Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.014 | 0.1299 | 0.2429 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0029 | 0.0074 | 0.0138 |
Onchocerca volvulus | 0.0034 | 0.0128 | 0.0239 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.0104 |
Plasmodium falciparum | glutathione reductase | 0.0041 | 0.0209 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.0554 | 0.0991 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.0185 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.0074 | 0.0138 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0025 | 0.0033 | 0.0111 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0029 | 0.0078 | 0.0139 |
Echinococcus granulosus | solute carrier family 5 | 0.0044 | 0.0235 | 0.0421 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0162 | 0.2396 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0405 | 0.0757 |
Schistosoma mansoni | sodium/solute symporter | 0.0044 | 0.0235 | 0.0568 |
Echinococcus granulosus | FTZ F1 alpha | 0.0029 | 0.0074 | 0.0132 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0029 | 0.0074 | 0.0138 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0112 | 0.0995 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0044 | 0.0235 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.5349 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0237 | 0.2381 | 0.4452 |
Plasmodium falciparum | thioredoxin reductase | 0.0041 | 0.0209 | 1 |
Onchocerca volvulus | 0.0029 | 0.0074 | 0.0138 | |
Plasmodium vivax | endoplasmin, putative | 0.0037 | 0.0162 | 0.7722 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.0074 | 0.0132 |
Echinococcus multilocularis | heat shock protein 90 | 0.0037 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0074 | 0.0138 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0029 | 0.0074 | 0.0178 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0029 | 0.0074 | 0.0138 |
Schistosoma mansoni | patched 1 | 0.0048 | 0.0285 | 0.0687 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0554 | 0.4712 |
Echinococcus granulosus | single minded 2 | 0.0072 | 0.0555 | 0.0992 |
Leishmania major | protein kinase, putative | 0.0025 | 0.0033 | 0.009 |
Onchocerca volvulus | 0.0072 | 0.0555 | 0.1037 | |
Echinococcus multilocularis | FTZ F1 alpha | 0.0029 | 0.0074 | 0.0074 |
Echinococcus multilocularis | Protein lozenge | 0.0063 | 0.0453 | 0.0453 |
Leishmania major | trypanothione reductase | 0.0041 | 0.0209 | 0.3252 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0074 | 0.0138 |
Echinococcus granulosus | lamin | 0.0031 | 0.0092 | 0.0164 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0075 | 0.0585 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.0194 | 0.0347 |
Schistosoma mansoni | lamin | 0.0031 | 0.0092 | 0.0221 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0396 | 0.4144 | 0.7406 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.0104 | 0.1356 |
Schistosoma mansoni | high-affinity choline transporter | 0.0396 | 0.4144 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.0074 | 0.0138 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0029 | 0.0074 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0085 | 0.016 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1342 | 0.3238 |
Mycobacterium ulcerans | putative regulatory protein | 0.0072 | 0.0555 | 1 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0025 | 0.0033 | 0.0111 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0029 | 0.0074 | 0.0074 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0094 | 0.0797 | 0.8674 |
Trichomonas vaginalis | heat shock protein, putative | 0.0029 | 0.0078 | 0.0274 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0075 | 0.0585 | 0.1046 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0162 | 0.2396 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0029 | 0.0074 | 0.0138 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0527 | 0.5596 | 0.5596 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0037 | 0.0162 | 0.2396 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0143 | 0.1342 | 0.1342 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0044 | 0.0234 | 0.0418 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0162 | 0.2396 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0029 | 0.0074 | 0.0132 |
Brugia malayi | heat shock protein 90 | 0.0037 | 0.0162 | 0.0302 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0025 | 0.0033 | 0.0059 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0025 | 0.0033 | 0.0111 |
Schistosoma mansoni | lipoxygenase | 0.0063 | 0.0449 | 0.1082 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0828 | 0.1998 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0075 | 0.0585 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0029 | 0.0074 | 0.0138 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0069 | 0.074 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 0.0074 | 0.0138 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.004 | 0.0194 | 0.0363 |
Schistosoma mansoni | inositol transporter | 0.0044 | 0.0235 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0074 | 0.0138 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0044 | 0.0235 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.027 | 0.2745 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0029 | 0.0074 | 0.0074 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0029 | 0.0074 | 0.0138 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0029 | 0.0074 | 0.0178 |
