Detailed information for compound 412532

Basic information

Technical information
  • TDR Targets ID: 412532
  • Name: 6-chloro-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-o xopropan-2-yl]-2-oxopyrrolidin-3-yl]-1H-indol e-2-sulfonamide
  • MW: 454.928 | Formula: C19H23ClN4O5S
  • H donors: 2 H acceptors: 4 LogP: 1.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)[nH]c(c2)S(=O)(=O)N[C@H]1CCN(C1=O)[C@H](C(=O)N1CCOCC1)C
  • InChi: 1S/C19H23ClN4O5S/c1-12(18(25)23-6-8-29-9-7-23)24-5-4-15(19(24)26)22-30(27,28)17-10-13-2-3-14(20)11-16(13)21-17/h2-3,10-12,15,21-22H,4-9H2,1H3/t12-,15-/m0/s1
  • InChiKey: YMUHEQCMXFHGRO-WFASDCNBSA-N  

Network

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Synonyms

  • 6-chloro-N-[(3S)-1-[(1S)-1-methyl-2-morpholino-2-oxo-ethyl]-2-oxo-pyrrolidin-3-yl]-1H-indole-2-sulfonamide
  • 6-chloro-N-[(3S)-1-[(1S)-1-methyl-2-morpholino-2-oxoethyl]-2-oxo-3-pyrrolidinyl]-1H-indole-2-sulfonamide
  • 6-chloro-N-[(3S)-1-[(2S)-1-morpholin-4-yl-1-oxo-propan-2-yl]-2-oxo-pyrrolidin-3-yl]-1H-indole-2-sulfonamide
  • 6-chloro-N-[(3S)-2-keto-1-[(1S)-2-keto-1-methyl-2-morpholino-ethyl]pyrrolidin-3-yl]-1H-indole-2-sulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0348 0.0321
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0051 0.0408 0.038
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0203 0.0175
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0198 0.0171
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0203 0.0231
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.035 0.0364
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0582 0.0556
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0258 0.2596 0.2575
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0203 0.069
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0124 0.1184 0.1159
Brugia malayi proteasome subunit alpha type 2 0.0051 0.0408 0.0504
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0258 0.2596 0.2575
Toxoplasma gondii peptidase, T1 family protein 0.0051 0.0408 0.1428
Leishmania major proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Plasmodium falciparum phd finger protein, putative 0.0031 0.0202 0.0777
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0203 0.0231
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis smad 0.0016 0.0045 0.0017
Schistosoma mansoni coup transcription factor 0.0031 0.0203 0.0175
Brugia malayi proteasome subunit beta type 2 0.0124 0.1184 0.1533
Schistosoma mansoni hypothetical protein 0.0536 0.5534 0.5522
Loa Loa (eye worm) RNA binding protein 0.0067 0.0582 0.0556
Echinococcus multilocularis lamin 0.0085 0.0775 0.0749
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0243 0.0216
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0203 0.0175
Toxoplasma gondii ABC1 family protein 0.0035 0.0243 0.0785
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0051 0.0408 0.157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0951 0.0925
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0202 0.0174
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0348 0.0321
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2242 0.8497
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0051 0.0408 0.038
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Brugia malayi Proteasome A-type and B-type family protein 0.0258 0.2596 0.3408
Giardia lamblia 20S proteasome alpha subunit 5 0.0051 0.0408 0.0693
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.2229 0.2207
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0734 0.0937
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.0411 0.071
Brugia malayi proteasome subunit beta type 1 0.02 0.1988 0.2601
Echinococcus granulosus GPCR family 2 0.0082 0.0734 0.0708
Loa Loa (eye worm) hypothetical protein 0.0258 0.2597 0.2576
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0729 0.0703
Loa Loa (eye worm) acetyltransferase 0.0154 0.1497 0.1473
Brugia malayi CXXC zinc finger family protein 0.0031 0.0198 0.0226
Brugia malayi nuclear hormone receptor 0.0031 0.0203 0.0231
Loa Loa (eye worm) Smad1 0.0016 0.0045 0.0017
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0051 0.0408 0.0698
Plasmodium vivax proteasome subunit beta type-5, putative 0.0258 0.2596 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0203 0.0175
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0203 0.0175
Schistosoma mansoni hypothetical protein 0.0176 0.1735 0.1711
Onchocerca volvulus Alhambra homolog 0.0031 0.0202 0.0687
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0411 0.071
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0043 0.0015
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.029 0.0262
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0051 0.0408 0.0455
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0051 0.0408 0.157
Plasmodium falciparum proteasome subunit beta type-4 0.0051 0.0408 0.157
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Schistosoma mansoni hypothetical protein 0.0031 0.0202 0.0174
Leishmania major proteasome beta-1 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) hypothetical protein 0.0121 0.1147 0.1121
Brugia malayi beta-lactamase family protein 0.0035 0.0243 0.0286
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.0411 0.071
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0051 0.0408 0.0698
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0051 0.0411 0.1582
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Mycobacterium ulcerans proteasome PrcB 0.0258 0.2596 1
Brugia malayi hypothetical protein 0.0016 0.0047 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0203 0.0231
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Brugia malayi hypothetical protein 0.0121 0.1147 0.1484
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0734 0.0937
Echinococcus granulosus geminin 0.0536 0.5534 0.5522
