Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 0.5 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 0.5 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 0 uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Escherichia coli | ChEMBL. | 14695838 |
I50 (binding) | = 0.00024 uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu | ChEMBL. | 14695838 |
I50 (binding) | = 0.026 uM l-1 | Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans | ChEMBL. | 14695838 |
I50 (binding) | = 0.084 uM l-1 | Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat | ChEMBL. | 14695838 |
IC50 (binding) | = uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Escherichia coli | ChEMBL. | 14695838 |
IC50 (binding) | = 0.00024 uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu | ChEMBL. | 14695838 |
IC50 (binding) | = 0.026 uM l-1 | Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans | ChEMBL. | 14695838 |
IC50 (binding) | = 0.08400000000000002 uM l-1 | Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat | ChEMBL. | 14695838 |
Ki (binding) | = 9.31 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
Log Ki (binding) | = 9.31 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
MIC (functional) | = 1 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM12 Strain | ChEMBL. | 14695838 |
MIC (functional) | = 1 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM27 quad deletion Strain | ChEMBL. | 14695838 |
MIC (functional) | = 1 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM12 Strain | ChEMBL. | 14695838 |
MIC (functional) | = 1 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM27 quad deletion Strain | ChEMBL. | 14695838 |
MIC (functional) | = 4 ug ml-1 | Inhibitory effect of the compound on Candida glabrata YEM75 WT Strain | ChEMBL. | 14695838 |
MIC (functional) | = 4 ug ml-1 | Inhibitory effect of the compound on Candida glabrata YEM216 pCDR1pCDR2pBEN YEM75 WT Strain | ChEMBL. | 14695838 |
MIC (functional) | = 32 ug ml-1 | Inhibitory effect of the compound on Candida albicans wild type YEM30 Strain | ChEMBL. | 14695838 |
MIC (functional) | = 32 ug ml-1 | Inhibitory effect of the compound on Candida glabrata YEM88 CgCDR1 CgCDR2up Strain | ChEMBL. | 14695838 |
MIC (functional) | = 32 ug ml-1 | Inhibitory effect of the compound on Candida albicans wild type YEM30 Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM13 BENup Strain | ChEMBL. | 14695838 |
MIC (functional) | = 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans wild type YEM14 Strain | ChEMBL. | 14695838 |
MIC (functional) | = 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM15 CDR1CDR2up Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM13 BENup Strain | ChEMBL. | 14695838 |
MIC (functional) | = 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans wild type YEM14 Strain | ChEMBL. | 14695838 |
MIC (functional) | = 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM15 CDR1CDR2up Strain | ChEMBL. | 14695838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.