Detailed information for compound 412532

Basic information

Technical information
  • TDR Targets ID: 412532
  • Name: 6-chloro-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-o xopropan-2-yl]-2-oxopyrrolidin-3-yl]-1H-indol e-2-sulfonamide
  • MW: 454.928 | Formula: C19H23ClN4O5S
  • H donors: 2 H acceptors: 4 LogP: 1.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)[nH]c(c2)S(=O)(=O)N[C@H]1CCN(C1=O)[C@H](C(=O)N1CCOCC1)C
  • InChi: 1S/C19H23ClN4O5S/c1-12(18(25)23-6-8-29-9-7-23)24-5-4-15(19(24)26)22-30(27,28)17-10-13-2-3-14(20)11-16(13)21-17/h2-3,10-12,15,21-22H,4-9H2,1H3/t12-,15-/m0/s1
  • InChiKey: YMUHEQCMXFHGRO-WFASDCNBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-N-[(3S)-1-[(1S)-1-methyl-2-morpholino-2-oxo-ethyl]-2-oxo-pyrrolidin-3-yl]-1H-indole-2-sulfonamide
  • 6-chloro-N-[(3S)-1-[(1S)-1-methyl-2-morpholino-2-oxoethyl]-2-oxo-3-pyrrolidinyl]-1H-indole-2-sulfonamide
  • 6-chloro-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-oxo-propan-2-yl]-2-oxo-pyrrolidin-3-yl]-1H-indole-2-sulfonamide
  • 6-chloro-N-[(3S)-2-keto-1-[(1S)-2-keto-1-methyl-2-morpholino-ethyl]pyrrolidin-3-yl]-1H-indole-2-sulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0331 0.0303
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Schistosoma mansoni hypothetical protein 0.0031 0.0202 0.0174
Brugia malayi hypothetical protein 0.0038 0.0276 0.0328
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0054 0.0442 0.0415
Mycobacterium ulcerans proteasome PrcA 0.0051 0.0408 0.0698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0348 0.0321
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0043 0.0015
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Brugia malayi proteasome subunit alpha type 1 0.0051 0.0408 0.0504
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0045 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0243 0.0286
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0258 0.2596 0.2575
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0217 0.0189
Trypanosoma brucei proteasome beta 6 subunit 0.02 0.1988 0.7417
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0051 0.0408 0.038
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0308 0.0281
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0203 0.0175
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0203 0.0231
Onchocerca volvulus Arrow homolog 0.0016 0.0043 0.0058
Trypanosoma brucei proteasome beta 7 subunit 0.0051 0.0408 0.0698
Brugia malayi hypothetical protein 0.0051 0.0411 0.0507
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0051 0.0408 0.0455
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.031 0.1196
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0203 0.069
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0051 0.0408 0.157
Brugia malayi MH2 domain containing protein 0.0016 0.0045 0.0022
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0051 0.0408 0.038
Echinococcus granulosus proteasome subunit beta type 6 0.0051 0.0408 0.038
Brugia malayi Proteasome A-type and B-type family protein 0.0258 0.2596 0.3408
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni aminopeptidase A (M01 family) 0.0051 0.0411 0.0383
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0542 0.1955
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.0411 0.071
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0124 0.1184 0.3996
Onchocerca volvulus 0.0035 0.0243 0.0852
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0051 0.0411 0.0383
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0043 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0203 0.069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0348 0.0321
Plasmodium vivax proteasome subunit beta type-4, putative 0.0051 0.0408 0.157
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0051 0.0408 0.0455
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0203 0.0175
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0958 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0203 0.0175
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0051 0.0408 0.0693
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.0411 0.1582
Loa Loa (eye worm) hypothetical protein 0.0041 0.0308 0.0281
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0051 0.0408 0.038
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.0411 0.1582
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.035 0.0323
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0258 0.2596 0.801
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.0411 0.071
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0051 0.0408 0.157
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0051 0.0408 0.157
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0051 0.0408 0.1428
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0203 0.0175
Brugia malayi CXXC zinc finger family protein 0.0031 0.0198 0.0226
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0051 0.0408 0.038
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0051 0.0408 0.038
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0243 0.0216
Plasmodium vivax SET domain protein, putative 0.0033 0.0217 0.0835
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis proteasome subunit alpha type 6 0.0051 0.0408 0.038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0203 0.0175
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0203 0.0175
Brugia malayi Fibulin-1 precursor 0.0016 0.0043 0.002
Onchocerca volvulus Alhambra homolog 0.0031 0.0202 0.0687
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0951 0.0925
Brugia malayi nuclear receptor NHR-88 0.0031 0.0203 0.0231
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0408 0.0561
