Detailed information for compound 411475

Basic information

Technical information
  • TDR Targets ID: 411475
  • Name: 5-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-[2-[(3 S)-3-(dimethylamino)piperidin-1-yl]-5-(triflu oromethyl)phenyl]-2-fluorobenzamide
  • MW: 526.529 | Formula: C27H26F4N6O
  • H donors: 2 H acceptors: 3 LogP: 4.41 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN([C@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(nc1)N)C(F)(F)F)C
  • InChi: 1S/C27H26F4N6O/c1-36(2)20-4-3-11-37(16-20)24-10-8-19(27(29,30)31)13-23(24)35-25(38)21-12-17(7-9-22(21)28)5-6-18-14-33-26(32)34-15-18/h7-10,12-15,20H,3-4,11,16H2,1-2H3,(H,35,38)(H2,32,33,34)/t20-/m0/s1
  • InChiKey: GMVQPWCWWLPOQT-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-[2-[(3S)-3-(dimethylamino)-1-piperidyl]-5-(trifluoromethyl)phenyl]-2-fluoro-benzamide
  • 5-[2-(2-amino-5-pyrimidinyl)ethynyl]-N-[2-[(3S)-3-(dimethylamino)-1-piperidinyl]-5-(trifluoromethyl)phenyl]-2-fluorobenzamide
  • 5-[2-(2-azanylpyrimidin-5-yl)ethynyl]-N-[2-[(3S)-3-(dimethylamino)piperidin-1-yl]-5-(trifluoromethyl)phenyl]-2-fluoro-benzamide
  • 5-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-[2-[(3S)-3-(dimethylamino)piperidino]-5-(trifluoromethyl)phenyl]-2-fluoro-benzamide
  • 5-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-[2-[(3S)-3-dimethylaminopiperidin-1-yl]-5-(trifluoromethyl)phenyl]-2-fluorobenzamide
  • 5-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-[2-[(3S)-3-dimethylamino-1-piperidyl]-5-(trifluoromethyl)phenyl]-2-fluoro-benzamide
  • 5-[2-(2-amino-5-pyrimidinyl)ethynyl]-N-[2-[(3S)-3-dimethylamino-1-piperidinyl]-5-(trifluoromethyl)phenyl]-2-fluorobenzamide
  • 5-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-[2-[(3S)-3-dimethylaminopiperidin-1-yl]-5-(trifluoromethyl)phenyl]-2-fluoro-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 Starlite/ChEMBL References
Homo sapiens EPH receptor B4 Starlite/ChEMBL References
Homo sapiens IL2-inducible T-cell kinase Starlite/ChEMBL References
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens LYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens FES proto-oncogene, tyrosine kinase Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, beta polypeptide References
Homo sapiens c-src tyrosine kinase Starlite/ChEMBL References
Homo sapiens insulin receptor Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, alpha polypeptide Starlite/ChEMBL References
Homo sapiens Janus kinase 3 Starlite/ChEMBL References
Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Starlite/ChEMBL References
Homo sapiens Janus kinase 1 Starlite/ChEMBL References
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens FGR proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References
Homo sapiens TEK tyrosine kinase, endothelial Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/FER protein kinase Get druggable targets OG5_131882 All targets in OG5_131882
Onchocerca volvulus Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/EPH protein kinase Get druggable targets OG5_126715 All targets in OG5_126715
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131882 All targets in OG5_131882
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi ephrin receptor 1 precursor Get druggable targets OG5_126715 All targets in OG5_126715
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_133402 All targets in OG5_133402
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma japonicum Tyrosine-protein kinase CSK, putative Get druggable targets OG5_133402 All targets in OG5_133402
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Echinococcus multilocularis c src tyrosine kinase Get druggable targets OG5_133402 All targets in OG5_133402
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Onchocerca volvulus Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni ephrin receptor Get druggable targets OG5_126715 All targets in OG5_126715
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus multilocularis tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131882 All targets in OG5_131882
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi SH2 domain containing protein Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum Tyrosine-protein kinase BTK, putative Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fps85D Get druggable targets OG5_131882 All targets in OG5_131882
Echinococcus granulosus c src tyrosine kinase Get druggable targets OG5_133402 All targets in OG5_133402
Loa Loa (eye worm) SH2 domain-containing protein Get druggable targets OG5_133402 All targets in OG5_133402
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase csk Get druggable targets OG5_133402 All targets in OG5_133402
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus macrophage colony stimulating factor 1 receptor Get druggable targets OG5_132967 All targets in OG5_132967
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_131882 All targets in OG5_131882
Loa Loa (eye worm) TK/CSK protein kinase Get druggable targets OG5_133402 All targets in OG5_133402
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi SH2 domain containing protein Get druggable targets OG5_131882 All targets in OG5_131882
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K05109 Eph receptor A8, putative Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fps85D Get druggable targets OG5_131882 All targets in OG5_131882
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0128 0.0314 0.6177
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0698 0.225 0.2647
Brugia malayi p70 ribosomal S6 kinase beta 0.0182 0.0496 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.0521 0.0514
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0273 0.0807 0.0982
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0041 0.002 0.0016
Echinococcus granulosus protein kinase c epsilon type 0.0132 0.0328 0.0378
Loa Loa (eye worm) hypothetical protein 0.0181 0.0494 0.0488
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Echinococcus granulosus mitogen activated protein kinase 14 0.0168 0.0451 0.0525
Onchocerca volvulus Tyrosine kinase homolog 0.0399 0.1233 1
Echinococcus multilocularis nervana 2 0.0081 0.0156 0.0183
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0041 0.002 0.0015
Loa Loa (eye worm) TK/CSK protein kinase 0.007 0.0117 0.0111
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0246 0.0714 0.0835
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0168 0.0451 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0072 0.0123 0.2161
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Echinococcus granulosus Glutaredoxin protein 5 0.0081 0.0156 0.0176
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0168 0.0451 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0054 0.0063 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.0169 0.0192
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0041 0.002 0.0486
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0181 0.0494 0.0575
Echinococcus granulosus growth factor receptor bound protein 2 0.0054 0.0063 0.0066
Onchocerca volvulus Bile acid receptor homolog 0.0181 0.0494 0.3972
Schistosoma mansoni protein kinase 0.0041 0.002 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0181 0.0494 0.0488
