TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.495 | Formula: C23H28N4O
H donors: 3 H acceptors: 2 LogP: 3.7 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cccc(c1)NC(=O)NCCC[C@@H]1NCC[C@H](C1)Cc1ccccc1
InChi: 1S/C23H28N4O/c24-17-20-8-4-9-22(16-20)27-23(28)26-12-5-10-21-15-19(11-13-25-21)14-18-6-2-1-3-7-18/h1-4,6-9,16,19,21,25H,5,10-15H2,(H2,26,27,28)/t19-,21-/m0/s1
InChiKey: FFTNCZSASXDDKK-FPOVZHCZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 3	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 2	Starlite/ChEMBL	References
Homo sapiens	chemokine (C-C motif) receptor 3	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 3	620 aa	579 aa	33.2 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 2	617 aa	638 aa	32.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	proteasome alpha 1 subunit, putative	0.0083	0.0167	0.0123
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0083	0.0167	0.0149
Echinococcus granulosus	geminin	0.0169	0.0778	0.0762
Schistosoma mansoni	protein kinase	0.0112	0.0373	0.0405
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0188	0.0918	0.1118
Schistosoma mansoni	hypothetical protein	0.0063	0.0027	0.0029
Echinococcus granulosus	fetal alzheimer antigen falz	0.0068	0.0061	0.0043
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0082	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1658	0.1658
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.0084	0.0065
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.0423	0.0423
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0083	0.0167	0.0123
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0018	0.0018
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0083	0.0167	0.0182
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Brugia malayi	hypothetical protein	0.0112	0.0373	0.0464
Trypanosoma brucei	proteasome beta 7 subunit	0.0083	0.0167	0.0123
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0083	0.0167	0.5
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0083	0.0167	0.0182
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0083	0.0167	0.0123
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0129	0.0495	0.0604
Brugia malayi	proteasome subunit alpha type 2	0.0083	0.0167	0.0208
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Leishmania major	proteasome beta 3 subunit, putative	0.0083	0.0167	0.0123
Loa Loa (eye worm)	hypothetical protein	0.1463	1	1
Brugia malayi	PHD-finger family protein	0.0075	0.0112	0.0139
Brugia malayi	proteasome subunit alpha type 4	0.0083	0.0167	0.0208
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0083	0.0167	0.0123
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0129	0.0495	0.0537
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0109	0.0351	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0199	0.0998	0.0998
Schistosoma mansoni	hypothetical protein	0.0169	0.0778	0.0846
Loa Loa (eye worm)	beta-lactamase	0.0071	0.0084	0.0084
Toxoplasma gondii	heat shock protein hslv, putative	0.0083	0.0167	0.0123
Entamoeba histolytica	cysteine proteinase, putative	0.0188	0.0918	0.1229
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0456	0.2823	0.281
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0112	0.0373	0.0464
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0083	0.0167	0.0243
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0081	0.0151	0.0164
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0063	0.0027	0.0027
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0083	0.0167	0.0125
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0083	0.0167	0.0123
Toxoplasma gondii	proteasome beta subunit	0.0083	0.0167	0.0123
Trichomonas vaginalis	conserved hypothetical protein	0.0427	0.2621	0.3729
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0083	0.0167	0.0123
Trypanosoma cruzi	cysteine protease, putative	0.0101	0.0298	0.0433
Schistosoma mansoni	hypothetical protein	0.0063	0.0027	0.0029
Entamoeba histolytica	cysteine proteinase, putative	0.0101	0.0298	0.0317
Trypanosoma brucei	proteasome beta 6 subunit	0.0083	0.0167	0.0123
Giardia lamblia	Cathepsin B precursor	0.0129	0.0495	0.0487
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Brugia malayi	proteasome subunit alpha type 1	0.0083	0.0167	0.0208
Echinococcus granulosus	caspase	0.0789	0.5202	0.5193
Onchocerca volvulus		0.0188	0.0918	0.1229
Trypanosoma cruzi	cysteine peptidase, putative	0.0188	0.0918	0.1333
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1878	0.2041
Leishmania major	cysteine peptidase A (CPA)	0.0188	0.0918	0.1227
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0083	0.0167	0.0123
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0188	0.0918	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0373	0.0373
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0083	0.0167	0.0167
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0083	0.0167	0.0123
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0112	0.0373	0.0356
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Plasmodium vivax	vivapain-2	0.0188	0.0918	0.1333
Brugia malayi	Cathepsin L-like precursor	0.0188	0.0918	0.1142
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0083	0.0167	0.0243
Leishmania major	proteasome alpha 1 subunit, putative	0.0083	0.0167	0.0123
