Detailed information for compound 41196

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 610.782 | Formula: C38H46N2O5
  • H donors: 1 H acceptors: 0 LogP: 5.65 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: C(OCc1ccccc1)CCOc1ccc(cc1)[C@H]1CCNC[C@@H]1OCc1ccc2c(c1)ccc(c2)OCCN1CCOCC1
  • InChi: 1S/C38H46N2O5/c1-2-5-30(6-3-1)28-42-20-4-21-43-35-12-9-32(10-13-35)37-15-16-39-27-38(37)45-29-31-7-8-34-26-36(14-11-33(34)25-31)44-24-19-40-17-22-41-23-18-40/h1-3,5-14,25-26,37-39H,4,15-24,27-29H2/t37-,38+/m1/s1
  • InChiKey: NFGSWDKOHGAPRT-AMAPPZPBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens renin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin X renin 406 aa 352 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0101 0.0746 0.1585
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0028 0.0038
Entamoeba histolytica hypothetical protein 0.0036 0.0212 0.045
Loa Loa (eye worm) hypothetical protein 0.0105 0.0774 0.1037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0395 0.3164 0.4236
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0841 0.1786
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0132 0.1002 0.1342
Loa Loa (eye worm) hypothetical protein 0.0079 0.0567 0.076
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0044 0.006
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0059 0.0399 0.0399
Brugia malayi Protein kinase domain containing protein 0.0015 0.0036 0.0049
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0036 0.0055
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0196 0.0262
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0096 0.0128
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0028 0.0038
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0079 0.0567 0.483
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.028 0.2216 0.4707
Plasmodium falciparum plasmepsin III 0.0014 0.0028 0.0083
Trypanosoma brucei purine nucleoside transporter 0.0101 0.0746 0.0999
Onchocerca volvulus 0.0395 0.3164 0.4788
Echinococcus multilocularis allatostatin A receptor 0.0395 0.3164 0.3164
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0349
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0101 0.0746 0.0999
Brugia malayi ORL1-like opioid receptor 0.0395 0.3164 0.4236
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0059
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0247 0.0247
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0105 0.0774 0.0774
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Trypanosoma cruzi nucleoside transporter 1, putative 0.0101 0.0746 0.0999
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0044 0.0059
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0582 0.4707 0.7124
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0101 0.0746 0.1585
Echinococcus multilocularis rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0841 0.0841
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0395 0.3164 0.4236
Trypanosoma cruzi nucleoside transporter-like, putative 0.0101 0.0746 0.0999
Brugia malayi G-protein coupled receptor 0.0395 0.3164 0.4236
Echinococcus multilocularis G protein coupled receptor 139 0.0395 0.3164 0.3164
Onchocerca volvulus 0.0395 0.3164 0.4788
Echinococcus multilocularis rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Schistosoma mansoni opsin-like receptor 0.0395 0.3164 0.4236
Trypanosoma cruzi nucleoside transporter-like, putative 0.0101 0.0746 0.0999
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0349
Onchocerca volvulus 0.0395 0.3164 0.4788
Schistosoma mansoni cathepsin D (A01 family) 0.0174 0.1345 0.1802
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0427 0.3427 0.3427
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.049 0.0657
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0044 0.006
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.049 0.0657
Trypanosoma brucei adenosine transporter 2, putative 0.0101 0.0746 0.0999
Trichomonas vaginalis ribokinase, putative 0.0105 0.0774 0.1645
Trichomonas vaginalis ribokinase, putative 0.0105 0.0774 0.1645
Trypanosoma cruzi adenosine kinase, putative 0.0918 0.7468 1
Echinococcus granulosus neuropeptides capa receptor 0.0395 0.3164 0.3164
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0105 0.0774 0.6742
Onchocerca volvulus 0.0813 0.6607 1
Echinococcus granulosus g-protein coupled receptor 0.0395 0.3164 0.3164
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0427 0.3427 1
Echinococcus multilocularis solute carrier family 28 0.1225 1 1
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Schistosoma mansoni neuropeptide F-like receptor 0.0395 0.3164 0.4236
Brugia malayi G protein-coupled receptor 0.0395 0.3164 0.4236
Echinococcus granulosus ribokinase 0.0105 0.0774 0.0774
Trypanosoma brucei purine nucleoside transporter 0.0101 0.0746 0.0999
Echinococcus granulosus 7tm_1 domain containing protein 0.0395 0.3164 0.3164
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0567 0.1655
Onchocerca volvulus 0.0395 0.3164 0.4788
Loa Loa (eye worm) neuropeptide F receptor 0.0395 0.3164 0.4236
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0059 0.0399 0.0535
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.049 0.0657
Echinococcus granulosus neuropeptide receptor 0.0395 0.3164 0.3164
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0841 0.1126
