Detailed information for compound 412507

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 300.801 | Formula: C15H23ClNO3-
  • H donors: 1 H acceptors: 0 LogP: 2.89 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N1CCC2(CC1)OOC1(O2)C2CC3CC1CC(C2)C3.[Cl-]
  • InChi: 1S/C15H23NO3.ClH/c1-3-16-4-2-14(1)17-15(19-18-14)12-6-10-5-11(8-12)9-13(15)7-10;/h10-13,16H,1-9H2;1H/p-1/t10?,11?,12?,13?,15-;
  • InChiKey: IXMRDWYORJQRBO-QBWDEGHJSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus caspase 2 0.0321 0.3128 0.3126
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.1012 0.0931
Echinococcus multilocularis Transglutaminase 0.0071 0.0444 0.0436
Leishmania major cathepsin L-like protease 0.0124 0.1012 0.0527
Onchocerca volvulus 0.0124 0.1012 0.3218
Plasmodium falciparum proteasome subunit beta type-5 0.096 1 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0078 0.0512 0.0509
Brugia malayi proteasome subunit beta type 3 0.0078 0.0512 0.0512
Plasmodium vivax SET domain protein, putative 0.0031 0.0016 0.0008
Schistosoma mansoni bromodomain containing protein 0.007 0.0433 0.0426
Trypanosoma brucei proteasome beta 7 subunit 0.0078 0.0512 0.0107
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0078 0.0512 0.0504
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1291 0.0886
Brugia malayi jmjC domain containing protein 0.0162 0.1421 0.1421
Trypanosoma cruzi metacaspase 5, putative 0.0158 0.1374 0.1296
Toxoplasma gondii peptidase, T1 family protein 0.0078 0.0512 0.0504
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0102 0.0772 0.0769
Plasmodium falciparum cysteine proteinase falcipain 1 0.0068 0.0409 0.0402
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0078 0.0512 0.0504
Loa Loa (eye worm) cathepsin B 0.0114 0.0901 0.0894
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0078 0.0512 0.0397
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0102 0.0772 0.0764
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2978 0.2845
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0241 0.0241
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.096 1 1
Echinococcus granulosus proteasome subunit alpha type 6 0.0078 0.0512 0.0509
Plasmodium falciparum cysteine proteinase falcipain 3 0.0124 0.1012 0.1005
Loa Loa (eye worm) hypothetical protein 0.0124 0.1012 0.1005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2978 0.2845
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0078 0.0512 0.0426
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0078 0.0512 0.0504
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.2307 0.2301
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0078 0.0512 0.0504
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0078 0.0512 0.0107
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0078 0.0512 0.0504
Trypanosoma cruzi metacaspase 5, putative 0.0158 0.1374 0.1296
Brugia malayi Proteasome subunit alpha type 1 0.0078 0.0512 0.0512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0601 0.0422
Brugia malayi Cathepsin L-like precursor 0.0124 0.1012 0.1012
Loa Loa (eye worm) hypothetical protein 0.0163 0.1433 0.1426
Brugia malayi Bromodomain containing protein 0.0037 0.0075 0.0075
Leishmania major cysteine peptidase A (CPA) 0.0124 0.1012 0.0527
Echinococcus granulosus lysine specific demethylase 5A 0.0101 0.0763 0.076
Onchocerca volvulus 0.0124 0.1012 0.3218
Brugia malayi Proteasome A-type and B-type family protein 0.0078 0.0512 0.0512
Leishmania major cathepsin L-like protease 0.0124 0.1012 0.0527
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0078 0.0512 0.0504
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0078 0.0512 0.0504
Brugia malayi cathepsin L-like precursor 0.0086 0.0601 0.0601
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.2978 0.2973
Plasmodium vivax hypothetical protein, conserved 0.0158 0.1374 0.1367
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0187 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1012 0.0841
Leishmania major cathepsin L-like protease 0.0124 0.1012 0.0527
Brugia malayi hypothetical protein 0.0244 0.2307 0.2307
Onchocerca volvulus 0.0086 0.0601 0.1901
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0078 0.0512 0.0504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2978 0.2845
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2978 0.2845
Echinococcus granulosus Transglutaminase 0.0071 0.0444 0.0441
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0114 0.0901 0.041
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0078 0.0512 0.0504
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0114 0.0901 0.0818
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0078 0.0512 0.0504
Onchocerca volvulus 0.0163 0.1433 0.4567
Schistosoma mansoni hypothetical protein 0.0036 0.0063 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0208 0.0201
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0078 0.0512 0.0504
Plasmodium vivax proteasome subunit beta type-2, putative 0.0102 0.0772 0.0764
Loa Loa (eye worm) hypothetical protein 0.0036 0.0063 0.0056
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0078 0.0512 0.0397
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0078 0.0512 0.0397
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0078 0.0512 0.0331
