Detailed information for compound 412568

Basic information

Technical information
  • TDR Targets ID: 412568
  • Name: 1-[3-[(2R,4R)-4-benzylpiperidin-2-yl]propyl]- 3-(3-cyanophenyl)urea
  • MW: 376.495 | Formula: C23H28N4O
  • H donors: 3 H acceptors: 2 LogP: 3.7 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccc(c1)NC(=O)NCCC[C@H]1NCC[C@H](C1)Cc1ccccc1
  • InChi: 1S/C23H28N4O/c24-17-20-8-4-9-22(16-20)27-23(28)26-12-5-10-21-15-19(11-13-25-21)14-18-6-2-1-3-7-18/h1-4,6-9,16,19,21,25H,5,10-15H2,(H2,26,27,28)/t19-,21+/m0/s1
  • InChiKey: FFTNCZSASXDDKK-PZJWPPBQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-[(2R,4R)-4-benzyl-2-piperidyl]propyl]-3-(3-cyanophenyl)urea
  • 1-[3-[(2R,4R)-4-benzyl-2-piperidinyl]propyl]-3-(3-cyanophenyl)urea
  • 1-(3-cyanophenyl)-3-[3-[(2R,4R)-4-(phenylmethyl)piperidin-2-yl]propyl]urea
  • 3-(3-cyanophenyl)-1-[3-[(2R,4R)-4-(phenylmethyl)piperidin-2-yl]propyl]urea
  • 3-(3-cyanophenyl)-1-[3-[(2R,4R)-4-(phenylmethyl)-2-piperidyl]propyl]urea
  • 3-(3-cyanophenyl)-1-[3-[(2R,4R)-4-(phenylmethyl)-2-piperidinyl]propyl]urea
  • 1-[3-[(2R,4R)-4-(benzyl)-2-piperidyl]propyl]-3-(3-cyanophenyl)urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Guanylyl cyclase protein 23 0.0112 0.0373 0.0464
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0083 0.0167 0.0125
Leishmania major proteasome alpha 2 subunit, putative 0.0083 0.0167 0.0123
Plasmodium vivax vivapain-3 0.0101 0.0298 0.0433
Plasmodium falciparum metacaspase 1 0.0427 0.2621 0.3651
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0083 0.0167 0.0182
Leishmania major proteasome beta 2 subunit, putative 0.0083 0.0167 0.0123
Echinococcus granulosus cathepsin L cysteine protease 0.0101 0.0298 0.028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0323 0.1878 0.2041
Loa Loa (eye worm) hypothetical protein 0.0112 0.0373 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0427 0.2621 0.3729
Trichomonas vaginalis conserved hypothetical protein 0.0427 0.2621 0.3729
Echinococcus granulosus glutamate receptor 2 0.0112 0.0373 0.0356
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0083 0.0167 0.0123
Giardia lamblia Cathepsin B precursor 0.0129 0.0495 0.0487
Schistosoma mansoni caspase-7 (C14 family) 0.0789 0.5202 0.5652
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.018 0.0859 0.0842
Echinococcus multilocularis nmda type glutamate receptor 0.0112 0.0373 0.0356
Loa Loa (eye worm) PAS-3 protein 0.0083 0.0167 0.0167
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0083 0.0167 0.0243
Echinococcus multilocularis GPCR, family 3, C terminal 0.0193 0.0951 0.0935
Onchocerca volvulus Poor gastrulation protein homolog 0.0193 0.0951 0.1277
Echinococcus multilocularis serotonin transporter 0.0292 0.1658 0.1642
Brugia malayi Pre-SET motif family protein 0.0203 0.1026 0.1276
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.144 0.1424
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0083 0.0167 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Plasmodium falciparum proteasome subunit beta type-5 0.1026 0.6887 1
Brugia malayi MH2 domain containing protein 0.0119 0.0423 0.0526
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0018 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Echinococcus multilocularis receptor type guanylyl cyclase 0.0112 0.0373 0.0356
Plasmodium vivax proteasome subunit beta type-6, putative 0.0083 0.0167 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Onchocerca volvulus 0.0188 0.0918 0.1229
Echinococcus granulosus cathepsin b 0.0323 0.1878 0.1863
Loa Loa (eye worm) hypothetical protein 0.0129 0.0495 0.0495
Schistosoma mansoni metabotropic glutamate receptor 0.0579 0.3704 0.4024
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0083 0.0167 0.0243
Brugia malayi Cathepsin L-like precursor 0.0129 0.0495 0.0616
Brugia malayi cathepsin L-like precursor 0.0129 0.0495 0.0616
Leishmania major cathepsin L-like protease 0.0188 0.0918 0.1227
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0083 0.0167 0.0243
Plasmodium vivax proteasome subunit beta type-4, putative 0.0083 0.0167 0.0243
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0083 0.0167 0.0123
Loa Loa (eye worm) glutamate receptor 0.1188 0.8044 0.8044
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0298 0.0371
Loa Loa (eye worm) hypothetical protein 0.0427 0.2621 0.2621
Brugia malayi Cathepsin L-like precursor 0.0188 0.0918 0.1142
Echinococcus multilocularis cathepsin b 0.0323 0.1878 0.1863
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.1351 0.9204 1
Schistosoma mansoni bromodomain containing protein 0.0191 0.0936 0.1017
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1227 0.168
Trypanosoma brucei proteasome alpha 7 subunit 0.0083 0.0167 0.0123
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0188 0.0918 0.0902
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0083 0.0167 0.0167
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1026 0.1026
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0083 0.0167 0.0243
Trypanosoma cruzi cysteine proteinase, putative 0.0101 0.0298 0.0433
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0298 0.0317
Schistosoma mansoni hypothetical protein 0.0063 0.0027 0.0029