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0109	0.0351	0.0382
Schistosoma mansoni	caspase-3 (C14 family)	0.0789	0.5202	0.5652
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0083	0.0167	0.0123
Echinococcus granulosus	proteasome subunit beta type 6	0.0083	0.0167	0.0149
Onchocerca volvulus		0.0456	0.2823	0.4032
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0083	0.0167	0.0125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1878	0.2041
Schistosoma mansoni	cathepsin F (C01 family)	0.0188	0.0918	0.0998
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0083	0.0167	0.0123
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0427	0.2621	0.3258
Echinococcus multilocularis	cathepsin L cysteine protease	0.0188	0.0918	0.0902
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0199	0.0998	0.0998
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0427	0.2621	0.3729
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0083	0.0167	0.0243
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0995	0.6669	0.6663
Echinococcus granulosus	GPCR family 2	0.0063	0.0027	0.0009
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0083	0.0167	0.0123
Schistosoma mansoni	hypothetical protein	0.0136	0.0549	0.0596
Brugia malayi	proteasome subunit alpha type 6	0.0083	0.0167	0.0208
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0083	0.0167	0.0125
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0018	0.002
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0112	0.0373	0.0373
Schistosoma mansoni	hypothetical protein	0.0063	0.0027	0.0029
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0083	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0373	0.0373
Trypanosoma cruzi	cysteine peptidase, putative	0.0235	0.1249	0.1814
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0083	0.0167	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0456	0.2823	0.2823
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0112	0.0373	0.0356
Trypanosoma cruzi	metacaspase, putative	0.0427	0.2621	0.3805
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0101	0.0298	0.0315
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0083	0.0167	0.0182
Loa Loa (eye worm)	cathepsin B	0.0129	0.0495	0.0495
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0083	0.0167	0.0123
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Leishmania major	extracellular receptor, putative	0.0112	0.0373	0.0426
Echinococcus multilocularis	caspase	0.0789	0.5202	0.5193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0129	0.0495	0.0605
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.1026	0.6887	1
Onchocerca volvulus		0.0112	0.0373	0.0426
Schistosoma mansoni	microtubule-associated protein tau	0.0674	0.4382	0.4761
Trypanosoma brucei	metacaspase 5, putative	0.0427	0.2621	0.3729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0083	0.0167	0.0243
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0109	0.0351	0.0394
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0083	0.0167	0.0182
Echinococcus multilocularis	cysteine protease	0.0188	0.0918	0.0902
Schistosoma mansoni	hypothetical protein	0.0193	0.0951	0.1034
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0084	0.0091
Echinococcus multilocularis	glutamate receptor 2	0.0112	0.0373	0.0356
Echinococcus granulosus	survival motor neuron protein 1	0.0261	0.144	0.1424
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0101	0.0298	0.0195
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0083	0.0167	0.0167
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0188	0.0918	0.1118
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0199	0.0998	0.1241
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0083	0.0167	0.0243
Brugia malayi	latrophilin 2 splice variant baaae	0.0136	0.0549	0.0682
Echinococcus granulosus	cathepsin L	0.0101	0.0298	0.028
Trypanosoma cruzi	metacaspase 5, putative	0.0427	0.2621	0.3805
Trypanosoma cruzi	cysteine proteinase, putative	0.0101	0.0298	0.0433
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.1658	0.5
Echinococcus granulosus	serotonin transporter	0.0292	0.1658	0.1642
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0101	0.0298	0.0315
Entamoeba histolytica	cysteine proteinase 1, putative	0.0101	0.0298	0.0317
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.0084	0.0104
Echinococcus granulosus	histone lysine methyltransferase setb	0.0081	0.0151	0.0133
Brugia malayi	Cell death protein 3 precursor	0.1025	0.6878	0.8551
Echinococcus granulosus	nmda type glutamate receptor	0.0112	0.0373	0.0356
Onchocerca volvulus		0.0231	0.1227	0.1682
Schistosoma mansoni	tyrosine kinase	0.0112	0.0373	0.0405
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0083	0.0167	0.0182
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0068	0.0061	0.0066
Loa Loa (eye worm)	cysteine protease	0.0188	0.0918	0.0918
Onchocerca volvulus		0.0188	0.0918	0.1229
Schistosoma mansoni	hypothetical protein	0.0071	0.0082	0.0089
Entamoeba histolytica	cysteine proteinase, putative	0.0101	0.0298	0.0317
Trypanosoma brucei	Metacaspase-4	0.0427	0.2621	0.3729
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0083	0.0167	0.0243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.0918	0.1227
Toxoplasma gondii	cathepsin CPL	0.0188	0.0918	0.1227
Echinococcus granulosus	cathepsin l1	0.0188	0.0918	0.0902