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0044 0.0044
Loa Loa (eye worm) G-protein coupled receptor 0.0395 0.3164 0.4236
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0427 0.3427 0.7281
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0841 0.1126
Brugia malayi Dopamine receptor 0.0395 0.3164 0.4236
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0059 0.0399 0.0535
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.0774 0.1037
Schistosoma mansoni neuropeptide receptor 0.0395 0.3164 0.4236
Loa Loa (eye worm) neuropeptide F receptor 0.0395 0.3164 0.4236
Brugia malayi Adenosine kinase-like 0.0918 0.7468 1
Trypanosoma brucei adenosine transporter 2, putative 0.0101 0.0746 0.0999
Schistosoma mansoni netrin receptor unc5 0.0015 0.0036 0.0049
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0057 0.0077
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0427 0.3427 0.5
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0059 0.0399 0.0399
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0395 0.3164 0.3164
Entamoeba histolytica nucleoside transporter, putative 0.0101 0.0746 0.1585
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0395 0.3164 0.4236
Leishmania major putative PfkB family sugar kinase 0.0105 0.0774 0.1037
Echinococcus granulosus neuropeptide Y receptor 0.0395 0.3164 0.3164
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0011 0.0023
Leishmania major nucleobase transporter 0.0101 0.0746 0.0999
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Chlamydia trachomatis endonuclease IV 0.0079 0.0567 0.1236
Onchocerca volvulus 0.0395 0.3164 0.4788
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Entamoeba histolytica fructokinase, putative 0.0105 0.0774 0.1645
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0774 0.1037
Echinococcus granulosus Ankyrin 0.0015 0.0037 0.0037
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0036 0.0036
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0395 0.3164 0.4236
Onchocerca volvulus 0.0014 0.0028 0.0043
Plasmodium vivax aspartyl protease, putative 0.0014 0.0028 0.0083
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0395 0.3164 0.4236
Onchocerca volvulus Putative pyridoxal kinase 0.0105 0.0774 0.1172
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0427 0.3427 0.4589
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0164 0.0479
Echinococcus granulosus sex peptide receptor 0.0395 0.3164 0.3164
Echinococcus granulosus Na+ dependent nucleoside transporter 0.1225 1 1
Brugia malayi Death domain containing protein 0.0015 0.0036 0.0049
Toxoplasma gondii kinase, pfkB family protein 0.0918 0.7468 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Schistosoma mansoni amine GPCR 0.0395 0.3164 0.4236
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0044 0.006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0395 0.3164 0.4236
Echinococcus granulosus adenylate cyclase 9 0.0078 0.0552 0.0552
Loa Loa (eye worm) G-protein coupled receptor 0.0395 0.3164 0.4236
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0074 0.0214
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0395 0.3164 0.4236
Schistosoma mansoni hypothetical protein 0.0346 0.2763 0.3699
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0395 0.3164 0.3164
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132 0.1002 0.1342
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0262
Schistosoma mansoni protein kinase 0.0101 0.0746 0.0999
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0164 0.0479
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0049
Echinococcus multilocularis adenosine kinase 0.0918 0.7468 0.7468
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0841 0.1786
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0101 0.0746 0.0999
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0036 0.0212 0.045
Giardia lamblia Hypothetical protein 0.0582 0.4707 1
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0049
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0122 0.0357
Echinococcus granulosus tm gpcr rhodopsin 0.0395 0.3164 0.3164
Trypanosoma cruzi nucleobase transporter, putative 0.0101 0.0746 0.0999
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0279 0.2214 0.2964
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0028 0.0038
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0279 0.2214 0.4703
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0038
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0164 0.0349
Brugia malayi Adenylyl cyclase protein 0.0078 0.0552 0.0739
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.0399 0.0535
Loa Loa (eye worm) STAT protein 0.0136 0.1035 0.1386
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0427 0.3427 0.4589
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.049 0.0657
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0122 0.0357
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0122 0.0164
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0582 0.4707 0.4707
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0295 0.2339 0.3132
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0215 0.1682 0.2546
Schistosoma mansoni biogenic amine receptor 0.0395 0.3164 0.4236
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0044 0.0059