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0203 0.0175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0203 0.0175
Brugia malayi hypothetical protein 0.0051 0.0411 0.0507
Toxoplasma gondii proteasome subunit alpha type, putative 0.0051 0.0408 0.1428
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.1497 0.1949
Schistosoma mansoni hypothetical protein 0.0148 0.1441 0.1417
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0051 0.0408 0.0698
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0051 0.0408 0.0698
Brugia malayi MH2 domain containing protein 0.024 0.2406 0.3155
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Brugia malayi proteasome subunit alpha type 1 0.0051 0.0408 0.0504
Echinococcus granulosus smad 0.0016 0.0045 0.0017
Onchocerca volvulus 0.0048 0.0384 0.1407
Toxoplasma gondii aminopeptidase n, putative 0.0051 0.0411 0.144
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0051 0.0408 0.157
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.035 0.0364
Brugia malayi Pre-SET motif family protein 0.0223 0.2229 0.2921
Echinococcus multilocularis proteasome subunit beta type 6 0.0051 0.0408 0.038
Loa Loa (eye worm) hypothetical protein 0.0082 0.0734 0.0708
Giardia lamblia 20S proteasome alpha subunit 7 0.0051 0.0408 0.0693
Echinococcus granulosus proteasome subunit beta type 7 0.0051 0.0408 0.038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Schistosoma mansoni hypothetical protein 0.0082 0.0734 0.0708
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0047 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0217 0.0189
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0051 0.0408 0.0455
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0384 0.0356
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0124 0.1184 0.1159
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0203 0.0175
Schistosoma mansoni hypothetical protein 0.0038 0.0276 0.0248
Plasmodium falciparum proteasome subunit beta type-5 0.0258 0.2596 1
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0411 0.0507
Brugia malayi TAR-binding protein 0.0067 0.0582 0.0735
Echinococcus granulosus Smad4 0.0016 0.0045 0.0017
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0258 0.2596 1
Echinococcus multilocularis proteasome subunit alpha type 2 0.0051 0.0408 0.038
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0051 0.0408 0.0698
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0203 0.0175
Trypanosoma cruzi 20S proteasome subunit 0.0124 0.1184 0.3996
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0051 0.0408 0.038
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0734 0.0708
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0203 0.0175
Plasmodium vivax proteasome subunit beta type-6, putative 0.0051 0.0408 0.157
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0331 0.0303
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0051 0.0408 0.038
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0203 0.0175
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0348 0.0321
Echinococcus granulosus cpg binding protein 0.0033 0.0217 0.0189
Onchocerca volvulus 0.0148 0.1441 0.5594
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Echinococcus multilocularis proteasome subunit beta type 7 0.0051 0.0408 0.038
Entamoeba histolytica aminopeptidase, putative 0.0051 0.0411 0.0466
Schistosoma mansoni smad1 5 8 and 0.0016 0.0045 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0348 0.0321
Giardia lamblia 20S proteasome alpha subunit 1 0.0051 0.0408 0.0693
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0043 0.002
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Echinococcus granulosus laminin 0.0016 0.0043 0.0015
Toxoplasma gondii proteasome subunit beta type 1, putative 0.02 0.1988 0.762
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.2406 0.2384
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0153 0.1484 0.5276
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0051 0.0408 0.0455
Loa Loa (eye worm) hypothetical protein 0.0084 0.0759 0.0732
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0411 0.071
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0043 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0203 0.0231
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0258 0.2596 1
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0051 0.0408 0.0455
Echinococcus multilocularis fibrillin 1 0.0016 0.0043 0.0015
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0051 0.0408 0.038
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.1451 0.1427
Trypanosoma brucei proteasome beta 6 subunit 0.02 0.1988 0.7417
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.035 0.1203
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0203 0.0175
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0124 0.1184 0.321
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0051 0.0408 0.157
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0203 0.0175
Leishmania major proteasome beta 2 subunit, putative 0.0124 0.1184 0.3996
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0051 0.0408 0.157
Echinococcus multilocularis GPCR, family 2 0.0082 0.0734 0.0708
Onchocerca volvulus 0.0254 0.2554 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0203 0.0175
Schistosoma mansoni hypothetical protein 0.0082 0.0734 0.0708
Brugia malayi MH2 domain containing protein 0.0016 0.0045 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0203 0.0175
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0203 0.0175
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.029 0.0262
Leishmania major proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Leishmania major proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Trypanosoma brucei proteasome beta 7 subunit 0.0051 0.0408 0.0698
