TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 412.378 | Formula: C20H20F4N2O3
H donors: 2 H acceptors: 1 LogP: 5.21 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1OC(F)(F)F)N[C@@H]1CC[C@@H](CC1)Oc1ccc(cc1)F
InChi: 1S/C20H20F4N2O3/c21-13-5-9-15(10-6-13)28-16-11-7-14(8-12-16)25-19(27)26-17-3-1-2-4-18(17)29-20(22,23)24/h1-6,9-10,14,16H,7-8,11-12H2,(H2,25,26,27)/t14-,16+
InChiKey: YQQSESYILPKSAI-FZNQNYSPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epoxide hydrolase 2, cytoplasmic	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	Get druggable targets OG5_129061	All targets in OG5_129061
Mycobacterium ulcerans	epoxide hydrolase EphA	Get druggable targets OG5_129061	All targets in OG5_129061

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0286	0.0286
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0034	0.0472	0.0472
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0286	0.0286
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0034	0.0472	0.0472
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0286	0.0286
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0034	0.0472	0.0472
Trypanosoma brucei	proteasome beta 7 subunit	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0286	0.0286
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0286	0.0286
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0034	0.0472	0.0385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0286	0.0286
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0449	1	1
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0034	0.0472	0.0472
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0286	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Loa Loa (eye worm)	PAS-3 protein	0.0034	0.0472	0.0385
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0286	0.0286
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0472	0.0472
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0449	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0286	0.0286
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0286	0.0286
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0034	0.0472	0.0472
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0286	0.0286
Echinococcus multilocularis	cysteine protease	0.0026	0.0286	0.0286
Leishmania major	proteasome alpha 2 subunit, putative	0.0034	0.0472	0.0192
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0034	0.0472	0.0472
Onchocerca volvulus		0.0026	0.0286	0.512
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0034	0.0472	0.0472
Onchocerca volvulus		0.0026	0.0286	0.512
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0034	0.0472	0.0472
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.0472	0.0472
Trypanosoma brucei	proteasome alpha 7 subunit	0.0034	0.0472	0.0472
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.0472	0.0472
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0034	0.0472	0.0192
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0034	0.0472	0.0192
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0472	0.0192
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0034	0.0472	0.0472
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0286	0.0286
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0286	0.0286
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0034	0.0472	0.0472
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.0472	0.0385
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.0472	0.0472
Brugia malayi	Proteasome subunit alpha type 7-1	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0034	0.0472	0.0472
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0472	0.0192
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0034	0.0472	0.0472
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0034	0.0472	0.0472
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0034	0.0472	0.0472
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0034	0.0472	0.0192
Leishmania major	proteasome beta 5 subunit, putative	0.0449	1	1
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	20S proteasome subunit	0.0034	0.0472	0.0472
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0034	0.0472	0.0192
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0034	0.0472	0.0472
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0286	0.512
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0449	1	1
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0034	0.0472	0.0472
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0034	0.0472	0.0472
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0034	0.0472	0.0472
Echinococcus granulosus	proteasome prosome macropain	0.0449	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0091	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0034	0.0472	0.0472
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0286	0.0197
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0034	0.0472	0.0385
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0034	0.0472	0.0472
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0091	0.0091
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0034	0.0472	0.0192
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0472	0.0472
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0286	0.0286
Echinococcus granulosus	cathepsin l1	0.0026	0.0286	0.0286
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.0472	0.0472
Leishmania major	proteasome alpha 1 subunit, putative	0.0034	0.0472	0.0192
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0034	0.0472	0.0472
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0472	0.0472
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0034	0.0472	0.0472
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0034	0.0472	0.0385
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0286	0.0286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0286	0.0286
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0034	0.0472	0.0472
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0472	0.0192
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0286	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Onchocerca volvulus		0.0026	0.0286	0.512
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0034	0.0472	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0286	0.0197
