Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0128 | 0.0122 | 0.0122 |
Leishmania major | cathepsin L-like protease | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0261 | 0.1802 | 0.1802 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0261 | 0.1802 | 0.1802 |
Plasmodium falciparum | metacaspase 1 | 0.0261 | 0.1802 | 0.1701 |
Brugia malayi | hypothetical protein | 0.0241 | 0.1545 | 0.1441 |
Echinococcus granulosus | caspase | 0.0477 | 0.4531 | 0.4464 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.2481 | 0.2481 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Leishmania major | cysteine peptidase A (CPA) | 0.0128 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | fibroinase | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Leishmania major | cathepsin L-like protease | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.091 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0128 | 0.0122 | 0.0122 |
Echinococcus granulosus | cathepsin b | 0.0315 | 0.2481 | 0.2388 |
Brugia malayi | Cell death protein 3 precursor | 0.0545 | 0.5393 | 0.5337 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0315 | 0.2481 | 0.2481 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0315 | 0.2481 | 0.2481 |
Leishmania major | cathepsin L-like protease | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Echinococcus granulosus | caspase 2 | 0.0545 | 0.5393 | 0.5337 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0128 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | cysteine protease | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0315 | 0.2481 | 0.2481 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0477 | 0.4531 | 0.4464 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.5393 | 0.5393 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0477 | 0.4531 | 0.4531 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.091 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma cruzi | metacaspase, putative | 0.0261 | 0.1802 | 0.1802 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.091 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0261 | 0.1802 | 0.1802 |
Trypanosoma brucei | metacaspase | 0.0261 | 0.1802 | 0.1802 |
Echinococcus granulosus | proteasome prosome macropain | 0.091 | 1 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0261 | 0.1802 | 0.1802 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0241 | 0.1545 | 0.1441 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Schistosoma mansoni | hypothetical protein | 0.0284 | 0.209 | 0.209 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.091 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0261 | 0.1802 | 0.1802 |
Plasmodium vivax | hypothetical protein, conserved | 0.0261 | 0.1802 | 0.1701 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.091 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma brucei | metacaspase 5, putative | 0.0261 | 0.1802 | 0.1802 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0122 | 0.0122 |
Echinococcus multilocularis | cathepsin b | 0.0315 | 0.2481 | 0.2388 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0545 | 0.5393 | 0.5393 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.091 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0315 | 0.2481 | 0.2481 |
Mycobacterium ulcerans | proteasome PrcB | 0.091 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.209 | 0.209 |
Trypanosoma cruzi | metacaspase, putative | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0261 | 0.1802 | 0.1802 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0261 | 0.1802 | 0.1701 |
Trypanosoma cruzi | metacaspase, putative | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0261 | 0.1802 | 0.1802 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0128 | 0.0122 | 0.0122 |
Leishmania major | cathepsin L-like protease | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0128 | 0.0122 | 0.0122 |
Echinococcus multilocularis | caspase | 0.0477 | 0.4531 | 0.4464 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0128 | 0.0122 | 0.0122 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0315 | 0.2481 | 0.2388 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.091 | 1 | 1 |
Leishmania major | metacaspase, putative | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Onchocerca volvulus | 0.0284 | 0.209 | 0.3734 | |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma brucei | Metacaspase-4 | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0261 | 0.1802 | 0.1802 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0284 | 0.209 | 0.1993 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0241 | 0.1545 | 0.1441 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.091 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0284 | 0.209 | 0.1993 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.091 | 1 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0261 | 0.1802 | 0.1802 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0128 | 0.0122 | 0.0122 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0315 | 0.2481 | 0.2481 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Echinococcus multilocularis | cathepsin b | 0.0315 | 0.2481 | 0.2388 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Plasmodium vivax | metacaspase 1, putative | 0.0261 | 0.1802 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.1802 | 0.1802 |
Echinococcus granulosus | caspase 8 | 0.0261 | 0.1802 | 0.1701 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Leishmania major | cathepsin L-like protease | 0.0128 | 0.0122 | 0.0122 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0261 | 0.1802 | 0.1802 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.1545 | 0.1545 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0128 | 0.0122 | 0.0122 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.091 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.091 | 1 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0261 | 0.1802 | 0.1802 |
Echinococcus granulosus | caspase 3 | 0.0216 | 0.1228 | 0.112 |
Echinococcus multilocularis | caspase 8 | 0.0261 | 0.1802 | 0.1701 |
Echinococcus multilocularis | caspase 2 | 0.0545 | 0.5393 | 0.5337 |
Leishmania major | proteasome beta 5 subunit, putative | 0.091 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0261 | 0.1802 | 0.1802 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.091 | 1 | 1 |
Trypanosoma brucei | metacaspase MCA3 | 0.0261 | 0.1802 | 0.1802 |
Echinococcus multilocularis | caspase 3 | 0.0216 | 0.1228 | 0.112 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | ctsf protein | 0.0128 | 0.0122 | 0.0122 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0545 | 0.5393 | 1 |
Leishmania major | cathepsin L-like protease | 0.0128 | 0.0122 | 0.0122 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0261 | 0.1802 | 0.1802 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.091 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0128 | 0.0122 | 0.0122 |
Plasmodium falciparum | metacaspase-like protein | 0.0261 | 0.1802 | 0.1701 |
Echinococcus granulosus | cathepsin b | 0.0315 | 0.2481 | 0.2388 |
Trypanosoma brucei | metacaspase MCA2 | 0.0261 | 0.1802 | 0.1802 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0261 | 0.1802 | 0.1802 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.091 | 1 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0477 | 0.4531 | 0.4531 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0477 | 0.4531 | 0.4464 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0261 | 0.1802 | 0.1802 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0284 | 0.209 | 0.1993 |
Leishmania major | cathepsin L-like protease | 0.0128 | 0.0122 | 0.0122 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 uM | Inhibition of recombinant HIV integrase strand transfer activity | ChEMBL. | 16908139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.