Loa Loa (eye worm) hypothetical protein 0.0071 0.0084 0.0084
Mycobacterium ulcerans proteasome PrcA 0.0083 0.0167 0.0123
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0083 0.0167 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0427 0.2621 0.3729
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0083 0.0167 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0083 0.0167 0.0123
Brugia malayi metabotropic glutamate receptor type 2 0.0579 0.3704 0.4605
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0083 0.0167 0.0243
Plasmodium vivax hypothetical protein, conserved 0.0427 0.2621 0.3805
Loa Loa (eye worm) hypothetical protein 0.0261 0.144 0.144
Loa Loa (eye worm) hypothetical protein 0.0323 0.1878 0.1878
Echinococcus granulosus caspase 3 0.0362 0.2158 0.2144
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0427 0.2621 0.3729
Plasmodium vivax proteasome subunit beta type-3, putative 0.0083 0.0167 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0083 0.0167 0.0167
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0083 0.0167 0.0123
Echinococcus multilocularis cathepsin L cysteine protease 0.0188 0.0918 0.0902
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0495 0.0605
Brugia malayi Bromodomain containing protein 0.0115 0.0399 0.0496
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0083 0.0167 0.0123
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0083 0.0167 0.0182
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0082 0.0064
Loa Loa (eye worm) hypothetical protein 0.0112 0.0373 0.0373
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0109 0.0351 0.0274
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0084 0.0121
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0373 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.1658 0.2061
Brugia malayi 20S proteasome alpha5 subunit 0.0083 0.0167 0.0208
Echinococcus granulosus proteasome subunit beta type 7 0.0083 0.0167 0.0149
Schistosoma mansoni cathepsin F (C01 family) 0.0129 0.0495 0.0538
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0027 0.0009
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0112 0.0373 0.0356
Echinococcus granulosus cathepsin b 0.0323 0.1878 0.1863
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0018 0.002
Schistosoma mansoni hypothetical protein 0.0169 0.0778 0.0846
Trypanosoma cruzi extracellular receptor, putative 0.0112 0.0373 0.0542
Echinococcus multilocularis geminin 0.0169 0.0778 0.0762
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0083 0.0167 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Brugia malayi proteasome subunit beta type 3 0.0083 0.0167 0.0208
Trypanosoma cruzi cysteine peptidase, putative 0.0235 0.1249 0.1814
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0083 0.0167 0.0243
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0083 0.0167 0.0123
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0323 0.1878 0.2041
Brugia malayi TAR-binding protein 0.0062 0.0018 0.0023
Leishmania major cathepsin L-like protease 0.0235 0.1249 0.1713
Loa Loa (eye worm) hypothetical protein 0.0128 0.0493 0.0493
Toxoplasma gondii cathepsin B 0.0129 0.0495 0.0604
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.0998 0.1241
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0083 0.0167 0.0149
Loa Loa (eye worm) hypothetical protein 0.0123 0.0452 0.0452
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0083 0.0167 0.0243
Echinococcus granulosus cathepsin l1 0.0129 0.0495 0.0478
Echinococcus granulosus microtubule associated protein 2 0.0674 0.4382 0.4372
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0083 0.0167 0.0123
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0083 0.0167 0.0123
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0083 0.0167 0.0123
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0083 0.0167 0.0123
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0083 0.0167 0.0123
Echinococcus granulosus Proteasome subunit alpha beta 0.0083 0.0167 0.0149
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0083 0.0167 0.0149
Toxoplasma gondii proteasome subunit 0.0083 0.0167 0.0123
Loa Loa (eye worm) glutamate receptor 0.0467 0.2908 0.2908
Leishmania major cathepsin L-like protease 0.0235 0.1249 0.1713
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0083 0.0167 0.0125
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0112 0.0373 0.0356
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1026 0.6887 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0427 0.2621 0.3729
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0918 0.1227
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0083 0.0167 0.0123
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0083 0.0167 0.0149
Brugia malayi Cathepsin L-like precursor 0.0188 0.0918 0.1142
Trypanosoma cruzi metacaspase, putative 0.0427 0.2621 0.3805
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0083 0.0167 0.0167
Leishmania major proteasome beta-1 subunit, putative 0.0083 0.0167 0.0123
Loa Loa (eye worm) hypothetical protein 0.1025 0.6878 0.6878
Plasmodium vivax proteasome subunit beta type-2, putative 0.0109 0.0351 0.051