Brugia malayi | glutathione reductase | 0.0041 | 0.0209 | 0.0391 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0044 | 0.0235 | 0.0421 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.0074 | 0.0138 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0092 | 0.0171 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0029 | 0.0078 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0266 | 0.0641 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.0074 | 0.0132 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.024 | 0.2417 | 0.4519 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0029 | 0.0074 | 0.0138 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 0.0074 | 0.0138 |
Onchocerca volvulus | 0.0484 | 0.5126 | 0.9584 | |
Loa Loa (eye worm) | heat shock protein 90 | 0.0037 | 0.0162 | 0.0302 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0029 | 0.0074 | 0.0178 |
Onchocerca volvulus | 0.0031 | 0.0092 | 0.0171 | |
Loa Loa (eye worm) | glutathione reductase | 0.0041 | 0.0209 | 0.0391 |
Brugia malayi | Cytochrome P450 family protein | 0.0025 | 0.0028 | 0.0053 |
Schistosoma mansoni | lozenge | 0.0063 | 0.0453 | 0.1093 |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.0025 | 0.0033 | 0.0033 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0075 | 0.0585 | 0.5081 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.0028 | 0.0053 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0075 | 0.0585 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0092 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0554 | 0.1338 |
Schistosoma mansoni | endoplasmin | 0.0037 | 0.0162 | 0.039 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0029 | 0.0078 | 0.0894 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0032 | 0.0104 | 0.0104 |
Brugia malayi | hypothetical protein | 0.0504 | 0.5349 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0484 | 0.5126 | 0.9584 |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 0.0074 | 0.0138 |
Schistosoma mansoni | inositol transporter | 0.0044 | 0.0235 | 0.0568 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0029 | 0.0074 | 0.0138 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0037 | 0.0162 | 0.2396 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.4144 | 0.7747 |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.036 | 0.036 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.2066 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0094 | 0.0797 | 0.8603 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.0369 | 0.0691 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0092 | 0.0171 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0041 | 0.0209 | 0.1572 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0037 | 0.0162 | 0.2396 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0075 | 0.0585 | 0.1094 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0298 | 0.3057 | 0.5716 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0025 | 0.0033 | 0.0111 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.0194 | 0.0469 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0044 | 0.0235 | 0.0421 |
Echinococcus granulosus | geminin | 0.0341 | 0.3536 | 0.6318 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0128 | 0.6121 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0097 | 0.0828 | 0.1548 |
Brugia malayi | Cytochrome P450 family protein | 0.0025 | 0.0028 | 0.0053 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0069 | 0.3316 |
Echinococcus multilocularis | geminin | 0.0341 | 0.3536 | 0.3536 |
Schistosoma mansoni | thyroid hormone receptor | 0.0172 | 0.1665 | 0.4018 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0029 | 0.0074 | 0.0138 |
Echinococcus granulosus | endoplasmin | 0.0029 | 0.0078 | 0.0139 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.0194 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0029 | 0.0074 | 0.0138 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.2066 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0033 | 0.0062 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.0194 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0075 | 0.0585 | 0.1094 |
Brugia malayi | Pax transcription factor protein 2 | 0.0484 | 0.5126 | 0.9584 |
Echinococcus granulosus | neuropeptide s receptor | 0.0527 | 0.5596 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0075 | 0.0585 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0303 | 0.3114 | 0.5821 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0025 | 0.0033 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.5032 | 0.9408 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.0074 | 0.0074 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 0.0074 | 0.0138 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0476 | 0.5032 | 0.5032 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0044 | 0.0235 | 0.0421 |
Onchocerca volvulus | 0.0097 | 0.0828 | 0.1548 | |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0396 | 0.4144 | 0.4144 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0029 | 0.0074 | 0.0132 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0128 | 0.3537 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0048 | 0.0285 | 0.0509 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0069 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0995 | 0.186 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.016 | 0.1529 | 0.2733 |