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0083	0.0167	0.0243
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0083	0.0167	0.0182
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0083	0.0167	0.0243
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0083	0.0167	0.0149
Leishmania major	proteasome beta 5 subunit, putative	0.1026	0.6887	1
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0018	0.0018
Onchocerca volvulus		0.0188	0.0918	0.1229
Echinococcus multilocularis	cathepsin b	0.0323	0.1878	0.1863
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0083	0.0167	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0084	0.0084
Brugia malayi	beta-lactamase	0.0071	0.0084	0.0104
Toxoplasma gondii	proteasome subunit beta type, putative	0.1026	0.6887	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0101	0.0298	0.0324
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0108	0.0348	0.0331
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0454	0.2813	0.4011
Leishmania major	proteasome alpha 7 subunit, putative	0.0083	0.0167	0.0123
Trypanosoma cruzi	metacaspase, putative	0.0427	0.2621	0.3805
Giardia lamblia	Proteasome subunit beta type 2	0.0109	0.0351	0.0274
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0083	0.0167	0.0182
Giardia lamblia	Cathepsin B precursor	0.0129	0.0495	0.0487
Echinococcus granulosus	caspase 2	0.1025	0.6878	0.6872
Trypanosoma brucei	metacaspase MCA3	0.0427	0.2621	0.3729
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0951	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0549	0.0549
Leishmania major	metacaspase, putative	0.0427	0.2621	0.3729
Brugia malayi	Papain family cysteine protease containing protein	0.0101	0.0298	0.0371
Echinococcus granulosus	proteasome subunit alpha type 2	0.0083	0.0167	0.0149
Echinococcus granulosus	cysteine protease	0.0101	0.0298	0.028
Onchocerca volvulus	Cell death protein 3 homolog	0.1025	0.6878	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0084	0.0084
Schistosoma mansoni	hypothetical protein	0.0456	0.2823	0.3067
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0109	0.0351	0.0394
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0083	0.0167	0.0123
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0083	0.0167	0.0149
Schistosoma mansoni	hypothetical protein	0.0062	0.002	0.0022
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0193	0.0951	0.1277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.0918	0.1227
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.1658	0.1658
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0083	0.0167	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Onchocerca volvulus	Cathepsin L homolog	0.0188	0.0918	0.1229
Onchocerca volvulus		0.0129	0.0495	0.0606
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0083	0.0167	0.0167
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.1026	0.6887	0.6887
Brugia malayi	RNA binding protein	0.0062	0.0018	0.0023
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.0084	0.0065
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.0084	0.0121
Plasmodium vivax	vivapain-2	0.0188	0.0918	0.1333
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0323	0.1878	0.2727
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.1026	0.6887	1
Leishmania major	cathepsin L-like protease	0.0235	0.1249	0.1713
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0084	0.0091
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0083	0.0167	0.0243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.0918	0.1227
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0083	0.0167	0.0243
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0112	0.0373	0.0426
Brugia malayi	Proteasome A-type and B-type family protein	0.0083	0.0167	0.0208
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0083	0.0167	0.0123
Plasmodium vivax	vivapain-1	0.0101	0.0298	0.0433
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0083	0.0167	0.0182
Loa Loa (eye worm)	PHD-finger family protein	0.0062	0.002	0.002
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0083	0.0167	0.0123
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0129	0.0495	0.0604
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0083	0.0167	0.0243
Plasmodium vivax	proteasome subunit beta type-5, putative	0.1026	0.6887	1
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0083	0.0167	0.0125
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0083	0.0167	0.0182
Trichomonas vaginalis	conserved hypothetical protein	0.0427	0.2621	0.3729
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0082	0.0064
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0083	0.0167	0.0243
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0108	0.0348	0.0331
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0063	0.0027	0.0009
Schistosoma mansoni	cathepsin F (C01 family)	0.0188	0.0918	0.0998
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0083	0.0167	0.0125
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0112	0.0373	0.0356
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0081	0.0151	0.0133
Schistosoma mansoni	glutamate receptor NMDA	0.0112	0.0373	0.0405
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0083	0.0167	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0213	0.1095	0.1095
