Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0249 | 0.823 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 1 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0249 | 0.823 | 0.823 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0249 | 0.823 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0249 | 0.823 | 0.823 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0249 | 0.823 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0249 | 0.823 | 0.823 |
Mycobacterium ulcerans | proteasome PrcB | 0.0249 | 0.823 | 0.5 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.005 | 0 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0249 | 0.823 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 1 | 1 |
Onchocerca volvulus | 0.0292 | 1 | 1 | |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0249 | 0.823 | 0.823 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 1 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.0249 | 0.823 | 0.823 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0249 | 0.823 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0249 | 0.823 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0249 | 0.823 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0249 | 0.823 | 0.5 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0249 | 0.823 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0249 | 0.823 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0249 | 0.823 | 0.5 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0249 | 0.823 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.9 nM | Binding affinity to CCR3 | ChEMBL. | 16931001 |
Ki (binding) | = 305 nM | Inhibition of 5HTT | ChEMBL. | 16931001 |
Ki (binding) | = 305 nM | Inhibition of 5HTT | ChEMBL. | 16931001 |
Ki (binding) | = 524 nM | Inhibition of NET | ChEMBL. | 16931001 |
Ki (binding) | = 524 nM | Inhibition of NET | ChEMBL. | 16931001 |
Ki (binding) | = 621 nM | Inhibition of DAT | ChEMBL. | 16931001 |
Ki (binding) | = 621 nM | Inhibition of DAT | ChEMBL. | 16931001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.