Plasmodium vivax proteasome subunit beta type-3, putative 0.0051 0.0408 0.157
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0408 0.0561
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.1497 0.1473
Loa Loa (eye worm) proteasome subunit beta type 3 0.0051 0.0408 0.038
Treponema pallidum fructose-bisphosphate aldolase 0.0312 0.3172 0.5
Brugia malayi beta-lactamase 0.0035 0.0243 0.0286
Onchocerca volvulus Notchless protein homolog 0.0051 0.0408 0.1502
Loa Loa (eye worm) beta-lactamase 0.0035 0.0243 0.0216
Giardia lamblia Fructose-bisphosphate aldolase 0.0312 0.3172 1
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0051 0.0411 0.0383
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0951 0.0925
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0045 0.0017
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0775 0.0991
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0308 0.0281
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0535 0.1929
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0258 0.2596 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Giardia lamblia Proteasome subunit beta type 3 0.0051 0.0408 0.0693
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0051 0.0408 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0203 0.0231
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0045 0.0017
Loa Loa (eye worm) proteasome subunit beta type 1 0.02 0.1988 0.1966
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0535 0.0509
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.2597 0.3409
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Leishmania major proteasome beta 2 subunit, putative 0.0051 0.0408 0.0698
Echinococcus granulosus proteasome subunit alpha type 2 0.0051 0.0408 0.038
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0552 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0203 0.0231
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0408 0.0561
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.3172 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.0124 0.1184 0.4559
Echinococcus granulosus proteasome prosome macropain 0.0258 0.2596 0.2575
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0043 0.0015
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0045 0.0017
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0258 0.2596 0.8032
Schistosoma mansoni aminopeptidase A (M01 family) 0.0051 0.0411 0.0383
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0535 0.0509
Toxoplasma gondii proteasome subunit beta type, putative 0.0258 0.2596 1
Onchocerca volvulus 0.0051 0.0411 0.1514
Echinococcus granulosus tumor protein p63 0.033 0.3364 0.3345
Onchocerca volvulus 0.0051 0.0411 0.1514
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0051 0.0408 0.0455
Schistosoma mansoni cpg binding protein 0.0033 0.0217 0.0189
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0124 0.1184 0.321
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.02 0.1988 0.7417
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0775 0.0749
Onchocerca volvulus Huntingtin homolog 0.0121 0.1147 0.4428
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0051 0.0408 0.038
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0153 0.1484 0.5276
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0243 0.0938
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0051 0.0408 0.0698
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0051 0.0408 0.0698
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.1497 0.1473
Onchocerca volvulus Huntingtin homolog 0.0121 0.1147 0.4428
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0202 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0203 0.0231
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0276 0.0248
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.029 0.0262
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0051 0.0411 0.071
Onchocerca volvulus 0.0033 0.0217 0.0746
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0582 0.0556
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0051 0.0408 0.157
Brugia malayi 20S proteasome alpha5 subunit 0.0051 0.0408 0.0504
Onchocerca volvulus Arrow homolog 0.0016 0.0043 0.0058
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0047 0.0019
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0051 0.0408 0.038
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0051 0.0408 0.0455
Toxoplasma gondii proteasome subunit 0.0051 0.0408 0.1428
Brugia malayi ecdysteroid receptor 0.0031 0.0203 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0203 0.0175
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.02 0.1988 0.5957
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0051 0.0408 0.0698
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0582 0.0556
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0051 0.0408 0.0698
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0243 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0348 0.0321
Leishmania major proteasome beta 3 subunit, putative 0.0051 0.0408 0.0698
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0411 0.0571
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0203 0.0175
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.02 0.1988 0.1966
Loa Loa (eye worm) hypothetical protein 0.0051 0.0411 0.0383
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.02 0.1988 0.1966
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0051 0.0411 0.071
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0051 0.0408 0.157
Echinococcus multilocularis laminin 0.0016 0.0043 0.0015
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.0411 0.071
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.0411 0.071
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0051 0.0408 0.1428
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.02 0.1988 0.7417