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0109	0.0351	0.0334
Schistosoma mansoni	metabotropic glutamate receptor	0.0995	0.6669	0.7246
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0083	0.0167	0.0123
Brugia malayi	Metabotropic glutamate receptor precursor.	0.1188	0.8044	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0063	0.0027	0.0033
Echinococcus granulosus	glutamate receptor 2	0.0112	0.0373	0.0356
Toxoplasma gondii	peptidase, T1 family protein	0.0083	0.0167	0.0123
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0083	0.0167	0.0243
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.1026	0.6887	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.1026	0.6887	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0427	0.2621	0.3729
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0083	0.0167	0.0243
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0112	0.0373	0.0356
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0083	0.0167	0.0123
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0083	0.0167	0.0123
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0083	0.0167	0.0123
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0789	0.5202	0.5193
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0109	0.0351	0.051
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0083	0.0167	0.0243
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0083	0.0167	0.0182
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.1658	0.1658
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0083	0.0167	0.0123
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0083	0.0167	0.0149
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0112	0.0373	0.0356
Echinococcus granulosus	tumor protein p63	0.033	0.193	0.1915
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0083	0.0167	0.0123
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0083	0.0167	0.0125
Brugia malayi	beta-lactamase family protein	0.0071	0.0084	0.0104
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Brugia malayi	proteasome subunit beta type 2	0.0109	0.0351	0.0437
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0083	0.0167	0.0167
Echinococcus multilocularis	GPCR, family 2	0.0063	0.0027	0.0009
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0188	0.0918	0.0918
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0101	0.0298	0.0315
Entamoeba histolytica	cysteine proteinase 2	0.0101	0.0298	0.0317
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.1026	0.6887	1
Onchocerca volvulus		0.0188	0.0918	0.1229
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0083	0.0167	0.0167
Brugia malayi	hypothetical protein	0.0071	0.0082	0.0102
Echinococcus multilocularis	caspase 3	0.0362	0.2158	0.2144
Echinococcus granulosus	tyrosine kinase	0.0112	0.0373	0.0356
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0083	0.0167	0.0123
Echinococcus granulosus	proteasome prosome macropain	0.1026	0.6887	0.6882
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0188	0.0918	0.0902
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.0918	0.1227
Brugia malayi	Proteasome A-type and B-type family protein	0.0083	0.0167	0.0208
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0083	0.0167	0.0243
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0083	0.0167	0.0123
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0083	0.0167	0.0243
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0427	0.2621	0.3729
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.1026	0.6887	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0129	0.0495	0.0604
Echinococcus multilocularis	caspase 2	0.1025	0.6878	0.6872
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0109	0.0351	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0495	0.0495
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0109	0.0351	0.0351
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.018	0.0859	0.0842
Trypanosoma cruzi	metacaspase 5, putative	0.0427	0.2621	0.3805
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0083	0.0167	0.0149
Onchocerca volvulus		0.0188	0.0918	0.1229
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0188	0.0918	0.0902
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0101	0.0298	0.0324
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0083	0.0167	0.0123
Echinococcus multilocularis	tyrosine kinase	0.0112	0.0373	0.0356
Echinococcus multilocularis	cysteine protease	0.0188	0.0918	0.0902
Entamoeba histolytica	hypothetical protein	0.0112	0.0373	0.0427
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0427	0.2621	0.3729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Echinococcus multilocularis	proteasome subunit beta type 6	0.0083	0.0167	0.0149
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0068	0.0061	0.0043
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0083	0.0167	0.0149
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0112	0.0373	0.0373
Onchocerca volvulus	Cathepsin F homolog	0.0188	0.0918	0.1229
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0083	0.0167	0.0123
Trypanosoma cruzi	20S proteasome subunit	0.0109	0.0351	0.051
Leishmania major	cathepsin L-like protease	0.0188	0.0918	0.1227
Trypanosoma cruzi	metacaspase, putative	0.0427	0.2621	0.3805
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0427	0.2621	0.3729