Trichomonas vaginalis AGC family protein kinase 0.0185 0.0509 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.0494 0.0488
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0109 0.0251 0.0245
Entamoeba histolytica protein kinase, putative 0.0058 0.0076 0.1483
Onchocerca volvulus 0.0065 0.01 0.076
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0085 0.0169 0.0199
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0121 0.029 0.0347
Loa Loa (eye worm) hypothetical protein 0.0149 0.0386 0.0381
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0123 0.2157
Echinococcus granulosus mitogen activated protein kinase 3 0.0072 0.0123 0.0136
Echinococcus granulosus retinoic acid receptor rxr beta a 0.2534 0.8478 1
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0372 0.0365
Schistosoma mansoni tyrosine kinase 0.0071 0.012 0.0113
Echinococcus multilocularis tyrosine protein kinase Srms 0.01 0.022 0.0261
Brugia malayi tailless protein 0.0085 0.0169 0.0163
Echinococcus granulosus defective proboscis extension response 0.0058 0.0077 0.0082
Schistosoma mansoni coup transcription factor 0.0181 0.0494 0.0487
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0108 0.1856
Giardia lamblia Kinase, CMGC CDK 0.0109 0.0251 0.7849
Brugia malayi Temporarily assigned gene name protein 59 0.0139 0.0351 0.0344
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0085 0.0169 0.0163
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0145 0.0372 0.043
Echinococcus multilocularis neuroglian 0.0072 0.0123 0.0143
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0211 0.0597 0.0696
Loa Loa (eye worm) hypothetical protein 0.0181 0.0494 0.0488
Echinococcus multilocularis tyrosine kinase 0.0065 0.01 0.0114
Leishmania major protein kinase, putative 0.0048 0.0044 0.0574
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0016 0.0009
Echinococcus granulosus tyrosine protein kinase Lyn 0.0138 0.0347 0.0402
Brugia malayi cell division control protein 2 homolog 0.0109 0.0251 0.0244
Loa Loa (eye worm) TK protein kinase 0.024 0.0694 0.0688
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0123 0.2441
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0072 0.0123 0.0117
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0109 0.0251 0.0288
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0121 0.029 0.0347
Loa Loa (eye worm) hypothetical protein 0.0096 0.0204 0.0198
Toxoplasma gondii AGC kinase 0.0182 0.0496 1
Brugia malayi nuclear receptor NHR-88 0.0085 0.0169 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0181 0.0494 0.0598
Trypanosoma brucei protein kinase, putative 0.0048 0.0044 0.0506
Loa Loa (eye worm) hypothetical protein 0.0083 0.0162 0.0156
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0181 0.0494 0.0487
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.009 0.0083
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.01 0.022 0.0251
Brugia malayi Sex muscle abnormal protein 5 0.0054 0.0063 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0283 0.5408
Onchocerca volvulus 0.0103 0.023 0.1819
Schistosoma mansoni nck2/grb4 0.0054 0.0063 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0181 0.0494 0.0488
Echinococcus multilocularis NCK adaptor protein 0.0054 0.0063 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0181 0.0494 0.0487
Echinococcus granulosus thyroid hormone receptor alpha 0.0085 0.0169 0.0192
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0123 0.2157
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0216 0.0612 0.0714
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0064 0.0096 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0283 0.5408
Echinococcus multilocularis tyrosine protein kinase Blk 0.01 0.022 0.0261
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.2982 1 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.0494 0.0488
Echinococcus granulosus c src tyrosine kinase 0.0124 0.03 0.0346
Loa Loa (eye worm) TK/ABL protein kinase 0.0065 0.01 0.0094
Trichomonas vaginalis AGC family protein kinase 0.01 0.022 0.4136
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0283 0.5408
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0181 0.0494 0.0598
Brugia malayi Protein kinase domain containing protein 0.0118 0.028 0.0273
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0041 0.002 0.0014
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0105 0.0235 0.0229
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.004 0.0016 0.0009
Brugia malayi protein kinase C II. 0.0132 0.0328 0.0321
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0102 0.0226 0.4824
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0041 0.002 0.0004
Echinococcus granulosus cyclin dependent kinase 5 0.0109 0.0251 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0472 0.0466
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0189 0.0521 0.0606
Trypanosoma cruzi cdc2-related kinase 3 0.0109 0.0251 0.5384
Echinococcus multilocularis mitogen activated protein kinase 14 0.0168 0.0451 0.0546
Entamoeba histolytica protein kinase, putative 0.005 0.005 0.0989
Schistosoma mansoni tyrosine kinase 0.0121 0.029 0.0283
Brugia malayi Protein kinase domain containing protein 0.0506 0.1596 0.159
Schistosoma mansoni zinc finger protein 0.0085 0.0169 0.0163
Trypanosoma brucei cdc2-related kinase 1 0.0109 0.0251 0.4718
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0057 0.0074 0.0079
Trichomonas vaginalis STE family protein kinase 0.0057 0.0074 0.1164
Plasmodium falciparum protein kinase 5 0.0109 0.0251 0.7849
Loa Loa (eye worm) hypothetical protein 0.0083 0.0162 0.0156
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0181 0.0494 0.0487
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Echinococcus granulosus tyrosine protein kinase Src42A 0.0121 0.029 0.0334
Echinococcus multilocularis myosin iiia 0.0073 0.0126 0.0146
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0181 0.0494 0.0575
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0273 0.0807 0.0944
Echinococcus multilocularis ecdysone induced protein 78C 0.0181 0.0494 0.0598
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0057 0.0074 0.0082
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0054 0.0063 0.0056
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0123 0.2441
Brugia malayi Protein kinase c protein 2 0.0091 0.0189 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0181 0.0494 0.0488
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0189 0.0521 0.0515
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0109 0.0251 0.5349
Trichomonas vaginalis STE family protein kinase 0.0073 0.0126 0.2225
Echinococcus granulosus tyrosine protein kinase Fyn 0.0121 0.029 0.0334
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.01 0.0094
Brugia malayi SRC-1 0.0121 0.029 0.0283
Loa Loa (eye worm) hypothetical protein 0.0242 0.07 0.0694
Entamoeba histolytica serine/threonine protein kinase, putative 0.0041 0.002 0.0386
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.0044 0.0506
Schistosoma mansoni serine/threonine protein kinase 0.01 0.022 0.0213
Echinococcus granulosus serine:threonine kinase SAD 1 0.0041 0.002 0.0015
Brugia malayi hypothetical protein 0.0065 0.01 0.0093