Toxoplasma gondii aminopeptidase N protein 0.0051 0.0411 0.144
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.0411 0.071
Loa Loa (eye worm) hypothetical protein 0.0084 0.0759 0.0732
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0217 0.0189
Schistosoma mansoni smad 0.0016 0.0045 0.0017
Echinococcus multilocularis laminin 0.0016 0.0043 0.0015
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0411 0.0507
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Echinococcus granulosus GPCR family 2 0.0082 0.0734 0.0708
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0203 0.0231
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0051 0.0408 0.038
Echinococcus granulosus proteasome subunit beta type 7 0.0051 0.0408 0.038
Leishmania major proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0092 0.0085
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0202 0.0174
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0051 0.0408 0.038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0203 0.0231
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0051 0.0408 0.0455
Schistosoma mansoni smad1 5 8 and 0.0016 0.0045 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.1735 0.2265
Loa Loa (eye worm) hypothetical protein 0.0053 0.0437 0.041
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0535 0.0509
Schistosoma mansoni lamin 0.0085 0.0775 0.0749
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0051 0.0408 0.0698
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0203 0.0175
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0582 0.0735
Brugia malayi Pre-SET motif family protein 0.0033 0.0217 0.025
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0411 0.0507
Leishmania major proteasome alpha 2 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) proteasome subunit beta type 3 0.0051 0.0408 0.038
Plasmodium falciparum proteasome subunit beta type-4 0.0051 0.0408 0.157
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0203 0.0175
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0951 0.0925
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0411 0.071
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.2406 0.2384
Schistosoma mansoni smad1 5 8 and 0.0016 0.0045 0.0017
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0051 0.0408 0.157
Leishmania major proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0582 0.0556
Onchocerca volvulus 0.0051 0.0411 0.1514
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Brugia malayi nuclear hormone receptor 0.0031 0.0203 0.0231
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0051 0.0408 0.157
Schistosoma mansoni lamin 0.0085 0.0775 0.0749
Onchocerca volvulus 0.0085 0.0775 0.2957
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0202 0.0174
Trypanosoma brucei proteasome alpha 7 subunit 0.0051 0.0408 0.0698
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0051 0.0408 0.0698
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0047 0.0025
Echinococcus granulosus Tolloid protein 1 0.0016 0.0043 0.0015
Echinococcus granulosus Smad4 0.0016 0.0045 0.0017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0734 0.0937
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0051 0.0408 0.157
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0411 0.0507
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0051 0.0408 0.0455
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0203 0.0175
Onchocerca volvulus 0.0085 0.0775 0.2957
Onchocerca volvulus 0.0033 0.0217 0.0746
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0051 0.0408 0.0698
Trichomonas vaginalis set domain proteins, putative 0.0254 0.2554 0.7889
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0258 0.2596 0.2575
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0051 0.0408 0.0698
Leishmania major proteasome beta 5 subunit, putative 0.0258 0.2596 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.1735 0.1711
Onchocerca volvulus 0.0051 0.0411 0.1514
Toxoplasma gondii proteasome subunit 0.0051 0.0408 0.1428
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.0411 0.071
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.4513 0.4497
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0051 0.0408 0.0455
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0258 0.2596 0.8032
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0203 0.0175
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0258 0.2596 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0348 0.0321
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0051 0.0408 0.038
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0124 0.1184 0.321
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0217 0.0189
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0582 0.0556
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0153 0.1484 0.5276
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0258 0.2596 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2242 0.8497
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0045 0.0017
Onchocerca volvulus 0.0048 0.0384 0.1407
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0203 0.0175
Toxoplasma gondii heat shock protein hslv, putative 0.0051 0.0408 0.1428
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0051 0.0408 0.038
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0203 0.069
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0411 0.0571
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0045 0.0017
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0258 0.2596 1
Brugia malayi proteasome subunit alpha type 3 0.0051 0.0408 0.0504
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.029 0.0262
