TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 347.364 | Formula: C16H14FN3O3S
H donors: 2 H acceptors: 4 LogP: 2.83 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCn1c(=O)c(C(=O)NCc2ccc(cc2)F)c(c2c1scn2)O
InChi: 1S/C16H14FN3O3S/c1-2-20-15(23)11(13(21)12-16(20)24-8-19-12)14(22)18-7-9-3-5-10(17)6-4-9/h3-6,8,21H,2,7H2,1H3,(H,18,22)
InChiKey: ITUWCZMJNMOGDN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.006	0.0085	0.0085
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.006	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0204	0.0204
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.006	0.0085	0.0085
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit beta type-7, putative	0.006	0.0085	0.0085
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.006	0.0085	0.0085
Echinococcus multilocularis	cathepsin b	0.029	0.3526	0.3526
Giardia lamblia	Cathepsin B precursor	0.0107	0.0788	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.006	0.0085	0.0085
Brugia malayi	cathepsin B-like cysteine proteinase	0.029	0.3526	0.3526
Brugia malayi	Proteasome subunit alpha type 1	0.006	0.0085	0.0085
Trypanosoma cruzi	cysteine peptidase, putative	0.0097	0.0642	0.0642
Onchocerca volvulus	Cathepsin L homolog	0.0097	0.0642	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0724	1	1
Leishmania major	cathepsin L-like protease	0.0097	0.0642	0.0562
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.006	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0097	0.0642	0.0642
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0724	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.006	0.0085	0.0085
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.006	0.0085	0.0085
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0724	1	1
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.006	0.0085	0.0085
Entamoeba histolytica	cysteine proteinase, putative	0.0097	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Entamoeba histolytica	cysteine proteinase, putative	0.0097	0.0642	0.0642
Brugia malayi	proteasome subunit alpha type 2	0.006	0.0085	0.0085
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0083	0.044	0.044
Leishmania major	cathepsin L-like protease	0.0097	0.0642	0.0562
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.006	0.0085	0.0085
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.006	0.0085	0.0085
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0097	0.0642	0.0642
Loa Loa (eye worm)	cysteine protease	0.0097	0.0642	0.0562
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.006	0.0085	0.0085
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0097	0.0642	0.0642
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0083	0.044	0.044
Plasmodium falciparum	proteasome subunit beta type-4	0.006	0.0085	0.0085
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0097	0.0642	0.0642
Brugia malayi	Cathepsin L-like precursor	0.0097	0.0642	0.0642
Plasmodium vivax	vivapain-2	0.0097	0.0642	0.0642
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.006	0.0085	0.0085
Loa Loa (eye worm)	ctsf protein	0.0097	0.0642	0.0562
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.006	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.006	0.0085	0.0085
Echinococcus granulosus	proteasome subunit beta type 6	0.006	0.0085	0.0085
Toxoplasma gondii	proteasome subunit beta type, putative	0.0724	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0642	0.0642
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.006	0.0085	0.0085
Echinococcus granulosus	Proteasome subunit alpha beta	0.006	0.0085	0.0085
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.006	0.0085	0.0085
Brugia malayi	Proteasome A-type and B-type family protein	0.006	0.0085	0.0085
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.006	0.0085	0.0085
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.006	0.0085	0.0085
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0083	0.044	0.044
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.006	0.0085	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0724	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0204	0.0204
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0083	0.044	0.044
Trypanosoma brucei	proteasome alpha 7 subunit	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit beta type-6, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	cysteine peptidase, putative	0.0097	0.0642	0.0642
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.006	0.0085	0.0085
Brugia malayi	proteasome subunit beta type 2	0.0083	0.044	0.044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0724	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.029	0.3526	0.3526
Echinococcus granulosus	proteasome prosome macropain	0.0724	1	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0204	0.012
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.006	0.0085	0.0085
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0107	0.0788	0.0788
Echinococcus multilocularis	proteasome subunit beta type 7	0.006	0.0085	0.0085
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.006	0.0085	0.0085
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.006	0.0085	0.0085
Onchocerca volvulus	Cathepsin L homolog	0.0097	0.0642	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0204	0.012
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit beta type-4, putative	0.006	0.0085	0.0085
Toxoplasma gondii	cathepsin CPL	0.0097	0.0642	0.0562
Giardia lamblia	Cathepsin B precursor	0.0107	0.0788	0.0709
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.006	0.0085	0.0085
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0724	1	1
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.006	0.0085	0.0085
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.006	0.0085	0.0085
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0083	0.044	0.0359
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.006	0.0085	0.0085
Echinococcus multilocularis	cathepsin L cysteine protease	0.0097	0.0642	0.0642
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.006	0.0085	0.0085
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	cysteine peptidase, putative	0.0097	0.0642	0.0642
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.006	0.0085	0.0085