Schistosoma mansoni smad 0.0016 0.0045 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0542 0.1955
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0258 0.2596 0.801
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0356 0.0435
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0043 0.0015
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0051 0.0408 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0243 0.0216
Leishmania major proteasome beta 7 subunit, putative 0.0051 0.0408 0.0698
Brugia malayi Pre-SET motif family protein 0.0033 0.0217 0.025
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0411 0.071
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0958 1 1
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0043 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0217 0.0189
Brugia malayi proteasome subunit beta type 3 0.0051 0.0408 0.0504
Brugia malayi nuclear receptor RXR 0.0016 0.0047 0.0025
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.4513 0.4497
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0051 0.0408 0.157
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0734 0.0708
Giardia lamblia Proteasome subunit beta type 1 0.02 0.1988 0.6014
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0051 0.0408 0.0698
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0051 0.0408 0.1428
Loa Loa (eye worm) hypothetical protein 0.0033 0.0217 0.0189
Giardia lamblia Proteasome subunit beta type 2 0.0124 0.1184 0.3305
Brugia malayi Smad1 0.0016 0.0045 0.0022
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0258 0.2596 1
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0051 0.0408 0.0693
Echinococcus granulosus lamin dm0 0.0085 0.0775 0.0749
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0203 0.0175
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0045 0.0017
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0203 0.069
Toxoplasma gondii proteasome beta subunit 0.0051 0.0408 0.1428
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0051 0.0408 0.038
Brugia malayi steroid hormone receptor 0.0031 0.0203 0.0231
Leishmania major proteasome beta 5 subunit, putative 0.0258 0.2596 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0203 0.0175
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.031 0.0366
Loa Loa (eye worm) aminopeptidase N 0.0051 0.0411 0.0383
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0271 0.0243
Schistosoma mansoni smad1 5 8 and 0.0016 0.0045 0.0017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0217 0.0189
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0276 0.0248
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0197 0.0169
Brugia malayi PHD-finger family protein 0.0031 0.0202 0.023
Schistosoma mansoni egf-like domain protein 0.0016 0.0043 0.0015
Plasmodium vivax proteasome subunit beta type-1, putative 0.02 0.1988 0.766
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0051 0.0408 0.038
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Brugia malayi jmjC domain containing protein 0.0102 0.0951 0.1224
Echinococcus granulosus Proteasome subunit alpha type 7 0.0051 0.0408 0.038
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0203 0.0175
Schistosoma mansoni cpg binding protein 0.0033 0.0217 0.0189
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0348 0.0425
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.3172 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0045 0.0017
Echinococcus granulosus subfamily T1A non peptidase ue 0.0051 0.0408 0.038
Leishmania major proteasome alpha 2 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0051 0.0408 0.038
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0051 0.0408 0.038
Echinococcus multilocularis musashi 0.0085 0.0775 0.0749
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0051 0.0408 0.0698
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.0411 0.1582
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0051 0.0408 0.038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0348 0.0321
Loa Loa (eye worm) PAS-3 protein 0.0051 0.0408 0.038
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0051 0.0408 0.0698
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0153 0.1484 0.5276
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0203 0.0231
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0051 0.0408 0.038
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.0411 0.071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0203 0.0231
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0051 0.0408 0.0698
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0051 0.0411 0.1582
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0217 0.0189
Echinococcus multilocularis proteasome subunit alpha type 6 0.0051 0.0408 0.038
Echinococcus multilocularis geminin 0.0536 0.5534 0.5522
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0051 0.0408 0.0698
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Schistosoma mansoni hypothetical protein 0.0082 0.0734 0.0708
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0051 0.0408 0.0698
Plasmodium vivax proteasome subunit beta type-7, putative 0.0051 0.0408 0.157
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0051 0.0408 0.157
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0411 0.0507
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0582 0.0735
Plasmodium falciparum proteasome subunit beta type-1, putative 0.02 0.1988 0.766
Loa Loa (eye worm) hypothetical protein 0.0031 0.0202 0.0174
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0202 0.0174
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.2597 0.2576
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0203 0.0175
Schistosoma mansoni lamin 0.0085 0.0775 0.0749
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Onchocerca volvulus 0.0085 0.0775 0.2957
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0047 0.0019