Brugia malayi C1-like domain containing protein 0.0135 0.0338 0.0331
Loa Loa (eye worm) TK protein kinase 0.0067 0.0107 0.01
Entamoeba histolytica protein kinase, putative 0.0182 0.0496 0.9742
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0058 0.0077 0.0085
Brugia malayi nuclear receptor NHR-67 0.0085 0.0169 0.0163
Schistosoma mansoni tyrosine kinase 0.0121 0.029 0.0283
Echinococcus granulosus mitogen activated protein kinase 11 0.0168 0.0451 0.0525
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.01 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0181 0.0494 0.0487
Brugia malayi Variant SH3 domain containing protein 0.0054 0.0063 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.01 0.022 0.0213
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0121 0.029 0.0347
Entamoeba histolytica PH domain containing protein kinase, putative 0.0102 0.0226 0.4443
Schistosoma mansoni thyroid hormone receptor 0.0181 0.0494 0.0487
Schistosoma mansoni tyrosine kinase 0.0057 0.0072 0.0066
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0119 0.0283 0.6096
Brugia malayi Nuclear hormone receptor E75 0.0085 0.0169 0.0163
Brugia malayi nuclear hormone receptor family member nhr-6 0.0085 0.0169 0.0163
Echinococcus multilocularis cyclin dependent kinase 5 0.0109 0.0251 0.0299
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0181 0.0494 0.0575
Entamoeba histolytica protein kinase, putative 0.0185 0.0509 1
Echinococcus multilocularis roundabout 2 0.009 0.0185 0.0219
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0191 0.0527 0.0614
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0011 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0181 0.0494 0.0487
Brugia malayi Protein kinase domain containing protein 0.0109 0.0251 0.0244
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0041 0.002 0.0015
Schistosoma mansoni kinase 0.0068 0.0112 0.0105
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0064 0.0096 0.0105
Echinococcus multilocularis cyclin dependent kinase 1 0.0109 0.0251 0.0299
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0085 0.0169 0.0199
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.01 0.022 0.0214
Echinococcus granulosus NDR protein kinase 0.01 0.022 0.0252
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0096 0.0204 0.0242
Giardia lamblia Kinase, STE STE20 0.0057 0.0074 0.1835
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0181 0.0494 0.0487
Schistosoma mansoni vesicular amine transporter 0.0058 0.0077 0.007
Trichomonas vaginalis AGC family protein kinase 0.0185 0.0509 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.01 0.022 0.0262
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0069 0.0115 0.0128
Giardia lamblia Kinase, CMGC CDK 0.0109 0.0251 0.7849
Echinococcus multilocularis RNA directed DNA polymerase 0.0043 0.0025 0.0022
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0086 0.017 0.0164
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.01 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0181 0.0494 0.0487
Plasmodium falciparum NIMA related kinase 1 0.0128 0.0314 1
Echinococcus multilocularis rho associated protein kinase 0.0174 0.0471 0.0569
Brugia malayi steroid hormone receptor 0.0181 0.0494 0.0487
Echinococcus granulosus tyrosine protein kinase csk 0.007 0.0117 0.013
Brugia malayi SH2 domain containing protein 0.0103 0.023 0.0223
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0181 0.0494 0.0575
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0011 0.0005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0121 0.029 0.0347
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Echinococcus granulosus tyrosine protein kinase Src42A 0.0069 0.0112 0.0125
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0057 0.0074 0.0079
Schistosoma mansoni growth factor receptor-bound protein 0.0054 0.0063 0.0056
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0181 0.0494 0.0598
Entamoeba histolytica SH2-protein kinase domain containing protein 0.005 0.005 0.0989
Brugia malayi hypothetical protein 0.0085 0.0169 0.0163
Loa Loa (eye worm) TK/EPH protein kinase 0.0116 0.0272 0.0266
Schistosoma mansoni protein kinase 0.0041 0.002 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0072
Entamoeba histolytica protein kinase 2, putative 0.0098 0.0213 0.4185
Loa Loa (eye worm) hypothetical protein 0.004 0.0016 0.001
Schistosoma mansoni tyrosine kinase 0.0102 0.0227 0.022
Loa Loa (eye worm) TK protein kinase 0.01 0.022 0.0214
Giardia lamblia Kinase, PLK 0.0119 0.0283 0.8944
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.002 0.0013
Brugia malayi hypothetical protein 0.0096 0.0204 0.0197
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0065 0.01 0.1967
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0112 0.194
Loa Loa (eye worm) hypothetical protein 0.0065 0.01 0.0094
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0251 0.4754
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0111 0.0257 0.5507
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.002 0.0013
Echinococcus granulosus nervana 2 0.0081 0.0156 0.0176
Echinococcus granulosus Protein kinase C brain isozyme 0.0175 0.0472 0.0549
Echinococcus granulosus NCK adaptor protein 0.0054 0.0063 0.0066
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0041 0.002 0.0016
Echinococcus granulosus serine threonine protein kinase nrc 0.0098 0.0213 0.0243
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0085 0.0169 0.0192
Onchocerca volvulus 0.0353 0.1079 0.8745
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0258 0.0754 0.0749
Onchocerca volvulus 0.0065 0.01 0.076
Onchocerca volvulus 0.0122 0.0294 0.2339
Schistosoma mansoni protein kinase 0.0057 0.0074 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0283 0.5408
Brugia malayi P38 map kinase family protein 2 0.0168 0.0451 0.0445
Brugia malayi Protein kinase domain containing protein 0.0185 0.0509 0.0503
Brugia malayi protein kinase C3,putative 0.0047 0.004 0.0033
Loa Loa (eye worm) hypothetical protein 0.0069 0.0115 0.0109
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0085 0.0169 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0076 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0181 0.0494 0.0488
Schistosoma mansoni growth factor receptor-bound protein 0.0054 0.0063 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Loa Loa (eye worm) hypothetical protein 0.0149 0.0386 0.0381
Loa Loa (eye worm) TK/FER protein kinase 0.0273 0.0807 0.0801
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0085 0.0169 0.0163
Loa Loa (eye worm) hypothetical protein 0.0065 0.01 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0527 0.0521
Echinococcus granulosus epidermal growth factor receptor 0.0102 0.0227 0.026
Loa Loa (eye worm) hypothetical protein 0.0041 0.002 0.0014
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0072 0.0123 0.2384
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0098 0.0213 0.0243
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0068 0.0112 0.1937
Schistosoma mansoni serine/threonine kinase 0.01 0.022 0.0213
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0181 0.0494 0.0487
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0182 0.0496 0.049