Leishmania major tagatose-6-phosphate kinase-like protein 0.0105 0.0774 0.1037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Echinococcus multilocularis g protein coupled receptor 0.0395 0.3164 0.3164
Echinococcus granulosus g protein coupled receptor 0.0395 0.3164 0.3164
Echinococcus granulosus neuropeptide Y receptor 0.0395 0.3164 0.3164
Mycobacterium ulcerans fructokinase, PfkB 0.0105 0.0774 0.2061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0044 0.0044
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0481 0.3875 0.3875
Echinococcus multilocularis g-protein coupled receptor 0.0395 0.3164 0.3164
Schistosoma mansoni biogenic amine receptor 0.0395 0.3164 0.4236
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0147 0.1125 0.239
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0395 0.3164 0.3164
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0122 0.0164
Brugia malayi hypothetical protein 0.0036 0.0212 0.0283
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0132 0.1002 0.1342
Echinococcus granulosus G protein coupled receptor 139 0.0395 0.3164 0.3164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Brugia malayi Eukaryotic aspartyl protease family protein 0.0014 0.0028 0.0038
Echinococcus granulosus neuropeptide receptor A26 0.0395 0.3164 0.3164
Plasmodium vivax aspartyl protease, putative 0.0014 0.0028 0.0083
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0059
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0582 0.4707 0.4707
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0774 0.1037
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0427 0.3427 0.4589
Echinococcus multilocularis g protein coupled receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Schistosoma mansoni neuropeptide receptor 0.0395 0.3164 0.4236
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.049 0.049
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0841 0.2074
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Onchocerca volvulus 0.0105 0.0774 0.1172
Onchocerca volvulus 0.0395 0.3164 0.4788
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0164 0.0349
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0841 0.1786
Entamoeba histolytica hypothetical protein 0.0036 0.0212 0.045
Leishmania major nucleoside transporter 1, putative 0.0101 0.0746 0.0999
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0427 0.3427 0.4589
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0279 0.2214 0.2964
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0105 0.0774 0.1645
Brugia malayi G-protein coupled receptor 0.0395 0.3164 0.4236
Schistosoma mansoni neuropeptide receptor 0.0395 0.3164 0.4236
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) pax transcription factor protein 2 0.0242 0.1907 0.2554
Echinococcus multilocularis adenylate cyclase 9 0.0078 0.0552 0.0552
Plasmodium falciparum plasmepsin V 0.0014 0.0028 0.0083
Schistosoma mansoni adenoreceptor 0.0395 0.3164 0.4236
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0427 0.3427 0.3427
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0395 0.3164 0.4236
Echinococcus granulosus alpha 1A adrenergic receptor 0.0395 0.3164 0.3164
Brugia malayi GnHR receptor homolog 0.0395 0.3164 0.4236
Entamoeba histolytica ribokinase, putative 0.0105 0.0774 0.1645
Echinococcus multilocularis GPCR, family 2 0.0016 0.0044 0.0044
Echinococcus multilocularis sex peptide receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0105 0.0774 0.1037
Trypanosoma brucei unspecified product 0.0101 0.0746 0.0999
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Plasmodium falciparum plasmepsin VIII, putative 0.0014 0.0028 0.0083
Brugia malayi neuropeptide F receptor 0.0395 0.3164 0.4236
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0079 0.0567 0.4626
Brugia malayi phosphofructokinase 0.0113 0.0841 0.1126
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.084 0.683 0.683
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0542 0.0542
Schistosoma mansoni alpha-1 adrenergic receptor 0.0395 0.3164 0.4236
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132 0.1002 0.1342
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0427 0.3427 0.7281
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0164 0.0479
Onchocerca volvulus 0.0395 0.3164 0.4788
Brugia malayi Ribokinase 0.0105 0.0774 0.1037
Brugia malayi AKH receptor 0.0395 0.3164 0.4236
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0427 0.3427 0.7281
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0395 0.3164 0.4236
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Echinococcus granulosus equilibrative nucleoside transporter 0.0582 0.4707 0.4707
Brugia malayi Serotonin receptor 0.0395 0.3164 0.4236
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0427 0.3427 0.4589
Schistosoma mansoni adenosine kinase 0.0918 0.7468 1
Brugia malayi sulfakinin receptor protein 0.0395 0.3164 0.4236
Trypanosoma brucei adenosine transporter 2 0.0101 0.0746 0.0999
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0427 0.3427 0.3427
Echinococcus multilocularis G-protein coupled receptor, putative 0.0395 0.3164 0.3164
Schistosoma mansoni memapsin-2 (A01 family) 0.0014 0.0028 0.0038
Loa Loa (eye worm) hypothetical protein 0.028 0.2216 0.2967
Brugia malayi putative neuropeptide receptor 0.0395 0.3164 0.4236
Entamoeba histolytica nucleoside transporter, putative 0.0582 0.4707 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Loa Loa (eye worm) TYRA-2 protein 0.0395 0.3164 0.4236
