Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0177 | 0.1263 | 0.1221 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0066 | 0.0144 | 0.0144 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0177 | 0.1263 | 0.1263 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0177 | 0.1263 | 0.1263 |
Onchocerca volvulus | 0.0177 | 0.1263 | 0.1136 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0244 | 0.1946 | 0.2088 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0973 | 0.9318 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0177 | 0.1263 | 0.1263 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0177 | 0.1263 | 0.1263 |
Onchocerca volvulus | 0.0177 | 0.1263 | 0.1136 | |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0177 | 0.1263 | 0.1263 |
Plasmodium falciparum | amino acid transporter, putative | 0.0177 | 0.1263 | 0.1221 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0973 | 0.9318 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0177 | 0.1263 | 0.1263 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0177 | 0.1263 | 0.1263 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0076 | 0.0243 | 0.0243 |
Plasmodium falciparum | transporter, putative | 0.0177 | 0.1263 | 0.1221 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0066 | 0.0144 | 0.0144 |
Echinococcus multilocularis | serotonin transporter | 0.1041 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0177 | 0.1263 | 0.1221 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0177 | 0.1263 | 0.1263 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0066 | 0.0144 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.1041 | 1 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0177 | 0.1263 | 0.1263 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0066 | 0.0144 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0243 | 0.0243 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0177 | 0.1263 | 0.1263 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0177 | 0.1263 | 0.1263 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0285 | 0.2362 | 0.2362 |
Loa Loa (eye worm) | hypothetical protein | 0.1041 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0177 | 0.1263 | 0.1263 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1263 | 0.1263 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0066 | 0.0144 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0177 | 0.1263 | 0.1263 |
Trypanosoma brucei | pteridine reductase 1 | 0.0066 | 0.0144 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0973 | 0.9318 | 1 |
Plasmodium vivax | amine transporter, putative | 0.0177 | 0.1263 | 0.1221 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0261 | 0.2119 | 0.2119 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0066 | 0.0144 | 0.0144 |
Plasmodium vivax | hypothetical protein, conserved | 0.0177 | 0.1263 | 0.1221 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0973 | 0.9318 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0076 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0066 | 0.0144 | 0.0144 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0177 | 0.1263 | 0.1263 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0973 | 0.9318 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0066 | 0.0144 | 0.0144 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0177 | 0.1263 | 0.1263 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0066 | 0.0144 | 0.0144 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0076 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1263 | 0.1263 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0973 | 0.9318 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1263 | 0.1263 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.1041 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1263 | 0.1263 |
Leishmania major | pteridine reductase 1 | 0.0066 | 0.0144 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0066 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0177 | 0.1263 | 0.1263 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0177 | 0.1263 | 0.1263 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0285 | 0.2362 | 0.2362 |
Loa Loa (eye worm) | hypothetical protein | 0.1041 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0261 | 0.2119 | 0.2119 |
Echinococcus granulosus | serotonin transporter | 0.1041 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0973 | 0.9318 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1263 | 0.1263 |
Toxoplasma gondii | hypothetical protein | 0.0177 | 0.1263 | 0.1221 |
Brugia malayi | hypothetical protein | 0.0177 | 0.1263 | 0.1263 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0066 | 0.0144 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0177 | 0.1263 | 0.1263 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0177 | 0.1263 | 0.1263 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0177 | 0.1263 | 0.1221 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0177 | 0.1263 | 0.1221 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.1041 | 1 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0066 | 0.0144 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0261 | 0.2119 | 0.2119 |
Echinococcus granulosus | voltage gated potassium channel | 0.0076 | 0.0243 | 0.0243 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0973 | 0.9318 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0076 | 0.0243 | 0.0243 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0177 | 0.1263 | 0.1263 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0066 | 0.0144 | 0.0144 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0177 | 0.1263 | 0.1263 |
Onchocerca volvulus | 0.1041 | 1 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0076 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0066 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1771 | 0.1771 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0177 | 0.1263 | 0.1263 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0261 | 0.2119 | 0.2119 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0144 | 0.0144 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0177 | 0.1263 | 0.1263 |
Loa Loa (eye worm) | norepinephrine transporter | 0.1041 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0973 | 0.9318 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1263 | 0.1263 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0177 | 0.1263 | 0.1263 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1263 | 0.1263 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0066 | 0.0144 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0076 | 0.0243 | 0.0243 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0066 | 0.0144 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0066 | 0.0144 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0066 | 0.0144 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0066 | 0.0144 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0177 | 0.1263 | 0.1263 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0177 | 0.1263 | 0.1263 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0177 | 0.1263 | 0.1263 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0244 | 0.1946 | 0.2088 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.1041 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1041 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.1041 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0177 | 0.1263 | 0.1221 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0177 | 0.1263 | 0.1263 |
Onchocerca volvulus | 0.0177 | 0.1263 | 0.1136 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human mitochondrial PDF | ChEMBL. | 17201406 | |
IC50 (binding) | 0 | Inhibition of human mitochondrial PDF | ChEMBL. | 17201406 |
IC50 (binding) | = 250 uM | Inhibition of PDF2 | ChEMBL. | 17201406 |
IC50 (binding) | = 560 uM | Inhibition of PDF1B | ChEMBL. | 17201406 |
IC50 (binding) | = 560 uM | Inhibition of PDF1B | ChEMBL. | 17201406 |
IC50 (binding) | = 790 uM | Inhibition of Arabidopsis thaliana mitochondrial PDF1A | ChEMBL. | 17201406 |
IC50 (binding) | = 790 uM | Inhibition of Arabidopsis thaliana mitochondrial PDF1A | ChEMBL. | 17201406 |
MIC (functional) | 0 | Antibacterial activity against Bacillus subtilis | ChEMBL. | 17201406 |
MIC (functional) | 0 | Antibacterial activity against Escherichia coli K37 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Escherichia coli JM101Tr | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Escherichia coli CAG1284 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Bacillus subtilis 168 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Bacillus subtilis D101 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Bacillus subtilis Y101 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Bacillus subtilis MO3482 | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Escherichia coli JM101Tr | ChEMBL. | 17201406 |
MIC (functional) | > 300 ug ml-1 | Antibacterial activity against Escherichia coli CAG1284 | ChEMBL. | 17201406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.