TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 527.343 | Formula: C23H15Cl2F3N2O3S
H donors: 1 H acceptors: 3 LogP: 6.47 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(c(c1)Cn1c(cc2c1cccc2)C(=O)NS(=O)(=O)c1cccc(c1)C(F)(F)F)Cl
InChi: 1S/C23H15Cl2F3N2O3S/c24-17-8-9-19(25)15(10-17)13-30-20-7-2-1-4-14(20)11-21(30)22(31)29-34(32,33)18-6-3-5-16(12-18)23(26,27)28/h1-12H,13H2,(H,29,31)
InChiKey: VFLGTYZQDWVTJQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peroxisome proliferator-activated receptor gamma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	ecdysone induced protein 78C	peroxisome proliferator-activated receptor gamma	477 aa	447 aa	28.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0101	0.0113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.141	0.1585
Brugia malayi	Cathepsin L-like precursor	0.0126	0.141	0.1567
Brugia malayi	hypothetical protein	0.0256	0.4382	0.4868
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Entamoeba histolytica	cysteine proteinase, putative	0.0069	0.0101	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0452	0.8898	1
Loa Loa (eye worm)	hypothetical protein	0.0211	0.336	0.3733
Schistosoma mansoni	cathepsin F (C01 family)	0.0087	0.0517	0.0517
Trypanosoma cruzi	cysteine proteinase, putative	0.0069	0.0101	0.0113
Toxoplasma gondii	cathepsin CPL	0.0126	0.141	0.1585
Echinococcus granulosus	cathepsin L cysteine protease	0.0069	0.0101	0.0101
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0126	0.141	0.141
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0211	0.336	0.336
Entamoeba histolytica	cysteine proteinase, putative	0.0069	0.0101	0.0113
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0211	0.336	0.3776
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Onchocerca volvulus		0.0126	0.141	0.1052
Plasmodium vivax	hypothetical protein, conserved	0.0211	0.336	0.3776
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1161	0.1161
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0305	0.5525	0.6209
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Echinococcus multilocularis	cathepsin L cysteine protease	0.0126	0.141	0.141
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0452	0.8898	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Echinococcus granulosus	caspase 8	0.0211	0.336	0.336
Brugia malayi	Cathepsin L-like precursor	0.0126	0.141	0.1567
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0452	0.8898	0.8898
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0115	0.1161	0.1305
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0211	0.336	0.3776
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0452	0.8898	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0211	0.336	0.3776
Leishmania major	cathepsin L-like protease	0.0126	0.141	0.1585
Echinococcus granulosus	caspase 2	0.0457	0.9002	0.9002
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0126	0.141	0.1567
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0069	0.0101	0.0101
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.141	0.1585
Giardia lamblia	Cathepsin B precursor	0.0115	0.1161	0.1305
Loa Loa (eye worm)	hypothetical protein	0.0457	0.9002	1
Trypanosoma brucei	Metacaspase-4	0.0211	0.336	0.3776
Entamoeba histolytica	cysteine protease, putative	0.0126	0.141	0.1585
Trypanosoma cruzi	cysteine protease, putative	0.0069	0.0101	0.0113
Onchocerca volvulus		0.0126	0.141	0.1052
Plasmodium falciparum	metacaspase 1	0.0211	0.336	0.3776
Echinococcus granulosus	cathepsin b	0.0305	0.5525	0.5525
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0211	0.336	0.3776
Trypanosoma brucei	metacaspase	0.0211	0.336	0.3776
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.141	0.1585
Echinococcus granulosus	caspase 3	0.0289	0.5153	0.5153
Brugia malayi	Papain family cysteine protease containing protein	0.0069	0.0101	0.0112
Toxoplasma gondii	cathepsin B	0.0115	0.1161	0.1305
Echinococcus granulosus	proteasome prosome macropain	0.0452	0.8898	0.8898
Loa Loa (eye worm)	ctsf protein	0.0126	0.141	0.1567
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0126	0.141	0.1585
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Onchocerca volvulus	Cathepsin L homolog	0.0126	0.141	0.1052
Entamoeba histolytica	cysteine proteinase, putative	0.0069	0.0101	0.0113
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.141	0.1585
Echinococcus multilocularis	cathepsin L cysteine protease	0.0126	0.141	0.141
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0517	0.0575
Giardia lamblia	Cathepsin B precursor	0.0115	0.1161	0.1305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Trypanosoma cruzi	cysteine peptidase, putative	0.0126	0.141	0.1585
Brugia malayi	hypothetical protein	0.0246	0.4156	0.4616
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0069	0.0101	0.0113
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0211	0.336	0.3776
Entamoeba histolytica	cysteine proteinase, putative	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0126	0.141	0.1585
Echinococcus granulosus	cathepsin b	0.0305	0.5525	0.5525
Trypanosoma cruzi	cruzipain precursor, putative	0.0126	0.141	0.1585