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0286	0.0286
Echinococcus granulosus	proteasome subunit alpha type 2	0.0034	0.0472	0.0472
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0034	0.0472	0.0385
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0034	0.0472	0.0472
Leishmania major	proteasome alpha 7 subunit, putative	0.0034	0.0472	0.0192
Brugia malayi	proteasome subunit beta type 2	0.0034	0.0472	0.0472
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0034	0.0472	0.0472
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0034	0.0472	0.0472
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0034	0.0472	0.0192
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.0472	0.0385
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0286	0.0286
Onchocerca volvulus		0.0026	0.0286	0.512
Brugia malayi	20S proteasome alpha5 subunit	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0472	0.0472
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0034	0.0472	0.0192
Leishmania major	proteasome beta-1 subunit, putative	0.0034	0.0472	0.0192
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0034	0.0472	0.0472
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0286	0.0286
Loa Loa (eye worm)	ctsf protein	0.0026	0.0286	0.0197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0091	0.0091
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0034	0.0472	0.0472
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0034	0.0472	0.0192
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0472	0.0472
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0034	0.0472	0.0472
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0197	0.4224	0.3938
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0286	0.0286
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0034	0.0472	0.0472
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0286	0.0286
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0034	0.0472	0.0472
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0034	0.0472	0.0472
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0286	0.0286
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0286	0.0286
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0034	0.0472	0.0472
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0472	0.0192
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0034	0.0472	0.0472
Onchocerca volvulus		0.0026	0.0286	0.512
Echinococcus multilocularis	cysteine protease	0.0026	0.0286	0.0286
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit beta type-4	0.0034	0.0472	0.0472
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0449	1	1
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.0472	0.0472
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.0472	0.0472
Brugia malayi	proteasome subunit alpha type 4	0.0034	0.0472	0.0472
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0034	0.0472	0.0472
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0034	0.0472	0.0192
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0034	0.0472	0.5
Toxoplasma gondii	peptidase, T1 family protein	0.0034	0.0472	0.0192
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0034	0.0472	0.0472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0286	0.0286
Echinococcus granulosus	proteasome subunit alpha type 6	0.0034	0.0472	0.0472
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0034	0.0472	0.0385
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0286	0.0286
Echinococcus granulosus	Proteasome subunit alpha beta	0.0034	0.0472	0.0472
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0034	0.0472	0.0472
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.0472	0.0472
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0286	0.0286
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0034	0.0472	0.0472
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0472	0.0192
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.0472	0.0385
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0286	0.0286
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0034	0.0472	0.0472
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0034	0.0472	0.0192
Brugia malayi	proteasome subunit alpha type 6	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0472	0.0472
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0034	0.0472	0.0472
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0034	0.0472	0.0472
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0286	0.512
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0034	0.0472	0.0472
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0449	1	1
Echinococcus granulosus	proteasome subunit beta type 7	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0286	0.0286
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0286	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0449	1	1
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0034	0.0472	0.0472
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0034	0.0472	0.0385
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0034	0.0472	0.0472
Brugia malayi	cathepsin L-like precursor	0.0017	0.0091	0.0091
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0034	0.0472	0.0472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0034	0.0472	0.0472
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0034	0.0472	0.0385
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0449	1	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0034	0.0472	0.0472
Brugia malayi	proteasome subunit beta type 1	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0034	0.0472	0.0472
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0286	0.0286
Onchocerca volvulus		0.0026	0.0286	0.512
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0034	0.0472	0.0472
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0034	0.0472	0.0472
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0286	0.0286
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0034	0.0472	0.0472
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0017	0.0091	0.0091
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0286	0.0286
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0034	0.0472	0.0472
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0034	0.0472	0.0385
