Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | raf kinase | 0.0093 | 0.1105 | 0.1013 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.2059 | 0.1977 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0247 | 0.4002 | 0.5069 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1105 | 0.1013 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0055 | 0.039 | 0.0495 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0093 | 0.1105 | 0.1105 |
Brugia malayi | protein kinase C3,putative | 0.0096 | 0.1159 | 0.1355 |
Entamoeba histolytica | protein kinase, putative | 0.0111 | 0.1456 | 0.1174 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3895 | 0.3832 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1196 | 0.1105 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0055 | 0.039 | 0.0495 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0107 | 0.1365 | 0.1729 |
Echinococcus multilocularis | protein kinase c iota type | 0.0199 | 0.3111 | 0.394 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0239 | 0.3858 | 0.4819 |
Loa Loa (eye worm) | SRC-1 | 0.0055 | 0.039 | 0.0291 |
Schistosoma mansoni | rac gtpase activating protein | 0.0093 | 0.1105 | 0.1105 |
Schistosoma mansoni | tyrosine kinase | 0.0055 | 0.039 | 0.0168 |
Entamoeba histolytica | protein kinase, putative | 0.0107 | 0.1365 | 0.0869 |
Brugia malayi | protein kinase C II. | 0.0453 | 0.7895 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0453 | 0.7895 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.7995 | 0.7974 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0453 | 0.7895 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0251 | 0.4093 | 1 |
Brugia malayi | Pleckstrin Homology Domain | 0.0098 | 0.1196 | 0.1404 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0093 | 0.1105 | 0.1013 |
Brugia malayi | RhoGAP domain containing protein | 0.0093 | 0.1105 | 0.1287 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0048 | 0.0262 | 0.0161 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0107 | 0.1365 | 0.1729 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0107 | 0.1365 | 0.1729 |
Echinococcus granulosus | myotubularin protein 13 | 0.0098 | 0.1196 | 0.1515 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0395 | 0.6802 | 0.8616 |
Schistosoma mansoni | tyrosine kinase | 0.0055 | 0.039 | 0.0168 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0048 | 0.0262 | 0.0161 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0111 | 0.1456 | 0.1368 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0103 | 0.13 | 0.1647 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0107 | 0.1365 | 0.1276 |
Trichomonas vaginalis | AGC family protein kinase | 0.0107 | 0.1365 | 0.3693 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0107 | 0.1365 | 0.1276 |
Brugia malayi | Variant SH3 domain containing protein | 0.0048 | 0.0262 | 0.0205 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0055 | 0.039 | 0.0168 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.1365 | 0.1445 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.2059 | 0.1977 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0239 | 0.3858 | 0.3794 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0055 | 0.039 | 0.0495 |
Trichomonas vaginalis | AGC family protein kinase | 0.0111 | 0.1456 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0055 | 0.039 | 0.0495 |
Echinococcus granulosus | N chimaerin | 0.0117 | 0.1562 | 0.1979 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0107 | 0.1365 | 0.1276 |
Echinococcus granulosus | NDR protein kinase | 0.0107 | 0.1365 | 0.1729 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0107 | 0.1365 | 0.1729 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0048 | 0.0262 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3804 | 0.374 |
Brugia malayi | Variant SH3 domain containing protein | 0.0048 | 0.0262 | 0.0205 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0096 | 0.1159 | 0.1467 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.4602 | 0.4546 |
Brugia malayi | Protein kinase domain containing protein | 0.0111 | 0.1456 | 0.1737 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0107 | 0.1365 | 0.1729 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0055 | 0.039 | 0.0495 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0117 | 0.1562 | 0.1979 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0055 | 0.039 | 0.0495 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0395 | 0.6802 | 0.8568 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0093 | 0.1105 | 0.14 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0107 | 0.1365 | 0.1729 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0055 | 0.039 | 0.0495 |
