TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.459 | Formula: C22H18FN3O4S
H donors: 2 H acceptors: 4 LogP: 3.93 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Cn1c(=O)c(C(=O)NCc2ccc(cc2)F)c(c2c1scn2)O
InChi: 1S/C22H18FN3O4S/c1-30-16-8-4-14(5-9-16)11-26-21(29)17(19(27)18-22(26)31-12-25-18)20(28)24-10-13-2-6-15(23)7-3-13/h2-9,12,27H,10-11H2,1H3,(H,24,28)
InChiKey: LYUYNFHPPKZKGN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Proteasome subunit alpha beta	0.0024	0.0419	0.0419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Entamoeba histolytica	cysteine protease, putative	0.0022	0.034	0.034
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0024	0.0419	0.0419
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0024	0.0419	0.0419
Toxoplasma gondii	peptidase, T1 family protein	0.0024	0.0419	0.0082
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Brugia malayi	proteasome subunit alpha type 3	0.0024	0.0419	0.0419
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0024	0.0419	0.5
Plasmodium falciparum	proteasome subunit beta type-5	0.0319	1	1
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0024	0.0419	0.0419
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0024	0.0419	0.0419
Leishmania major	proteasome alpha 3 subunit, putative	0.0024	0.0419	0.0082
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0024	0.0419	0.0419
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0024	0.0419	0.0419
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0108	0.0108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0024	0.0419	0.0419
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0024	0.0419	0.0419
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0024	0.0419	0.0082
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.034	0.034
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0014	0.0108	0.0108
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0024	0.0419	0.0419
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0024	0.0419	0.0419
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0024	0.0419	0.0419
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0024	0.0419	0.0082
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.034	0.034
Echinococcus multilocularis	proteasome subunit beta type 6	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0024	0.0419	0.0419
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0024	0.0419	0.0419
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0024	0.0419	0.0419
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0319	1	1
Brugia malayi	20S proteasome alpha5 subunit	0.0024	0.0419	0.0419
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0024	0.0419	0.0419
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0024	0.0419	0.0419
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0319	1	1
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0024	0.0419	0.0315
Brugia malayi	Cathepsin L-like precursor	0.0022	0.034	0.034
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0024	0.0419	0.0419
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0024	0.0419	0.0082
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0319	1	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0024	0.0419	0.0419
Brugia malayi	Cathepsin L-like precursor	0.0022	0.034	0.034
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0319	1	1
Toxoplasma gondii	heat shock protein hslv, putative	0.0024	0.0419	0.0082
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0024	0.0419	0.0419
Leishmania major	proteasome beta 2 subunit, putative	0.0024	0.0419	0.0082
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.034	0.034
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0024	0.0419	0.0419
Echinococcus granulosus	proteasome subunit beta t family	0.0024	0.0419	0.0419
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0024	0.0419	0.0419
Brugia malayi	proteasome subunit beta type 3	0.0024	0.0419	0.0419
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0024	0.0419	0.0419
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0024	0.0419	0.0315
Brugia malayi	Cathepsin L-like precursor	0.0022	0.034	0.034
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0022	0.034	0.0235
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0024	0.0419	0.0082
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0024	0.0419	0.0419
Brugia malayi	proteasome subunit alpha type 2	0.0024	0.0419	0.0419
Leishmania major	proteasome alpha 1 subunit, putative	0.0024	0.0419	0.0082
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0024	0.0419	0.0419
Echinococcus granulosus	proteasome subunit beta type 6	0.0024	0.0419	0.0419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Loa Loa (eye worm)	hypothetical protein	0.0022	0.034	0.0235
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0024	0.0419	0.0419
Entamoeba histolytica	cysteine proteinase, putative	0.0014	0.0108	0.0108
Trypanosoma cruzi	20S proteasome subunit	0.0024	0.0419	0.0419
Leishmania major	proteasome beta 3 subunit, putative	0.0024	0.0419	0.0082
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0024	0.0419	0.0419
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.034	0.034
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.034	0.7454
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0024	0.0419	0.0419
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0024	0.0419	0.0419
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0024	0.0419	0.0419
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0024	0.0419	0.0419
Plasmodium falciparum	proteasome subunit beta type-4	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0024	0.0419	0.0419
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.034	0.034
Mycobacterium ulcerans	proteasome PrcB	0.0319	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Brugia malayi	Cathepsin L-like precursor	0.0022	0.034	0.034
Brugia malayi	proteasome subunit alpha type 6	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0024	0.0419	0.0419
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0024	0.0419	0.0419
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0024	0.0419	0.0419
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0024	0.0419	0.0082
Brugia malayi	Proteasome A-type and B-type family protein	0.0024	0.0419	0.0419
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0024	0.0419	0.0419
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0024	0.0419	0.0419
Brugia malayi	proteasome subunit beta type 1	0.0024	0.0419	0.0419