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0112 0.2198
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0034 0.0027
Brugia malayi Protein kinase domain containing protein 0.0065 0.01 0.0093
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0121 0.029 0.0334
Brugia malayi Protein kinase domain containing protein 0.0065 0.01 0.0093
Loa Loa (eye worm) AGC/AKT protein kinase 0.0185 0.0509 0.0503
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0119 0.0283 0.0339
Loa Loa (eye worm) hypothetical protein 0.0088 0.0178 0.0172
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0073 0.0126 0.2172
Giardia lamblia Kinase, NEK 0.0128 0.0314 1
Brugia malayi Protein kinase domain containing protein 0.0175 0.0474 0.0468
Onchocerca volvulus 0.004 0.0015 0.0064
Loa Loa (eye worm) hypothetical protein 0.0181 0.0494 0.0488
Echinococcus multilocularis protein kinase shaggy 0.0068 0.0112 0.0129
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0072 0.0123 0.2103
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0058 0.0076 0.0081
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0117 0.0135
Trichomonas vaginalis AGC family protein kinase 0.01 0.022 0.4136
Brugia malayi Variant SH3 domain containing protein 0.0064 0.0096 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0283 0.5408
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0195 0.0543 0.0632
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0135 0.0338 0.0332
Loa Loa (eye worm) hypothetical protein 0.0096 0.0204 0.0198
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0098 0.0213 0.6575
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0117 0.0135
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0211 0.0597 0.0724
Entamoeba histolytica PH domain containing protein kinase, putative 0.0102 0.0226 0.4443
Loa Loa (eye worm) AGC/PKN protein kinase 0.01 0.022 0.0214
Schistosoma mansoni nuclear hormone receptor 0.0085 0.0169 0.0163
Onchocerca volvulus 0.0065 0.01 0.076
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0041 0.002 0.0013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0181 0.0494 0.0575
Echinococcus multilocularis mitogen activated protein kinase 0.0072 0.0123 0.0142
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0181 0.0494 0.0487
Loa Loa (eye worm) hypothetical protein 0.0122 0.0294 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.2982 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0085 0.0169 0.0163
Schistosoma mansoni nuclear hormone receptor 0.0085 0.0169 0.0163
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0068 0.0112 0.0129
Loa Loa (eye worm) hypothetical protein 0.0073 0.0127 0.0121
Brugia malayi hypothetical protein 0.0096 0.0204 0.0197
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0108 0.1856
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Echinococcus granulosus Immunoglobulin 0.0058 0.0077 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0181 0.0494 0.0487
Giardia lamblia Kinase, AGC PKA 0.0098 0.0213 0.6575
Schistosoma mansoni tyrosine kinase 0.0048 0.0044 0.0037
Brugia malayi SH2 domain containing protein 0.0273 0.0807 0.08
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0096 0.0204 0.0198
Echinococcus multilocularis activin receptor type 0.0048 0.0044 0.0046
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.01 0.0094
Echinococcus granulosus twitchin 0.0089 0.0181 0.0205
Trichomonas vaginalis AGC family protein kinase 0.0185 0.0509 1
Brugia malayi Protein kinase domain containing protein 0.0189 0.0521 0.0514
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0061 0.0087 0.0081
Echinococcus granulosus serine/threonine protein kinase 0.0102 0.0226 0.0259
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0283 0.5408
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Entamoeba histolytica protein kinase, putative 0.0043 0.0024 0.048
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.002 0.0013
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0068 0.0112 0.2196
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0098 0.0213 0.6741
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Brugia malayi intracellular kinase 0.0068 0.0112 0.0105
Brugia malayi Nuclear hormone receptor E75 0.0085 0.0169 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0016 0.0009
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.01 0.0094
Brugia malayi hypothetical protein 0.0065 0.01 0.0093
Echinococcus multilocularis epidermal growth factor receptor 0.0102 0.0227 0.027
Loa Loa (eye worm) nuclear receptor NHR-67 0.0085 0.0169 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0185 0.0509 1
Giardia lamblia Kinase, NEK 0.0128 0.0314 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0041 0.002 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0181 0.0494 0.0487
Plasmodium falciparum calcium-dependent protein kinase 2 0.0041 0.002 0.0006
Loa Loa (eye worm) hypothetical protein 0.025 0.0727 0.0721
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0112 0.194
Brugia malayi Immunoglobulin I-set domain containing protein 0.0454 0.1421 0.1415
Brugia malayi Fibronectin type III domain containing protein 0.0065 0.01 0.0093
Loa Loa (eye worm) nuclear hormone receptor 0.0085 0.0169 0.0163
Loa Loa (eye worm) hypothetical protein 0.0086 0.0172 0.0166
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.01 0.0094
Loa Loa (eye worm) hypothetical protein 0.0096 0.0204 0.0198
Trypanosoma brucei rac serine-threonine kinase, putative 0.0185 0.0509 1
Echinococcus multilocularis protein kinase c iota type 0.0131 0.0323 0.0388
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0109 0.0251 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Echinococcus granulosus Nuclear hormone receptor HR96 0.0085 0.0169 0.0192
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0045 0.0034 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.002 0.0013
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0107 0.0244 0.0237
Echinococcus multilocularis c src tyrosine kinase 0.0124 0.03 0.036
Echinococcus granulosus nervana 2 0.0081 0.0156 0.0176
Schistosoma mansoni adapter molecule crk 0.0054 0.0063 0.0056
Brugia malayi nuclear receptor RXR 0.0085 0.0169 0.0163
Plasmodium falciparum calcium-dependent protein kinase 1 0.0041 0.002 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0251 0.0244
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Loa Loa (eye worm) hypothetical protein 0.0181 0.0494 0.0488
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0041 0.002 0.0014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0181 0.0494 0.0488
Echinococcus granulosus N chimaerin 0.0064 0.0096 0.0105
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0121 0.029 0.0347
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0057 0.0074 0.0082
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0181 0.0494 0.0598
Loa Loa (eye worm) hypothetical protein 0.0065 0.01 0.0094
Schistosoma mansoni RAR-like nuclear receptor 0.0181 0.0494 0.0487
Echinococcus granulosus tyrosine protein kinase Fyn 0.0121 0.029 0.0334
Echinococcus multilocularis insulin receptor 0.0188 0.0519 0.0629
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0044 0.0872
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0145 0.0372 0.0447
