TDR Targets

Basic information

Technical information

TDR Targets ID: 411180
Name: 2-methyl-2-[4-[[[4-(trifluoromethyl)-2-[4-(tr ifluoromethyl)phenyl]-1,3-thiazole-5-carbonyl ]amino]methyl]phenoxy]propanoic acid
MW: 532.455 | Formula: C23H18F6N2O4S
H donors: 2 H acceptors: 4 LogP: 5.68 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(Oc1ccc(cc1)CNC(=O)c1sc(nc1C(F)(F)F)c1ccc(cc1)C(F)(F)F)(C)C
InChi: 1S/C23H18F6N2O4S/c1-21(2,20(33)34)35-15-9-3-12(4-10-15)11-30-18(32)16-17(23(27,28)29)31-19(36-16)13-5-7-14(8-6-13)22(24,25)26/h3-10H,11H2,1-2H3,(H,30,32)(H,33,34)
InChiKey: HCSJCPSQGSDDFT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-methyl-2-[4-[[[4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]thiazole-5-carbonyl]amino]methyl]phenoxy]propanoic acid
2-methyl-2-[4-[[[oxo-[4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]amino]methyl]phenoxy]propanoic acid
2-methyl-2-[4-[[[4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]carbonylamino]methyl]phenoxy]propanoic acid
2-methyl-2-[4-[[[4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]thiazole-5-carbonyl]amino]methyl]phenoxy]propionic acid
2-methyl-2-[4-[[[4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]1,3-thiazole-5-carbonyl]amino]methyl]phenoxy]propanoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peroxisome proliferator-activated receptor delta	Starlite/ChEMBL	References
Homo sapiens	peroxisome proliferator-activated receptor gamma	Starlite/ChEMBL	References
Homo sapiens	peroxisome proliferator-activated receptor alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma japonicum	IPR008946,Nuclear receptor, ligand-binding,domain-containing	Get druggable targets OG5_137778	All targets in OG5_137778