Echinococcus multilocularis rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0164
Entamoeba histolytica hypothetical protein 0.0036 0.0212 0.045
Echinococcus multilocularis neuropeptide FF receptor 2 0.0395 0.3164 0.3164
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.028 0.2216 0.2967
Echinococcus multilocularis orexin receptor type 2 0.0395 0.3164 0.3164
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0395 0.3164 0.3164
Brugia malayi G protein-coupled receptor F59B2.13 0.0395 0.3164 0.4236
Schistosoma mansoni neuropeptide F-like receptor 0.0395 0.3164 0.4236
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0044 0.0044
Plasmodium falciparum plasmepsin VII 0.0014 0.0028 0.0083
Echinococcus multilocularis neuropeptide receptor A26 0.0395 0.3164 0.3164
Plasmodium vivax plasmepsin IV, putative 0.0059 0.0399 0.1165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0427 0.3427 0.4589
Brugia malayi aspartic protease BmAsp-1, identical 0.0014 0.0028 0.0038
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Toxoplasma gondii nucleoside transporter protein 0.0101 0.0746 0.0999
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0096 0.0203
Brugia malayi hypothetical protein 0.0101 0.0746 0.0999
Brugia malayi Nucleoside transporter family protein 0.0582 0.4707 0.6303
Brugia malayi hypothetical protein 0.0582 0.4707 0.6303
Trypanosoma brucei adenosine transporter 2, putative 0.0101 0.0746 0.0999
Echinococcus granulosus rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0101 0.0746 0.0999
Brugia malayi Dopamine receptor protein 1 0.0395 0.3164 0.4236
Toxoplasma gondii nucleoside transporter protein 0.0101 0.0746 0.0999
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0101 0.0746 0.0999
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0212 0.0212
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0427 0.3427 0.4589
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Schistosoma mansoni hypothetical protein 0.0036 0.0212 0.0283
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0014 0.0028 0.0038
Echinococcus granulosus neuropeptide s receptor 0.0395 0.3164 0.3164
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.049 0.0657
Schistosoma mansoni cathepsin D (A01 family) 0.0174 0.1345 0.1802
Echinococcus granulosus dro:myosuppressin receptor 0.0395 0.3164 0.3164
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0105 0.0774 0.1645
Trypanosoma cruzi adenosine kinase, putative 0.0918 0.7468 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0044 0.0059
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0841 0.1126
Mycobacterium tuberculosis Ribokinase RbsK 0.0105 0.0774 0.6742
Loa Loa (eye worm) hypothetical protein 0.0329 0.2619 0.3508
Leishmania major nucleoside transporter 1, putative 0.0101 0.0746 0.0999
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0212 0.0283
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0799 0.6492 0.6492
Trypanosoma brucei nucleoside transporter 1, putative 0.0101 0.0746 0.0999
Echinococcus multilocularis neuropeptide Y receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) melatonin receptor type 1A 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0582 0.4707 0.6303
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0059
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0036 0.0049
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0096 0.0203
Brugia malayi isocitrate dehydrogenase 0.0016 0.0044 0.006
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.1225 1 1
Onchocerca volvulus 0.0074 0.0525 0.0794
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0395 0.3164 0.4236
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0427 0.3427 0.4589
Plasmodium vivax plasmepsin V, putative 0.0014 0.0028 0.0083
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0427 0.3427 0.7281
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Brugia malayi STAT protein, DNA binding domain containing protein 0.0136 0.1035 0.1386
Trypanosoma cruzi nucleoside transporter 1, putative 0.0101 0.0746 0.0999
Trypanosoma brucei adenosine transporter 2, putative 0.0101 0.0746 0.0999
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0774 0.1645
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0044 0.006
Trypanosoma brucei adenosine transporter 2, putative 0.0101 0.0746 0.0999
Leishmania major adenosine kinase-like protein 0.0105 0.0774 0.1037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0086 0.0115
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0582 0.4707 0.7124
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0395 0.3164 0.3164
Echinococcus multilocularis neuropeptides capa receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Plasmodium vivax aspartyl protease, putative 0.0014 0.0028 0.0083
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0427 0.3427 1
Echinococcus multilocularis tumor protein p63 0.0359 0.2865 0.2865
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0164 0.022
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0011 0.0015
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0086 0.0379
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0427 0.3427 0.4589
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0841 0.1126
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0841 0.1786