Mycobacterium ulcerans	proteasome PrcB	0.0449	1	1
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0034	0.0472	0.0472
Echinococcus multilocularis	proteasome subunit beta type 7	0.0034	0.0472	0.0472
Leishmania major	proteasome alpha 7 subunit, putative	0.0034	0.0472	0.0192
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0091	0.0091
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0449	1	1
Loa Loa (eye worm)	fibroinase	0.0026	0.0286	0.0197
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0034	0.0472	0.0472
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0034	0.0472	0.0472
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0286	0.512
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0034	0.0472	0.0472
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit beta type-5	0.0449	1	1
Brugia malayi	proteasome subunit alpha type 2	0.0034	0.0472	0.0472
Echinococcus granulosus	cathepsin l1	0.0017	0.0091	0.0091
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0034	0.0472	0.0472
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0197	0.4224	0.3938
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0091	0.0091
Onchocerca volvulus		0.0026	0.0286	0.512
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0034	0.0472	0.0472
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0286	0.0197
Leishmania major	proteasome alpha 3 subunit, putative	0.0034	0.0472	0.0192
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0034	0.0472	0.0472
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0034	0.0472	0.0472
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.0472	0.0472
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0034	0.0472	0.0472
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0286	0.0286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Brugia malayi	proteasome subunit beta type 3	0.0034	0.0472	0.0472
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0449	1	1
Brugia malayi	proteasome subunit alpha type 1	0.0034	0.0472	0.0472
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0034	0.0472	0.0472
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0472	0.0472
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0034	0.0472	0.0472
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0034	0.0472	0.0472
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0034	0.0472	0.0472
Trypanosoma brucei	proteasome beta 6 subunit	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0034	0.0472	0.0472
Brugia malayi	Proteasome subunit alpha type 1	0.0034	0.0472	0.0472
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0034	0.0472	0.0472
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0449	1	1
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0034	0.0472	0.0192
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Leishmania major	proteasome beta 2 subunit, putative	0.0034	0.0472	0.0192
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0286	0.0286
Echinococcus multilocularis	proteasome subunit beta type 6	0.0034	0.0472	0.0472
Toxoplasma gondii	proteasome subunit	0.0034	0.0472	0.0192
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0034	0.0472	0.0472
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0472	0.0472
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0034	0.0472	0.0472
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0034	0.0472	0.0472
Echinococcus granulosus	proteasome subunit beta t family	0.0034	0.0472	0.0472
Leishmania major	proteasome beta 2 subunit, putative	0.0034	0.0472	0.0192
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0472	0.0472
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0286	0.0286
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0034	0.0472	0.0472
Loa Loa (eye worm)	cysteine protease	0.0026	0.0286	0.0197
Toxoplasma gondii	proteasome subunit beta type, putative	0.0449	1	1
Onchocerca volvulus	Notchless protein homolog	0.0034	0.0472	1
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0034	0.0472	0.0472
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0472	0.0192
Plasmodium vivax	vivapain-2	0.0026	0.0286	0.0286
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0449	1	1
Toxoplasma gondii	heat shock protein hslv, putative	0.0034	0.0472	0.0192
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.0472	0.0472
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0449	1	1
Plasmodium vivax	vivapain-2	0.0026	0.0286	0.0286
Echinococcus granulosus	proteasome subunit beta type 6	0.0034	0.0472	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0286	0.0286
Leishmania major	proteasome beta 7 subunit, putative	0.0034	0.0472	0.0192
Brugia malayi	proteasome subunit alpha type 3	0.0034	0.0472	0.0472
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0034	0.0472	0.0472
Leishmania major	proteasome alpha 1 subunit, putative	0.0034	0.0472	0.0192
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0034	0.0472	0.0472
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0034	0.0472	0.0472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0091	0.0091
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0034	0.0472	0.0192
Leishmania major	proteasome beta 3 subunit, putative	0.0034	0.0472	0.0192
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0034	0.0472	0.0472
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0034	0.0472	0.0385
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0286	0.0286
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.0472	0.0472
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0017	0.0091	0.0091
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286
Toxoplasma gondii	proteasome beta subunit	0.0034	0.0472	0.0192
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0286	0.0286

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 100 nM	Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay	ChEMBL.	16949285
IC50 (binding)	= 100 nM	Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay	ChEMBL.	16949285
Inhibition (binding)	= 2 %	Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay	ChEMBL.	16949285
Inhibition (binding)	= 2 %	Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay	ChEMBL.	16949285

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL426555

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 412077