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0411 0.0507
Brugia malayi nuclear receptor NHR-88 0.0031 0.0203 0.0231
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0051 0.0408 0.038
Loa Loa (eye worm) peptidase family M1 containing protein 0.0051 0.0411 0.0383
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0203 0.0231
Loa Loa (eye worm) hypothetical protein 0.0085 0.0775 0.0749
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0203 0.0175
Brugia malayi Proteasome subunit alpha type 1 0.0051 0.0408 0.0504
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0535 0.0509
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0203 0.0175
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0124 0.1184 0.4559
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0203 0.0175
Trichomonas vaginalis set domain proteins, putative 0.0254 0.2554 0.7889
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Onchocerca volvulus 0.0085 0.0775 0.2957
Leishmania major proteasome alpha 1 subunit, putative 0.0051 0.0408 0.0698
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0331 0.0303
Giardia lamblia 20S proteasome alpha subunit 2 0.0051 0.0408 0.0693
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0203 0.0175
Giardia lamblia 20S proteasome alpha subunit 3 0.0051 0.0408 0.0693
Schistosoma mansoni smad1 5 8 and 0.0016 0.0045 0.0017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0203 0.0175
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0243 0.0216
Brugia malayi hypothetical protein 0.0051 0.0411 0.0507
Brugia malayi intermediate filament protein 0.0085 0.0775 0.0991
Brugia malayi proteasome subunit alpha type 6 0.0051 0.0408 0.0504
Brugia malayi Proteasome subunit alpha type 7-1 0.0051 0.0408 0.0504
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0047 0.0019
Echinococcus granulosus dnaJ subfamily B 0.0439 0.4513 0.4497
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0258 0.2596 0.8059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0203 0.0231
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0051 0.0408 0.038
Toxoplasma gondii aminopeptidase N, putative 0.0051 0.0411 0.144
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Onchocerca volvulus 0.0035 0.0243 0.0852
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0051 0.0408 0.157
Loa Loa (eye worm) hypothetical protein 0.0121 0.1147 0.1121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0203 0.0231
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0535 0.1241
Trypanosoma brucei aminopeptidase, putative 0.0051 0.0411 0.071
Loa Loa (eye worm) hypothetical protein 0.004 0.0292 0.0264
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0051 0.0408 0.157
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0411 0.0571
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0243 0.0286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0348 0.0321
Toxoplasma gondii proteasome subunit alpha1, putative 0.0051 0.0408 0.1428
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.031 0.1196
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0051 0.0408 0.0455
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0051 0.0408 0.038
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0051 0.0408 0.1428
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0203 0.069
Echinococcus granulosus Proteasome subunit alpha beta 0.0051 0.0408 0.038
Brugia malayi RNA binding protein 0.0067 0.0582 0.0735
Echinococcus granulosus lamin 0.0085 0.0775 0.0749
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Brugia malayi hypothetical protein 0.0016 0.0047 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0203 0.0175
Echinococcus granulosus proteasome prosome macropain subunit beta 0.02 0.1988 0.1966
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0124 0.1184 0.3996
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0958 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0203 0.0175
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni Smad4 0.0016 0.0045 0.0017
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0045 0.0017
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0202 0.0622
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0535 0.1241
Schistosoma mansoni lamin 0.0085 0.0775 0.0749
Loa Loa (eye worm) proteasome subunit beta type 2 0.0124 0.1184 0.1159
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0203 0.0175
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0051 0.0408 0.0698
Brugia malayi Proteasome A-type and B-type family protein 0.0051 0.0408 0.0504
Loa Loa (eye worm) hypothetical protein 0.0176 0.1735 0.1711
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0356 0.0329
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0203 0.0175
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0775 0.0749
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0051 0.0408 0.0455
Echinococcus granulosus survival motor neuron protein 1 0.0728 0.7563 0.7556
Schistosoma mansoni intermediate filament proteins 0.0085 0.0775 0.0749
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.0411 0.1582
Loa Loa (eye worm) hypothetical protein 0.004 0.0292 0.0264
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0051 0.0408 0.038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Trypanosoma brucei proteasome alpha 7 subunit 0.0051 0.0408 0.0698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0217 0.0189
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0217 0.0189
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0051 0.0408 0.038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0203 0.0175
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Echinococcus multilocularis cpg binding protein 0.0033 0.0217 0.0189
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0073 0.0045
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.035 0.1349