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0112 0.2198
Echinococcus multilocularis FTZ F1 alpha 0.0181 0.0494 0.0598
Echinococcus granulosus Nuclear hormone receptor HR96 0.0085 0.0169 0.0192
Loa Loa (eye worm) hypothetical protein 0.0181 0.0494 0.0488
Trypanosoma cruzi cdc2-related kinase 1 0.0109 0.0251 0.5384
Echinococcus granulosus protein kinase shaggy 0.0068 0.0112 0.0124
Brugia malayi ecdysteroid receptor 0.0181 0.0494 0.0487
Loa Loa (eye worm) SRC-1 0.0121 0.029 0.0284
Trichomonas vaginalis AGC family protein kinase 0.0128 0.0314 0.6038
Entamoeba histolytica protein kinase, putative 0.0038 0.0008 0.0149
Echinococcus multilocularis tyrosine protein kinase Fyn 0.01 0.022 0.0261
Echinococcus granulosus raf serine:threonine protein kinase 0.0062 0.009 0.0098
Onchocerca volvulus 0.0085 0.0169 0.1326
Echinococcus multilocularis rac serine:threonine kinase 0.0102 0.0226 0.0269
Loa Loa (eye worm) hypothetical protein 0.0128 0.0314 0.0308
Trichomonas vaginalis STE family protein kinase 0.0057 0.0074 0.1164
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0058 0.0076 0.0084
Schistosoma mansoni tyrosine kinase 0.0225 0.0644 0.0637
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0121 0.029 0.0347
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Plasmodium vivax protein kinase Crk2 0.0109 0.0251 0.7953
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0175 0.0472 0.0571
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.004 0.0016 0.0002
Loa Loa (eye worm) hypothetical protein 0.0058 0.0077 0.0071
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0073 0.0126 0.2473
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0251 0.0244
Echinococcus granulosus nuclear receptor nhr 48 0.0085 0.0169 0.0192
Schistosoma mansoni thyroid hormone receptor 0.0181 0.0494 0.0487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0181 0.0494 0.0488
Loa Loa (eye worm) AGC/NDR protein kinase 0.01 0.022 0.0214
Schistosoma mansoni ephrin receptor 0.0038 0.001 0.0003
Echinococcus granulosus epidermal growth factor receptor 0.0102 0.0227 0.026
Schistosoma mansoni protein kinase 0.0216 0.0612 0.0605
Echinococcus granulosus tyrosine kinase 0.01 0.022 0.0251
Schistosoma mansoni protein kinase 0.0048 0.0044 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0181 0.0494 0.0487
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.01 0.0094
Onchocerca volvulus Protein ultraspiracle homolog 0.0181 0.0494 0.3972
Echinococcus granulosus cyclin dependent kinase 1 0.0109 0.0251 0.0288
Brugia malayi protein-tyrosine kinase 0.01 0.022 0.0213
Brugia malayi Steroid receptor seven-up type 2 0.0181 0.0494 0.0487
Brugia malayi Hr1 repeat family protein 0.01 0.022 0.0213
Echinococcus granulosus cyclin dependent kinase 0.0109 0.0251 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0181 0.0494 0.0487
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0211 0.0597 0.0591
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.0597 0.059
Onchocerca volvulus Serine\/threonine kinase homolog 0.0119 0.0283 0.2251
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0181 0.0494 0.0487
Loa Loa (eye worm) hypothetical protein 0.0096 0.0204 0.0198
Echinococcus granulosus protein kinase C gamma type 0.0144 0.037 0.0428
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Trichomonas vaginalis AGC family protein kinase 0.0185 0.0509 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0181 0.0494 0.0487
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0041 0.002 0.0004
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0073 0.0126 0.2473
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0083 0.0163 0.2972
Echinococcus multilocularis mitogen activated protein kinase 11 0.0168 0.0451 0.0546
Echinococcus multilocularis serine threonine protein kinase 0.0144 0.037 0.0445
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0328 0.0321
Leishmania major protein kinase, putative 0.0073 0.0126 0.2462
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0132 0.0328 0.0322
Schistosoma mansoni serine/threonine-protein kinase 0.0102 0.0226 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0114 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0185 0.0509 1
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0233 0.4403
Plasmodium falciparum calcium-dependent protein kinase 3 0.0041 0.002 0.0006
Loa Loa (eye worm) CAMK protein kinase 0.0037 0.0007 0.0001
Echinococcus multilocularis tyrosine protein kinase HCK 0.0067 0.0107 0.0122
Brugia malayi Cam kinase protein 1 0.0041 0.002 0.0013
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0068 0.0112 0.0106
Echinococcus multilocularis Glutaredoxin protein 5 0.0081 0.0156 0.0183
Loa Loa (eye worm) TK/EGFR protein kinase 0.0102 0.0227 0.0221
Giardia lamblia Kinase, CMGC GSK 0.0068 0.0112 0.3136
Onchocerca volvulus 0.0149 0.0386 0.3097
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0081 0.0156 0.0183
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0111 0.0256 0.0294
Trypanosoma cruzi cdc2-related kinase 3 0.0109 0.0251 0.5384
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0121 0.029 0.0334
Loa Loa (eye worm) SH2 domain-containing protein 0.0072 0.0123 0.0117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.0169 0.0199
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0081 0.0156 0.0176
Brugia malayi hypothetical protein 0.0085 0.0169 0.0163
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0058 0.0077 0.007
Brugia malayi STE20-like kinase MST 0.0258 0.0754 0.0748
Giardia lamblia Kinase, NEK 0.0128 0.0314 1
Echinococcus granulosus RNA directed DNA polymerase 0.0043 0.0025 0.0021
Schistosoma mansoni protein kinase 0.0057 0.0074 0.0067
Brugia malayi putative serine/threonine kinase SADA gamma 0.0041 0.002 0.0013
Echinococcus granulosus tyrosine protein kinase csk 0.007 0.0117 0.013
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0065 0.01 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Echinococcus granulosus tyrosine protein kinase shark 0.0065 0.01 0.011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0181 0.0494 0.0598
Echinococcus multilocularis serine:threonine protein kinase 3 0.0258 0.0754 0.0918
Leishmania major protein kinase, putative 0.0041 0.002 0.0004
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0057 0.0074 0.0079
Echinococcus granulosus ephrin type A receptor 4 A 0.0113 0.0264 0.0303
Loa Loa (eye worm) hypothetical protein 0.0065 0.01 0.0094
Loa Loa (eye worm) hypothetical protein 0.0092 0.0193 0.0187
Giardia lamblia Kinase, CMGC MAPK 0.0072 0.0123 0.3498
Schistosoma mansoni nephrin 0.0079 0.0146 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0181 0.0494 0.0488
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0073 0.0126 0.2518
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0181 0.0494 0.0487
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.01 0.022 0.0252
Echinococcus granulosus mitogen activated protein kinase 0.0072 0.0123 0.0136
Echinococcus granulosus serine:threonine protein kinase 3 0.0258 0.0754 0.0882
Brugia malayi ecdysone receptor 0.0085 0.0169 0.0163
Echinococcus granulosus tyrosine protein kinase HCK 0.0067 0.0107 0.0118
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0068 0.0112 0.0106