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0024	0.0419	0.0419
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0024	0.0419	0.0419
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0024	0.0419	0.0419
Brugia malayi	proteasome subunit alpha type 4	0.0024	0.0419	0.0419
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0024	0.0419	0.0419
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0024	0.0419	0.0419
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.034	0.0235
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.034	0.034
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0319	1	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0024	0.0419	0.0419
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0024	0.0419	0.0315
Onchocerca volvulus	Cathepsin F homolog	0.0022	0.034	0.7454
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0024	0.0419	0.0419
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.034	0.034
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0024	0.0419	0.0419
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0024	0.0419	0.0419
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.034	0.034
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0024	0.0419	0.0419
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0024	0.0419	0.0082
Trypanosoma brucei	proteasome alpha 7 subunit	0.0024	0.0419	0.0419
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0024	0.0419	0.0315
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0024	0.0419	0.0419
Echinococcus granulosus	cathepsin l1	0.0014	0.0108	0.0108
Loa Loa (eye worm)	PAS-3 protein	0.0024	0.0419	0.0315
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0024	0.0419	0.0419
Echinococcus granulosus	proteasome prosome macropain	0.0319	1	1
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0024	0.0419	0.0419
Onchocerca volvulus		0.0022	0.034	0.7454
Plasmodium vivax	vivapain-2	0.0022	0.034	0.034
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0024	0.0419	0.0419
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.034	0.034
Leishmania major	proteasome beta 5 subunit, putative	0.0319	1	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0024	0.0419	0.0419
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0024	0.0419	0.0082
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0024	0.0419	0.0419
Echinococcus granulosus	proteasome subunit beta type 7	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Echinococcus multilocularis	cysteine protease	0.0022	0.034	0.034
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0319	1	1
Loa Loa (eye worm)	fibroinase	0.0022	0.034	0.0235
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0024	0.0419	0.0419
Leishmania major	proteasome alpha 7 subunit, putative	0.0024	0.0419	0.0082
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0108	0.0108
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0024	0.0419	0.0419
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0024	0.0419	0.0419
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0108	0.0108
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0024	0.0419	0.0082
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0024	0.0419	0.0419
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0319	1	1
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0024	0.0419	0.0419
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0024	0.0419	0.0419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Brugia malayi	cathepsin L-like precursor	0.0014	0.0108	0.0108
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0022	0.034	0.034
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0024	0.0419	0.0419
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.034	0.034
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0024	0.0419	0.0419
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0319	1	1
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0024	0.0419	0.0419
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0024	0.0419	0.0419
Onchocerca volvulus	Notchless protein homolog	0.0024	0.0419	1
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0024	0.0419	0.0315
Leishmania major	proteasome alpha 1 subunit, putative	0.0024	0.0419	0.0082
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0024	0.0419	0.0419
Echinococcus multilocularis	proteasome subunit beta type 7	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0024	0.0419	0.0419
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0024	0.0419	0.0419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0024	0.0419	0.0315
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0024	0.0419	0.0082
Brugia malayi	Proteasome A-type and B-type family protein	0.0024	0.0419	0.0419
Toxoplasma gondii	proteasome beta subunit	0.0024	0.0419	0.0082
Onchocerca volvulus		0.0022	0.034	0.7454
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0024	0.0419	0.0419
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0024	0.0419	0.0315
Schistosoma mansoni	cathepsin F (C01 family)	0.0014	0.0108	0.0108
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0319	1	1
Onchocerca volvulus		0.0022	0.034	0.7454
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.034	0.034
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0024	0.0419	0.0419
Brugia malayi	Cathepsin L-like precursor	0.0022	0.034	0.034
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0024	0.0419	0.0419
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0022	0.034	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0024	0.0419	0.0082
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0024	0.0419	0.0419
Echinococcus granulosus	proteasome subunit alpha type 2	0.0024	0.0419	0.0419
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0024	0.0419	0.0315
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.034	0.034
Brugia malayi	proteasome subunit alpha type 1	0.0024	0.0419	0.0419
Leishmania major	proteasome alpha 7 subunit, putative	0.0024	0.0419	0.0082
Brugia malayi	proteasome subunit beta type 2	0.0024	0.0419	0.0419
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0024	0.0419	0.0419
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0024	0.0419	0.0419
Loa Loa (eye worm)	cysteine protease	0.0022	0.034	0.0235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0022	0.034	0.034
Onchocerca volvulus		0.0022	0.034	0.7454
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0024	0.0419	0.0419
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0024	0.0419	0.0419