Brugia malayi Cathepsin L-like precursor 0.0129 0.0495 0.0616
Loa Loa (eye worm) hypothetical protein 0.0129 0.0495 0.0495
Onchocerca volvulus 0.0292 0.1658 0.2317
Brugia malayi Proteasome subunit alpha type 7-1 0.0083 0.0167 0.0208
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0083 0.0167 0.0243
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0083 0.0167 0.0182
Leishmania major cathepsin L-like protease 0.0188 0.0918 0.1227
Echinococcus granulosus receptor type guanylyl cyclase 0.0112 0.0373 0.0356
Echinococcus multilocularis proteasome subunit beta type 7 0.0083 0.0167 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Leishmania major cathepsin L-like protease 0.0188 0.0918 0.1227
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0083 0.0167 0.0149
Trypanosoma brucei metacaspase MCA2 0.0427 0.2621 0.3729
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Brugia malayi hypothetical protein 0.0456 0.2823 0.3509
Echinococcus multilocularis caspase 8 0.0427 0.2621 0.2607
Echinococcus granulosus apoptotic protease activating factor 1 0.0456 0.2823 0.281
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0109 0.0351 0.0394
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0918 0.1227
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0083 0.0167 0.0123
Schistosoma mansoni caspase-7 (C14 family) 0.1025 0.6878 0.7473
Onchocerca volvulus Notchless protein homolog 0.0083 0.0167 0.0123
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0373 0.0373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0918 0.1227
Plasmodium falciparum cysteine proteinase falcipain 3 0.0188 0.0918 0.1118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0112 0.0373 0.0356
Echinococcus granulosus proteasome subunit alpha type 6 0.0083 0.0167 0.0149
Brugia malayi cathepsin B-like cysteine proteinase 0.0323 0.1878 0.2335
Echinococcus granulosus proteasome subunit beta t family 0.0083 0.0167 0.0149
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0083 0.0167 0.0125
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0083 0.0167 0.0125
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0083 0.0167 0.0149
Brugia malayi proteasome subunit beta type 1 0.0083 0.0167 0.0208
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0193 0.0951 0.1183
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0083 0.0167 0.0149
Plasmodium falciparum metacaspase-like protein 0.0427 0.2621 0.3651
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0427 0.2621 0.3729
Echinococcus granulosus metabotropic glutamate receptor 2 0.0995 0.6669 0.6663
Schistosoma mansoni tyrosine kinase 0.0112 0.0373 0.0405
Loa Loa (eye worm) ctsf protein 0.0188 0.0918 0.0918
Entamoeba histolytica cysteine proteinase, putative 0.0129 0.0495 0.0607
Brugia malayi Papain family cysteine protease containing protein 0.0188 0.0918 0.1142
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0083 0.0167 0.0182
Entamoeba histolytica cysteine protease, putative 0.0188 0.0918 0.1229
Loa Loa (eye worm) RNA binding protein 0.0062 0.0018 0.0018
Onchocerca volvulus 0.0112 0.0373 0.0426
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0083 0.0167 0.0123
Loa Loa (eye worm) hypothetical protein 0.0081 0.0151 0.0151
Leishmania major proteasome beta 2 subunit, putative 0.0109 0.0351 0.0394
Loa Loa (eye worm) hypothetical protein 0.0112 0.0373 0.0373
Leishmania major proteasome alpha 7 subunit, putative 0.0083 0.0167 0.0123
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0175 0.0826 0.12
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0083 0.0167 0.0149
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0298 0.0317
Brugia malayi Proteasome subunit alpha type 1 0.0083 0.0167 0.0208
Plasmodium vivax metacaspase 1, putative 0.0427 0.2621 0.3805
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0083 0.0167 0.0123
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0083 0.0167 0.0243
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0112 0.0373 0.0373
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0427 0.2621 0.3729
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0129 0.0495 0.0718
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0083 0.0167 0.0243
Brugia malayi Cathepsin L-like cysteine proteinase 0.0129 0.0495 0.0616
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0101 0.0298 0.0433
Brugia malayi Bromodomain containing protein 0.0226 0.1187 0.1476
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0305 0.1747 0.1747
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0427 0.2621 0.3729
Loa Loa (eye worm) hypothetical protein 0.0071 0.0084 0.0084
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0427 0.2621 0.3729
Echinococcus multilocularis metabotropic glutamate receptor 5 0.1463 1 1
Brugia malayi Proteasome A-type and B-type family protein 0.0083 0.0167 0.0208
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0427 0.2621 0.3729
Loa Loa (eye worm) hypothetical protein 0.0112 0.0373 0.0373
Echinococcus multilocularis tumor protein p63 0.033 0.193 0.1915
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0083 0.0167 0.0243
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0083 0.0167 0.0149