Trypanosoma cruzi	metacaspase, putative	0.0211	0.336	0.3776
Loa Loa (eye worm)	fibroinase	0.0126	0.141	0.1567
Giardia lamblia	Cathepsin B precursor	0.0115	0.1161	0.1305
Schistosoma mansoni	cathepsin F (C01 family)	0.0126	0.141	0.141
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Echinococcus multilocularis	cathepsin L	0.0069	0.0101	0.0101
Entamoeba histolytica	cysteine proteinase, putative	0.0087	0.0517	0.0581
Plasmodium vivax	unspecified product	0.0069	0.0101	0.0113
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0069	0.0101	0.0101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Onchocerca volvulus		0.0126	0.141	0.1052
Mycobacterium ulcerans	proteasome PrcB	0.0452	0.8898	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Onchocerca volvulus		0.0126	0.141	0.1052
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0126	0.141	0.141
Leishmania major	cathepsin L-like protease	0.0126	0.141	0.1585
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0126	0.141	0.141
Brugia malayi	Cathepsin L-like precursor	0.0087	0.0517	0.0575
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Toxoplasma gondii	proteasome subunit beta type, putative	0.0452	0.8898	1
Brugia malayi	cathepsin L-like precursor	0.0087	0.0517	0.0575
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0087	0.0517	0.0581
Echinococcus multilocularis	cysteine protease	0.0126	0.141	0.141
Trypanosoma cruzi	metacaspase 5, putative	0.0211	0.336	0.3776
Plasmodium falciparum	proteasome subunit beta type-5	0.0452	0.8898	1
Entamoeba histolytica	cysteine proteinase, putative	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Echinococcus multilocularis	caspase 8	0.0211	0.336	0.336
Schistosoma mansoni	cathepsin F (C01 family)	0.0126	0.141	0.141
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0452	0.8898	0.9884
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.141	0.1585
Trypanosoma cruzi	metacaspase, putative	0.0211	0.336	0.3776
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0126	0.141	0.1585
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0452	0.8898	1
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0211	0.336	0.3733
Loa Loa (eye worm)	cysteine protease	0.0126	0.141	0.1567
Loa Loa (eye worm)	hypothetical protein	0.0246	0.4156	0.4616
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0101	0.0113
Leishmania major	cathepsin L-like protease	0.0126	0.141	0.1585
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0069	0.0101	0.0113
Brugia malayi	Proteasome A-type and B-type family protein	0.0452	0.8898	0.9884
Brugia malayi	cathepsin B-like cysteine proteinase	0.0305	0.5525	0.6137
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0211	0.336	0.3776
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0101	0.0113
Trypanosoma cruzi	cysteine proteinase, putative	0.0069	0.0101	0.0113
Echinococcus multilocularis	caspase 3	0.0289	0.5153	0.5153
Trypanosoma brucei	metacaspase MCA3	0.0211	0.336	0.3776
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Brugia malayi	Cathepsin L-like precursor	0.0126	0.141	0.1567
Entamoeba histolytica	cysteine proteinase, putative	0.0069	0.0101	0.0113
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0211	0.336	0.3776
Leishmania major	cathepsin L-like protease	0.0126	0.141	0.1585
Trypanosoma cruzi	metacaspase, putative	0.0211	0.336	0.3776
Onchocerca volvulus		0.0126	0.141	0.1052
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0115	0.1161	0.1305
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.141	0.1585
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0452	0.8898	0.8898
Schistosoma mansoni	caspase-7 (C14 family)	0.05	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0126	0.141	0.1567
Entamoeba histolytica	cysteine proteinase 1, putative	0.0069	0.0101	0.0113
Leishmania major	cathepsin L-like protease	0.0126	0.141	0.1585
Trichomonas vaginalis	conserved hypothetical protein	0.0211	0.336	0.3776
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.141	0.1585
Echinococcus multilocularis	caspase 2	0.0457	0.9002	0.9002
Plasmodium vivax	metacaspase 1, putative	0.0211	0.336	0.3776
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.05	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0211	0.336	0.3776
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0126	0.141	0.1567
Leishmania major	cathepsin L-like protease	0.0126	0.141	0.1585
Leishmania major	metacaspase, putative	0.0211	0.336	0.3776
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0305	0.5525	0.5525
Echinococcus granulosus	survival motor neuron protein 1	0.0256	0.4382	0.4382
Echinococcus granulosus	caspase	0.05	1	1
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Trypanosoma brucei	metacaspase MCA2	0.0211	0.336	0.3776
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0211	0.336	0.3776
Trypanosoma cruzi	metacaspase, putative	0.0211	0.336	0.3776
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Echinococcus multilocularis	cysteine protease	0.0126	0.141	0.141
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Echinococcus granulosus	cathepsin l1	0.0126	0.141	0.141
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0126	0.141	0.141