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0841 0.1786
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0295 0.2339 0.3132
Brugia malayi RE15519p 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Echinococcus multilocularis dro:myosuppressin receptor 0.0395 0.3164 0.3164
Trypanosoma cruzi nucleobase transporter, putative 0.0101 0.0746 0.0999
Brugia malayi larval opioid receptor 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Trypanosoma brucei ribokinase, putative 0.0105 0.0774 0.1037
Echinococcus granulosus orexin receptor type 2 0.0395 0.3164 0.3164
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0122 0.0357
Brugia malayi neuropeptide F receptor 0.0395 0.3164 0.4236
Brugia malayi Serotonin receptor 0.0395 0.3164 0.4236
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0582 0.4707 1
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0567 0.1655
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0044 0.0044
Onchocerca volvulus 0.0078 0.0552 0.0835
Loa Loa (eye worm) hypothetical protein 0.0052 0.0346 0.0463
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0132 0.1002 0.1342
Trypanosoma brucei unspecified product 0.0101 0.0746 0.0999
Echinococcus multilocularis Ankyrin 0.0015 0.0037 0.0037
Brugia malayi Uncoordinated protein 44 0.0015 0.0036 0.0049
Echinococcus multilocularis neuropeptide s receptor 0.0395 0.3164 0.3164
Schistosoma mansoni equilibrative nucleoside transporter 0.0101 0.0746 0.0999
Onchocerca volvulus 0.0395 0.3164 0.4788
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0101 0.0746 0.0999
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0147 0.1125 0.1507
Onchocerca volvulus 0.0395 0.3164 0.4788
Onchocerca volvulus 0.0395 0.3164 0.4788
Plasmodium vivax aspartyl proteinase, putative 0.0014 0.0028 0.0083
Toxoplasma gondii nucleoside transporter protein 0.0101 0.0746 0.0999
Echinococcus granulosus GPCR family 2 0.0016 0.0044 0.0044
Brugia malayi Dopamine receptor protein 2 0.0395 0.3164 0.4236
Echinococcus multilocularis neuropeptide Y receptor 0.0395 0.3164 0.3164
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0101 0.0746 0.1585
Echinococcus granulosus peptide allatostatin:somatostatin 0.0395 0.3164 0.3164
Loa Loa (eye worm) aspartyl protease 6 0.0014 0.0028 0.0038
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0427 0.3427 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0841 0.226
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0427 0.3427 0.4589
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.028 0.2216 0.2967
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0037 0.0107
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Echinococcus granulosus fmrfamide receptor 0.0395 0.3164 0.3164
Giardia lamblia Ribokinase 0.0105 0.0774 0.1645
Brugia malayi 6-phosphofructokinase 0.0113 0.0841 0.1126
Trypanosoma brucei nucleoside transporter 1, putative 0.0101 0.0746 0.0999
Echinococcus granulosus rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0079
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0011 0.0015
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0427 0.3427 0.4589
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0212 0.0212
Onchocerca volvulus 0.0395 0.3164 0.4788
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0028 0.0038
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0841 0.1126
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0086 0.0129
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.049 0.1042
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0841 0.1126
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.028 0.2216 0.2216
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0395 0.3164 0.4236
Loa Loa (eye worm) adenylyl cyclase 3 0.0078 0.0552 0.0739
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0427 0.3427 1
Schistosoma mansoni amine GPCR 0.0395 0.3164 0.4236
Echinococcus multilocularis rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0582 0.4707 0.6303
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0395 0.3164 0.3164
Trypanosoma brucei adenosine kinase, putative 0.0918 0.7468 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0164 0.0479
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0395 0.3164 0.3164
Echinococcus granulosus somatostatin receptor 0.0395 0.3164 0.3164
Echinococcus granulosus biogenic amine 5HT receptor 0.0395 0.3164 0.3164
Trypanosoma brucei adenosine transporter 2 0.0101 0.0746 0.0999
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0164 0.022
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0395 0.3164 0.3164
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0427 0.3427 0.4589
Plasmodium falciparum plasmepsin VI 0.0059 0.0399 0.1165
Echinococcus multilocularis g protein coupled receptor 0.0395 0.3164 0.3164
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0044 0.006
Trypanosoma cruzi nucleobase transporter, putative 0.0101 0.0746 0.0999
Toxoplasma gondii aspartyl protease ASP3 0.0014 0.0028 0.0038
Brugia malayi Pepsin A precursor 0.0014 0.0028 0.0038
Brugia malayi hypothetical protein 0.0016 0.0048 0.0065
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.049 0.049
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0122 0.0164
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0028 0.0038
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0395 0.3164 0.3164