Brugia malayi | Hr1 repeat family protein | 0.0107 | 0.1365 | 0.162 |
Schistosoma mansoni | tyrosine kinase | 0.0055 | 0.039 | 0.0168 |
Schistosoma mansoni | vav2 | 0.0122 | 0.1653 | 0.1822 |
Brugia malayi | SRC-1 | 0.0055 | 0.039 | 0.037 |
Trichomonas vaginalis | AGC family protein kinase | 0.0111 | 0.1456 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0055 | 0.039 | 0.0495 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0146 | 0.2112 | 0.203 |
Trichomonas vaginalis | AGC family protein kinase | 0.0111 | 0.1456 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0111 | 0.1456 | 1 |
Brugia malayi | RhoGEF domain containing protein | 0.0093 | 0.1105 | 0.1287 |
Onchocerca volvulus | 0.0143 | 0.2059 | 0.1133 | |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.7995 | 0.7974 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.1365 | 0.1445 |
Trichomonas vaginalis | AGC family protein kinase | 0.0111 | 0.1456 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0199 | 0.3104 | 0.3033 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0453 | 0.7895 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0107 | 0.1365 | 0.1729 |
Onchocerca volvulus | 0.0236 | 0.3804 | 0.3741 | |
Echinococcus granulosus | c src tyrosine kinase | 0.0055 | 0.039 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.7995 | 0.7974 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0395 | 0.6802 | 0.8616 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.1159 | 0.1174 |
Echinococcus granulosus | protein kinase c eta type | 0.0093 | 0.1105 | 0.14 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0395 | 0.6802 | 0.8568 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.1105 | 0.1105 |
Entamoeba histolytica | protein kinase, putative | 0.0107 | 0.1365 | 0.0869 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0055 | 0.039 | 0.0495 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0303 | 0.5057 | 0.6405 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0117 | 0.1562 | 0.1979 |
Brugia malayi | diacylglycerol kinase | 0.0093 | 0.1105 | 0.1287 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0055 | 0.039 | 0.0495 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0186 | 0.2856 | 0.3618 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0107 | 0.1365 | 0.1276 |
Echinococcus multilocularis | protein kinase c eta type | 0.0093 | 0.1105 | 0.14 |
Trichomonas vaginalis | AGC family protein kinase | 0.0107 | 0.1365 | 0.3693 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.974 | 0.9738 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0055 | 0.039 | 0.0495 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0107 | 0.1365 | 0.1276 |
Echinococcus multilocularis | NCK adaptor protein | 0.0048 | 0.0262 | 0.0332 |
Echinococcus granulosus | protein kinase C gamma type | 0.0303 | 0.5057 | 0.6405 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0107 | 0.1365 | 0.1729 |
Brugia malayi | Protein kinase c protein 2 | 0.0292 | 0.485 | 0.6093 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0096 | 0.1159 | 0.1067 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.1365 | 0.1445 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0107 | 0.1365 | 0.162 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.1159 | 0.1174 |
Brugia malayi | Protein kinase domain containing protein | 0.0107 | 0.1365 | 0.162 |
Echinococcus granulosus | NCK adaptor protein | 0.0048 | 0.0262 | 0.0332 |
Echinococcus granulosus | unc 13 munc13 | 0.0103 | 0.13 | 0.1647 |
Schistosoma mansoni | unc-13 (munc13) | 0.0103 | 0.13 | 0.136 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0093 | 0.1105 | 0.1105 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.01 | 0.1234 | 0.1562 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0055 | 0.039 | 0.0495 |
Schistosoma mansoni | tyrosine kinase | 0.0055 | 0.039 | 0.0168 |
Entamoeba histolytica | protein kinase, putative | 0.0111 | 0.1456 | 0.1174 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0055 | 0.039 | 0.0495 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0453 | 0.7895 | 0.7873 |
Brugia malayi | Protein kinase domain containing protein | 0.0096 | 0.1159 | 0.1355 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0093 | 0.1105 | 0.1287 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0186 | 0.2856 | 0.3618 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0055 | 0.039 | 0.0495 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0055 | 0.039 | 0.0495 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0117 | 0.1562 | 0.1475 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0093 | 0.1105 | 0.1013 |