Echinococcus multilocularis survival motor neuron protein 1 0.0728 0.7563 0.7556
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0153 0.1484 0.5276
Brugia malayi hypothetical protein 0.0441 0.4529 0.5973
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0203 0.0231
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0308 0.0281
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0243 0.0216
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0051 0.0408 0.0698
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.0411 0.071
Toxoplasma gondii peptidase, T1 family protein 0.0051 0.0408 0.1428
Onchocerca volvulus 0.0031 0.0198 0.0673
Loa Loa (eye worm) hypothetical protein 0.0033 0.0217 0.0189
Loa Loa (eye worm) hypothetical protein 0.004 0.0292 0.0264
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.2597 0.2576
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.031 0.0366
Schistosoma mansoni hypothetical protein 0.0439 0.4513 0.4497
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0051 0.0408 0.157
Echinococcus granulosus lamin dm0 0.0085 0.0775 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0203 0.0231
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0276 0.0248
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0124 0.1184 0.4559
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0535 0.1241
Brugia malayi hypothetical protein 0.0728 0.7563 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.029 0.0262
Giardia lamblia 20S proteasome alpha subunit 1 0.0051 0.0408 0.0693
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0356 0.0435
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0043 0.0015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0734 0.0708
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0051 0.0408 0.0455
Trypanosoma cruzi Aminopeptidase M1, putative 0.0051 0.0411 0.071
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0203 0.0175
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0203 0.0175
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0051 0.0408 0.157
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0051 0.0408 0.0698
Brugia malayi proteasome subunit beta type 3 0.0051 0.0408 0.0504
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis cpg binding protein 0.0033 0.0217 0.0189
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0203 0.0175
Toxoplasma gondii proteasome subunit beta type 1, putative 0.02 0.1988 0.762
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni cpg binding protein 0.0033 0.0217 0.0189
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Onchocerca volvulus 0.0031 0.0203 0.069
Schistosoma mansoni smad1 5 8 and 0.0016 0.0045 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0535 0.1241
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Brugia malayi steroid hormone receptor 0.0031 0.0203 0.0231
Plasmodium falciparum proteasome subunit beta type-5 0.0258 0.2596 1
Treponema pallidum fructose-bisphosphate aldolase 0.0312 0.3172 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.1451 0.1427
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Leishmania major proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0203 0.0175
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0276 0.0248
Loa Loa (eye worm) Smad1 0.0016 0.0045 0.0017
Brugia malayi Proteasome A-type and B-type family protein 0.0051 0.0408 0.0504
Schistosoma mansoni coup transcription factor 0.0031 0.0203 0.0175
Echinococcus multilocularis lamin dm0 0.0085 0.0775 0.0749
Echinococcus granulosus proteasome subunit alpha type 2 0.0051 0.0408 0.038
Echinococcus granulosus tar DNA binding protein 0.0067 0.0582 0.0556
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0051 0.0408 0.038
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0202 0.0174
Echinococcus granulosus survival motor neuron protein 1 0.0728 0.7563 0.7556
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0384 0.0356
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0203 0.0231
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0051 0.0408 0.038
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0051 0.0408 0.0455
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni hypothetical protein 0.0536 0.5534 0.5522
Onchocerca volvulus 0.0035 0.0243 0.0852
Echinococcus multilocularis Smad4 0.0016 0.0045 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0203 0.0231
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0535 0.1241
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0124 0.1184 0.1159
Brugia malayi beta-lactamase family protein 0.0035 0.0243 0.0286
Echinococcus granulosus proteasome prosome macropain 0.0258 0.2596 0.2575
Brugia malayi TATA binding protein associated factor 0.0051 0.0411 0.0507
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.2229 0.2207
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0051 0.0411 0.1582
Schistosoma mansoni Smad4 0.0016 0.0045 0.0017
Brugia malayi proteasome subunit alpha type 6 0.0051 0.0408 0.0504
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.1497 0.1473
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0582 0.0556
Giardia lamblia 20S proteasome alpha subunit 4 0.0051 0.0408 0.0693
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0202 0.0622
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.2406 0.2384
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.02 0.1988 0.5957
Echinococcus granulosus geminin 0.0536 0.5534 0.5522
Giardia lamblia Fructose-bisphosphate aldolase 0.0312 0.3172 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0043 0.002
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.0411 0.071
Brugia malayi MH2 domain containing protein 0.0016 0.0045 0.0022