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	ecdysteroid receptor	peroxisome proliferator-activated receptor alpha	468 aa	397 aa	25.4 %
Brugia malayi	ecdysteroid receptor	peroxisome proliferator-activated receptor delta	441 aa	369 aa	24.7 %
Echinococcus granulosus	ecdysone induced protein 78C	peroxisome proliferator-activated receptor gamma	477 aa	447 aa	28.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0879	0.1652	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0061	0.0072	0.0072
Echinococcus multilocularis	acetylcholinesterase	0.5204	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0034	0.0019	0.0019
Trichomonas vaginalis	spcc417.12 protein, putative	0.0879	0.1652	1
Onchocerca volvulus		0.0879	0.1652	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0879	0.1652	0.1652
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0019	0.0019
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.0256	0.3871
Brugia malayi	Steroid receptor seven-up type 2	0.0034	0.0019	0.0019
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0036	0.0023	0.0023
Schistosoma mansoni	hypothetical protein	0.0185	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0879	0.1652	0.1652
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.0083	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0034	0.0019	0.0019
Brugia malayi	ecdysteroid receptor	0.0034	0.0019	0.0019
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.0083	0.0083
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.033	0.0592	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0034	0.0019	0.0019
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.0037	0.5
Echinococcus granulosus	BC026374 protein S09 family	0.0879	0.1652	0.1652
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0879	0.1652	0.1652
Brugia malayi	nuclear hormone receptor	0.0034	0.0019	0.0019
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0019	0.0019
Onchocerca volvulus		0.0879	0.1652	1
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0012	0.0012
Onchocerca volvulus		0.0034	0.0019	0.0046
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0036	0.0023	0.0023
Brugia malayi	photoreceptor-specific nuclear receptor	0.0034	0.0019	0.0019
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0061	0.0072	0.0072
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0879	0.1652	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0036	0.0023	0.0023
Chlamydia trachomatis	glutamine binding protein	0.0061	0.0071	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0034	0.0019	0.0019
Onchocerca volvulus		0.0879	0.1652	1
Loa Loa (eye worm)	carboxylesterase	0.0879	0.1652	0.1652
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0034	0.0019	0.0019
Brugia malayi	steroid hormone receptor	0.0034	0.0019	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0019	0.0019
Echinococcus granulosus	carboxylesterase 5A	0.5204	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0019
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0061	0.0071	0.5
Echinococcus multilocularis	lamin dm0	0.003	0.0012	0.0012
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0034	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0879	0.1652	0.1652
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0036	0.0023	0.0023
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0034	0.0019	0.0019
Loa Loa (eye worm)	carboxylesterase	0.0879	0.1652	0.1652
Schistosoma mansoni	lipoxygenase	0.0061	0.0072	0.0072
Mycobacterium ulcerans	hypothetical protein	0.0174	0.029	0.1386
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0019
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0083	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0879	0.1652	0.1652
Echinococcus multilocularis	glutamate receptor 2	0.0036	0.0023	0.0023
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0019	0.0019
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0083	0.0077
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0034	0.0019	0.0019
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0879	0.1652	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0879	0.1652	0.1652
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0019	0.0019
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.0045	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0432	0.0789	0.0789
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0019	0.0019
Echinococcus multilocularis	geminin	0.0185	0.0312	0.0312
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.0037	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0879	0.1652	0.1652
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0034	0.0019	0.0019
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0034	0.0019	0.0019
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0174	0.029	0.1386
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.033	0.0592	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0034	0.0019	0.0019
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.0037	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0034	0.0019	0.0019
Loa Loa (eye worm)	acetylcholinesterase 1	0.5204	1	1
Schistosoma mansoni	lamin	0.003	0.0012	0.0012
Onchocerca volvulus	Bile acid receptor homolog	0.0034	0.0019	0.0046
Brugia malayi	Carboxylesterase family protein	0.0879	0.1652	0.1652
Loa Loa (eye worm)	acetyltransferase	0.0159	0.0262	0.0262
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0034	0.0019	0.0019
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0012	0.0012
Echinococcus multilocularis	neuroligin	0.0879	0.1652	0.1652
Brugia malayi	Carboxylesterase family protein	0.0879	0.1652	0.1652
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0034	0.0019	0.0019
Echinococcus granulosus	acetylcholinesterase	0.5204	1	1
Echinococcus granulosus	intermediate filament protein	0.003	0.0012	0.0012
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0034	0.0019	0.0019
Schistosoma mansoni	intermediate filament proteins	0.003	0.0012	0.0012
Schistosoma mansoni	coup transcription factor	0.0034	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.5204	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0034	0.0019	0.0019
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0155	0.0254	0.0254
Echinococcus granulosus	nmda type glutamate receptor	0.0084	0.0117	0.0117
Schistosoma mansoni	RAR-like nuclear receptor	0.0034	0.0019	0.0019
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0879	0.1652	0.1652
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.0256	0.3397
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0034	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0879	0.1652	0.1652
Onchocerca volvulus		0.0879	0.1652	1
Brugia malayi	intermediate filament protein	0.003	0.0012	0.0012
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0156	0.0256	0.3871
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0034	0.0019	0.0019
Schistosoma mansoni	BC026374 protein (S09 family)	0.0879	0.1652	0.1652
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.0083	0.0077
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0019	0.0019
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0036	0.0023	0.0023
Echinococcus multilocularis	musashi	0.003	0.0012	0.0012
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0061	0.0071	0.5
Schistosoma mansoni	hypothetical protein	0.0185	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.5204	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0034	0.0019	0.0019
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0034	0.0019	0.0019
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.0045	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0034	0.0019	0.0019
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0036	0.0023	0.0023
Schistosoma mansoni	acetylcholinesterase	0.0879	0.1652	0.1652
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0019	0.0019
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.033	0.0592	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0034	0.0019	0.0019
Echinococcus multilocularis	FTZ F1 alpha	0.0034	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0879	0.1652	0.1652
Schistosoma mansoni	gliotactin	0.0879	0.1652	0.1652
Echinococcus multilocularis	carboxylesterase 5A	0.5204	1	1
Echinococcus granulosus	glutamate receptor 2	0.0036	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.003	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0019
Echinococcus granulosus	para nitrobenzyl esterase	0.0879	0.1652	0.1652
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0083	0.0083
Echinococcus granulosus	geminin	0.0185	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0019
Schistosoma mansoni	lamin	0.003	0.0012	0.0012
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0034	0.0019	0.0019
Echinococcus granulosus	acetylcholinesterase	0.5204	1	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0879	0.1652	0.1652
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0061	0.0071	0.5
Loa Loa (eye worm)	hypothetical protein	0.0879	0.1652	0.1652
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0879	0.1652	0.1652
Schistosoma mansoni	glutamate receptor NMDA	0.0036	0.0023	0.0023
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0019	0.0019
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0199	0.0339	0.0339
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0034	0.0019	0.0019
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0019
Echinococcus multilocularis	acetylcholinesterase	0.5204	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0019
Toxoplasma gondii	hypothetical protein	0.0053	0.0057	0.3206
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0011	0.0011
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0057	0.0064	0.0358
Leishmania major	mitochondrial DNA polymerase beta	0.033	0.0592	1
Loa Loa (eye worm)	carboxylesterase	0.5204	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0019	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0034	0.0019	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0034	0.0019	0.0019
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0199	0.0339	0.0339
Onchocerca volvulus		0.0879	0.1652	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.0083	0.0083
Echinococcus granulosus	FTZ F1 alpha	0.0034	0.0019	0.0019
Onchocerca volvulus	Protein ultraspiracle homolog	0.0034	0.0019	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0019
Mycobacterium ulcerans	carboxylesterase, LipT	0.0879	0.1652	1
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0019	0.0019
Brugia malayi	Cytochrome P450 family protein	0.0054	0.0058	0.0058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0034	0.0019	0.0019
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0034	0.0019	0.0019
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0019	0.0019
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0034	0.0019	0.0019
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.5204	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0034	0.0019	0.0019
Echinococcus granulosus	neuroligin	0.0879	0.1652	0.1652
Echinococcus multilocularis	ecdysone induced protein 78C	0.0034	0.0019	0.0019
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0879	0.1652	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0879	0.1652	0.1652
Brugia malayi	Carboxylesterase family protein	0.0879	0.1652	0.1652
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0159	0.0262	0.0262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0034	0.0019	0.0019
Echinococcus granulosus	lamin dm0	0.003	0.0012	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0019	0.0019
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0879	0.1652	0.1652
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0036	0.0023	0.0023
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0159	0.0262	0.0262
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.0058	0.0058
Echinococcus granulosus	lamin	0.003	0.0012	0.0012
Brugia malayi	acetyltransferase, GNAT family protein	0.0159	0.0262	0.0262
Echinococcus multilocularis	para nitrobenzyl esterase	0.0879	0.1652	0.1652
Brugia malayi	Carboxylesterase family protein	0.5204	1	1
Echinococcus multilocularis	lamin	0.003	0.0012	0.0012
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0034	0.0019	0.0019
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0019	0.0019
Brugia malayi	Carboxylesterase family protein	0.0879	0.1652	0.1652
Schistosoma mansoni	glutamate receptor NMDA	0.0199	0.0339	0.0339
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0084	0.0117	0.0117
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0034	0.0019	0.0046
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0034	0.0019	0.0019
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0083	0.0077
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0019	0.0019
Echinococcus multilocularis	nmda type glutamate receptor	0.0084	0.0117	0.0117
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0036	0.0023	0.0023

