Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | 0.0081 | 0.3642 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.7603 | 0.8354 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.043 | 0.043 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.043 | 0.043 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0081 | 0.3642 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0047 | 0.1414 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0151 | 0.8312 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0032 | 0.043 | 0.043 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0081 | 0.3642 | 0.3741 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0047 | 0.1414 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1414 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.1414 | 0.1414 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0151 | 0.8312 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0081 | 0.3642 | 0.3741 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0162 | 0.9017 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0081 | 0.3642 | 0.3741 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0162 | 0.9017 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0081 | 0.3642 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0081 | 0.3642 | 0.3741 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0047 | 0.1414 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2109 | 0.1955 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0081 | 0.3642 | 0.3741 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0162 | 0.9017 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0177 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0047 | 0.1414 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.1414 | 0.1414 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0047 | 0.1414 | 0.1145 |
Leishmania major | cytochrome p450-like protein | 0.0081 | 0.3642 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0162 | 0.9017 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0032 | 0.043 | 0.043 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0081 | 0.3642 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.043 | 0.043 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0032 | 0.043 | 0.043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 | ChEMBL. | 17181171 |
IC50 (functional) | > 20 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 | ChEMBL. | 17181171 |
IC50 (functional) | > 20 ug ml-1 | Antifungal activity against Aspergillus fumigatus ATCC 90906 | ChEMBL. | 17181171 |
IC50 (functional) | > 20 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 | ChEMBL. | 17181171 |
IC50 (functional) | > 20 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 | ChEMBL. | 17181171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.