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0203 0.0175
Loa Loa (eye worm) hypothetical protein 0.0258 0.2597 0.2576
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.02 0.1988 0.7417
Echinococcus granulosus lamin 0.0085 0.0775 0.0749
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0202 0.0174
Brugia malayi ecdysteroid receptor 0.0031 0.0203 0.0231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0203 0.0175
Brugia malayi nuclear receptor RXR 0.0016 0.0047 0.0025
Loa Loa (eye worm) hypothetical protein 0.0051 0.0411 0.0383
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0045 0.0017
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0411 0.071
Onchocerca volvulus Notchless protein homolog 0.0051 0.0408 0.1502
Brugia malayi 20S proteasome alpha5 subunit 0.0051 0.0408 0.0504
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Brugia malayi Bromodomain containing protein 0.0035 0.0241 0.0283
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0051 0.0408 0.038
Giardia lamblia 20S proteasome alpha subunit 7 0.0051 0.0408 0.0693
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0047 0.0019
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0047 0.0019
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.1497 0.1949
Echinococcus multilocularis peregrin 0.0035 0.0241 0.0214
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0073 0.0045
Brugia malayi Pre-SET motif family protein 0.0223 0.2229 0.2921
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Brugia malayi Proteasome subunit alpha type 1 0.0051 0.0408 0.0504
Loa Loa (eye worm) hypothetical protein 0.004 0.0292 0.0264
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0051 0.0408 0.038
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.031 0.012
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0243 0.0938
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Echinococcus multilocularis tumor protein p63 0.033 0.3364 0.3345
Loa Loa (eye worm) aminopeptidase N 0.0051 0.0411 0.0383
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0051 0.0408 0.038
Echinococcus granulosus proteasome subunit beta t family 0.0051 0.0408 0.038
Giardia lamblia 20S proteasome alpha subunit 5 0.0051 0.0408 0.0693
Toxoplasma gondii proteasome subunit alpha1, putative 0.0051 0.0408 0.1428
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Brugia malayi Smad1 0.0016 0.0045 0.0022
Giardia lamblia Proteasome subunit beta type 1 0.02 0.1988 0.6014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0051 0.0408 0.1428
Echinococcus granulosus smad 0.0016 0.0045 0.0017
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0734 0.0708
Giardia lamblia 20S proteasome alpha subunit 2 0.0051 0.0408 0.0693
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0276 0.0248
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0051 0.0408 0.038
Brugia malayi hypothetical protein 0.0016 0.0047 0.0025
Brugia malayi proteasome subunit beta type 1 0.02 0.1988 0.2601
Loa Loa (eye worm) hypothetical protein 0.0121 0.1147 0.1121
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0203 0.0175
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.029 0.0262
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Toxoplasma gondii aminopeptidase N, putative 0.0051 0.0411 0.144
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0051 0.0408 0.0698
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0051 0.0408 0.1428
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0203 0.0231
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0243 0.0216
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0051 0.0408 0.0698
Leishmania major proteasome beta 2 subunit, putative 0.0124 0.1184 0.3996
Schistosoma mansoni hypothetical protein 0.0536 0.5534 0.5522
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0051 0.0408 0.038
Plasmodium falciparum phd finger protein, putative 0.0031 0.0202 0.0777
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0051 0.0408 0.0698
Brugia malayi MH1 domain containing protein 0.0016 0.0045 0.0022
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.0411 0.071
Leishmania major proteasome alpha 3 subunit, putative 0.0051 0.0408 0.0698
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0408 0.0561
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.035 0.0364
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0202 0.0622
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0124 0.1184 0.3134
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0203 0.0231
Schistosoma mansoni hypothetical protein 0.0082 0.0734 0.0708
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0535 0.0509
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Echinococcus granulosus Proteasome subunit alpha beta 0.0051 0.0408 0.038
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0535 0.0509
Toxoplasma gondii ABC1 family protein 0.0035 0.0243 0.0785
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0203 0.0175
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0348 0.0321
Brugia malayi proteasome subunit beta type 2 0.0124 0.1184 0.1533
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0258 0.2596 1
Giardia lamblia 20S proteasome alpha subunit 3 0.0051 0.0408 0.0693
Schistosoma mansoni hypothetical protein 0.0038 0.0276 0.0248
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0051 0.0408 0.0455
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0051 0.0408 0.0455
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0729 0.0703
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0051 0.0408 0.038
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0331 0.0303
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0838 0.8725 0.8722
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0051 0.0408 0.157
