEMBL. 17300165
Ratio Ki (binding) = 45 Selectivity for human adenosine A1 receptor over human adenosine A3 receptor ChEMBL. 17300165
Ratio Ki (binding) > 300 Selectivity for human adenosine A1 receptor over human adenosine A2A receptor ChEMBL. 17300165

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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