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0101 0.0746 0.0999
Loa Loa (eye worm) hypothetical protein 0.0078 0.0552 0.0739
Plasmodium vivax aspartyl proteinase, putative 0.0059 0.0399 0.1165
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0279 0.2214 0.2964
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0327 0.0437
Schistosoma mansoni hypothetical protein 0.0346 0.2763 0.3699
Mycobacterium tuberculosis Adenosine kinase 0.0105 0.0774 0.6742
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0427 0.3427 0.7281
Echinococcus granulosus serotonin receptor 0.0395 0.3164 0.3164
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0582 0.4707 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0395 0.3164 0.3164
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0044 0.013
Brugia malayi hypothetical protein 0.0014 0.0028 0.0038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0059
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0044 0.0044
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0036 0.0049
Brugia malayi aspartic protease BmAsp-2, identical 0.0014 0.0028 0.0038
Echinococcus granulosus neuropeptide FF receptor 2 0.0395 0.3164 0.3164
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0395 0.3164 0.3164
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0427 0.3427 0.7281
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0105 0.0774 0.0774
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132 0.1002 0.1342
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0395 0.3164 0.3164
Schistosoma mansoni myosin xvIII 0.0395 0.3164 0.4236
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0427 0.3427 0.4589
Schistosoma mansoni hypothetical protein 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Plasmodium falciparum plasmepsin I 0.0059 0.0399 0.1165
Plasmodium falciparum plasmepsin II 0.0059 0.0399 0.1165
Schistosoma mansoni histamine h1 receptor 0.0395 0.3164 0.4236
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0427 0.3427 0.4589
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0542 0.0542
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0044 0.006
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0427 0.3427 0.7281
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0395 0.3164 0.4236
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0395 0.3164 0.4236
Schistosoma mansoni opsin-like receptor 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0395 0.3164 0.4236
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0147 0.1127 1
Trypanosoma brucei adenosine transporter, putative 0.0101 0.0746 0.0999
Loa Loa (eye worm) hypothetical protein 0.005 0.0327 0.0437
Brugia malayi Pax transcription factor protein 2 0.0242 0.1907 0.2554
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0841 0.1786
Echinococcus multilocularis fmrfamide receptor 0.0395 0.3164 0.3164
Brugia malayi hypothetical protein 0.0025 0.0122 0.0164
Leishmania major hypothetical protein, conserved 0.0025 0.0122 0.0164
Schistosoma mansoni adenosine kinase 0.0918 0.7468 1
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0582 0.4707 0.4707
Echinococcus granulosus allatostatin A receptor 0.0395 0.3164 0.3164
Onchocerca volvulus 0.0395 0.3164 0.4788
Echinococcus granulosus neuropeptide receptor 0.0395 0.3164 0.3164
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0427 0.3427 0.7281
Loa Loa (eye worm) hypothetical protein 0.0582 0.4707 0.6303
Leishmania major ribokinase, putative 0.0105 0.0774 0.1037
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0014 0.0028 0.0038
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Echinococcus granulosus geminin 0.0346 0.2763 0.2763
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0036 0.0049
Schistosoma mansoni biogenic amine receptor 0.0395 0.3164 0.4236
Trypanosoma brucei adenosine transporter, putative 0.0101 0.0746 0.0999
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0044 0.006
Brugia malayi follicle stimulating hormone receptor 0.0633 0.5126 0.6864
Schistosoma mansoni biogenic amine (5HT) receptor 0.0395 0.3164 0.4236
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0903 0.1209
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0395 0.3164 0.3164
Schistosoma mansoni neuropeptide receptor 0.0395 0.3164 0.4236
Onchocerca volvulus 0.0242 0.1907 0.2887
Mycobacterium ulcerans endonuclease IV 0.0079 0.0567 0.1442
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0349
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0427 0.3427 0.3427
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0035 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0395 0.3164 0.4236
Schistosoma mansoni biogenic amine (5HT) receptor 0.0395 0.3164 0.4236
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0044 0.0044
Mycobacterium leprae Probable adenosine kinase adk 0.0105 0.0774 0.6614
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0633 0.5126 0.6864
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0086 0.0115
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0122 0.0164
Echinococcus multilocularis neuropeptides capa receptor 0.0395 0.3164 0.3164
Onchocerca volvulus 0.0395 0.3164 0.4788
Echinococcus granulosus neuropeptides capa receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0059 0.0399 0.0535
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0059 0.0399 0.0848