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.1342 0.1335
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0078 0.0512 0.0331
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.023 0.2148 0.2145
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0078 0.0512 0.0504
Echinococcus granulosus proteasome subunit beta t family 0.0078 0.0512 0.0509
Plasmodium falciparum metacaspase-like protein 0.0158 0.1374 0.1367
Trypanosoma cruzi cruzipain precursor, putative 0.0124 0.1012 0.0931
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0102 0.0772 0.0596
Leishmania major proteasome beta 2 subunit, putative 0.0102 0.0772 0.0274
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0393 0.039
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0078 0.0512 0.0504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1012 0.0841
Echinococcus multilocularis proteasome (prosome, macropain) 0.096 1 1
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0078 0.0512 0.0504
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0393 0.0385
Entamoeba histolytica cysteine proteinase 2 0.0068 0.0409 0.0293
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0078 0.0512 0.0504
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0078 0.0512 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1374 0.121
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0078 0.0512 0.0426
Echinococcus multilocularis cathepsin L 0.0068 0.0409 0.0402
Brugia malayi Cathepsin L-like precursor 0.0086 0.0601 0.0601
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0078 0.0512 0.0331
Brugia malayi Pre-SET motif family protein 0.0219 0.2028 0.2028
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0078 0.0512 0.0397
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0078 0.0512 0.0504
Brugia malayi Proteasome A-type and B-type family protein 0.0078 0.0512 0.0512
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.0763 0.0755
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0078 0.0512 0.0504
Onchocerca volvulus Cell death protein 3 homolog 0.0321 0.3128 1
Brugia malayi Cathepsin L-like precursor 0.0124 0.1012 0.1012
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0078 0.0512 0.0397
Onchocerca volvulus Cathepsin F homolog 0.0124 0.1012 0.3218
Trypanosoma brucei metacaspase MCA2 0.0158 0.1374 0.1006
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.2307 0.2304
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0078 0.0512 0.5
Toxoplasma gondii proteasome subunit beta type, putative 0.096 1 1
Onchocerca volvulus 0.0249 0.2353 0.7516
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0124 0.1012 0.1005
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0078 0.0512 0.0397
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0078 0.0512 0.0504
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0158 0.1374 0.1367
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0158 0.1374 0.1367
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.2978 0.2893
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0078 0.0512 0.0426
Brugia malayi proteasome subunit beta type 2 0.0102 0.0772 0.0772
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1374 0.121
Toxoplasma gondii heat shock protein hslv, putative 0.0078 0.0512 0.0504
Giardia lamblia 20S proteasome alpha subunit 2 0.0078 0.0512 0.0504
Echinococcus granulosus cathepsin l1 0.0086 0.0601 0.0598
Trypanosoma brucei cysteine peptidase C (CPC) 0.0114 0.0901 0.0512
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0158 0.1374 0.121
Loa Loa (eye worm) hypothetical protein 0.0086 0.0601 0.0594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0078 0.0512 0.0426
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0078 0.0512 0.0426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1012 0.0841
Giardia lamblia 20S proteasome alpha subunit 4 0.0078 0.0512 0.0504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0208 0.0201
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0102 0.0772 0.0688
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0078 0.0512 0.0107
Toxoplasma gondii proteasome beta subunit 0.0078 0.0512 0.0504
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0158 0.1374 0.121
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0158 0.1374 0.121
Giardia lamblia Proteasome subunit beta type 3 0.0078 0.0512 0.0504
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0078 0.0512 0.0504
Schistosoma mansoni cathepsin s 0.0038 0.009 0.0082
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0078 0.0512 0.0504
Giardia lamblia Hypothetical protein 0.0071 0.0444 0.0436
Trypanosoma brucei proteasome subunit beta type-5, putative 0.096 1 1
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0078 0.0512 0.0504
Plasmodium vivax proteasome subunit beta type-1, putative 0.0078 0.0512 0.0504
Entamoeba histolytica cysteine protease, putative 0.0124 0.1012 0.0903
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0078 0.0512 0.0071
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0016 0.0008
Brugia malayi Thioredoxin family protein 0.0071 0.0444 0.0444
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0078 0.0512 0.0504
Echinococcus granulosus cathepsin L 0.0068 0.0409 0.0406