Trichomonas vaginalis | AGC family protein kinase | 0.0111 | 0.1456 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0107 | 0.1365 | 0.1445 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0103 | 0.13 | 0.1647 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0055 | 0.039 | 0.0495 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0098 | 0.1196 | 0.1515 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1105 | 0.1013 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1105 | 0.1013 |
Toxoplasma gondii | AGC kinase | 0.0107 | 0.1365 | 1 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0096 | 0.1159 | 0.1467 |
Schistosoma mansoni | atypical protein kinase C | 0.0199 | 0.3111 | 0.3732 |
Brugia malayi | Protein kinase domain containing protein | 0.0107 | 0.1365 | 0.162 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0093 | 0.1105 | 0.14 |
Schistosoma mansoni | protein kinase C mu | 0.0093 | 0.1105 | 0.1105 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0093 | 0.1105 | 0.14 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0055 | 0.039 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1105 | 0.1013 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0111 | 0.1456 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.035 | 0.5955 | 0.7542 |
Schistosoma mansoni | protein kinase C | 0.0103 | 0.13 | 0.136 |
Brugia malayi | diacylglycerol kinase | 0.0093 | 0.1105 | 0.1287 |
Schistosoma mansoni | protein kinase C mu | 0.0239 | 0.3858 | 0.4711 |
Trichomonas vaginalis | AGC family protein kinase | 0.0111 | 0.1456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.2856 | 0.2783 |
Brugia malayi | Variant SH3 domain containing protein | 0.0117 | 0.1562 | 0.1873 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0055 | 0.039 | 0.0495 |
Onchocerca volvulus | 0.0241 | 0.3895 | 0.3877 | |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1105 | 0.1013 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0055 | 0.039 | 0.037 |
Echinococcus granulosus | protein kinase c iota type | 0.0199 | 0.3111 | 0.394 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1105 | 0.1013 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0058 | 0.0444 | 0.0562 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0186 | 0.2856 | 0.3618 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0055 | 0.039 | 0.0495 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0117 | 0.1562 | 0.1703 |
Onchocerca volvulus | 0.0459 | 0.7995 | 1 | |
Schistosoma mansoni | unc-13 (munc13) | 0.0103 | 0.13 | 0.136 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0093 | 0.1105 | 0.14 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.1234 | 0.1273 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0117 | 0.1562 | 0.1703 |
Trichomonas vaginalis | AGC family protein kinase | 0.0111 | 0.1456 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0055 | 0.039 | 0.0495 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0048 | 0.0262 | 0.0332 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0048 | 0.0262 | 0.0205 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.01 | 0.1234 | 0.1562 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0107 | 0.1365 | 0.1729 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.1365 | 0.1445 |
Echinococcus multilocularis | N chimaerin | 0.0117 | 0.1562 | 0.1979 |
Brugia malayi | RhoGAP domain containing protein | 0.0117 | 0.1562 | 0.1873 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.13 | 0.121 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0103 | 0.13 | 0.1647 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0093 | 0.1105 | 0.1013 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0107 | 0.1365 | 0.1276 |
Brugia malayi | C1-like domain containing protein | 0.0239 | 0.3858 | 0.4819 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0262 | 0.0161 |
Trichomonas vaginalis | AGC family protein kinase | 0.0107 | 0.1365 | 0.3693 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 77 % | Inhibition of prostate weight in Sprague-Dawley rat at 2 mg/day, po relative to control | ChEMBL. | 16959487 |
Inhibition (functional) | = 85 % | Inhibition of seminal vesicle weight in Sprague-Dawley rat at 2 mg/day, po relative to control | ChEMBL. | 16959487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.