Onchocerca volvulus 0.0254 0.2554 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0051 0.0408 0.038
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0124 0.1184 0.3996
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0958 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0535 0.1929
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0047 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0047 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0203 0.0231
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0051 0.0408 0.0698
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.02 0.1988 0.7417
Brugia malayi beta-lactamase 0.0035 0.0243 0.0286
Schistosoma mansoni hypothetical protein 0.0082 0.0734 0.0708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0203 0.0175
Plasmodium vivax proteasome subunit beta type-5, putative 0.0258 0.2596 1
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0203 0.0231
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0051 0.0408 0.0698
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.0411 0.071
Loa Loa (eye worm) acetyltransferase 0.0154 0.1497 0.1473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0348 0.0321
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0203 0.0175
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0051 0.0408 0.5
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0203 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0348 0.0425
Leishmania major proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.02 0.1988 0.1966
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.1497 0.1473
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0051 0.0408 0.0698
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.035 0.0364
Giardia lamblia Proteasome subunit beta type 3 0.0051 0.0408 0.0693
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0047 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.2597 0.3409
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0124 0.1184 0.4468
Brugia malayi TAR-binding protein 0.0067 0.0582 0.0735
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0051 0.0408 0.038
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0051 0.0408 0.1428
Leishmania major proteasome beta 2 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0203 0.0175
Echinococcus granulosus aminopeptidase N 0.0051 0.0411 0.0383
Echinococcus multilocularis geminin 0.0536 0.5534 0.5522
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0411 0.0571
Brugia malayi RNA binding protein 0.0067 0.0582 0.0735
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0775 0.0991
Loa Loa (eye worm) RNA binding protein 0.0067 0.0582 0.0556
Schistosoma mansoni intermediate filament proteins 0.0085 0.0775 0.0749
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0045 0.0017
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0047 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0734 0.0708
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0408 0.0561
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0051 0.0408 0.0693
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.035 0.1203
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0043 0.0015
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0124 0.1184 0.1159
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0051 0.0408 0.0455
Mycobacterium ulcerans proteasome PrcB 0.0258 0.2596 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0348 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0203 0.0175
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0051 0.0408 0.157
Echinococcus multilocularis proteasome (prosome, macropain) 0.0258 0.2596 0.2575
Loa Loa (eye worm) hypothetical protein 0.0031 0.0202 0.0174
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0775 0.0749
Loa Loa (eye worm) TATA binding protein associated factor 0.0051 0.0411 0.0383
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0217 0.0189
Plasmodium vivax proteasome subunit beta type-6, putative 0.0051 0.0408 0.157
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0051 0.0408 0.157
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0203 0.0231
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0217 0.068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0203 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0203 0.0231
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0045 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0217 0.0189
Plasmodium falciparum proteasome subunit beta type-1, putative 0.02 0.1988 0.766
Loa Loa (eye worm) hypothetical protein 0.0051 0.0411 0.0383
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0051 0.0408 0.038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Echinococcus granulosus tumor protein p63 0.033 0.3364 0.3345
Echinococcus granulosus proteasome prosome macropain subunit beta 0.02 0.1988 0.1966
Echinococcus granulosus Proteasome subunit alpha type 7 0.0051 0.0408 0.038
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0051 0.0408 0.157
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0153 0.1484 0.5276
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0535 0.1241
Leishmania major proteasome beta 3 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni survival motor neuron protein 0.0148 0.1441 0.1417
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0775 0.0749
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0124 0.1184 0.1159
Plasmodium vivax proteasome subunit beta type-2, putative 0.0124 0.1184 0.4559
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Echinococcus granulosus cpg binding protein 0.0033 0.0217 0.0189
Onchocerca volvulus 0.0035 0.0243 0.0852