Echinococcus granulosus g protein coupled receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0038
Echinococcus granulosus tumor protein p63 0.0359 0.2865 0.2865
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0044 0.0044
Brugia malayi MH2 domain containing protein 0.012 0.0903 0.1209
Brugia malayi Tachykinin-like peptides receptor 99D 0.0395 0.3164 0.4236
Echinococcus multilocularis somatostatin receptor 0.0395 0.3164 0.3164
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0395 0.3164 0.4236
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0327 0.0437
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0582 0.4707 1
Echinococcus multilocularis serotonin receptor 0.0395 0.3164 0.3164
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0028 0.0038
Schistosoma mansoni neuropeptide f receptor 76f 0.0395 0.3164 0.4236
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0427 0.3427 0.4589
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0044 0.013
Onchocerca volvulus 0.0395 0.3164 0.4788
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.028 0.2216 0.4707
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0427 0.3427 0.4589
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0044 0.0044
Schistosoma mansoni amine GPCR 0.0395 0.3164 0.4236
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0395 0.3164 0.4788
Loa Loa (eye worm) hypothetical protein 0.0212 0.1655 0.2216
Echinococcus granulosus hypothetical protein 0.0395 0.3164 0.3164
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0028 0.0038
Onchocerca volvulus 0.0395 0.3164 0.4788
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0101 0.0746 0.0999
Echinococcus multilocularis serotonin receptor 0.0395 0.3164 0.3164
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0279 0.2214 0.2964
Loa Loa (eye worm) hypothetical protein 0.0918 0.7468 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0395 0.3164 0.3164
Schistosoma mansoni ribokinase 0.0105 0.0774 0.1037
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0841 0.0841
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0349
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0346 0.0463
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0427 0.3427 0.7281
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Echinococcus granulosus adenosine kinase 0.0918 0.7468 0.7468
Leishmania major nucleobase transporter 0.0101 0.0746 0.0999
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0247 0.0247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0395 0.3164 0.4236
Leishmania major tagatose-6-phosphate kinase-like protein 0.0105 0.0774 0.1037
Loa Loa (eye worm) RecQ helicase 0.0022 0.0096 0.0128
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0395 0.3164 0.4236
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0395 0.3164 0.4236
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0395 0.3164 0.4236
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0395 0.3164 0.4236
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0395 0.3164 0.4236
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0841 0.7355
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0427 0.3427 1
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0101 0.0746 0.0999
Brugia malayi Melatonin receptor type 1A 0.0395 0.3164 0.4236
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0841 0.7251
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0395 0.3164 0.3164
Brugia malayi 6-phosphofructokinase 0.0113 0.0841 0.1126
Schistosoma mansoni hypothetical protein 0.0395 0.3164 0.4236
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0147 0.1127 1
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0841 0.1126
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0395 0.3164 0.3164
Echinococcus granulosus death domain containing protein 0.0015 0.0036 0.0036
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0395 0.3164 0.4236
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.049 0.0657
Schistosoma mansoni hypothetical protein 0.0395 0.3164 0.4236
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0395 0.3164 0.4236
Entamoeba histolytica kinase, PfkB family 0.0105 0.0774 0.1645
Echinococcus granulosus g protein coupled receptor 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0327 0.0437
Echinococcus granulosus rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.1225 1 1
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Trypanosoma brucei ribokinase, putative 0.0105 0.0774 0.1037
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0096 0.0096
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0164 0.0349
Brugia malayi hypothetical protein 0.0126 0.0952 0.1275
Leishmania major adenosine kinase, putative 0.0918 0.7468 1
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0164 0.022
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0028 0.0038
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0101 0.0746 0.1585
Onchocerca volvulus 0.0014 0.0028 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0044 0.006
Plasmodium falciparum plasmepsin IX 0.0014 0.0028 0.0083
Schistosoma mansoni amine GPCR 0.0395 0.3164 0.4236
Echinococcus granulosus bloom syndrome protein 0.0022 0.0096 0.0096
Onchocerca volvulus Ribokinase homolog 0.0105 0.0774 0.1172
Entamoeba histolytica nucleoside transporter, putative 0.0101 0.0746 0.1585
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0395 0.3164 0.3164