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0115	0.1161	0.1305
Echinococcus multilocularis	caspase	0.05	1	1
Plasmodium vivax	vivapain-2	0.0126	0.141	0.1585
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.5525	0.5525
Leishmania major	cysteine peptidase A (CPA)	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0517	0.0581
Brugia malayi	Papain family cysteine protease containing protein	0.0069	0.0101	0.0112
Leishmania major	proteasome beta 5 subunit, putative	0.0452	0.8898	1
Trichomonas vaginalis	conserved hypothetical protein	0.0211	0.336	0.3776
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0517	0.0575
Trichomonas vaginalis	conserved hypothetical protein	0.0211	0.336	0.3776
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.5525	0.5525
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0452	0.8898	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0101	0.0113
Brugia malayi	Cathepsin L-like precursor	0.0126	0.141	0.1567
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0211	0.336	0.3776
Plasmodium vivax	vivapain-3	0.0069	0.0101	0.0113
Leishmania major	cathepsin L-like protease	0.0126	0.141	0.1585
Echinococcus multilocularis	cathepsin b	0.0305	0.5525	0.5525
Loa Loa (eye worm)	hypothetical protein	0.0305	0.5525	0.6137
Echinococcus multilocularis	survival motor neuron protein 1	0.0256	0.4382	0.4382
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Echinococcus granulosus	cysteine protease	0.0069	0.0101	0.0101
Brugia malayi	Cathepsin L-like precursor	0.0126	0.141	0.1567
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Brugia malayi	Cell death protein 3 precursor	0.0457	0.9002	1
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0452	0.8898	0.5
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0087	0.0517	0.0575
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.141	0.1585
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.141	0.1585
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0452	0.8898	1
Plasmodium vivax	vivapain-1	0.0069	0.0101	0.0113
Onchocerca volvulus	Cell death protein 3 homolog	0.0457	0.9002	1
Onchocerca volvulus		0.0126	0.141	0.1052
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0211	0.336	0.3776
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0115	0.1161	0.1305
Schistosoma mansoni	hypothetical protein	0.0246	0.4156	0.4156
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0452	0.8898	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.141	0.1585
Plasmodium vivax	vivapain-2	0.0126	0.141	0.1585
Trypanosoma cruzi	cysteine peptidase, putative	0.0126	0.141	0.1585
Leishmania major	cathepsin L-like protease	0.0126	0.141	0.1585
Brugia malayi	Cathepsin L-like precursor	0.0126	0.141	0.1567
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0101	0.0113
Trichomonas vaginalis	conserved hypothetical protein	0.0211	0.336	0.3776
Onchocerca volvulus	Cathepsin F homolog	0.0126	0.141	0.1052
Trypanosoma cruzi	metacaspase 5, putative	0.0211	0.336	0.3776
Echinococcus granulosus	cathepsin L	0.0069	0.0101	0.0101
Echinococcus multilocularis	cathepsin b	0.0305	0.5525	0.5525
Loa Loa (eye worm)	hypothetical protein	0.0256	0.4382	0.4868
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0211	0.336	0.3776
Loa Loa (eye worm)	cathepsin B	0.0115	0.1161	0.129
Onchocerca volvulus	Cathepsin L homolog	0.0126	0.141	0.1052
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0452	0.8898	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0305	0.5525	0.5525
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0211	0.336	0.3776
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0126	0.141	0.1585
Echinococcus granulosus	apoptotic protease activating factor 1	0.0246	0.4156	0.4156
Trypanosoma cruzi	cysteine peptidase, putative	0.0126	0.141	0.1585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0517	0.0581
Onchocerca volvulus		0.0246	0.4156	0.4288
Onchocerca volvulus		0.0126	0.141	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0517	0.0575
Plasmodium falciparum	metacaspase-like protein	0.0211	0.336	0.3776
Schistosoma mansoni	caspase-3 (C14 family)	0.05	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0211	0.336	0.3776
Trypanosoma brucei	metacaspase 5, putative	0.0211	0.336	0.3776
Entamoeba histolytica	cysteine proteinase 2	0.0069	0.0101	0.0113
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0069	0.0101	0.0101
Echinococcus granulosus	cathepsin l1	0.0087	0.0517	0.0517
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.141	0.1585
Loa Loa (eye worm)	hypothetical protein	0.0126	0.141	0.1567
Trypanosoma cruzi	cysteine peptidase, putative	0.0126	0.141	0.1585
Brugia malayi	Cathepsin L-like precursor	0.0087	0.0517	0.0575
Schistosoma mansoni	caspase-7 (C14 family)	0.0457	0.9002	0.9002
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0246	0.4156	0.4156
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0101	0.0113

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 380 nM	Displacement of Fluormone from PPAR gamma	ChEMBL.	16919947
IC50 (binding)	= 380 nM	Displacement of Fluormone from PPAR gamma	ChEMBL.	16919947

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 412036