Brugia malayi Receptor family ligand binding region containing protein 0.0305 0.1747 0.2172
Brugia malayi Receptor family ligand binding region containing protein 0.0112 0.0373 0.0464
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0018 0.002
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0109 0.0351 0.0382
Trypanosoma cruzi major cysteine proteinase, putative 0.0088 0.0206 0.0299
Brugia malayi proteasome subunit alpha type 3 0.0083 0.0167 0.0208
Plasmodium vivax unspecified product 0.0101 0.0298 0.0433
Loa Loa (eye worm) proteasome subunit beta type 3 0.0083 0.0167 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0188 0.0918 0.0918
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0083 0.0167 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0083 0.0167 0.0125
Echinococcus multilocularis glutamate receptor 2 0.0112 0.0373 0.0356
Mycobacterium ulcerans proteasome PrcB 0.1026 0.6887 1
Brugia malayi Cathepsin L-like precursor 0.0188 0.0918 0.1142
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0083 0.0167 0.0149
Echinococcus granulosus atrial natriuretic peptide receptor 0.0112 0.0373 0.0356
Onchocerca volvulus Cathepsin L homolog 0.0188 0.0918 0.1229
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0084 0.0121
Entamoeba histolytica cysteine proteinase, putative 0.0188 0.0918 0.1229
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0305 0.1747 0.1747
Leishmania major proteasome beta 7 subunit, putative 0.0083 0.0167 0.0123
Loa Loa (eye worm) hypothetical protein 0.0305 0.1747 0.1747
Trypanosoma cruzi cruzipain precursor, putative 0.0235 0.1249 0.1814
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0083 0.0167 0.0243
Loa Loa (eye worm) hypothetical protein 0.0292 0.1658 0.1658
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.1658 0.1801
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0027 0.0033
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0083 0.0167 0.0243
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0083 0.0167 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0918 0.1227
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0027 0.0009
Leishmania major cathepsin L-like protease 0.0188 0.0918 0.1227
Trypanosoma cruzi cysteine peptidase, putative 0.0235 0.1249 0.1814
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0112 0.0373 0.0356
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0427 0.2621 0.2848
Toxoplasma gondii proteasome subunit alpha type, putative 0.0083 0.0167 0.0123
Plasmodium vivax proteasome subunit beta type-7, putative 0.0083 0.0167 0.0243
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0188 0.0918 0.0918
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0101 0.0298 0.0324
Loa Loa (eye worm) hypothetical protein 0.0116 0.0401 0.0401
Echinococcus granulosus cathepsin L cysteine proteinase 0.0188 0.0918 0.0902
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.1076 0.7247 0.901
Echinococcus granulosus subfamily T1A non peptidase ue 0.0083 0.0167 0.0149
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1026 0.6887 0.7483
Leishmania major proteasome alpha 3 subunit, putative 0.0083 0.0167 0.0123
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.1658 0.1801
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0109 0.0351 0.0394
Brugia malayi hypothetical protein 0.0261 0.144 0.179
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0083 0.0167 0.0243
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0083 0.0167 0.0125
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1026 0.6887 1
Echinococcus multilocularis cathepsin L 0.0101 0.0298 0.028
Brugia malayi Cathepsin L-like precursor 0.0188 0.0918 0.1142
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0083 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0071 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0918 0.1227
Echinococcus granulosus GPCR family 3 C terminal 0.0193 0.0951 0.0935
Brugia malayi beta-lactamase family protein 0.0071 0.0084 0.0104
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0789 0.5202 0.5193
Loa Loa (eye worm) fibroinase 0.0188 0.0918 0.0918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0298 0.0315
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Brugia malayi Cathepsin L-like precursor 0.0188 0.0918 0.1142
Trichomonas vaginalis conserved hypothetical protein 0.0427 0.2621 0.3729
Onchocerca volvulus 0.0188 0.0918 0.1229
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0129 0.0495 0.0604
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0083 0.0167 0.0123
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0083 0.0167 0.0182
Trypanosoma brucei proteasome beta 7 subunit 0.0083 0.0167 0.0123
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0083 0.0167 0.5
Echinococcus multilocularis apoptotic protease activating factor 1 0.0456 0.2823 0.281
Entamoeba histolytica cysteine proteinase, putative 0.0188 0.0918 0.1229
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0112 0.0373 0.0464
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0083 0.0167 0.0243
Loa Loa (eye worm) hypothetical protein 0.0199 0.0998 0.0998
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0109 0.0351 0.0334