Echinococcus granulosus tm gpcr rhodopsin 0.0395 0.3164 0.3164
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0582 0.4707 1
Trypanosoma cruzi nucleoside transporter 1, putative 0.0101 0.0746 0.0999
Echinococcus granulosus tm gpcr rhodopsin 0.0395 0.3164 0.3164
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0036 0.0036
Echinococcus multilocularis ribokinase 0.0105 0.0774 0.0774
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Trypanosoma cruzi ribokinase, putative 0.0105 0.0774 0.1037
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Toxoplasma gondii aspartyl protease ASP1 0.0059 0.0399 0.0535
Echinococcus granulosus biogenic amine 5HT receptor 0.0395 0.3164 0.3164
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.001
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0427 0.3427 0.4589
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.028 0.2216 0.2216
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0395 0.3164 0.4236
Onchocerca volvulus 0.0395 0.3164 0.4788
Echinococcus multilocularis neuropeptide receptor 0.0395 0.3164 0.3164
Echinococcus multilocularis rhodopsin orphan GPCR 0.0395 0.3164 0.3164
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Trypanosoma brucei adenosine kinase, putative 0.0918 0.7468 1
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0349
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0044 0.006
Schistosoma mansoni hypothetical protein 0.0395 0.3164 0.4236
Plasmodium falciparum plasmepsin IV 0.0059 0.0399 0.1165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.005
Brugia malayi hypothetical protein 0.0105 0.0774 0.1037
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0101 0.0746 0.0999
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0395 0.3164 0.4236
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0427 0.3427 0.4589
Echinococcus multilocularis geminin 0.0346 0.2763 0.2763
Toxoplasma gondii endonuclease IV APN 0.0079 0.0567 0.076
Leishmania major adenosine kinase-like protein 0.0105 0.0774 0.1037
Echinococcus multilocularis neuropeptide receptor 0.0395 0.3164 0.3164
Brugia malayi putative neuropeptide receptor NPR1 0.0395 0.3164 0.4236
Onchocerca volvulus Neuropeptide F receptor homolog 0.0395 0.3164 0.4788
Schistosoma mansoni growth hormone secretagogue receptor 0.0395 0.3164 0.4236
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0395 0.3164 0.4236
Brugia malayi hypothetical protein 0.0395 0.3164 0.4236
Toxoplasma gondii aspartyl protease 0.0014 0.0028 0.0038
Onchocerca volvulus 0.0395 0.3164 0.4788
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0036 0.0036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0007 0.0007
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0101 0.0746 0.1585
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0105 0.0774 0.2061
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0037 0.005
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0078 0.0552 0.0835
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0841 0.1126
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0841 0.1786
Echinococcus multilocularis fmrfamide receptor 0.0395 0.3164 0.3164
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0079 0.0567 0.076
Schistosoma mansoni hypothetical protein 0.0034 0.0196 0.0262
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0903 0.1209
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0395 0.3164 0.4236
Onchocerca volvulus 0.0052 0.0346 0.0523
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0395 0.3164 0.4236
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0427 0.3427 0.4589
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.049 0.0657
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0164 0.0349
Brugia malayi hypothetical protein 0.0014 0.0028 0.0038
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0044 0.006
Loa Loa (eye worm) hypothetical protein 0.0395 0.3164 0.4236
Echinococcus granulosus 7TM GPCR rhodopsin 0.0395 0.3164 0.3164
Plasmodium falciparum plasmepsin X 0.0014 0.0028 0.0083
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0395 0.3164 0.3164
Schistosoma mansoni amine GPCR 0.0395 0.3164 0.4236
Trichomonas vaginalis ribokinase, putative 0.0105 0.0774 0.1645
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0059
Schistosoma mansoni opsin-like receptor 0.0395 0.3164 0.4236

Activities

Activity type Activity value Assay description Source Reference
cLogP (ADMET) = 6.2 Partition coefficient of the compound ChEMBL. 10360745
IC50 (binding) = 22 nM Inhibitory activity against purified recombinant human renin ChEMBL. 10360745
IC50 (binding) = 22 nM Inhibitory activity against purified recombinant human renin ChEMBL. 10360745
IC50 (binding) = 1400 nM Inhibitory activity against human plasma renin ChEMBL. 10360745
IC50 (binding) = 1400 nM Inhibitory activity against human plasma renin ChEMBL. 10360745
Log Kw 0 Distribution coefficient of the compound was determined at pH 7.4; ND means not determined ChEMBL. 10360745
Ratio (binding) = 64 Ratio of IC50 against human plasma renin to that of purified recombinant human renin ChEMBL. 10360745
Ratio (binding) = 64 Ratio of IC50 against human plasma renin to that of purified recombinant human renin ChEMBL. 10360745

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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