Brugia malayi proteasome subunit alpha type 4 0.0051 0.0408 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0203 0.0231
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0051 0.0408 0.157
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0051 0.0408 0.038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0203 0.0175
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0051 0.0408 0.0455
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0734 0.0708
Echinococcus multilocularis lamin 0.0085 0.0775 0.0749
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0051 0.0408 0.038
Toxoplasma gondii proteasome beta subunit 0.0051 0.0408 0.1428
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0202 0.0777
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0051 0.0408 0.0698
Giardia lamblia Proteasome subunit beta type 2 0.0124 0.1184 0.3305
Schistosoma mansoni egf-like domain protein 0.0016 0.0043 0.0015
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis aminopeptidase N 0.0051 0.0411 0.0383
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0051 0.0411 0.0383
Brugia malayi jmjC domain containing protein 0.0039 0.029 0.0347
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0734 0.0937
Loa Loa (eye worm) hypothetical protein 0.0048 0.0384 0.0356
Echinococcus multilocularis GPCR, family 2 0.0082 0.0734 0.0708
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0051 0.0408 0.0698
Schistosoma mansoni cpg binding protein 0.0033 0.0217 0.0189
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Echinococcus multilocularis proteasome subunit beta type 6 0.0051 0.0408 0.038
Brugia malayi MH1 domain containing protein 0.0016 0.0045 0.0022
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0051 0.0408 0.038
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0051 0.0408 0.0455
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0051 0.0408 0.157
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0203 0.0175
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0051 0.0408 0.0455
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0051 0.0408 0.038
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0552 0.0525
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0271 0.0243
Brugia malayi MH2 domain containing protein 0.024 0.2406 0.3155
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni hypothetical protein 0.0176 0.1735 0.1711
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0258 0.2596 0.8059
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0051 0.0408 0.0698
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0051 0.0408 0.0698
Echinococcus granulosus peregrin 0.0035 0.0241 0.0214
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0051 0.0408 0.038
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0051 0.0408 0.157
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0051 0.0408 0.157
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0197 0.0169
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0045 0.0017
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.0411 0.071
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0356 0.0329
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0203 0.0175
Brugia malayi hypothetical protein 0.0051 0.0411 0.0507
Onchocerca volvulus Huntingtin homolog 0.0121 0.1147 0.4428
Brugia malayi Proteasome subunit alpha type 7-1 0.0051 0.0408 0.0504
Schistosoma mansoni hypothetical protein 0.0148 0.1441 0.1417
Giardia lamblia 20S proteasome alpha subunit 6 0.0051 0.0408 0.0693
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0198 0.0171
Entamoeba histolytica proteasome subunit beta type 1, putative 0.02 0.1988 0.5912
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0203 0.0175
Brugia malayi PHD-finger family protein 0.0031 0.0202 0.023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.1441 0.1875
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0124 0.1184 0.1159
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0958 1 1
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0051 0.0408 0.1428
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.02 0.1988 0.7417
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0051 0.0408 0.0455
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0051 0.0408 0.157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0576 0.0549
Loa Loa (eye worm) hypothetical protein 0.0121 0.1147 0.1121
Schistosoma mansoni cpg binding protein 0.0031 0.0198 0.0171
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0243 0.0216
Echinococcus granulosus laminin 0.0016 0.0043 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0348 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Brugia malayi proteasome subunit alpha type 2 0.0051 0.0408 0.0504
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0051 0.0408 0.0693
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0051 0.0408 0.0455
Brugia malayi intermediate filament protein 0.0085 0.0775 0.0991
Toxoplasma gondii aminopeptidase n, putative 0.0051 0.0411 0.144
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.029 0.0262
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.02 0.1988 0.1966
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0051 0.0408 0.157
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0258 0.2596 1
Loa Loa (eye worm) proteasome subunit beta type 1 0.02 0.1988 0.1966
Toxoplasma gondii proteasome subunit beta type, putative 0.0258 0.2596 1
Brugia malayi Proteasome A-type and B-type family protein 0.0051 0.0408 0.0504
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0734 0.0708
Echinococcus multilocularis proteasome subunit beta type 7 0.0051 0.0408 0.038
Brugia malayi beta-lactamase family protein 0.0035 0.0243 0.0286