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.0084	0.0084
Trypanosoma brucei	metacaspase	0.0427	0.2621	0.3729
Brugia malayi	Proteasome A-type and B-type family protein	0.1026	0.6887	0.8563
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0063	0.0027	0.0009
Trypanosoma cruzi	cysteine peptidase, putative	0.0101	0.0298	0.0433
Echinococcus granulosus	caspase 8	0.0427	0.2621	0.2607
Echinococcus multilocularis	microtubule associated protein 2	0.0674	0.4382	0.4372
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0084	0.0084
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.0423	0.0423
Echinococcus multilocularis	proteasome (prosome, macropain)	0.1026	0.6887	0.6882
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0018	0.002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0188	0.0918	0.1227
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0083	0.0167	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1658	0.1658
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0081	0.0151	0.0164
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0083	0.0167	0.0125
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0193	0.0951	0.0935
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0083	0.0167	0.0243
Loa Loa (eye worm)	PAS-3 protein	0.0083	0.0167	0.0167
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.018	0.0859	0.0842
Echinococcus multilocularis	nmda type glutamate receptor	0.0112	0.0373	0.0356
Brugia malayi	MH2 domain containing protein	0.0119	0.0423	0.0526
Plasmodium falciparum	proteasome subunit beta type-5	0.1026	0.6887	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0083	0.0167	0.0123
Echinococcus multilocularis	survival motor neuron protein 1	0.0261	0.144	0.1424
Brugia malayi	Pre-SET motif family protein	0.0203	0.1026	0.1276
Echinococcus multilocularis	serotonin transporter	0.0292	0.1658	0.1642
Onchocerca volvulus	Poor gastrulation protein homolog	0.0193	0.0951	0.1277
Echinococcus granulosus	cathepsin L cysteine protease	0.0101	0.0298	0.028
Plasmodium falciparum	metacaspase 1	0.0427	0.2621	0.3651
Leishmania major	proteasome beta 2 subunit, putative	0.0083	0.0167	0.0123
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0083	0.0167	0.0182
Plasmodium vivax	vivapain-3	0.0101	0.0298	0.0433
Brugia malayi	Guanylyl cyclase protein 23	0.0112	0.0373	0.0464
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0083	0.0167	0.0125
Leishmania major	proteasome alpha 2 subunit, putative	0.0083	0.0167	0.0123
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0083	0.0167	0.0123
Echinococcus granulosus	glutamate receptor 2	0.0112	0.0373	0.0356
Schistosoma mansoni	caspase-7 (C14 family)	0.0789	0.5202	0.5652
Giardia lamblia	Cathepsin B precursor	0.0129	0.0495	0.0487
Trichomonas vaginalis	conserved hypothetical protein	0.0427	0.2621	0.3729
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0373	0.0373
Trichomonas vaginalis	conserved hypothetical protein	0.0427	0.2621	0.3729
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1878	0.2041
Trypanosoma brucei	proteasome alpha 7 subunit	0.0083	0.0167	0.0123
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0188	0.0918	0.0902
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.1227	0.168
Echinococcus multilocularis	cathepsin b	0.0323	0.1878	0.1863
Loa Loa (eye worm)	hypothetical protein	0.0427	0.2621	0.2621
Brugia malayi	Cathepsin L-like precursor	0.0188	0.0918	0.1142
Schistosoma mansoni	bromodomain containing protein	0.0191	0.0936	0.1017
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.1351	0.9204	1
Loa Loa (eye worm)	glutamate receptor	0.1188	0.8044	0.8044
Brugia malayi	Papain family cysteine protease containing protein	0.0101	0.0298	0.0371
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0083	0.0167	0.0123
Brugia malayi	metabotropic glutamate receptor type 2	0.0579	0.3704	0.4605
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0083	0.0167	0.0182
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0084	0.0084
Schistosoma mansoni	hypothetical protein	0.0063	0.0027	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0427	0.2621	0.3729
Mycobacterium ulcerans	proteasome PrcA	0.0083	0.0167	0.0123
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0083	0.0167	0.0125
Entamoeba histolytica	cysteine proteinase, putative	0.0101	0.0298	0.0317
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0083	0.0167	0.0243
Trypanosoma cruzi	cysteine proteinase, putative	0.0101	0.0298	0.0433
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0083	0.0167	0.0167
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.1026	0.1026
Onchocerca volvulus		0.0188	0.0918	0.1229
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0112	0.0373	0.0356
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0083	0.0167	0.0243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0018	0.0023
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0083	0.0167	0.0243
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0083	0.0167	0.0123
Leishmania major	cathepsin L-like protease	0.0188	0.0918	0.1227
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0083	0.0167	0.0243
Brugia malayi	Cathepsin L-like precursor	0.0129	0.0495	0.0616
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0083	0.0167	0.0243
Brugia malayi	cathepsin L-like precursor	0.0129	0.0495	0.0616
