TDR Targets

Basic information

Technical information

TDR Targets ID: 412663
Name: 3-[4-[[3-[4-[(2,4-dimethylphenyl)carbamoylami no]-3-methoxyphenyl]-2-oxopyridin-1-yl]methyl ]phenyl]propanoic acid
MW: 525.595 | Formula: C31H31N3O5
H donors: 3 H acceptors: 4 LogP: 4.54 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(ccc1NC(=O)Nc1ccc(cc1C)C)c1cccn(c1=O)Cc1ccc(cc1)CCC(=O)O
InChi: 1S/C31H31N3O5/c1-20-6-13-26(21(2)17-20)32-31(38)33-27-14-12-24(18-28(27)39-3)25-5-4-16-34(30(25)37)19-23-9-7-22(8-10-23)11-15-29(35)36/h4-10,12-14,16-18H,11,15,19H2,1-3H3,(H,35,36)(H2,32,33,38)
InChiKey: HBEPZEPTRFMZPI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[4-[[3-[4-[(2,4-dimethylphenyl)carbamoylamino]-3-methoxy-phenyl]-2-oxo-1-pyridyl]methyl]phenyl]propanoic acid
3-[4-[[3-[4-[[(2,4-dimethylanilino)-oxomethyl]amino]-3-methoxyphenyl]-2-oxo-1-pyridyl]methyl]phenyl]propanoic acid
3-[4-[[3-[4-[(2,4-dimethylphenyl)carbamoylamino]-3-methoxy-phenyl]-2-oxo-pyridin-1-yl]methyl]phenyl]propanoic acid
3-[4-[[3-[4-[(2,4-dimethylphenyl)carbamoylamino]-3-methoxy-phenyl]-2-keto-1-pyridyl]methyl]phenyl]propionic acid
3-[4-[[3-[4-[[[(2,4-dimethylphenyl)amino]-oxomethyl]amino]-3-methoxyphenyl]-2-oxo-1-pyridyl]methyl]phenyl]propanoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Integrin beta-PS precursor, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma japonicum	ko:K06464 integrin beta 2, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma mansoni	integrin beta subunit	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma japonicum	Integrin beta-3 precursor, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Loa Loa (eye worm)	integrin beta-2	Get druggable targets OG5_127959	All targets in OG5_127959
Echinococcus multilocularis	integrin beta 2	Get druggable targets OG5_127959	All targets in OG5_127959
Echinococcus granulosus	integrin beta 2	Get druggable targets OG5_127959	All targets in OG5_127959
Brugia malayi	Integrin beta pat-3 precursor	Get druggable targets OG5_127959	All targets in OG5_127959