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.2978 0.5
Echinococcus multilocularis peregrin 0.0037 0.0075 0.0067
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0124 0.1012 0.1005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2978 0.2845
Brugia malayi proteasome subunit beta type 1 0.0078 0.0512 0.0512
Onchocerca volvulus 0.005 0.0215 0.0663
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0078 0.0512 0.0426
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0078 0.0512 0.0504
Giardia lamblia 20S proteasome alpha subunit 7 0.0078 0.0512 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0409 0.0227
Toxoplasma gondii proteasome subunit alpha1, putative 0.0078 0.0512 0.0504
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0078 0.0512 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1374 0.121
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0208 0.0205
Onchocerca volvulus 0.0124 0.1012 0.3218
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0063 0.0063
Giardia lamblia 20S proteasome alpha subunit 5 0.0078 0.0512 0.0504
Plasmodium vivax proteasome subunit beta type-4, putative 0.0078 0.0512 0.0504
Echinococcus multilocularis lysine specific demethylase 5A 0.0099 0.0741 0.0734
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0078 0.0512 0.0331
Schistosoma mansoni cathepsin F (C01 family) 0.0124 0.1012 0.1005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0158 0.1374 0.121
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0158 0.1374 0.121
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0078 0.0512 0.0426
Brugia malayi cathepsin B-like cysteine proteinase 0.0301 0.2916 0.2916
Schistosoma mansoni hypothetical protein 0.0071 0.0444 0.0436
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0078 0.0512 0.0504
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0078 0.0512 0.0397
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0208 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Trypanosoma cruzi 20S proteasome subunit 0.0102 0.0772 0.0688
Trichomonas vaginalis set domain proteins, putative 0.0249 0.2353 0.2208
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0102 0.0772 0.0764
Brugia malayi Cathepsin L-like precursor 0.0124 0.1012 0.1012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0409 0.0227
Giardia lamblia Transglutaminase/protease, putative 0.0071 0.0444 0.0436
Onchocerca volvulus 0.0124 0.1012 0.3218
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0078 0.0512 0.0504
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0078 0.0512 0.0509
Brugia malayi Pre-SET motif family protein 0.0031 0.0016 0.0016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0158 0.1374 0.121
Echinococcus granulosus proteasome prosome macropain 0.096 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0301 0.2916 0.291
Loa Loa (eye worm) hypothetical protein 0.0086 0.0601 0.0594
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0078 0.0512 0.0509
Echinococcus granulosus cathepsin L cysteine proteinase 0.0124 0.1012 0.1009
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0078 0.0512 0.0397
Toxoplasma gondii cathepsin CPL 0.0124 0.1012 0.1005
Plasmodium vivax vivapain-3 0.0068 0.0409 0.0402
Echinococcus multilocularis caspase 8 0.0158 0.1374 0.1367
Brugia malayi Bromodomain containing protein 0.0082 0.0566 0.0566
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.096 1 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0158 0.1374 0.1367
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0078 0.0512 0.0504
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0241 0.0241
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0008 0.0005
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0078 0.0512 0.0504
Schistosoma mansoni caspase-3 (C14 family) 0.023 0.2148 0.2142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Loa Loa (eye worm) hypothetical protein 0.0052 0.0241 0.0234
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1027 0.102
Loa Loa (eye worm) cysteine protease 0.0124 0.1012 0.1005
Onchocerca volvulus Cathepsin L homolog 0.0124 0.1012 0.3218
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0124 0.1012 0.0841
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Loa Loa (eye worm) hypothetical protein 0.0321 0.3128 0.3123
Echinococcus granulosus caspase 8 0.0158 0.1374 0.1371
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0078 0.0512 0.0504
Echinococcus multilocularis cathepsin b 0.0301 0.2916 0.291
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0078 0.0512 0.0504
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0078 0.0512 0.0426
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.096 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Toxoplasma gondii cathepsin B 0.0114 0.0901 0.0894
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0187 0.0183
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0241 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0078 0.0512 0.0107
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0078 0.0512 0.0504
Mycobacterium ulcerans proteasome PrcB 0.096 1 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0078 0.0512 0.0331
Loa Loa (eye worm) proteasome subunit beta type 1 0.0078 0.0512 0.0504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Loa Loa (eye worm) fibroinase 0.0124 0.1012 0.1005