Echinococcus granulosus	cathepsin b	0.0323	0.1878	0.1863
Schistosoma mansoni	metabotropic glutamate receptor	0.0579	0.3704	0.4024
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0495	0.0495
Brugia malayi	20S proteasome alpha5 subunit	0.0083	0.0167	0.0208
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.1658	0.2061
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0112	0.0373	0.0373
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0084	0.0121
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0109	0.0351	0.0274
Brugia malayi	proteasome subunit beta type 3	0.0083	0.0167	0.0208
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0083	0.0167	0.0243
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0083	0.0167	0.0243
Trypanosoma cruzi	cysteine peptidase, putative	0.0235	0.1249	0.1814
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0018	0.002
Echinococcus granulosus	cathepsin b	0.0323	0.1878	0.1863
Echinococcus multilocularis	geminin	0.0169	0.0778	0.0762
Schistosoma mansoni	hypothetical protein	0.0169	0.0778	0.0846
Trypanosoma cruzi	extracellular receptor, putative	0.0112	0.0373	0.0542
Schistosoma mansoni	cathepsin F (C01 family)	0.0129	0.0495	0.0538
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0063	0.0027	0.0009
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0112	0.0373	0.0356
Echinococcus granulosus	proteasome subunit beta type 7	0.0083	0.0167	0.0149
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0427	0.2621	0.3729
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0083	0.0167	0.0243
Echinococcus granulosus	caspase 3	0.0362	0.2158	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0261	0.144	0.144
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0083	0.0167	0.0243
Plasmodium vivax	hypothetical protein, conserved	0.0427	0.2621	0.3805
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1878	0.1878
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0082	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0373	0.0373
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0083	0.0167	0.0182
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0083	0.0167	0.0123
Brugia malayi	Bromodomain containing protein	0.0115	0.0399	0.0496
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0129	0.0495	0.0605
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0083	0.0167	0.0167
Echinococcus multilocularis	cathepsin L cysteine protease	0.0188	0.0918	0.0902
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0083	0.0167	0.0123
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0083	0.0167	0.0125
Leishmania major	cathepsin L-like protease	0.0235	0.1249	0.1713
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0112	0.0373	0.0356
Toxoplasma gondii	proteasome subunit	0.0083	0.0167	0.0123
Loa Loa (eye worm)	glutamate receptor	0.0467	0.2908	0.2908
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0083	0.0167	0.0123
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0083	0.0167	0.0123
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0083	0.0167	0.0149
Echinococcus granulosus	Proteasome subunit alpha beta	0.0083	0.0167	0.0149
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0083	0.0167	0.0123
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0083	0.0167	0.0123
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Brugia malayi	Cathepsin L-like precursor	0.0188	0.0918	0.1142
Trypanosoma cruzi	metacaspase, putative	0.0427	0.2621	0.3805
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0083	0.0167	0.0167
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0083	0.0167	0.0149
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.1026	0.6887	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0427	0.2621	0.3729
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0083	0.0167	0.0123
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.0918	0.1227
Leishmania major	cathepsin L-like protease	0.0235	0.1249	0.1713
Brugia malayi	TAR-binding protein	0.0062	0.0018	0.0023
Toxoplasma gondii	cathepsin B	0.0129	0.0495	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0493	0.0493
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0323	0.1878	0.2041
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0083	0.0167	0.0123
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0083	0.0167	0.0123
Echinococcus granulosus	cathepsin l1	0.0129	0.0495	0.0478
Echinococcus granulosus	microtubule associated protein 2	0.0674	0.4382	0.4372
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0452	0.0452
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0083	0.0167	0.0149
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0083	0.0167	0.0243
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0199	0.0998	0.1241
Schistosoma mansoni	caspase-7 (C14 family)	0.1025	0.6878	0.7473
Onchocerca volvulus	Notchless protein homolog	0.0083	0.0167	0.0123
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.0918	0.1227
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0112	0.0373	0.0373
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0083	0.0167	0.0123
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.0918	0.1227
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0083	0.0167	0.0149
Echinococcus granulosus	proteasome subunit beta t family	0.0083	0.0167	0.0149
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0083	0.0167	0.0125