Echinococcus granulosus	cathepsin b	0.029	0.3526	0.3526
Echinococcus multilocularis	proteasome subunit beta type 6	0.006	0.0085	0.0085
Onchocerca volvulus		0.0097	0.0642	1
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.006	0.0085	0.0085
Echinococcus multilocularis	survival motor neuron protein 1	0.0241	0.279	0.279
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.006	0.0085	0.0085
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.006	0.0085	0.0085
Echinococcus granulosus	proteasome subunit alpha type 6	0.006	0.0085	0.0085
Brugia malayi	proteasome subunit alpha type 3	0.006	0.0085	0.0085
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.006	0.0085	0.0085
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.006	0.0085	0.0085
Echinococcus granulosus	cathepsin l1	0.0068	0.0204	0.0204
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.006	0.0085	0.0085
Giardia lamblia	Cathepsin B precursor	0.0107	0.0788	0.0709
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0097	0.0642	0.0562
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.006	0.0085	0.0085
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.006	0.0085	0.0085
Toxoplasma gondii	cathepsin B	0.0107	0.0788	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.006	0.0085	0.0085
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0097	0.0642	0.0562
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.006	0.0085	0.0085
Entamoeba histolytica	cysteine protease, putative	0.0097	0.0642	0.0642
Echinococcus multilocularis	cysteine protease	0.0097	0.0642	0.0642
Onchocerca volvulus		0.0097	0.0642	1
Trypanosoma brucei	proteasome beta 6 subunit	0.006	0.0085	0.0085
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.006	0.0085	0.0085
Trypanosoma cruzi	20S proteasome subunit	0.0083	0.044	0.044
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.006	0.0085	0.0085
Leishmania major	cathepsin L-like protease	0.0097	0.0642	0.0562
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.006	0.0085	0.0085
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0097	0.0642	0.0642
Echinococcus multilocularis	proteasome subunit alpha type 6	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.006	0.0085	0.0085
Leishmania major	cathepsin L-like protease	0.0097	0.0642	0.0562
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0083	0.044	0.044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0642	0.0642
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.006	0.0085	0.0085
Echinococcus granulosus	Proteasome subunit alpha type 7	0.006	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0642	0.0562
Schistosoma mansoni	cathepsin F (C01 family)	0.0097	0.0642	0.0642
Trypanosoma brucei	proteasome beta 7 subunit	0.006	0.0085	0.0085
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0204	0.0204
Echinococcus granulosus	cathepsin b	0.029	0.3526	0.3526
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.006	0.0085	0.0085
Schistosoma mansoni	cathepsin F (C01 family)	0.0097	0.0642	0.0642
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.006	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0642	0.0642
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0724	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0097	0.0642	1
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.006	0.0085	0.0085
Onchocerca volvulus		0.0068	0.0204	0.2142
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.006	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0097	0.0642	0.0642
Leishmania major	proteasome beta 2 subunit, putative	0.0083	0.044	0.0359
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0068	0.0204	0.0204
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.006	0.0085	0.0085
Echinococcus granulosus	proteasome subunit beta t family	0.006	0.0085	0.0085
Brugia malayi	Cathepsin L-like precursor	0.0097	0.0642	0.0642
Echinococcus multilocularis	cathepsin b	0.029	0.3526	0.3526
Leishmania major	proteasome beta 5 subunit, putative	0.0724	1	1
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.006	0.0085	0.0085
Brugia malayi	cathepsin L-like precursor	0.0068	0.0204	0.0204
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0097	0.0642	0.0642
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.006	0.0085	0.0085
Giardia lamblia	Proteasome subunit beta type 2	0.0083	0.044	0.0359
Brugia malayi	proteasome subunit alpha type 1	0.006	0.0085	0.0085
Plasmodium falciparum	proteasome subunit beta type-5	0.0724	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.006	0.0085	0.0085
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0083	0.044	0.044
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0068	0.0204	0.0204
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.006	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0642	0.0642
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.006	0.0085	0.0085
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0083	0.044	0.0359
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0083	0.044	0.044
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0097	0.0642	0.0642
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit beta type-1, putative	0.006	0.0085	0.0085
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0083	0.044	0.044
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0107	0.0788	0.0788
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.006	0.0085	0.0085
Onchocerca volvulus		0.0097	0.0642	1
Brugia malayi	proteasome subunit beta type 1	0.006	0.0085	0.0085
Loa Loa (eye worm)	cathepsin B	0.0107	0.0788	0.0709
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.006	0.0085	0.0085
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.006	0.0085	0.0085
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0724	1	1
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.006	0.0085	0.0085
Echinococcus multilocularis	cysteine protease	0.0097	0.0642	0.0642
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.006	0.0085	0.0085
Echinococcus granulosus	proteasome subunit alpha type 2	0.006	0.0085	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.006	0.0085	0.0085
Brugia malayi	Cathepsin L-like precursor	0.0097	0.0642	0.0642
Plasmodium vivax	vivapain-2	0.0097	0.0642	0.0642
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.006	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Brugia malayi	hypothetical protein	0.0241	0.279	0.279