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0078 0.0512 0.0504
Trichomonas vaginalis peptide N-glycanase, putative 0.0071 0.0444 0.0262
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0078 0.0512 0.0397
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0102 0.0772 0.0378
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0078 0.0512 0.0426
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0078 0.0512 0.0504
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.096 1 1
Echinococcus multilocularis cathepsin b 0.0301 0.2916 0.291
Echinococcus multilocularis cathepsin L cysteine protease 0.0124 0.1012 0.1005
Echinococcus multilocularis cathepsin L cysteine protease 0.0124 0.1012 0.1005
Loa Loa (eye worm) PAS-3 protein 0.0078 0.0512 0.0504
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0078 0.0512 0.0504
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0137 0.0129
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0102 0.0772 0.066
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0078 0.0512 0.0426
Toxoplasma gondii proteasome subunit alpha type, putative 0.0078 0.0512 0.0504
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0137 0.0133
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0409 0.0409
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Schistosoma mansoni jumonji domain containing protein 0.0141 0.1199 0.1192
Echinococcus granulosus peregrin 0.0037 0.0075 0.0071
Echinococcus granulosus proteasome subunit beta type 6 0.0078 0.0512 0.0509
Trypanosoma cruzi cysteine proteinase, putative 0.0068 0.0409 0.0323
Brugia malayi proteasome subunit alpha type 1 0.0078 0.0512 0.0512
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0016 0.0008
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0016 0.0008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.0763 0.0755
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0078 0.0512 0.0504
Leishmania major cathepsin L-like protease 0.0124 0.1012 0.0527
Echinococcus multilocularis caspase 3 0.0072 0.0453 0.0445
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0124 0.1012 0.1005
Entamoeba histolytica cysteine proteinase 1, putative 0.0068 0.0409 0.0293
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0078 0.0512 0.0397
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0078 0.0512 0.0107
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0078 0.0512 0.0397
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0082
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0301 0.2916 0.291
Echinococcus granulosus Proteasome subunit alpha type 7 0.0078 0.0512 0.0509
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0078 0.0512 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Leishmania major cathepsin L-like protease 0.0124 0.1012 0.0527
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0078 0.0512 0.0504
Leishmania major cathepsin L-like protease 0.0124 0.1012 0.0527
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0078 0.0512 0.0504
Giardia lamblia Proteasome subunit beta type 1 0.0078 0.0512 0.0504
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0078 0.0512 0.0504
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0078 0.0512 0.0504
Giardia lamblia Cathepsin B precursor 0.0114 0.0901 0.0894
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0409 0.0402
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0078 0.0512 0.0426
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0301 0.2916 0.291
Toxoplasma gondii proteasome subunit 0.0078 0.0512 0.0504
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0078 0.0512 0.0426
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0409 0.0402
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0078 0.0512 0.0107
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0102 0.0772 0.0764
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0078 0.0512 0.0426
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0409 0.0293
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0016 0.0008
Trypanosoma brucei proteasome alpha 7 subunit 0.0078 0.0512 0.0107
Giardia lamblia 20S proteasome alpha subunit 6 0.0078 0.0512 0.0504
Trypanosoma cruzi cysteine proteinase, putative 0.0068 0.0409 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0102 0.0772 0.0764
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0078 0.0512 0.0504
Onchocerca volvulus 0.0124 0.1012 0.3218
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0078 0.0512 0.0397
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0078 0.0512 0.0504
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0084 0.0077
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1291 0.0886
Brugia malayi PHD-finger family protein 0.0031 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0244 0.2307 0.2301
Schistosoma mansoni survival motor neuron protein 0.005 0.0215 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Echinococcus granulosus proteasome subunit alpha type 2 0.0078 0.0512 0.0509
Loa Loa (eye worm) hypothetical protein 0.0069 0.042 0.0413
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0068 0.0409 0.0323
Giardia lamblia 20S proteasome alpha subunit 1 0.0078 0.0512 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Trypanosoma cruzi metacaspase, putative 0.0158 0.1374 0.1296