Toxoplasma gondii heat shock protein hslv, putative 0.0083 0.0167 0.0123
Schistosoma mansoni hypothetical protein 0.0169 0.0778 0.0846
Loa Loa (eye worm) beta-lactamase 0.0071 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.1463 1 1
Brugia malayi PHD-finger family protein 0.0075 0.0112 0.0139
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0083 0.0167 0.0123
Brugia malayi proteasome subunit alpha type 4 0.0083 0.0167 0.0208
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0495 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Leishmania major proteasome beta 3 subunit, putative 0.0083 0.0167 0.0123
Brugia malayi proteasome subunit alpha type 2 0.0083 0.0167 0.0208
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0082 0.0089
Echinococcus granulosus fetal alzheimer antigen falz 0.0068 0.0061 0.0043
Schistosoma mansoni hypothetical protein 0.0063 0.0027 0.0029
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0188 0.0918 0.1118
Leishmania major proteasome alpha 1 subunit, putative 0.0083 0.0167 0.0123
Echinococcus granulosus Proteasome subunit alpha type 7 0.0083 0.0167 0.0149
Schistosoma mansoni protein kinase 0.0112 0.0373 0.0405
Echinococcus granulosus geminin 0.0169 0.0778 0.0762
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Brugia malayi hypothetical protein 0.0112 0.0373 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0018 0.0018
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0083 0.0167 0.0182
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0083 0.0167 0.0123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0084 0.0065
Loa Loa (eye worm) hypothetical protein 0.0292 0.1658 0.1658
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0423 0.0423
Plasmodium vivax vivapain-2 0.0188 0.0918 0.1333
Leishmania major proteasome alpha 1 subunit, putative 0.0083 0.0167 0.0123
Brugia malayi Cathepsin L-like precursor 0.0188 0.0918 0.1142
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0083 0.0167 0.0243
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0083 0.0167 0.0123
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0112 0.0373 0.0356
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0083 0.0167 0.0167
Echinococcus granulosus proteasome subunit beta type 6 0.0083 0.0167 0.0149
Schistosoma mansoni caspase-3 (C14 family) 0.0789 0.5202 0.5652
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0083 0.0167 0.0123
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0109 0.0351 0.0382
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0298 0.0317
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Giardia lamblia Cathepsin B precursor 0.0129 0.0495 0.0487
Trypanosoma brucei proteasome beta 6 subunit 0.0083 0.0167 0.0123
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0083 0.0167 0.0123
Trypanosoma cruzi cysteine protease, putative 0.0101 0.0298 0.0433
Schistosoma mansoni hypothetical protein 0.0063 0.0027 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0427 0.2621 0.3729
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0083 0.0167 0.0123
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0083 0.0167 0.0125
Toxoplasma gondii proteasome beta subunit 0.0083 0.0167 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0151 0.0164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0188 0.0918 0.1227
Loa Loa (eye worm) hypothetical protein 0.0112 0.0373 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0323 0.1878 0.2041
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0083 0.0167 0.0123
Leishmania major cysteine peptidase A (CPA) 0.0188 0.0918 0.1227
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0918 0.1333
Onchocerca volvulus 0.0188 0.0918 0.1229
Brugia malayi proteasome subunit alpha type 1 0.0083 0.0167 0.0208
Echinococcus granulosus caspase 0.0789 0.5202 0.5193
Trypanosoma cruzi cysteine peptidase, putative 0.0235 0.1249 0.1814
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0083 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0112 0.0373 0.0373
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0112 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0063 0.0027 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0018 0.002
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.4382 0.4761
Trypanosoma brucei metacaspase 5, putative 0.0427 0.2621 0.3729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Leishmania major extracellular receptor, putative 0.0112 0.0373 0.0426
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1026 0.6887 1
Onchocerca volvulus 0.0112 0.0373 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0495 0.0605
Echinococcus multilocularis caspase 0.0789 0.5202 0.5193
Loa Loa (eye worm) cathepsin B 0.0129 0.0495 0.0495
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0083 0.0167 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0083 0.0167 0.0123
Trypanosoma cruzi metacaspase, putative 0.0427 0.2621 0.3805
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0112 0.0373 0.0356
Loa Loa (eye worm) hypothetical protein 0.0456 0.2823 0.2823
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0083 0.0167 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0298 0.0315