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.3172 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0348 0.0321
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.0411 0.071
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0051 0.0411 0.0383
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.035 0.1349
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0203 0.0175
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0217 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0203 0.0175
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0411 0.071
Echinococcus granulosus proteasome subunit alpha type 6 0.0051 0.0408 0.038
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0051 0.0408 0.038
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0203 0.0175
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0043 0.0015
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0124 0.1184 0.321
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0411 0.0571
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) hypothetical protein 0.0728 0.7563 0.7556
Loa Loa (eye worm) hypothetical protein 0.0051 0.0411 0.0383
Loa Loa (eye worm) beta-lactamase 0.0035 0.0243 0.0216
Echinococcus granulosus dnaJ subfamily B 0.0439 0.4513 0.4497
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0243 0.0216
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0408 0.0561
Schistosoma mansoni hypothetical protein 0.0082 0.0734 0.0708
Onchocerca volvulus 0.0148 0.1441 0.5594
Echinococcus multilocularis fibrillin 1 0.0016 0.0043 0.0015
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0203 0.0175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0203 0.0231
Echinococcus multilocularis proteasome subunit alpha type 2 0.0051 0.0408 0.038
Loa Loa (eye worm) hypothetical protein 0.0085 0.0775 0.0749
Leishmania major proteasome beta-1 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis musashi 0.0085 0.0775 0.0749
Brugia malayi Proteasome A-type and B-type family protein 0.0051 0.0408 0.0504
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0051 0.0411 0.071
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0203 0.0175
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Loa Loa (eye worm) PAS-3 protein 0.0051 0.0408 0.038
Trypanosoma brucei aminopeptidase, putative 0.0051 0.0411 0.071
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0051 0.0408 0.038
Plasmodium vivax proteasome subunit beta type-1, putative 0.02 0.1988 0.766
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0051 0.0408 0.038
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0535 0.0509
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0203 0.0175
Echinococcus granulosus subfamily T1A non peptidase ue 0.0051 0.0408 0.038
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0203 0.0231
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.2597 0.3409
Onchocerca volvulus Huntingtin homolog 0.0121 0.1147 0.4428
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0051 0.0408 0.0698
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0051 0.0411 0.071
Loa Loa (eye worm) proteasome subunit beta type 2 0.0124 0.1184 0.1159
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Plasmodium vivax proteasome subunit beta type-3, putative 0.0051 0.0408 0.157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Onchocerca volvulus 0.0051 0.0411 0.1514
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0203 0.0175
Schistosoma mansoni hypothetical protein 0.0082 0.0734 0.0708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0203 0.0175
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.3172 1
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis smad 0.0016 0.0045 0.0017
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Toxoplasma gondii proteasome subunit alpha type, putative 0.0051 0.0408 0.1428
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0051 0.0411 0.1582
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0051 0.0408 0.157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0203 0.0175
Loa Loa (eye worm) peptidase family M1 containing protein 0.0051 0.0411 0.0383
Leishmania major proteasome beta 7 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0051 0.0408 0.038
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0051 0.0408 0.0455
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0051 0.0408 0.038
Brugia malayi jmjC domain containing protein 0.0102 0.0951 0.1224
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0043 0.0015
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0411 0.071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0217 0.0189
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0535 0.1241
Brugia malayi hypothetical protein 0.0016 0.0047 0.0025
Entamoeba histolytica aminopeptidase, putative 0.0051 0.0411 0.0466
Trypanosoma cruzi 20S proteasome subunit 0.0124 0.1184 0.3996
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.035 0.1203
Brugia malayi hypothetical protein 0.0121 0.1147 0.1484
Loa Loa (eye worm) hypothetical protein 0.0082 0.0734 0.0708
Plasmodium vivax proteasome subunit beta type-7, putative 0.0051 0.0408 0.157
Echinococcus granulosus intermediate filament protein 0.0085 0.0775 0.0749

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 170 nM Binding affinity at factor 10a ChEMBL. 16982192
Ki (binding) = 170 nM Inhibition of human factor Xa by fluorescence assay ChEMBL. 17338508
Ki (binding) = 170 nM Binding affinity at factor 10a ChEMBL. 16982192
Ki (binding) = 170 nM Inhibition of human factor Xa by fluorescence assay ChEMBL. 17338508

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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