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0158 0.1374 0.1374
Echinococcus granulosus Proteasome subunit alpha beta 0.0078 0.0512 0.0509
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0078 0.0512 0.0426
Entamoeba histolytica cysteine proteinase, putative 0.0124 0.1012 0.0903
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0301 0.2916 0.2852
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0078 0.0512 0.0504
Onchocerca volvulus 0.0124 0.1012 0.3218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Loa Loa (eye worm) proteasome subunit beta type 3 0.0078 0.0512 0.0504
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.1012 0.0931
Brugia malayi Proteasome subunit alpha type 7-1 0.0078 0.0512 0.0512
Leishmania major proteasome beta 5 subunit, putative 0.096 1 1
Brugia malayi Cathepsin L-like precursor 0.0124 0.1012 0.1012
Brugia malayi Cathepsin L-like cysteine proteinase 0.0086 0.0601 0.0601
Trypanosoma cruzi metacaspase, putative 0.0158 0.1374 0.1296
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0162 0.1421 0.1418
Loa Loa (eye worm) hypothetical protein 0.004 0.0112 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1012 0.0841
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0078 0.0512 0.0397
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0078 0.0512 0.0504
Brugia malayi Bromodomain containing protein 0.0044 0.0151 0.0151
Brugia malayi proteasome subunit alpha type 6 0.0078 0.0512 0.0512
Brugia malayi Cathepsin L-like precursor 0.0086 0.0601 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1374 0.121
Trypanosoma brucei metacaspase MCA3 0.0158 0.1374 0.1006
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0078 0.0512 0.0331
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0078 0.0512 0.0397
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0158 0.1374 0.121
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.1342 0.1335
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0078 0.0512 0.0331
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0078 0.0512 0.0426
Schistosoma mansoni hypothetical protein 0.0163 0.1433 0.1426
Giardia lamblia Proteasome subunit beta type 5 precursor 0.096 1 1
Plasmodium vivax unspecified product 0.0038 0.009 0.0082
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0409 0.0293
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0086 0.0601 0.0516
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0102 0.0772 0.0596
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0078 0.0512 0.0426
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0158 0.1374 0.121
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0078 0.0512 0.0504
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0078 0.0512 0.0426
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0078 0.0512 0.0504
Loa Loa (eye worm) hypothetical protein 0.0074 0.0477 0.047
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0078 0.0512 0.0397
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0078 0.0512 0.0107
Trypanosoma brucei metacaspase 5, putative 0.0158 0.1374 0.1006
Brugia malayi jmjC domain containing protein 0.0101 0.0763 0.0763
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0078 0.0512 0.0426
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0084 0.0081
Loa Loa (eye worm) hypothetical protein 0.0158 0.1374 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.0901 0.0728
Giardia lamblia Cathepsin B precursor 0.0114 0.0901 0.0894
Mycobacterium leprae proteasome (beta subunit) PrcB 0.096 1 1
Brugia malayi MH2 domain containing protein 0.0125 0.1027 0.1027
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0078 0.0512 0.0504
Entamoeba histolytica cysteine proteinase, putative 0.0124 0.1012 0.0903
Giardia lamblia Proteasome subunit beta type 2 0.0102 0.0772 0.0764
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0215 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Echinococcus granulosus proteasome subunit beta type 7 0.0078 0.0512 0.0509
Plasmodium falciparum proteasome subunit beta type-4 0.0078 0.0512 0.0504
Plasmodium vivax proteasome subunit beta type-5, putative 0.096 1 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0078 0.0512 0.0426
Echinococcus granulosus cathepsin l cysteine peptidase 0.0124 0.1012 0.1009
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0158 0.1374 0.1367
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0187 0.0179
Loa Loa (eye worm) hypothetical protein 0.0049 0.0208 0.0201
Brugia malayi Cell death protein 3 precursor 0.0321 0.3128 0.3128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Echinococcus multilocularis proteasome subunit alpha type 6 0.0078 0.0512 0.0504
Echinococcus multilocularis apoptotic protease activating factor 1 0.0163 0.1433 0.1426
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0301 0.2916 0.291
Loa Loa (eye worm) jmjC domain-containing protein 0.0101 0.0763 0.0755
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.1012 0.0931
Brugia malayi proteasome subunit alpha type 2 0.0078 0.0512 0.0512
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0078 0.0512 0.0107
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0078 0.0512 0.0331