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.006	0.0085	0.0085
Echinococcus granulosus	cathepsin l1	0.0097	0.0642	0.0642
Leishmania major	cathepsin L-like protease	0.0097	0.0642	0.0562
Echinococcus granulosus	20S proteasome subunit alpha 6	0.006	0.0085	0.0085
Echinococcus granulosus	proteasome subunit beta type 7	0.006	0.0085	0.0085
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0097	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0241	0.279	0.2728
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.006	0.0085	0.0085
Leishmania major	cysteine peptidase A (CPA)	0.0097	0.0642	0.0562
Trypanosoma cruzi	cysteine peptidase, putative	0.0097	0.0642	0.0642
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0107	0.0788	0.0788
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0107	0.0788	0.0709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.006	0.0085	0.0085
Onchocerca volvulus		0.0097	0.0642	1
Echinococcus multilocularis	proteasome subunit alpha type 2	0.006	0.0085	0.0085
Brugia malayi	Cathepsin L-like precursor	0.0097	0.0642	0.0642
Echinococcus granulosus	subfamily T1A non peptidase ue	0.006	0.0085	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Brugia malayi	Cathepsin L-like precursor	0.0097	0.0642	0.0642
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.006	0.0085	0.0085
Mycobacterium ulcerans	proteasome PrcB	0.0724	1	1
Leishmania major	cathepsin L-like protease	0.0097	0.0642	0.0562
Brugia malayi	Proteasome subunit alpha type 7-1	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.006	0.0085	0.0085
Brugia malayi	20S proteasome alpha5 subunit	0.006	0.0085	0.0085
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0204	0.0204
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.006	0.0085	0.0085
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0724	1	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.006	0.0085	0.5
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.006	0.0085	0.0085
Brugia malayi	Cathepsin L-like precursor	0.0097	0.0642	0.0642
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.006	0.0085	0.0085
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0724	1	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.006	0.0085	0.0085
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0083	0.044	0.044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0642	0.0642
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.006	0.0085	0.0085
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.0204	0.0204
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.029	0.3526	0.3526
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.006	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0204	0.012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.006	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.029	0.3526	0.3471
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0724	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0068	0.0204	0.0204
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0083	0.044	0.044
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.006	0.0085	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Echinococcus multilocularis	cathepsin L cysteine protease	0.0097	0.0642	0.0642
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0097	0.0642	0.0642
Brugia malayi	proteasome subunit alpha type 4	0.006	0.0085	0.0085
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.006	0.0085	0.0085
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.006	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0642	0.0642
Onchocerca volvulus		0.0097	0.0642	1
Echinococcus granulosus	survival motor neuron protein 1	0.0241	0.279	0.279
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0642	0.0642
Brugia malayi	proteasome subunit beta type 3	0.006	0.0085	0.0085
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.029	0.3526	0.3526
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.006	0.0085	0.0085
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.006	0.0085	0.0085
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.006	0.0085	0.0085
Loa Loa (eye worm)	fibroinase	0.0097	0.0642	0.0562
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0724	1	1
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.006	0.0085	0.0085
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.029	0.3526	0.3526
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.006	0.0085	0.0085
Onchocerca volvulus		0.0097	0.0642	1
Plasmodium vivax	proteasome subunit beta type-3, putative	0.006	0.0085	0.0085
Brugia malayi	Proteasome A-type and B-type family protein	0.006	0.0085	0.0085
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.006	0.0085	0.0085
Leishmania major	cathepsin L-like protease	0.0097	0.0642	0.0562
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0083	0.044	0.044
Brugia malayi	Proteasome A-type and B-type family protein	0.006	0.0085	0.0085
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.006	0.0085	0.0085
Leishmania major	cathepsin L-like protease	0.0097	0.0642	0.0562
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0107	0.0788	0.0788
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.006	0.0085	0.0085
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.006	0.0085	0.0085
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.006	0.0085	0.0085
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.006	0.0085	0.0085
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.006	0.0085	0.0085
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.029	0.3526	0.3526
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	cruzipain precursor, putative	0.0097	0.0642	0.0642
Brugia malayi	proteasome subunit alpha type 6	0.006	0.0085	0.0085
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0642	0.0642
Onchocerca volvulus		0.0097	0.0642	1
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.006	0.0085	0.0085
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.006	0.0085	0.0085
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.006	0.0085	0.0085

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.03 uM	Inhibition of recombinant HIV integrase strand transfer activity	ChEMBL.	16908139

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 412213