Onchocerca volvulus | 0.0504 | 0.5349 | 1 | |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0029 | 0.0078 | 0.0894 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0025 | 0.0033 | 0.009 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Brugia malayi | ecdysteroid receptor | 0.0029 | 0.0074 | 0.0138 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0069 | 0.074 |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.0025 | 0.0033 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0069 | 0.013 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0029 | 0.0078 | 0.0509 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.0104 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0037 | 0.0162 | 0.2396 |
Schistosoma mansoni | endoplasmin | 0.0037 | 0.0162 | 0.039 |
Brugia malayi | hypothetical protein | 0.0476 | 0.5032 | 0.9408 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0094 | 0.0797 | 0.8603 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.0194 | 0.0194 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.016 | 0.1529 | 0.1529 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.004 | 0.0194 | 0.0363 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0032 | 0.0104 | 0.1356 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0172 | 0.1665 | 0.1665 |
Trichomonas vaginalis | heat shock protein, putative | 0.0029 | 0.0078 | 0.0274 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0098 | 0.0837 | 0.2021 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0029 | 0.0078 | 0.0945 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0029 | 0.0074 | 0.0138 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0029 | 0.0074 | 0.0178 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.0104 | 0.1356 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1299 | 0.2429 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0075 | 0.0585 | 0.0585 |
Mycobacterium tuberculosis | Probable reductase | 0.0094 | 0.0797 | 0.8603 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.3057 | 0.5716 |
Brugia malayi | CHE-14 protein | 0.0048 | 0.0285 | 0.0532 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0029 | 0.0074 | 0.0178 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0112 | 0.0995 | 0.1778 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0025 | 0.0033 | 0.009 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0.0104 | 0.0308 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0029 | 0.0074 | 0.0138 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0554 | 0.4712 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0074 | 0.0138 |
Echinococcus multilocularis | heat shock protein | 0.0037 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.027 | 0.2745 | 0.5131 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0069 | 0.3316 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0554 | 0.4712 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0048 | 0.0285 | 0.0285 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0069 | 0.074 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0128 | 0.0239 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.0194 | 0.0469 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0285 | 0.1029 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0162 | 0.2396 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0162 | 0.2396 |
Schistosoma mansoni | nuclear hormone receptor | 0.0029 | 0.0074 | 0.0178 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0162 | 0.2396 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0074 | 0.0138 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0048 | 0.0285 | 0.0532 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.0104 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0072 | 0.0555 | 0.0555 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0128 | 0.0309 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0037 | 0.0162 | 0.2396 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0063 | 0.0449 | 0.0449 |
Toxoplasma gondii | thioredoxin reductase | 0.0041 | 0.0209 | 0.8428 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0037 | 0.0162 | 0.5556 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0025 | 0.0033 | 0.009 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0044 | 0.0235 | 0.0235 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.0104 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.1299 | 0.2429 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0237 | 0.2381 | 0.4452 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0041 | 0.0209 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0044 | 0.0235 | 0.0235 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0094 | 0.0797 | 0.8603 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0162 | 0.2396 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0527 | 0.5596 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0097 | 0.0828 | 0.1998 |
Loa Loa (eye worm) | endoplasmin | 0.0037 | 0.0162 | 0.0302 |
