Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (binding) | = 1.4 uM | Induction of GTP-tubulin polymerization | ChEMBL. | 17263521 |
ED50 (binding) | = 1.4 uM | Induction of GTP-tubulin polymerization | ChEMBL. | 17263521 |
IC50 (ADMET) | = 550 nM | Cytotoxicity against PC3 cell line by MTT assay | ChEMBL. | 17263521 |
IC50 (ADMET) | = 550 nM | Cytotoxicity against PC3 cell line by MTT assay | ChEMBL. | 17263521 |
IC50 (ADMET) | = 1300 nM | Cytotoxicity against A2780 cell line | ChEMBL. | 17263521 |
IC50 (ADMET) | = 1300 nM | Cytotoxicity against A2780 cell line | ChEMBL. | 17263521 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17263521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.