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0123 0.2157
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0123 0.2157
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.01 0.0094
Schistosoma mansoni tyrosine kinase 0.0188 0.0519 0.0513
Onchocerca volvulus 0.0068 0.0112 0.0856
Onchocerca volvulus 0.0066 0.0103 0.0788
Loa Loa (eye worm) TK/FER protein kinase 0.0065 0.01 0.0094
Onchocerca volvulus 0.0157 0.0413 0.3314
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0085 0.0169 0.0199
Echinococcus multilocularis Immunoglobulin 0.0058 0.0077 0.0085
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0002
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0135 0.0338 0.0331
Entamoeba histolytica protein kinase, putative 0.0057 0.0074 0.1446
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0048 0.0044 0.052
Plasmodium falciparum calcium-dependent protein kinase 5 0.0041 0.002 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0472 0.0466
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0119 0.0283 0.0277
Echinococcus granulosus roundabout 2 0.009 0.0185 0.021
Schistosoma mansoni serine/threonine protein kinase 0.01 0.022 0.0213
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0064 0.0096 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0189 0.0521 0.0515
Entamoeba histolytica p21-activated kinase 0.0061 0.0087 0.1704
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0041 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0096 0.0204 0.0198
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0098 0.0213 0.4522
Entamoeba histolytica cell division protein kinase 2, putative 0.0109 0.0251 0.4922
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0041 0.002 0.0075
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0168 0.0451 0.882
Giardia lamblia Kinase, CMGC GSK 0.0068 0.0112 0.3136
Entamoeba histolytica protein kinase, putative 0.0068 0.0112 0.2198
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0041 0.002 0.0015
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0454 0.1421 0.1416
Entamoeba histolytica protein kinase, putative 0.0185 0.0509 1
Schistosoma mansoni nuclear receptor 0.0085 0.0169 0.0163
Schistosoma mansoni nuclear receptor nhr-48 0.0085 0.0169 0.0163
Echinococcus granulosus tyrosine protein kinase csk 0.007 0.0117 0.013
Loa Loa (eye worm) hypothetical protein 0.0041 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0118 0.0281 0.0275
Schistosoma mansoni protein kinase 0.0041 0.002 0.0013
Schistosoma mansoni retinoic acid receptor RXR 0.2534 0.8478 0.8477
Loa Loa (eye worm) hypothetical protein 0.0088 0.0178 0.0172
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0068 0.0112 0.2137
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0041 0.002 0.0492
Trichomonas vaginalis STE family protein kinase 0.0057 0.0074 0.1164
Plasmodium falciparum glycogen synthase kinase 3 0.0068 0.0112 0.3136
Entamoeba histolytica protein kinase, putative 0.0058 0.0076 0.1483
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0068 0.0112 0.0124
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0043 0.0025 0.0022
Trichomonas vaginalis STE family protein kinase 0.0057 0.0074 0.1164
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0041 0.002 0.0004
Trypanosoma cruzi cdc2-related kinase 1 0.0109 0.0251 0.5384
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0189 0.0521 0.063
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0073 0.0126 0.2518
Entamoeba histolytica protein kinase, putative 0.0041 0.002 0.0389
Schistosoma mansoni protein kinase 0.0216 0.0612 0.0605
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.004 0.0016 0.001
Brugia malayi nuclear hormone receptor family member odr-7 0.0085 0.0169 0.0163
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0145 0.0372 0.0365
Brugia malayi MAP kinase sur-1 0.0072 0.0123 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Schistosoma mansoni cell adhesion molecule 0.0076 0.0139 0.0132
Echinococcus multilocularis tyrosine protein kinase Abl 0.0086 0.017 0.0201
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0123 0.0116
Loa Loa (eye worm) TK/ROR protein kinase 0.0045 0.0034 0.0028
Echinococcus multilocularis mitogen activated protein kinase 14 0.0168 0.0451 0.0546
Loa Loa (eye worm) hypothetical protein 0.0043 0.0025 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0256 0.025
Loa Loa (eye worm) hypothetical protein 0.018 0.0489 0.0483
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0117 0.0135
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0049 0.0046 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0145 0.0372 0.0366
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0256 0.025
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0085 0.0169 0.1326
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0072 0.0123 0.2441
Brugia malayi nuclear hormone receptor 0.0085 0.0169 0.0163
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0069 0.0112 0.0129
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0045 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0181 0.0494 0.0488
Entamoeba histolytica protein kinase, putative 0.01 0.022 0.4324
Brugia malayi map kinase activated protein kinase protein 2 0.0211 0.0597 0.059
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0195 0.0543 0.0657
Onchocerca volvulus 0.0118 0.0281 0.2232
Brugia malayi nuclear hormone receptor 0.0181 0.0494 0.0487
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.0204 0.0197
Schistosoma mansoni ephrin receptor 0.0097 0.0211 0.0204
Schistosoma mansoni tyrosine kinase 0.0188 0.0519 0.0513
Plasmodium falciparum calcium-dependent protein kinase 4 0.0041 0.002 0.0006
Brugia malayi Protein kinase domain containing protein 0.0065 0.01 0.0093
Brugia malayi Immunoglobulin I-set domain containing protein 0.0065 0.01 0.0093
Echinococcus granulosus tyrosine protein kinase Fyn 0.0121 0.029 0.0334
Onchocerca volvulus 0.0174 0.0471 0.3782
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.0044 0.0644
Schistosoma mansoni nuclear hormone receptor 0.0181 0.0494 0.0487
Brugia malayi Protein kinase domain containing protein 0.0065 0.01 0.0093
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0098 0.0213 0.0253
Onchocerca volvulus 0.0085 0.0169 0.1326
Loa Loa (eye worm) hypothetical protein 0.0242 0.07 0.0694
Trichomonas vaginalis STE family protein kinase 0.0128 0.0314 0.6038
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0058 0.0075 0.0084
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0216 0.0612 0.0743
Echinococcus granulosus protein kinase c iota type 0.0131 0.0323 0.0373
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0054 0.0063 0.0057
Schistosoma mansoni atypical protein kinase C 0.0131 0.0323 0.0316
Loa Loa (eye worm) hypothetical protein 0.0149 0.0386 0.0381
Giardia lamblia Kinase, STE STE20 0.0073 0.0126 0.3613
Entamoeba histolytica cell division protein kinase 2, putative 0.0109 0.0251 0.4922
Brugia malayi Protein kinase domain containing protein 0.01 0.022 0.0213
Echinococcus multilocularis raf serine:threonine protein kinase 0.0062 0.009 0.0102
Schistosoma mansoni tyrosine kinase 0.0071 0.012 0.0113
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0181 0.0494 0.3972