Schistosoma mansoni | single-minded | 0.0098 | 0.0837 | 0.2021 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0025 | 0.0033 | 0.0033 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | runx1 | 0.0063 | 0.0453 | 0.0847 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0143 | 0.1342 | 0.2398 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0029 | 0.0074 | 0.0178 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0092 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.3396 | 0.6349 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0029 | 0.0074 | 0.0138 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0044 | 0.0235 | 0.0235 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0128 | 0.0128 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 0.0074 | 0.0138 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0554 | 0.4712 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0025 | 0.0033 | 0.0111 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0105 | 0.0913 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0063 | 0.0449 | 0.0802 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0114 | 0.0204 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Echinococcus granulosus | heat shock protein 90 | 0.0029 | 0.0078 | 0.0139 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0029 | 0.0074 | 0.0138 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0029 | 0.0074 | 0.0138 |
Brugia malayi | steroid hormone receptor | 0.0029 | 0.0074 | 0.0138 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0037 | 0.0162 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0041 | 0.0209 | 0.0391 |
Leishmania major | protein kinase, putative | 0.0025 | 0.0033 | 0.009 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0029 | 0.0074 | 0.0178 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.3536 | 0.8531 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0025 | 0.0028 | 0.0053 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0128 | 0.0128 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0029 | 0.0074 | 0.0138 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0128 | 0.0239 |
Brugia malayi | MH2 domain containing protein | 0.024 | 0.2417 | 0.4519 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0032 | 0.0104 | 0.4954 |
Brugia malayi | Thioredoxin reductase | 0.0041 | 0.0209 | 0.0391 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0033 | 0.0111 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0092 | 0.0164 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 0.1299 | 0.2429 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0044 | 0.0234 | 0.0234 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0048 | 0.0285 | 0.0509 |
Schistosoma mansoni | heat shock protein | 0.0037 | 0.0162 | 0.039 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.0554 | 0.1338 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0235 | 0.044 |
Echinococcus multilocularis | expressed conserved protein | 0.0105 | 0.092 | 0.092 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0033 | 0.0111 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0025 | 0.0033 | 0.009 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0476 | 0.5032 | 0.8994 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.0194 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0029 | 0.0074 | 0.0138 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0029 | 0.0074 | 0.0138 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0033 | 0.0117 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.0554 | 0.0554 |
Brugia malayi | hypothetical protein | 0.0328 | 0.3396 | 0.6349 |
Schistosoma mansoni | heat shock protein | 0.0037 | 0.0162 | 0.039 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0105 | 0.0913 | 1 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0025 | 0.0033 | 0.0111 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0114 | 0.1014 | 0.2448 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.0074 | 0.0132 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0032 | 0.0104 | 0.025 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0105 | 0.0913 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0029 | 0.0078 | 0.0274 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0025 | 0.0033 | 0.009 |
Schistosoma mansoni | lamin | 0.0031 | 0.0092 | 0.0221 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0032 | 0.0104 | 0.4954 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0094 | 0.0797 | 0.8603 |
Echinococcus multilocularis | heat shock protein 90 | 0.0029 | 0.0078 | 0.0078 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.0194 | 0.0194 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0029 | 0.0074 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0074 | 0.0138 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0128 | 0.0309 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0029 | 0.0074 | 0.0138 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0527 | 0.5596 | 0.5596 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.5349 | 1 |
Onchocerca volvulus | 0.0044 | 0.0235 | 0.044 | |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0369 | 0.0691 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0025 | 0.0033 | 0.009 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0554 | 0.1036 |
Onchocerca volvulus | 0.0031 | 0.0092 | 0.0171 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0029 | 0.0074 | 0.0178 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0029 | 0.0074 | 0.0178 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0025 | 0.0033 | 0.0062 |
Onchocerca volvulus | 0.0025 | 0.0033 | 0.0062 | |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0162 | 0.2396 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0037 | 0.0162 | 0.2396 |