Plasmodium vivax proteasome subunit beta type-1, putative 0.0083 0.0167 0.0243
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0427 0.2621 0.3729
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.0998 0.0998
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0995 0.6669 0.6663
Echinococcus multilocularis cathepsin L cysteine protease 0.0188 0.0918 0.0902
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0427 0.2621 0.3258
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0083 0.0167 0.0125
Onchocerca volvulus 0.0456 0.2823 0.4032
Schistosoma mansoni cathepsin F (C01 family) 0.0188 0.0918 0.0998
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0083 0.0167 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0323 0.1878 0.2041
Brugia malayi proteasome subunit alpha type 6 0.0083 0.0167 0.0208
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0083 0.0167 0.0125
Toxoplasma gondii proteasome subunit alpha1, putative 0.0083 0.0167 0.0123
Schistosoma mansoni hypothetical protein 0.0136 0.0549 0.0596
Echinococcus granulosus GPCR family 2 0.0063 0.0027 0.0009
Loa Loa (eye worm) cysteine protease 0.0188 0.0918 0.0918
Schistosoma mansoni hypothetical protein 0.0071 0.0082 0.0089
Onchocerca volvulus 0.0188 0.0918 0.1229
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0298 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0068 0.0061 0.0066
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0083 0.0167 0.0182
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Schistosoma mansoni tyrosine kinase 0.0112 0.0373 0.0405
Onchocerca volvulus 0.0231 0.1227 0.1682
Echinococcus granulosus cathepsin l1 0.0188 0.0918 0.0902
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0083 0.0167 0.0243
Toxoplasma gondii cathepsin CPL 0.0188 0.0918 0.1227
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0083 0.0167 0.0243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0918 0.1227
Trypanosoma brucei Metacaspase-4 0.0427 0.2621 0.3729
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0188 0.0918 0.1118
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0083 0.0167 0.0167
Plasmodium falciparum cysteine proteinase falcipain 1 0.0101 0.0298 0.0195
Echinococcus multilocularis cysteine protease 0.0188 0.0918 0.0902
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.144 0.1424
Echinococcus multilocularis glutamate receptor 2 0.0112 0.0373 0.0356
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0084 0.0091
Schistosoma mansoni hypothetical protein 0.0193 0.0951 0.1034
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0083 0.0167 0.0182
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0083 0.0167 0.0243
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0109 0.0351 0.0394
Echinococcus granulosus nmda type glutamate receptor 0.0112 0.0373 0.0356
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0151 0.0133
Brugia malayi Cell death protein 3 precursor 0.1025 0.6878 0.8551
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0298 0.0315
Echinococcus granulosus serotonin transporter 0.0292 0.1658 0.1642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0084 0.0104
Entamoeba histolytica cysteine proteinase 1, putative 0.0101 0.0298 0.0317
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.1658 0.5
Trypanosoma cruzi metacaspase 5, putative 0.0427 0.2621 0.3805
Trypanosoma cruzi cysteine proteinase, putative 0.0101 0.0298 0.0433
Echinococcus granulosus cathepsin L 0.0101 0.0298 0.028
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0083 0.0167 0.0243
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.0998 0.1241
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0549 0.0682
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0083 0.0167 0.0123
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0083 0.0167 0.0149
Schistosoma mansoni hypothetical protein 0.0062 0.002 0.0022
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0109 0.0351 0.0394
Loa Loa (eye worm) hypothetical protein 0.0071 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0456 0.2823 0.3067
Onchocerca volvulus Cell death protein 3 homolog 0.1025 0.6878 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0549 0.0549
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0298 0.0371
Leishmania major metacaspase, putative 0.0427 0.2621 0.3729
Echinococcus granulosus cysteine protease 0.0101 0.0298 0.028
Echinococcus granulosus proteasome subunit alpha type 2 0.0083 0.0167 0.0149
Brugia malayi RNA binding protein 0.0062 0.0018 0.0023
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0084 0.0065
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1026 0.6887 0.6887
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0083 0.0167 0.0167
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0084 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Onchocerca volvulus 0.0129 0.0495 0.0606
Onchocerca volvulus Cathepsin L homolog 0.0188 0.0918 0.1229
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.1658 0.1658
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0083 0.0167 0.0182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0918 0.1227