Leishmania major	proteasome beta 2 subunit, putative	0.0024	0.0419	0.0082
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0024	0.0419	0.0419
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0024	0.0419	0.0419
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	0.034	0.034
Loa Loa (eye worm)	ctsf protein	0.0022	0.034	0.0235
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0014	0.0108	0.0108
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0024	0.0419	0.0419
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0024	0.0419	0.0419
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0024	0.0419	0.0419
Leishmania major	proteasome alpha 2 subunit, putative	0.0024	0.0419	0.0082
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.034	0.034
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0024	0.0419	0.0419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Brugia malayi	Proteasome A-type and B-type family protein	0.0024	0.0419	0.0419
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0024	0.0419	0.0315
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0108	0.0108
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0024	0.0419	0.0419
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0024	0.0419	0.0419
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0024	0.0419	0.0082
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0024	0.0419	0.0082
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Echinococcus granulosus	proteasome subunit alpha type 6	0.0024	0.0419	0.0419
Brugia malayi	Proteasome subunit alpha type 7-1	0.0024	0.0419	0.0419
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0024	0.0419	0.0419
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0024	0.0419	0.0419
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0024	0.0419	0.0419
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0024	0.0419	0.0419
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.034	0.034
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0024	0.0419	0.0419
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0024	0.0419	0.0419
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.034	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0024	0.0419	0.0315
Brugia malayi	Cathepsin L-like precursor	0.0022	0.034	0.034
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0024	0.0419	0.0419
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0024	0.0419	0.0082
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0022	0.034	0.034
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0024	0.0419	0.0419
Echinococcus granulosus	cathepsin l1	0.0022	0.034	0.034
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0024	0.0419	0.0315
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0319	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.034	0.034
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0024	0.0419	0.0419
Onchocerca volvulus		0.0022	0.034	0.7454
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0024	0.0419	0.0419
Leishmania major	proteasome beta-1 subunit, putative	0.0024	0.0419	0.0082
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.034	0.034
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.034	0.034
Onchocerca volvulus		0.0022	0.034	0.7454
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.034	0.034
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0022	0.034	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.034	0.034
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0024	0.0419	0.0082
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0024	0.0419	0.0419
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0024	0.0419	0.0419
Toxoplasma gondii	proteasome subunit beta type, putative	0.0319	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.034	0.034
Plasmodium vivax	vivapain-2	0.0022	0.034	0.034
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0024	0.0419	0.0419
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0024	0.0419	0.0419
Leishmania major	proteasome beta 7 subunit, putative	0.0024	0.0419	0.0082
Brugia malayi	Proteasome subunit alpha type 1	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.034	0.034
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.034	0.034
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0024	0.0419	0.0082
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0024	0.0419	0.0419
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0024	0.0419	0.0419
Onchocerca volvulus		0.0022	0.034	0.7454
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0024	0.0419	0.0315
Echinococcus multilocularis	cysteine protease	0.0022	0.034	0.034
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0024	0.0419	0.0419
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.034	0.034
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0024	0.0419	0.0419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.034	0.034
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0319	1	1
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0319	1	1
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0024	0.0419	0.0419
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.034	0.7454
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0024	0.0419	0.0082
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0024	0.0419	0.0419
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0024	0.0419	0.0419
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0024	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.034	0.034
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0024	0.0419	0.0419
Trypanosoma brucei	proteasome beta 6 subunit	0.0024	0.0419	0.0419
Toxoplasma gondii	proteasome subunit	0.0024	0.0419	0.0082
Trypanosoma brucei	proteasome beta 7 subunit	0.0024	0.0419	0.0419
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0024	0.0419	0.0419
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0024	0.0419	0.0419
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0024	0.0419	0.0082
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0024	0.0419	0.0419
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0024	0.0419	0.0082
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0024	0.0419	0.0419
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0024	0.0419	0.0419

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4 uM	Inhibition of recombinant HIV integrase strand transfer activity	ChEMBL.	16908139

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 412120