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0408 0.0561
Plasmodium vivax proteasome subunit beta type-4, putative 0.0051 0.0408 0.157
Giardia lamblia 20S proteasome alpha subunit 6 0.0051 0.0408 0.0693
Schistosoma mansoni cpg binding protein 0.0031 0.0198 0.0171
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0051 0.0408 0.1428
Toxoplasma gondii heat shock protein hslv, putative 0.0051 0.0408 0.1428
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.2597 0.3409
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0535 0.1241
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0051 0.0408 0.0455
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0051 0.0408 0.157
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0308 0.0281
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0576 0.0549
Loa Loa (eye worm) hypothetical protein 0.0053 0.0437 0.041
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0408 0.0561
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0958 1 1
Brugia malayi hypothetical protein 0.0038 0.0276 0.0328
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.029 0.0262
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0535 0.0509
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0051 0.0408 0.0698
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0051 0.0408 0.157
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0124 0.1184 0.4468
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0051 0.0408 0.038
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0051 0.0408 0.0693
Echinococcus multilocularis proteasome (prosome, macropain) 0.0258 0.2596 0.2575
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0015
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.2406 0.2384
Echinococcus multilocularis tumor protein p63 0.033 0.3364 0.3345
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Onchocerca volvulus 0.0051 0.0411 0.1514
Onchocerca volvulus 0.0031 0.0198 0.0673
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0203 0.0231
Echinococcus granulosus intermediate filament protein 0.0085 0.0775 0.0749
Onchocerca volvulus 0.0035 0.0243 0.0852
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0217 0.068
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0051 0.0408 0.0455
Entamoeba histolytica proteasome subunit beta type 1, putative 0.02 0.1988 0.5912
Echinococcus multilocularis aminopeptidase N 0.0051 0.0411 0.0383
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0051 0.0408 0.1428
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0051 0.0411 0.0383
Echinococcus granulosus tar DNA binding protein 0.0067 0.0582 0.0556
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0051 0.0408 0.038
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.0411 0.071
Brugia malayi jmjC domain containing protein 0.0039 0.029 0.0347
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0203 0.0175
Brugia malayi Fibulin-1 precursor 0.0016 0.0043 0.002
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0411 0.0571
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Brugia malayi MH2 domain containing protein 0.0016 0.0045 0.0022
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.1441 0.1875
Brugia malayi hypothetical protein 0.0441 0.4529 0.5973
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0051 0.0408 0.157
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0276 0.0248
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0047 0.0019
Loa Loa (eye worm) hypothetical protein 0.0048 0.0384 0.0356
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0051 0.0408 0.0698
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0535 0.1241
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0051 0.0408 0.038
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0051 0.0408 0.038
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.0411 0.071
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0348 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0203 0.0175
Loa Loa (eye worm) TATA binding protein associated factor 0.0051 0.0411 0.0383
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0051 0.0408 0.038
Echinococcus granulosus proteasome subunit alpha type 6 0.0051 0.0408 0.038
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0051 0.0408 0.0455
Brugia malayi proteasome subunit alpha type 3 0.0051 0.0408 0.0504
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0202 0.0777
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0051 0.0408 0.038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0051 0.0408 0.0698
Echinococcus multilocularis survival motor neuron protein 1 0.0728 0.7563 0.7556
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0051 0.0408 0.157
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0202 0.0174
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0051 0.0408 0.038
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.1735 0.2265
Loa Loa (eye worm) hypothetical protein 0.0041 0.0308 0.0281
Schistosoma mansoni hypothetical protein 0.0082 0.0734 0.0708
Echinococcus granulosus peregrin 0.0035 0.0241 0.0214
Echinococcus granulosus aminopeptidase N 0.0051 0.0411 0.0383
Loa Loa (eye worm) hypothetical protein 0.0051 0.0411 0.0383
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0411 0.071
Mycobacterium ulcerans proteasome PrcA 0.0051 0.0408 0.0698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0203 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0051 0.0408 0.0455
Echinococcus multilocularis Smad4 0.0016 0.0045 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0092 0.0085
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0202 0.0622
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0051 0.0408 0.0455
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0051 0.0408 0.038
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Brugia malayi beta-lactamase family protein 0.0035 0.0243 0.0286