Plasmodium vivax vivapain-2 0.0124 0.1012 0.1005
Brugia malayi 20S proteasome alpha5 subunit 0.0078 0.0512 0.0512
Brugia malayi Cathepsin L-like precursor 0.0038 0.009 0.009
Onchocerca volvulus Notchless protein homolog 0.0078 0.0512 0.1615
Loa Loa (eye worm) ctsf protein 0.0124 0.1012 0.1005
Plasmodium vivax proteasome subunit beta type-7, putative 0.0078 0.0512 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1374 0.121
Brugia malayi Cathepsin L-like precursor 0.0124 0.1012 0.1012
Echinococcus granulosus cathepsin b 0.0301 0.2916 0.2914
Trypanosoma brucei Metacaspase-4 0.0158 0.1374 0.1006
Onchocerca volvulus 0.0124 0.1012 0.3218
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0078 0.0512 0.0426
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0078 0.0512 0.0504
Onchocerca volvulus 0.0031 0.0016 0.0025
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0038 0.009 0.009
Echinococcus granulosus caspase 3 0.0072 0.0453 0.045
Onchocerca volvulus Cathepsin L homolog 0.0124 0.1012 0.3218
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.1012 0.0931
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.096 1 1
Plasmodium vivax proteasome subunit beta type-6, putative 0.0078 0.0512 0.0504
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0158 0.1374 0.121
Mycobacterium ulcerans proteasome PrcA 0.0078 0.0512 0.0071
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0601 0.0487
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0078 0.0512 0.0107
Echinococcus granulosus caspase 0.023 0.2148 0.2145
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0358 0.0351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1012 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1374 0.121
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0078 0.0512 0.0397
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2978 0.2845
Loa Loa (eye worm) acetyltransferase 0.0155 0.1342 0.1335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1012 0.0841
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.096 1 1
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0078 0.0512 0.0426
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.2978 0.2893
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0162 0.1421 0.1414
Loa Loa (eye worm) hypothetical protein 0.0086 0.0601 0.0594
Trypanosoma brucei proteasome beta 6 subunit 0.0078 0.0512 0.0107
Plasmodium vivax proteasome subunit beta type-3, putative 0.0078 0.0512 0.0504
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Brugia malayi cathepsin F-like cysteine proteinase 0.0038 0.009 0.009
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0078 0.0512 0.0331
Echinococcus granulosus cathepsin l1 0.0124 0.1012 0.1009
Trypanosoma cruzi metacaspase, putative 0.0158 0.1374 0.1296
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0078 0.0512 0.0504
Echinococcus multilocularis caspase 2 0.0321 0.3128 0.3123
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0124 0.1012 0.1005
Brugia malayi proteasome subunit alpha type 4 0.0078 0.0512 0.0512
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.1342 0.1342
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0078 0.0512 0.0504
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0078 0.0512 0.0504
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0601 0.0594
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0078 0.0512 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1027 0.102
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0078 0.0512 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.1269 0.1266
Plasmodium vivax unspecified product 0.0068 0.0409 0.0402
Loa Loa (eye worm) hypothetical protein 0.0301 0.2916 0.291
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0078 0.0512 0.0504
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0082
Echinococcus granulosus apoptotic protease activating factor 1 0.0163 0.1433 0.143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1012 0.0841
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2978 0.2845
Echinococcus granulosus subfamily T1A non peptidase ue 0.0078 0.0512 0.0509
Trypanosoma brucei metacaspase 0.0158 0.1374 0.1006
Brugia malayi proteasome subunit alpha type 3 0.0078 0.0512 0.0512
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0187 0.0179
Plasmodium vivax vivapain-1 0.0068 0.0409 0.0402
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0409 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0124 0.1012 0.0841
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0078 0.0512 0.0504
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0078 0.0512 0.0331
Leishmania major cathepsin L-like protease 0.0124 0.1012 0.0527
Brugia malayi hypothetical protein 0.0163 0.1433 0.1433
Onchocerca volvulus 0.0248 0.2341 0.7477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0601 0.0422
Plasmodium vivax metacaspase 1, putative 0.0158 0.1374 0.1367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.0901 0.0894
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0078 0.0512 0.0426
Plasmodium falciparum metacaspase 1 0.0158 0.1374 0.1367
Trypanosoma cruzi metacaspase, putative 0.0158 0.1374 0.1296
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.012 0.0112
Leishmania major metacaspase, putative 0.0158 0.1374 0.0909
