Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 1 |
Brugia malayi | steroid hormone receptor | 0.0148 | 0.035 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0148 | 0.035 | 0.0364 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 0.035 | 0.035 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0148 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0148 | 0.035 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0148 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0148 | 0.035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0148 | 0.035 | 0.035 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.207 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0148 | 0.035 | 0.0364 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0148 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0148 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0148 | 0.035 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0148 | 0.035 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0148 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0148 | 0.035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0148 | 0.035 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0148 | 0.035 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0148 | 0.035 | 0.0364 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0148 | 0.035 | 0.035 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0148 | 0.035 | 0.0364 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0148 | 0.035 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0148 | 0.035 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0148 | 0.035 | 0.035 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0148 | 0.035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.035 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0148 | 0.035 | 0.0364 |
Brugia malayi | nuclear receptor NHR-88 | 0.0148 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0148 | 0.035 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0148 | 0.035 | 0.035 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0148 | 0.035 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0148 | 0.035 | 0.035 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0148 | 0.035 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0148 | 0.035 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0148 | 0.035 | 0.035 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0148 | 0.035 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0148 | 0.035 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0148 | 0.035 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0148 | 0.035 | 0.035 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0148 | 0.035 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0148 | 0.035 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0148 | 0.035 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0148 | 0.035 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0148 | 0.035 | 0.0364 |
Onchocerca volvulus | 0.0148 | 0.035 | 0.5 | |
Echinococcus multilocularis | FTZ F1 alpha | 0.0148 | 0.035 | 0.0364 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0148 | 0.035 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0148 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0148 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0148 | 0.035 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0148 | 0.035 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1992 | 0.9608 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0148 | 0.035 | 0.035 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0148 | 0.035 | 0.035 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0148 | 0.035 | 0.035 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0148 | 0.035 | 0.035 |
Brugia malayi | nuclear hormone receptor | 0.0148 | 0.035 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0148 | 0.035 | 0.0364 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0148 | 0.035 | 0.035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Survival of Swiss mouse infected with Plasmodium yoelii nigeriensis at 96 mg/kg, im after 28 days | ChEMBL. | 17266204 | |
Activity (functional) | 0 | Survival of Swiss mouse infected with Plasmodium yoelii nigeriensis at 96 mg/kg, im after 28 days | ChEMBL. | 17266204 |
Activity (functional) | = 71 % | Antimalarial activity against Plasmodium yoelii nigeriensis infected in Swiss mouse at 96 mg/kg, im after 4 days | ChEMBL. | 17266204 |
Activity (functional) | = 71 % | Antimalarial activity against Plasmodium yoelii nigeriensis infected in Swiss mouse at 96 mg/kg, im after 4 days | ChEMBL. | 17266204 |
Activity (functional) | = 100 % | Antimalarial activity against Plasmodium yoelii nigeriensis infected in Swiss mouse at 96 mg/kg, po after 4 days | ChEMBL. | 17266204 |
Activity (functional) | = 100 % | Antimalarial activity against Plasmodium yoelii nigeriensis infected in Swiss mouse at 48 mg/kg, po after 4 days | ChEMBL. | 17266204 |
Activity (functional) | = 100 % | Antimalarial activity against Plasmodium yoelii nigeriensis infected in Swiss mouse at 48 mg/kg, po after 4 days | ChEMBL. | 17266204 |
Activity (functional) | = 100 % | Antimalarial activity against Plasmodium yoelii nigeriensis infected in Swiss mouse at 96 mg/kg, po after 4 days | ChEMBL. | 17266204 |
LogP | = 5.65 | Partition coefficient, log P of the compound | ChEMBL. | 17266204 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.