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0251 0.4754
Trichomonas vaginalis AGC family protein kinase 0.0185 0.0509 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0041 0.002 0.0492
Brugia malayi Protein kinase domain containing protein 0.0065 0.01 0.0093
Brugia malayi Furin-like cysteine rich region family protein 0.0102 0.0227 0.022
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0121 0.029 0.0347
Brugia malayi conserved hypotetical protein 0.0085 0.0169 0.0163
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0128 0.0314 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0057 0.0074 0.0082
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0168 0.0451 0.0446
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0191 0.0527 0.0521
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.2438 0.8154 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0068 0.0112 0.347
Schistosoma mansoni tyrosine kinase 0.0102 0.0227 0.022
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.004 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0054 0.0063 0.0057
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0041 0.002 0.0014
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0041 0.002 0.0016
Brugia malayi Protein kinase domain containing protein 0.0188 0.0519 0.0513
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0096 0.0204 0.0197
Echinococcus multilocularis cyclin dependent kinase 1 0.0109 0.0251 0.0299
Loa Loa (eye worm) hypothetical protein 0.0066 0.0103 0.0097
Echinococcus multilocularis N chimaerin 0.0064 0.0096 0.0109
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0058 0.0077 0.007
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0109 0.0251 0.5349
Echinococcus multilocularis tyrosine protein kinase shark 0.0065 0.01 0.0114
Schistosoma mansoni tyrosine kinase 0.0065 0.01 0.0093
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0041 0.002 0.0004
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.01 0.022 0.0252
Trypanosoma brucei polo-like protein kinase 0.0119 0.0283 0.5377
Echinococcus granulosus ecdysone induced protein 78C 0.0181 0.0494 0.0575
Brugia malayi Variant SH3 domain containing protein 0.0054 0.0063 0.0056
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0041 0.002 0.0492
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0251 0.4754
Schistosoma mansoni serine/threonine-protein kinase 0.0102 0.0226 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0181 0.0494 0.0487
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0085 0.0169 0.1326
Brugia malayi nuclear receptor NHR-88 0.0181 0.0494 0.0487
Brugia malayi Protein kinase domain 0.0057 0.0074 0.0067
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.0044 0.0644
Echinococcus multilocularis serine:threonine protein kinase N2 0.01 0.022 0.0262
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0064 0.0096 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0283 0.5408
Brugia malayi Tyrosine-protein kinase abl-1 0.0086 0.017 0.0164
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.0204 0.0197
Onchocerca volvulus 0.0065 0.01 0.076
Trypanosoma brucei cdc2-related kinase 3 0.0109 0.0251 0.4718
Brugia malayi RhoGAP domain containing protein 0.0064 0.0096 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0064 0.0096 0.009
Echinococcus granulosus tyrosine protein kinase Blk 0.01 0.022 0.0251
Plasmodium vivax calcium-dependent protein kinase, putative 0.0041 0.002 0.0492
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.002 0.0068
Echinococcus multilocularis mitogen activated protein kinase 11 0.0168 0.0451 0.0546
Echinococcus multilocularis Immunoglobulin 0.0058 0.0077 0.0085
Trypanosoma cruzi polo-like protein kinase, putative 0.0119 0.0283 0.6125
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0181 0.0494 0.0487
Echinococcus multilocularis nuclear receptor nhr 48 0.0085 0.0169 0.0199
Loa Loa (eye worm) steroid hormone receptor 0.0181 0.0494 0.0488
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0119 0.0283 0.0326
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0189 0.0521 0.4191
Loa Loa (eye worm) hypothetical protein 0.0058 0.0077 0.0071
Echinococcus granulosus tyrosine protein kinase Srms 0.0065 0.01 0.011
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0121 0.029 0.0347
Loa Loa (eye worm) TK/INSR protein kinase 0.0188 0.0519 0.0514
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0072 0.0123 0.2441
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0096 0.0204 0.0197
Schistosoma mansoni tyrosine kinase 0.0102 0.0227 0.022
Brugia malayi serine/threonine-protein kinase plk-2 0.0119 0.0283 0.0276
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0037 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Schistosoma mansoni tyrosine kinase 0.0071 0.012 0.0113
Schistosoma mansoni tyrosine kinase 0.0124 0.03 0.0293
Onchocerca volvulus 0.0181 0.0494 0.3972
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0041 0.002 0.0075
Echinococcus multilocularis protein kinase c epsilon type 0.0132 0.0328 0.0393
Onchocerca volvulus 0.0065 0.01 0.076
Echinococcus granulosus tyrosine protein kinase Src64B 0.0121 0.029 0.0334
Echinococcus multilocularis serine:threonine protein kinase 38 0.01 0.022 0.0262
Echinococcus granulosus rho-associated protein kinase 1 0.0174 0.0471 0.0547
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0111 0.0256 0.0306
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0109 0.0251 0.0245
Trypanosoma cruzi polo-like protein kinase, putative 0.0119 0.0283 0.6125
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0117 0.0135
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0246 0.0714 0.0868
Schistosoma mansoni tyrosine kinase 0.0086 0.017 0.0164
Brugia malayi Protein kinase domain containing protein 0.01 0.022 0.0213
Trypanosoma cruzi Protein kinase B 0.0102 0.0226 0.4824
Brugia malayi ephrin receptor 1 precursor 0.0063 0.0092 0.0086
Entamoeba histolytica protein kinase, putative 0.0038 0.0008 0.0149
Schistosoma mansoni ste20-related kinase 0.0202 0.0566 0.0559
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.002 0.0013
Trypanosoma brucei protein kinase, putative 0.0072 0.0123 0.2103
Trichomonas vaginalis AGC family protein kinase 0.01 0.022 0.4136
Loa Loa (eye worm) TK protein kinase 0.0045 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0181 0.0494 0.0598
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0291 0.0868 0.0862
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0047 0.004 0.0034
Loa Loa (eye worm) hypothetical protein 0.0058 0.0077 0.0071
Giardia lamblia Kinase, AGC AKT 0.0107 0.0244 0.7634
Echinococcus granulosus tyrosine kinase 0.0065 0.01 0.011
Echinococcus multilocularis mitogen activated protein kinase 3 0.0072 0.0123 0.0142
Echinococcus multilocularis nervana 2 0.0081 0.0156 0.0183
Schistosoma mansoni steroid hormone receptor ad4bp 0.0181 0.0494 0.0487
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0189 0.0521 0.0514
Plasmodium falciparum protein kinase, putative 0.0048 0.0044 0.0842
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0109 0.0251 0.4848
Echinococcus multilocularis cyclin dependent kinase 0.0109 0.0251 0.0299
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.0283 0.0276