Schistosoma mansoni survival motor neuron protein 0.0148 0.1441 0.1417
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0043 0.0015
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0051 0.0408 0.157
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0051 0.0408 0.0698
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.031 0.012
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0203 0.0175
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0051 0.0408 0.157
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0124 0.1184 0.3996
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0203 0.0175
Onchocerca volvulus 0.0035 0.0243 0.0852
Onchocerca volvulus 0.0031 0.0203 0.069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.0175
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0051 0.0408 0.0455
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0734 0.0708
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0203 0.0175
Brugia malayi MH1 domain containing protein 0.0016 0.0045 0.0022
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.0411 0.071
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0051 0.0408 0.038
Brugia malayi Proteasome A-type and B-type family protein 0.0051 0.0408 0.0504
Brugia malayi TATA binding protein associated factor 0.0051 0.0411 0.0507
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0838 0.8725 0.8722
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0408 0.0698
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0047 0.0019
Echinococcus granulosus proteasome subunit beta t family 0.0051 0.0408 0.038
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0051 0.0408 0.0693
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0124 0.1184 0.1159
Echinococcus multilocularis peregrin 0.0035 0.0241 0.0214
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0051 0.0408 0.038
Schistosoma mansoni hypothetical protein 0.0536 0.5534 0.5522
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0051 0.0408 0.0698
Schistosoma mansoni hypothetical protein 0.0439 0.4513 0.4497
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0051 0.0408 0.038
Brugia malayi MH1 domain containing protein 0.0016 0.0045 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0582 0.0556
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0243 0.0216
Brugia malayi proteasome subunit alpha type 4 0.0051 0.0408 0.0504
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0258 0.2596 1
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.0411 0.071
Loa Loa (eye worm) hypothetical protein 0.0051 0.0411 0.0383
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0019
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0124 0.1184 0.1159
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.0411 0.071
Echinococcus granulosus proteasome subunit beta type 6 0.0051 0.0408 0.038
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0051 0.0411 0.0383
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0203 0.0231
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0051 0.0408 0.0455
Brugia malayi hypothetical protein 0.0728 0.7563 1
Echinococcus granulosus Tolloid protein 1 0.0016 0.0043 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0203 0.0231
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0124 0.1184 0.3134
Leishmania major proteasome alpha 3 subunit, putative 0.0051 0.0408 0.0698
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0051 0.0408 0.157
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0051 0.0408 0.038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0217 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0203 0.0175
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0734 0.0708
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.035 0.0323
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0045 0.0017
Echinococcus multilocularis lamin dm0 0.0085 0.0775 0.0749
Brugia malayi Proteasome A-type and B-type family protein 0.0051 0.0408 0.0504
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0051 0.0408 0.038
Giardia lamblia 20S proteasome alpha subunit 4 0.0051 0.0408 0.0693
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3172 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.035 0.1203
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0051 0.0408 0.038
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0411 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0203 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0216
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0051 0.0408 0.0698
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0047 0.0025
Plasmodium vivax SET domain protein, putative 0.0033 0.0217 0.0835
Trypanosoma cruzi Aminopeptidase M1, putative 0.0051 0.0411 0.071
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0054 0.0442 0.0415
Toxoplasma gondii aminopeptidase N protein 0.0051 0.0411 0.144
Brugia malayi Bromodomain containing protein 0.0035 0.0241 0.0283
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.02 0.1988 0.7417
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0535 0.1241
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0408 0.0561
Loa Loa (eye worm) hypothetical protein 0.0728 0.7563 0.7556
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0734 0.0708
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0051 0.0408 0.157

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 170 nM Binding affinity at factor 10a ChEMBL. 16982192
Ki (binding) = 170 nM Inhibition of human factor Xa by fluorescence assay ChEMBL. 17338508
Ki (binding) = 170 nM Binding affinity at factor 10a ChEMBL. 16982192
Ki (binding) = 170 nM Inhibition of human factor Xa by fluorescence assay ChEMBL. 17338508

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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