TDR Targets

Basic information

Technical information

TDR Targets ID: 411706
Name: 3-benzoyloxy-2-[(4-chlorophenyl)methyl]-7,8,9 ,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
MW: 471.932 | Formula: C28H22ClNO4
H donors: 1 H acceptors: 4 LogP: 7.09 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)Cc1nc2c(c(c1OC(=O)c1ccccc1)C(=O)O)ccc1c2CCCC1
InChi: 1S/C28H22ClNO4/c29-20-13-10-17(11-14-20)16-23-26(34-28(33)19-7-2-1-3-8-19)24(27(31)32)22-15-12-18-6-4-5-9-21(18)25(22)30-23/h1-3,7-8,10-15H,4-6,9,16H2,(H,31,32)
InChiKey: XYQUREUIGPWXDJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(4-chlorophenyl)methyl]-3-(phenylcarbonyloxy)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
3-benzoyloxy-2-(4-chlorobenzyl)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
3-(benzoyloxy)-2-[(4-chlorophenyl)methyl]-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
2-[(4-chlorophenyl)methyl]-3-(oxo-phenylmethoxy)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
3-(benzoyloxy)-2-(4-chlorobenzyl)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
2-[(4-chlorophenyl)methyl]-3-phenylcarbonyloxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0076	0.1218	0.0866
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0153	0.4284	0.4111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0199	0.6102	0.5946
Schistosoma mansoni	cathepsin s	0.0098	0.2108	0.1869
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0298	1	1
Giardia lamblia	Cathepsin B precursor	0.0055	0.0386	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0153	0.4284	0.4054
Leishmania major	cathepsin L-like protease	0.0298	1	1
Loa Loa (eye worm)	cathepsin B	0.0055	0.0386	0.0386
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0298	1	1
Echinococcus multilocularis	cysteine protease	0.0298	1	1
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0076	0.1218	0.0866
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Brugia malayi	fibroinase precursor	0.0055	0.0386	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Plasmodium vivax	vivapain-2	0.0298	1	1
Brugia malayi	Cathepsin L-like precursor	0.0098	0.2108	0.1869
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0298	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.0386	0.0095
Giardia lamblia	Hypothetical protein	0.0055	0.0386	0.5
Giardia lamblia	Cysteine protease	0.0055	0.0386	0.5
Giardia lamblia	Cathepsin B precursor	0.0055	0.0386	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2108	0.2108
Plasmodium vivax	unspecified product	0.0098	0.2108	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0298	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0055	0.0386	0.0095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Giardia lamblia	Cysteine protease	0.0055	0.0386	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0153	0.4284	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0298	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0153	0.4284	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0153	0.4284	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0153	0.4284	0.4054
Onchocerca volvulus		0.0055	0.0386	0.0095
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0055	0.0386	0.0095
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0298	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0386	0.0386
Trypanosoma cruzi	cysteine protease, putative	0.0153	0.4284	0.4054
Onchocerca volvulus		0.0298	1	1
Plasmodium vivax	unspecified product	0.0153	0.4284	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0298	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0298	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0298	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2108	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0199	0.6102	0.5946
Brugia malayi	Papain family cysteine protease containing protein	0.0153	0.4284	0.4111
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0298	1	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.6102	0.6102
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0298	1	1
Giardia lamblia	Cathepsin B precursor	0.0055	0.0386	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0199	0.6102	0.5984
Leishmania major	cysteine peptidase A (CPA)	0.0298	1	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0055	0.0386	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0298	1	1
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0298	1	1
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Echinococcus granulosus	cathepsin L	0.0153	0.4284	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.0386	0.0095
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0298	1	1
Echinococcus granulosus	cysteine protease	0.0153	0.4284	0.4054
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0076	0.1218	0.0866
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0298	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0199	0.6102	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0386	0.0095
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0386	0.0095
Schistosoma mansoni	cathepsin S (C01 family)	0.0055	0.0386	0.0095
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0055	0.0386	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0386	0.0095
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Giardia lamblia	Cysteine protease	0.0055	0.0386	0.5
Brugia malayi	cathepsin F-like cysteine proteinase	0.0098	0.2108	0.1869
Brugia malayi	Cathepsin L-like precursor	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0298	1	1
Giardia lamblia	Cathepsin B precursor	0.0055	0.0386	0.5
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0055	0.0386	0.0095
Trypanosoma cruzi	cysteine peptidase, putative	0.0153	0.4284	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0153	0.4284	0.4111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Echinococcus multilocularis	cysteine protease	0.0298	1	1
Leishmania major	cathepsin L-like protease	0.0298	1	1
Echinococcus granulosus	cathepsin l1	0.0298	1	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.6102	0.6102
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0199	0.6102	0.5946
Loa Loa (eye worm)	fibroinase	0.0298	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0386	0.0095
Giardia lamblia	Cathepsin L precursor	0.0055	0.0386	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0298	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0153	0.4284	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0298	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0055	0.0386	0.0386
Leishmania major	cathepsin L-like protease	0.0298	1	1
Giardia lamblia	Hypothetical protein	0.0055	0.0386	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0153	0.4284	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0298	1	1
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0298	1	1
Echinococcus granulosus	sodium:glucose cotransporter	0.0076	0.1218	0.0866