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0083	0.0167	0.0125
Brugia malayi	cathepsin B-like cysteine proteinase	0.0323	0.1878	0.2335
Echinococcus granulosus	proteasome subunit alpha type 6	0.0083	0.0167	0.0149
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0112	0.0373	0.0356
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0188	0.0918	0.1118
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Echinococcus multilocularis	proteasome subunit beta type 7	0.0083	0.0167	0.0149
Echinococcus granulosus	receptor type guanylyl cyclase	0.0112	0.0373	0.0356
Leishmania major	cathepsin L-like protease	0.0188	0.0918	0.1227
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0083	0.0167	0.0182
Onchocerca volvulus		0.0292	0.1658	0.2317
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0083	0.0167	0.0243
Brugia malayi	Proteasome subunit alpha type 7-1	0.0083	0.0167	0.0208
Loa Loa (eye worm)	hypothetical protein	0.1025	0.6878	0.6878
Leishmania major	proteasome beta-1 subunit, putative	0.0083	0.0167	0.0123
Brugia malayi	Cathepsin L-like precursor	0.0129	0.0495	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0495	0.0495
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0109	0.0351	0.051
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0109	0.0351	0.0394
Echinococcus granulosus	apoptotic protease activating factor 1	0.0456	0.2823	0.281
Echinococcus multilocularis	caspase 8	0.0427	0.2621	0.2607
Trypanosoma brucei	metacaspase MCA2	0.0427	0.2621	0.3729
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Brugia malayi	hypothetical protein	0.0456	0.2823	0.3509
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0083	0.0167	0.0149
Leishmania major	cathepsin L-like protease	0.0188	0.0918	0.1227
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0129	0.0495	0.0718
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0083	0.0167	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0373	0.0373
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.1658	0.1658
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0427	0.2621	0.3729
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0083	0.0167	0.0243
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0083	0.0167	0.0123
Plasmodium vivax	metacaspase 1, putative	0.0427	0.2621	0.3805
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0427	0.2621	0.3729
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0427	0.2621	0.3729
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0427	0.2621	0.3729
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0084	0.0084
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.1463	1	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0083	0.0167	0.0208
Brugia malayi	Bromodomain containing protein	0.0226	0.1187	0.1476
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0305	0.1747	0.1747
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0129	0.0495	0.0616
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0101	0.0298	0.0433
Entamoeba histolytica	cysteine protease, putative	0.0188	0.0918	0.1229
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0083	0.0167	0.0182
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Entamoeba histolytica	cysteine proteinase, putative	0.0129	0.0495	0.0607
Brugia malayi	Papain family cysteine protease containing protein	0.0188	0.0918	0.1142
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0083	0.0167	0.0149
Loa Loa (eye worm)	ctsf protein	0.0188	0.0918	0.0918
Schistosoma mansoni	tyrosine kinase	0.0112	0.0373	0.0405
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0995	0.6669	0.6663
Plasmodium falciparum	metacaspase-like protein	0.0427	0.2621	0.3651
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0427	0.2621	0.3729
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0193	0.0951	0.1183
Brugia malayi	proteasome subunit beta type 1	0.0083	0.0167	0.0208
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0175	0.0826	0.12
Leishmania major	proteasome alpha 7 subunit, putative	0.0083	0.0167	0.0123
Brugia malayi	Proteasome subunit alpha type 1	0.0083	0.0167	0.0208
Entamoeba histolytica	cysteine proteinase, putative	0.0101	0.0298	0.0317
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0083	0.0167	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0373	0.0373
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0083	0.0167	0.0123
Onchocerca volvulus		0.0112	0.0373	0.0426
Leishmania major	proteasome beta 2 subunit, putative	0.0109	0.0351	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0151	0.0151
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0018	0.0018
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0084	0.0121
Entamoeba histolytica	cysteine proteinase, putative	0.0188	0.0918	0.1229
Onchocerca volvulus	Cathepsin L homolog	0.0188	0.0918	0.1229
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0112	0.0373	0.0356
Brugia malayi	Cathepsin L-like precursor	0.0188	0.0918	0.1142
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0083	0.0167	0.0149
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.0918	0.1227
Leishmania major	cathepsin L-like protease	0.0188	0.0918	0.1227
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0063	0.0027	0.0009
Brugia malayi	Latrophilin receptor protein 2	0.0063	0.0027	0.0033