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.012 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Schistosoma mansoni caspase-7 (C14 family) 0.023 0.2148 0.2142
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0082
Plasmodium vivax vivapain-2 0.0124 0.1012 0.1005
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0078 0.0512 0.0504
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0078 0.0512 0.0504
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0078 0.0512 0.0509
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0078 0.0512 0.0331
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0409 0.0409
Echinococcus granulosus cathepsin b 0.0301 0.2916 0.2914
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1291 0.0886
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0078 0.0512 0.0107
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0078 0.0512 0.0504
Schistosoma mansoni cathepsin F (C01 family) 0.0124 0.1012 0.1005
Loa Loa (eye worm) hypothetical protein 0.0049 0.02 0.0193
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0078 0.0512 0.0331
Brugia malayi Proteasome A-type and B-type family protein 0.0078 0.0512 0.0512
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1012 0.0841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Echinococcus granulosus cathepsin L cysteine protease 0.0068 0.0409 0.0406
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.2028 0.2022
Loa Loa (eye worm) hypothetical protein 0.0047 0.0179 0.0171
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0124 0.1012 0.1005
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0124 0.1012 0.1005
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.096 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2978 0.2845
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0078 0.0512 0.0331
Schistosoma mansoni hypothetical protein 0.005 0.0215 0.0207
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Loa Loa (eye worm) proteasome subunit beta type 2 0.0102 0.0772 0.0764
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0078 0.0512 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0102 0.0772 0.0764
Giardia lamblia 20S proteasome alpha subunit 3 0.0078 0.0512 0.0504
Echinococcus multilocularis cysteine protease 0.0124 0.1012 0.1005
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0078 0.0512 0.0504
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0078 0.0512 0.0071
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0078 0.0512 0.0504
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0078 0.0512 0.0504
Trypanosoma cruzi cysteine protease, putative 0.0068 0.0409 0.0323
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.009 0.0082
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0409 0.0293
Echinococcus multilocularis proteasome subunit beta type 6 0.0078 0.0512 0.0504
Schistosoma mansoni caspase-7 (C14 family) 0.0321 0.3128 0.3123
Echinococcus multilocularis proteasome subunit alpha type 2 0.0078 0.0512 0.0504
Echinococcus granulosus cysteine protease 0.0068 0.0409 0.0406
Brugia malayi Papain family cysteine protease containing protein 0.0124 0.1012 0.1012
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0409 0.0402
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0409 0.0323
Echinococcus multilocularis proteasome subunit beta type 7 0.0078 0.0512 0.0504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0124 0.1012 0.0841
Brugia malayi Cathepsin L-like precursor 0.0124 0.1012 0.1012
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0078 0.0512 0.0504
Echinococcus multilocularis cysteine protease 0.0124 0.1012 0.1005
Leishmania major cathepsin L-like protease 0.0124 0.1012 0.0527
Entamoeba histolytica cysteine protease, putative 0.0068 0.0409 0.0293
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0078 0.0512 0.0504
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.023 0.2148 0.2142
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0078 0.0512 0.0426
Echinococcus multilocularis caspase 0.023 0.2148 0.2142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.1012 0.0628
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0078 0.0512 0.0504
Giardia lamblia Cathepsin B precursor 0.0114 0.0901 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.1012 0.0841

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 59 % Antimalarial activity in MORO mouse infected with Plasmodium berghei at 10 mg/kg, po ChEMBL. 16931006
Activity (functional) = 84 % Antimalarial activity in MORO mouse infected with Plasmodium berghei at 10 mg/kg, sc ChEMBL. 16931006
Activity (functional) = 6.3 day Survival of MORO mouse infected with Plasmodium berghei at 10 mg/kg, po after 30 day post-infection ChEMBL. 16931006
Activity (functional) = 7.7 day Survival of MORO mouse infected with Plasmodium berghei at 10 mg/kg, sc after 30 day post-infection ChEMBL. 16931006
IC50 (functional) = 0.15 ng/ml Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 16931006
IC50 (functional) = 0.34 ng/ml Antimalarial activity against Plasmodium falciparum NF54 ChEMBL. 16931006
Log D = 0.25 Lipophilicity, LogD of the compound at pH 7.4 ChEMBL. 16931006

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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