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0298	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0153	0.4284	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.6102	0.6102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Onchocerca volvulus		0.0298	1	1
Schistosoma mansoni	inositol transporter	0.0076	0.1218	0.0952
Brugia malayi	Papain family cysteine protease containing protein	0.0153	0.4284	0.4111
Giardia lamblia	Cathepsin L precursor	0.0055	0.0386	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0298	1	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0055	0.0386	0.0095
Giardia lamblia	Cathepsin L-like protease	0.0055	0.0386	0.5
Giardia lamblia	Cathepsin L-like protease	0.0055	0.0386	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0055	0.0386	0.5
Loa Loa (eye worm)	ctsf protein	0.0298	1	1
Schistosoma mansoni	inositol transporter	0.0076	0.1218	0.0952
Brugia malayi	Papain family cysteine protease containing protein	0.0298	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0386	0.0386
Onchocerca volvulus	Cathepsin F homolog	0.0298	1	1
Onchocerca volvulus		0.0298	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0153	0.4284	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.2108	0.1791
Giardia lamblia	Cathepsin B precursor	0.0055	0.0386	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0294	0.0294
Leishmania major	cathepsin L-like protease	0.0298	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0153	0.4284	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0298	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2108	0.2108
Brugia malayi	cathepsin L precursor	0.0055	0.0386	0.0095
Onchocerca volvulus		0.0298	1	1
Entamoeba histolytica	cysteine protease, putative	0.0298	1	1
Echinococcus granulosus	solute carrier family 5	0.0076	0.1218	0.0866
Trypanosoma cruzi	cysteine peptidase, putative	0.0298	1	1
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0298	1	1
Echinococcus granulosus	cathepsin l1	0.0199	0.6102	0.5946
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0098	0.2108	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0386	0.0386
Giardia lamblia	Cathepsin B precursor	0.0055	0.0386	0.5
Giardia lamblia	Cysteine protease	0.0055	0.0386	0.5
Brugia malayi	cathepsin B-like cysteine proteinase	0.0055	0.0386	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0386	0.0095
Brugia malayi	cathepsin L-like cysteine proteinase	0.0055	0.0386	0.0095
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Schistosoma mansoni	cathepsin C	0.0055	0.0386	0.0095
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0055	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0386	0.0386
Leishmania major	cathepsin L-like protease	0.0298	1	1
Onchocerca volvulus		0.0298	1	1
Toxoplasma gondii	cathepsin CPL	0.0298	1	1
Echinococcus multilocularis	cathepsin L	0.0153	0.4284	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0055	0.0386	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Brugia malayi	Cathepsin L-like precursor	0.0298	1	1
Onchocerca volvulus		0.0298	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0298	1	1
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0076	0.1218	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0386	0.0386
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0153	0.4284	0.4111
Giardia lamblia	Cathepsin L precursor	0.0055	0.0386	0.5
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Leishmania major	cathepsin L-like protease	0.0298	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0055	0.0386	0.0095
Plasmodium vivax	vivapain-3	0.0153	0.4284	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.0386	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0298	1	1
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0386	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0153	0.4284	0.4054
Brugia malayi	cathepsin L-like precursor	0.0199	0.6102	0.5984
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0055	0.0386	0.0095
Brugia malayi	Cathepsin L-like precursor	0.0298	1	1
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Giardia lamblia	Encystation-specific protease	0.0055	0.0386	0.5
Plasmodium vivax	vivapain-1	0.0153	0.4284	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0199	0.6102	0.5984
Giardia lamblia	Cathepsin B precursor	0.0055	0.0386	0.5
Leishmania major	cathepsin L-like protease	0.0298	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0298	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0153	0.4284	0.4054
Giardia lamblia	Cathepsin L precursor	0.0055	0.0386	0.5
Brugia malayi	Cathepsin L-like precursor	0.0199	0.6102	0.5984
Onchocerca volvulus	Cathepsin L homolog	0.0298	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0298	1	1
Loa Loa (eye worm)	cysteine protease	0.0298	1	1
Giardia lamblia	Cathepsin L precursor	0.0055	0.0386	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1
Onchocerca volvulus		0.0298	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0153	0.4284	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0386	0.0386
Onchocerca volvulus		0.0199	0.6102	0.5984
Entamoeba histolytica	cysteine proteinase 2	0.0153	0.4284	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0055	0.0386	0.0095
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0298	1	1
Entamoeba histolytica	cysteine protease, putative	0.0153	0.4284	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0386	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0294	0.0294
Echinococcus multilocularis	solute carrier family 5	0.0076	0.1218	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0386	0.0386
Brugia malayi	Cathepsin L-like precursor	0.0199	0.6102	0.5984
Schistosoma mansoni	cathepsin B (C01 family)	0.0055	0.0386	0.0095
Leishmania major	cathepsin L-like protease	0.0298	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0055	0.0386	0.5
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0098	0.2108	0.1869
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0055	0.0386	0.0386
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0386	0.0095
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0386	0.0095
Giardia lamblia	Cathepsin L precursor	0.0055	0.0386	0.5
Giardia lamblia	Cathepsin B precursor	0.0055	0.0386	0.5
Plasmodium vivax	vivapain-2	0.0298	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0153	0.4284	0.4054
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0055	0.0386	0.0095
Onchocerca volvulus	Cathepsin L homolog	0.0055	0.0386	0.0095
Schistosoma mansoni	cathepsin F (C01 family)	0.0298	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0098	0.2108	0.1791
Schistosoma mansoni	cathepsin F (C01 family)	0.0298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0298	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 190 uM	Inhibition of P-Selectin by Biacore assay	ChEMBL.	17201409
IC50 (binding)	= 190 uM	Inhibition of P-Selectin by Biacore assay	ChEMBL.	17201409

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 16100095

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 411706