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0083	0.0167	0.0243
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.1658	0.1801
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0083	0.0167	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1658	0.1658
Leishmania major	proteasome beta 7 subunit, putative	0.0083	0.0167	0.0123
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0305	0.1747	0.1747
Trypanosoma cruzi	cruzipain precursor, putative	0.0235	0.1249	0.1814
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0083	0.0167	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1747	0.1747
Brugia malayi	Receptor family ligand binding region containing protein	0.0112	0.0373	0.0464
Brugia malayi	Receptor family ligand binding region containing protein	0.0305	0.1747	0.2172
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0083	0.0167	0.0149
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0083	0.0167	0.0243
Echinococcus multilocularis	tumor protein p63	0.033	0.193	0.1915
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0373	0.0373
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0083	0.0167	0.0125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.1249	0.1713
Mycobacterium ulcerans	proteasome PrcB	0.1026	0.6887	1
Echinococcus multilocularis	glutamate receptor 2	0.0112	0.0373	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0918	0.0918
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0018	0.002
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0083	0.0167	0.0123
Brugia malayi	proteasome subunit alpha type 3	0.0083	0.0167	0.0208
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0083	0.0167	0.0167
Plasmodium vivax	unspecified product	0.0101	0.0298	0.0433
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0109	0.0351	0.0382
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0018	0.002
Trypanosoma cruzi	major cysteine proteinase, putative	0.0088	0.0206	0.0299
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0083	0.0167	0.0167
Brugia malayi	Cathepsin L-like precursor	0.0188	0.0918	0.1142
Echinococcus multilocularis	cathepsin L	0.0101	0.0298	0.028
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.1026	0.6887	1
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0083	0.0167	0.0125
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Onchocerca volvulus		0.0188	0.0918	0.1229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0101	0.0298	0.0315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.0918	0.1227
Loa Loa (eye worm)	fibroinase	0.0188	0.0918	0.0918
Brugia malayi	Cathepsin L-like precursor	0.0188	0.0918	0.1142
Entamoeba histolytica	cysteine protease, putative	0.0101	0.0298	0.0317
Trichomonas vaginalis	conserved hypothetical protein	0.0427	0.2621	0.3729
Brugia malayi	beta-lactamase family protein	0.0071	0.0084	0.0104
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0789	0.5202	0.5193
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.0918	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0084	0.0084
Echinococcus granulosus	GPCR family 3 C terminal	0.0193	0.0951	0.0935
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0083	0.0167	0.0149
Leishmania major	proteasome alpha 3 subunit, putative	0.0083	0.0167	0.0123
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.1026	0.6887	0.7483
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0101	0.0298	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0401	0.0401
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.1076	0.7247	0.901
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0188	0.0918	0.0902
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0188	0.0918	0.0918
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0083	0.0167	0.0243
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0427	0.2621	0.2848
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0112	0.0373	0.0356
Trypanosoma cruzi	cysteine peptidase, putative	0.0235	0.1249	0.1814
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0083	0.0167	0.0123
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0083	0.0167	0.0243
Brugia malayi	hypothetical protein	0.0261	0.144	0.179
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0109	0.0351	0.0394
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.1658	0.1801

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13 nM	Binding affinity to CCR3	ChEMBL.	16931001
IC50 (binding)	= 22 nM	Binding affinity to CCR3	ChEMBL.	16931001
IC50 (binding)	= 644 nM	Binding affinity to CCR3	ChEMBL.	16931001
Ki (binding)	= 10 nM	Inhibition of DAT	ChEMBL.	16931001
Ki (binding)	= 10 nM	Inhibition of DAT	ChEMBL.	16931001
Ki (binding)	= 34 nM	Inhibition of DAT	ChEMBL.	16931001
Ki (binding)	= 34 nM	Inhibition of DAT	ChEMBL.	16931001
Ki (binding)	= 35 nM	Inhibition of 5HTT	ChEMBL.	16931001
Ki (binding)	= 35 nM	Inhibition of 5HTT	ChEMBL.	16931001
Ki (binding)	= 37 nM	Inhibition of NET	ChEMBL.	16931001
Ki (binding)	= 37 nM	Inhibition of NET	ChEMBL.	16931001
Ki (binding)	= 46 nM	Inhibition of NET	ChEMBL.	16931001
Ki (binding)	= 46 nM	Inhibition of NET	ChEMBL.	16931001
Ki (binding)	= 54 nM	Inhibition of 5HTT	ChEMBL.	16931001
Ki (binding)	= 54 nM	Inhibition of 5HTT	ChEMBL.	16931001

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL218997

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 412662