Entamoeba histolytica serine/threonine protein kinase, putative 0.0119 0.0283 0.5555
Brugia malayi Nuclear hormone receptor-like 1 0.0181 0.0494 0.0487
Echinococcus granulosus FTZ F1 alpha 0.0181 0.0494 0.0575
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0096 0.0204 0.0233
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0121 0.029 0.0347
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0191 0.0527 0.0639
Echinococcus multilocularis thyroid hormone receptor alpha 0.0181 0.0494 0.0598
Schistosoma mansoni nuclear receptor 0.0085 0.0169 0.0163
Schistosoma mansoni protein kinase C mu 0.0135 0.0338 0.0331
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0102 0.0227 0.026
Trypanosoma brucei protein kinase, putative 0.0068 0.0112 0.1885
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0072 0.0123 0.2384
Echinococcus multilocularis epidermal growth factor receptor 0.0102 0.0227 0.027
Schistosoma mansoni vav2 0.0067 0.0109 0.0102
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0506 0.1596 0.1591
Echinococcus granulosus serine:threonine protein kinase N2 0.01 0.022 0.0252
Echinococcus granulosus activin receptor type 0.0048 0.0044 0.0044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0181 0.0494 0.0487
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.01 0.022 0.0262
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0168 0.0451 1
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.0471 0.0464
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0058 0.0075 0.0081
Brugia malayi nuclear receptor RXR 0.0096 0.0204 0.0197
Loa Loa (eye worm) hypothetical protein 0.0085 0.0169 0.0163
Echinococcus multilocularis ephrin type A receptor 4 A 0.0113 0.0264 0.0315
Brugia malayi photoreceptor-specific nuclear receptor 0.0181 0.0494 0.0487
Echinococcus multilocularis growth factor receptor bound protein 2 0.0054 0.0063 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0181 0.0494 0.0575
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.01 0.022 0.0262
Onchocerca volvulus 0.0088 0.0178 0.1394
Echinococcus granulosus tyrosine protein kinase ABL1 0.0065 0.01 0.011
Loa Loa (eye worm) DR-78 0.0085 0.0169 0.0163
Echinococcus granulosus insulin receptor 0.0188 0.0519 0.0605
Entamoeba histolytica protein kinase, putative 0.0067 0.0107 0.2092
Echinococcus granulosus neuroglian 0.0072 0.0123 0.0137
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0068 0.0112 0.0105
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0041 0.002 0.0015
Brugia malayi orphan nuclear receptor NR2E1 0.0085 0.0169 0.0163

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Inhibition of angiopoietin1-induced TIE2 phosphorylation in CD1 NU/NU mouse ChEMBL. 17253679
AUC (ADMET) = 800 ng.hr/ml AUC (0-infinity) in Sprague-Dawley rat at 5 mg/kg, po ChEMBL. 17253679
CL (ADMET) = 2.4 L/hr.Kg Clearance in Sprague-Dawley rat at 2 mg/kg, iv ChEMBL. 17253679
CL (ADMET) < 50 uL/min.mg Clearance in mouse liver microsomes at 10 uM ChEMBL. 17253679
CL (ADMET) = 677 uL/min.mg Clearance in rat liver microsomes at 10 uM ChEMBL. 17253679
Cp (ADMET) = 1660 nM Plasma concentration in CD1 NU/NU mouse at 10 mg/kg ChEMBL. 17253679
Cp (ADMET) = 1660 nM Plasma concentration in CD1 NU/NU mouse at 10 mg/kg ChEMBL. 17253679
F (ADMET) = 39 % Oral bioavailability in Sprague-Dawley rat at 5 mg/kg, po ChEMBL. 17253679
Fu (ADMET) = 32 nM Unbound ligand in CD1 NU/NU mouse plasma ChEMBL. 17253679
Fu (ADMET) = 32 nM Unbound ligand in CD1 NU/NU mouse plasma ChEMBL. 17253679
IC50 (binding) = 5 nM Inhibition of TIE2 by HTRF assay ChEMBL. 17253679
IC50 (binding) = 5 nM Inhibition of TIE2 by HTRF assay ChEMBL. 17253679
IC50 (functional) = 8 nM Inhibition of Ang1-stimulated TIE2 phosphorylation in EA.hy 926 endothelial cell line ChEMBL. 17253679
IC50 (functional) = 8 nM Inhibition of Ang1-stimulated TIE2 phosphorylation in EA.hy 926 endothelial cell line ChEMBL. 17253679
IC50 (binding) = 18 nM Inhibition of TrkA ChEMBL. 17253679
IC50 (binding) = 18 nM Inhibition of TrkA ChEMBL. 17253679
IC50 (binding) = 43 nM Inhibition of FGR ChEMBL. 17253679
IC50 (binding) = 43 nM Inhibition of FGR ChEMBL. 17253679
IC50 (binding) = 130 nM Inhibition of LCK ChEMBL. 17253679
IC50 (binding) = 130 nM Inhibition of LCK ChEMBL. 17253679
IC50 (binding) = 180 nM Inhibition of Lyn ChEMBL. 17253679
IC50 (binding) = 180 nM Inhibition of Lyn ChEMBL. 17253679
IC50 (binding) = 290 nM Inhibition of EpHB4 ChEMBL. 17253679
IC50 (binding) = 290 nM Inhibition of EpHB4 ChEMBL. 17253679
IC50 (binding) = 550 nM Inhibition of Jak2 ChEMBL. 17253679
IC50 (binding) = 550 nM Inhibition of Jak2 ChEMBL. 17253679
IC50 (binding) = 910 nM Inhibition of Fes ChEMBL. 17253679
IC50 (binding) = 910 nM Inhibition of Fes ChEMBL. 17253679
IC50 (binding) = 1030 nM Inhibition of KDR ChEMBL. 17253679
IC50 (binding) = 1030 nM Inhibition of KDR ChEMBL. 17253679
IC50 (binding) = 1300 nM Inhibition of Jak1 ChEMBL. 17253679
IC50 (binding) = 1300 nM Inhibition of Jak1 ChEMBL. 17253679
IC50 (binding) = 1700 nM Inhibition of Jak3 ChEMBL. 17253679
IC50 (binding) = 1700 nM Inhibition of Jak3 ChEMBL. 17253679
IC50 (binding) = 1800 nM Inhibition of CSK ChEMBL. 17253679
IC50 (binding) = 1800 nM Inhibition of CSK ChEMBL. 17253679
IC50 (binding) = 2800 nM Inhibition of c-Kit ChEMBL. 17253679
IC50 (binding) = 2800 nM Inhibition of c-Kit ChEMBL. 17253679
IC50 (binding) = 2900 nM Inhibition of INSR ChEMBL. 17253679
IC50 (binding) = 2900 nM Inhibition of INSR ChEMBL. 17253679
IC50 (binding) > 5000 nM Inhibition of ITK ChEMBL. 17253679
IC50 (binding) > 5000 nM Inhibition of PDGFR ChEMBL. 17253679
IC50 (binding) > 5000 nM Inhibition of ITK ChEMBL. 17253679
IC50 (binding) > 5000 nM Inhibition of PDGFR ChEMBL. 17253679
IC50 (binding) > 6700 nM Inhibition of c-Met ChEMBL. 17253679
IC50 (binding) > 6700 nM Inhibition of c-Met ChEMBL. 17253679
IC50 (binding) > 8300 nM Inhibition of p38alpha ChEMBL. 17253679
IC50 (binding) > 8300 nM Inhibition of p38alpha ChEMBL. 17253679
IC50 (binding) > 100000 nM Inhibition of CDK5 ChEMBL. 17253679
IC50 (binding) > 100000 nM Inhibition of CDK5 ChEMBL. 17253679
Inhibition (functional) = 50 % Inhibition of angiopoietin1-induced TIE2 phosphorylation in CD1 NU/NU mouse at 10 mg/kg ChEMBL. 17253679
Inhibition (functional) = 50 % Inhibition of angiopoietin1-induced TIE2 phosphorylation in CD1 NU/NU mouse at 10 mg/kg ChEMBL. 17253679
PPB (ADMET) = 97.9 % Plasma protein binding in CD1 NU/NU mouse ChEMBL. 17253679
PPB (ADMET) = 97.9 % Plasma protein binding in CD1 NU/NU mouse ChEMBL. 17253679
Ratio (binding) = 4 Selectivity for TIE2 over TrkA ChEMBL. 17253679
Ratio (binding) = 9 Selectivity for TIE2 over FGR ChEMBL. 17253679
Ratio (binding) = 58 Selectivity for TIE2 over EphB4 ChEMBL. 17253679
Ratio (binding) > 1000 Selectivity for TIE2 over PDGFR ChEMBL. 17253679
Ratio IC50 (binding) = 25 Selectivity for TIE2 over Lck ChEMBL. 17253679
Ratio IC50 (binding) = 205 Selectivity for TIE2 over KDR ChEMBL. 17253679
t1/2 (ADMET) = 7.9 hr Half life in Sprague-Dawley rat at 2 mg/kg, iv ChEMBL. 17253679
Vss (ADMET) = 11.8 L/Kg Volume of distribution in Sprague-Dawley rat at 2 mg/kg, iv ChEMBL. 17253679

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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