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0193 0.0951 0.1277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Brugia malayi beta-lactamase 0.0071 0.0084 0.0104
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0101 0.0298 0.0324
Toxoplasma gondii proteasome subunit beta type, putative 0.1026 0.6887 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0084 0.0084
Onchocerca volvulus 0.0188 0.0918 0.1229
Echinococcus multilocularis proteasome subunit alpha type 2 0.0083 0.0167 0.0149
Echinococcus multilocularis cathepsin b 0.0323 0.1878 0.1863
Leishmania major proteasome beta 5 subunit, putative 0.1026 0.6887 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0083 0.0167 0.0149
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0018 0.0018
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0083 0.0167 0.0182
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0083 0.0167 0.0243
Trypanosoma brucei metacaspase MCA3 0.0427 0.2621 0.3729
Loa Loa (eye worm) hypothetical protein 0.0193 0.0951 0.0951
Giardia lamblia Cathepsin B precursor 0.0129 0.0495 0.0487
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0083 0.0167 0.0182
Echinococcus granulosus caspase 2 0.1025 0.6878 0.6872
Leishmania major proteasome alpha 7 subunit, putative 0.0083 0.0167 0.0123
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.2813 0.4011
Trypanosoma cruzi metacaspase, putative 0.0427 0.2621 0.3805
Giardia lamblia Proteasome subunit beta type 2 0.0109 0.0351 0.0274
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0108 0.0348 0.0331
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0427 0.2621 0.3729
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1026 0.6887 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1026 0.6887 1
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0083 0.0167 0.0243
Toxoplasma gondii peptidase, T1 family protein 0.0083 0.0167 0.0123
Echinococcus granulosus glutamate receptor 2 0.0112 0.0373 0.0356
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0027 0.0033
Schistosoma mansoni metabotropic glutamate receptor 0.0995 0.6669 0.7246
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0109 0.0351 0.0334
Loa Loa (eye worm) hypothetical protein 0.0213 0.1095 0.1095
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0083 0.0167 0.0123
Brugia malayi Metabotropic glutamate receptor precursor. 0.1188 0.8044 1
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0109 0.0351 0.051
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0083 0.0167 0.0182
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0083 0.0167 0.0243
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0083 0.0167 0.0123
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0789 0.5202 0.5193
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0083 0.0167 0.0123
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0083 0.0167 0.0123
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0083 0.0167 0.0243
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0112 0.0373 0.0356
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.002 0.002
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0083 0.0167 0.0123
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0083 0.0167 0.0243
Plasmodium vivax proteasome subunit beta type-5, putative 0.1026 0.6887 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0129 0.0495 0.0604
Brugia malayi Proteasome A-type and B-type family protein 0.0083 0.0167 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0112 0.0373 0.0426
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0083 0.0167 0.0182
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0083 0.0167 0.0123
Plasmodium vivax vivapain-1 0.0101 0.0298 0.0433
Leishmania major cathepsin L-like protease 0.0235 0.1249 0.1713
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0918 0.1227
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1026 0.6887 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0083 0.0167 0.0243
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0084 0.0091
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0083 0.0167 0.0243
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0323 0.1878 0.2727
Plasmodium vivax vivapain-2 0.0188 0.0918 0.1333
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0083 0.0167 0.0125
Schistosoma mansoni glutamate receptor NMDA 0.0112 0.0373 0.0405
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0112 0.0373 0.0356
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0083 0.0167 0.0125
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0027 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0188 0.0918 0.0998
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0151 0.0133
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0083 0.0167 0.0243
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0108 0.0348 0.0331
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0083 0.0167 0.0182
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0083 0.0167 0.0125
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0082 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0427 0.2621 0.3729
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.0495 0.0604
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0109 0.0351 0.0395