Plasmodium falciparum | heat shock protein 90 | 0.0037 | 0.0162 | 0.7722 |
Echinococcus multilocularis | endoplasmin | 0.0029 | 0.0078 | 0.0078 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0162 | 0.2396 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0029 | 0.0074 | 0.0132 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0037 | 0.0162 | 0.2396 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0069 | 0.3316 |
Plasmodium vivax | heat shock protein 86, putative | 0.0037 | 0.0162 | 0.7722 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0266 | 0.0641 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0266 | 0.0641 |
Schistosoma mansoni | coup transcription factor | 0.0029 | 0.0074 | 0.0178 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0037 | 0.0162 | 0.2396 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0025 | 0.0033 | 0.009 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0092 | 0.0092 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0092 | 0.0221 |
Brugia malayi | Sodium:solute symporter family protein | 0.0044 | 0.0235 | 0.044 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0041 | 0.0209 | 0.0209 |
Brugia malayi | PAS domain containing protein | 0.0098 | 0.0837 | 0.1565 |
Echinococcus multilocularis | protein patched | 0.0048 | 0.0285 | 0.0285 |
Treponema pallidum | heat shock protein 90 | 0.0029 | 0.0078 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.3536 | 0.8531 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0092 | 0.0164 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.024 | 0.2417 | 0.4519 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0105 | 0.0913 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0041 | 0.0209 | 0.3252 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0033 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0285 | 0.0532 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0266 | 0.0641 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0128 | 0.0309 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0041 | 0.0209 | 0.0374 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.0104 | 0.1356 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0074 | 0.0138 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.0194 | 0.0347 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0112 | 0.0995 | 0.0995 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0029 | 0.0074 | 0.0132 |
Schistosoma mansoni | thyroid hormone receptor | 0.0172 | 0.1665 | 0.4018 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0029 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.0028 | 0.0053 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0092 | 0.0171 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0112 | 0.0995 | 0.186 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0029 | 0.0078 | 0.0894 |
Plasmodium falciparum | endoplasmin, putative | 0.0023 | 0.0003 | 0.0133 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0037 | 0.0162 | 0.5556 |
Echinococcus granulosus | heat shock protein | 0.0037 | 0.0162 | 0.0289 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.0025 | 0.0033 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1299 | 0.2429 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0092 | 0.0171 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0128 | 0.0229 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.0194 | 0.0469 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0128 | 0.0309 |
Echinococcus multilocularis | solute carrier family 5 | 0.0044 | 0.0235 | 0.0235 |
Plasmodium vivax | glutathione reductase, putative | 0.0041 | 0.0209 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0072 | 0.0555 | 0.1037 |
Brugia malayi | hypoxia-induced factor 1 | 0.0303 | 0.3114 | 0.5821 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0032 | 0.0104 | 0.1356 |
Trypanosoma brucei | trypanothione reductase | 0.0041 | 0.0209 | 0.3252 |
Brugia malayi | Endoplasmin precursor | 0.0037 | 0.0162 | 0.0302 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0069 | 0.074 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0094 | 0.0797 | 0.8603 |
Trichomonas vaginalis | heat shock protein, putative | 0.0037 | 0.0162 | 0.0579 |
Echinococcus granulosus | heat shock protein 90 | 0.0037 | 0.0162 | 0.0289 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0075 | 0.0585 | 0.1412 |
Echinococcus granulosus | expressed conserved protein | 0.0105 | 0.092 | 0.1644 |
Brugia malayi | GH02984p | 0.0396 | 0.4144 | 0.7747 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Activity against alternating currrent-induced arrhythmia in guinea pig left atrium at 10 uM | ChEMBL. | 17228875 |
Activity (functional) | = 8 % | Positive chronotropic activity in isolated guinea pig right atrium relative to control | ChEMBL. | 17228875 |
Activity (functional) | = 86 % | Negative inotropic activity assessed as decrease in developed tension in isolated guinea pig left atrium at 100 uM relative to control | ChEMBL. | 17228875 |
EC50 (functional) | = 0.31 uM | Negative inotropic activity assessed as decrease in developed tension in isolated guinea pig left atrium | ChEMBL. | 17228875 |
Inhibition (functional) | = 24 % | Inhibition of calcium-induced contraction of potassium ion depolarized guinea pig aortic strips at 100 uM | ChEMBL. | 17228875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.