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 54 %	Agonist potency at PPARdelta in CV1 cells relative to GW501516	ChEMBL.	17243659
Activity (functional)	= 54 %	Agonist potency at PPARdelta in CV1 cells relative to GW501516	ChEMBL.	17243659
Activity (functional)	= 63 %	Agonist potency at PPARgamma in CV1 cells relative to rosiglitazone	ChEMBL.	17243659
Activity (functional)	= 63 %	Agonist potency at PPARgamma in CV1 cells relative to rosiglitazone	ChEMBL.	17243659
Activity (functional)	= 98 %	Agonist potency at PPARalpha expressed in CV1 cells relative to GW590735	ChEMBL.	17243659
Activity (functional)	= 98 %	Agonist potency at PPARalpha expressed in CV1 cells relative to GW590735	ChEMBL.	17243659
EC50 (functional)	= 0.004 uM	Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay	ChEMBL.	17243659
EC50 (functional)	= 0.004 uM	Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay	ChEMBL.	17243659
EC50 (functional)	= 0.73 uM	Agonist potency at PPARgamma in CV1 cells by cell based transient transfection assay	ChEMBL.	17243659
EC50 (functional)	= 0.73 uM	Agonist potency at PPARgamma in CV1 cells by cell based transient transfection assay	ChEMBL.	17243659
EC50 (functional)	= 8.24 uM	Agonist potency at PPARdelta in CV1 cells by cell based transient transfection assay	ChEMBL.	17243659
EC50 (functional)	= 8.24 uM	Agonist potency at PPARdelta in CV1 cells by cell based transient transfection assay	ChEMBL.	17243659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL376641
PubChem: 10280116

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 411180