Echinococcus multilocularis caspase 2 0.1025 0.6878 0.6872
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0427 0.2621 0.3729
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1026 0.6887 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0083 0.0167 0.0123
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0083 0.0167 0.0243
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0083 0.0167 0.0243
Echinococcus granulosus proteasome prosome macropain 0.1026 0.6887 0.6882
Echinococcus granulosus cathepsin l cysteine peptidase 0.0188 0.0918 0.0902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0918 0.1227
Brugia malayi Proteasome A-type and B-type family protein 0.0083 0.0167 0.0208
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0083 0.0167 0.0149
Onchocerca volvulus 0.0188 0.0918 0.1229
Trypanosoma cruzi metacaspase 5, putative 0.0427 0.2621 0.3805
Loa Loa (eye worm) proteasome subunit beta type 2 0.0109 0.0351 0.0351
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.018 0.0859 0.0842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0235 0.1249 0.1713
Loa Loa (eye worm) hypothetical protein 0.0129 0.0495 0.0495
Brugia malayi beta-lactamase family protein 0.0071 0.0084 0.0104
Brugia malayi proteasome subunit beta type 2 0.0109 0.0351 0.0437
Entamoeba histolytica cysteine protease, putative 0.0101 0.0298 0.0317
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0083 0.0167 0.0167
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0083 0.0167 0.0125
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0083 0.0167 0.0123
Echinococcus granulosus tumor protein p63 0.033 0.193 0.1915
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0112 0.0373 0.0356
Loa Loa (eye worm) serotonin transporter b 0.0292 0.1658 0.1658
Echinococcus multilocularis proteasome subunit alpha type 6 0.0083 0.0167 0.0149
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0083 0.0167 0.0123
Echinococcus granulosus tyrosine kinase 0.0112 0.0373 0.0356
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0083 0.0167 0.0123
Brugia malayi hypothetical protein 0.0071 0.0082 0.0102
Echinococcus multilocularis caspase 3 0.0362 0.2158 0.2144
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1026 0.6887 1
Loa Loa (eye worm) proteasome subunit beta type 1 0.0083 0.0167 0.0167
Onchocerca volvulus 0.0188 0.0918 0.1229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0298 0.0315
Echinococcus multilocularis GPCR, family 2 0.0063 0.0027 0.0009
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0188 0.0918 0.0918
Entamoeba histolytica cysteine proteinase 2 0.0101 0.0298 0.0317
Trypanosoma brucei metacaspase 0.0427 0.2621 0.3729
Brugia malayi Proteasome A-type and B-type family protein 0.1026 0.6887 0.8563
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0084 0.0084
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0427 0.2621 0.3729
Loa Loa (eye worm) hypothetical protein 0.0292 0.1658 0.1658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0151 0.0164
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0083 0.0167 0.0125
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0083 0.0167 0.0125
Loa Loa (eye worm) hypothetical protein 0.0063 0.0027 0.0027
Echinococcus multilocularis proteasome (prosome, macropain) 0.1026 0.6887 0.6882
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0423 0.0423
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0188 0.0918 0.1227
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0018 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0298 0.0433
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0027 0.0009
Loa Loa (eye worm) hypothetical protein 0.0071 0.0084 0.0084
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.4382 0.4372
Echinococcus granulosus caspase 8 0.0427 0.2621 0.2607
Echinococcus multilocularis proteasome subunit beta type 6 0.0083 0.0167 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0918 0.1227
Entamoeba histolytica hypothetical protein 0.0112 0.0373 0.0427
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0427 0.2621 0.3729
Echinococcus multilocularis cysteine protease 0.0188 0.0918 0.0902
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0101 0.0298 0.0324
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0188 0.0918 0.0902
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0083 0.0167 0.0123
Echinococcus multilocularis tyrosine kinase 0.0112 0.0373 0.0356
Trypanosoma cruzi metacaspase, putative 0.0427 0.2621 0.3805
Leishmania major cathepsin L-like protease 0.0188 0.0918 0.1227
Trypanosoma cruzi 20S proteasome subunit 0.0109 0.0351 0.051
Onchocerca volvulus Cathepsin F homolog 0.0188 0.0918 0.1229
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0083 0.0167 0.0123
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0083 0.0167 0.0149
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0373 0.0373
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0068 0.0061 0.0043

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 386 nM Binding affinity to CCR3 ChEMBL. 16931001

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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