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Kelch motif family protein	0.0057	0.0757	0.0757
Brugia malayi	Proteasome subunit alpha type 7-1	0.0035	0.0257	0.0257
Brugia malayi	hypothetical protein	0.0057	0.0757	0.0757
Trypanosoma brucei	proteasome beta 7 subunit	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0257	0.0257
Brugia malayi	Proteasome A-type and B-type family protein	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0035	0.0257	0.0257
Brugia malayi	Proteasome A-type and B-type family protein	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0468	1	1
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0035	0.0257	0.0257
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	integrin beta subunit	0.0223	0.4479	0.4479
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0257	0.0257
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0035	0.0257	0.0257
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0468	1	1
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0035	0.0257	0.0257
Onchocerca volvulus	Notchless protein homolog	0.0035	0.0257	1
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0035	0.0257	0.0257
Echinococcus granulosus	integrin beta 2	0.028	0.5773	0.5773
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0468	1	1
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0035	0.0257	0.0257
Leishmania major	proteasome alpha 3 subunit, putative	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit beta type-4	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0035	0.0257	0.0257
Mycobacterium ulcerans	proteasome PrcB	0.0468	1	1
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0035	0.0257	0.0257
Brugia malayi	Proteasome subunit alpha type 1	0.0035	0.0257	0.0257
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0468	1	1
Toxoplasma gondii	heat shock protein hslv, putative	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0257	0.0257
Leishmania major	proteasome alpha 7 subunit, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0035	0.0257	0.0257
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome beta subunit	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0035	0.0257	0.0257
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0468	1	1
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0035	0.0257	0.0257
Loa Loa (eye worm)	PAS-3 protein	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome alpha 7 subunit	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome subunit beta t family	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0035	0.0257	0.0257
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0035	0.0257	0.0257
Leishmania major	proteasome beta 7 subunit, putative	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0035	0.0257	0.0257
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0035	0.0257	0.0257
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome subunit beta type 7	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0035	0.0257	0.0257
Brugia malayi	Proteasome A-type and B-type family protein	0.0035	0.0257	0.0257
Echinococcus granulosus	Proteasome subunit alpha beta	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome subunit alpha type 6	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0035	0.0257	0.0257
Brugia malayi	proteasome subunit beta type 1	0.0035	0.0257	0.0257
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0468	1	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0468	1	1
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0035	0.0257	0.0257
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0035	0.0257	0.0257
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome prosome macropain	0.0468	1	1
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0035	0.0257	0.0257
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0035	0.0257	0.0257
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0035	0.0257	0.0257
Toxoplasma gondii	peptidase, T1 family protein	0.0035	0.0257	0.0257
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0035	0.0257	0.0257
Brugia malayi	Integrin beta pat-3 precursor	0.0378	0.798	0.798
Leishmania major	proteasome beta 5 subunit, putative	0.0468	1	1
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0035	0.0257	0.0257
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0468	1	1
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome subunit alpha type 2	0.0035	0.0257	0.0257
Leishmania major	proteasome beta 2 subunit, putative	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0257	0.0257
Leishmania major	proteasome beta 3 subunit, putative	0.0035	0.0257	0.0257
Leishmania major	proteasome alpha 2 subunit, putative	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome subunit beta type 6	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome subunit beta type 7	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0035	0.0257	0.0257
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0468	1	1
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0035	0.0257	0.0257
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0035	0.0257	0.0257
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0035	0.0257	0.0257
Leishmania major	proteasome alpha 1 subunit, putative	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome beta 6 subunit	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0468	1	1
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0468	1	1
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0035	0.0257	0.0257
Brugia malayi	proteasome subunit alpha type 3	0.0035	0.0257	0.0257
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0057	0.0757	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0757	0.0757
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0035	0.0257	0.0257
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome subunit beta type, putative	0.0468	1	1
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0035	0.0257	0.0257
Brugia malayi	proteasome subunit beta type 3	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0035	0.0257	0.0257
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit beta type-5	0.0468	1	1
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome subunit	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0035	0.0257	0.0257
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0035	0.0257	0.0257
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0257	0.0257
Brugia malayi	20S proteasome alpha5 subunit	0.0035	0.0257	0.0257
Brugia malayi	proteasome subunit alpha type 4	0.0035	0.0257	0.0257
Echinococcus multilocularis	integrin beta 2	0.028	0.5773	0.5773
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0035	0.0257	0.0257
Brugia malayi	proteasome subunit alpha type 1	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0035	0.0257	0.0257
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0257	0.0257
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0035	0.0257	0.0257
Brugia malayi	proteasome subunit beta type 2	0.0035	0.0257	0.0257
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0257	0.0257
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0257	0.0257
Brugia malayi	proteasome subunit alpha type 2	0.0035	0.0257	0.0257
Loa Loa (eye worm)	integrin beta-2	0.0378	0.798	0.798
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0468	1	1
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0257	0.0257
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0035	0.0257	0.0257
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0035	0.0257	0.0257
Brugia malayi	proteasome subunit alpha type 6	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0035	0.0257	0.0257
Echinococcus multilocularis	proteasome subunit beta type 6	0.0035	0.0257	0.0257
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0257	0.0257
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0257	0.0257
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0035	0.0257	0.0257
Leishmania major	proteasome alpha 7 subunit, putative	0.0035	0.0257	0.0257
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0257	0.0257
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0035	0.0257	0.5
Trypanosoma cruzi	20S proteasome subunit	0.0035	0.0257	0.0257
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0035	0.0257	0.0257
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0035	0.0257	0.0257
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0035	0.0257	0.0257
Leishmania major	proteasome alpha 1 subunit, putative	0.0035	0.0257	0.0257
Leishmania major	proteasome beta-1 subunit, putative	0.0035	0.0257	0.0257
Leishmania major	proteasome beta 2 subunit, putative	0.0035	0.0257	0.0257

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= -7.6	Inhibition of integrin alpha4beta1 receptor expressed in Jurkat J6 cells by SPA	ChEMBL.	16931004
Log Ki (binding)	= 7.6	Inhibition of integrin alpha4beta1 receptor expressed in Jurkat J6 cells by SPA	ChEMBL.	16931004

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 23647666

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 412663