TDR Targets

Basic information

Technical information

TDR Targets ID: 413523
Name: 2-[(1S)-5-[3-[4-(4,5-dimethyl-1,3-thiazol-2-y l)phenoxy]propoxy]-2,3-dihydro-1H-inden-1-yl] acetic acid
MW: 437.551 | Formula: C25H27NO4S
H donors: 1 H acceptors: 3 LogP: 5.54 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C[C@@H]1CCc2c1ccc(c2)OCCCOc1ccc(cc1)c1sc(c(n1)C)C
InChi: 1S/C25H27NO4S/c1-16-17(2)31-25(26-16)18-6-8-21(9-7-18)29-12-3-13-30-22-10-11-23-19(14-22)4-5-20(23)15-24(27)28/h6-11,14,20H,3-5,12-13,15H2,1-2H3,(H,27,28)/t20-/m0/s1
InChiKey: KZAIHPRSXFXXNU-FQEVSTJZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(1S)-5-[3-[4-(4,5-dimethylthiazol-2-yl)phenoxy]propoxy]indan-1-yl]acetic acid
2-[(1S)-5-[3-[4-(4,5-dimethyl-2-thiazolyl)phenoxy]propoxy]-1-indanyl]acetic acid
2-[(1S)-5-[3-[4-(4,5-dimethyl-1,3-thiazol-2-yl)phenoxy]propoxy]-2,3-dihydro-1H-inden-1-yl]ethanoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	peroxisome proliferator activated receptor gamma	Starlite/ChEMBL	References
Homo sapiens	peroxisome proliferator-activated receptor delta	Starlite/ChEMBL	References
Homo sapiens	peroxisome proliferator-activated receptor alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR008946,Nuclear receptor, ligand-binding,domain-containing	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma japonicum	ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	Get druggable targets OG5_137778	All targets in OG5_137778

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	ecdysteroid receptor	peroxisome proliferator-activated receptor delta	441 aa	369 aa	24.7 %
Brugia malayi	ecdysteroid receptor	peroxisome proliferator-activated receptor alpha	468 aa	397 aa	25.4 %
Brugia malayi	photoreceptor-specific nuclear receptor	peroxisome proliferator activated receptor gamma	475 aa	395 aa	26.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0023	0.0129	0.0365
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0023	0.0129	0.0129
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0023	0.0129	0.0365
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0165	0.3544	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0382	0.1077
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0023	0.0129	0.0365
Trichomonas vaginalis	tubulin, putative	0.0025	0.0167	0.011
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0023	0.0129	0.0365
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0167	0.0167
Brugia malayi	Tubulin beta-1 chain	0.0025	0.0167	0.0471
Echinococcus granulosus	tubulin beta 1 chain	0.0025	0.0167	0.0471
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0023	0.0129	0.0129
Onchocerca volvulus	Protein ultraspiracle homolog	0.0034	0.0382	1
Echinococcus multilocularis	tubulin subunit beta	0.0025	0.0167	0.0471
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0034	0.0382	1
Plasmodium falciparum	tubulin beta chain	0.0025	0.0167	0.011
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0023	0.0129	0.0365
Echinococcus granulosus	proteasome subunit alpha type 2	0.0023	0.0129	0.0365
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0034	0.0382	0.0382
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0023	0.0129	0.0129
Loa Loa (eye worm)	tubulin beta chain	0.0025	0.0167	0.0471
Entamoeba histolytica	tubulin family protein	0.0025	0.0167	0.011
Giardia lamblia	Proteasome subunit beta type 2	0.0073	0.134	0.3546
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0034	0.0382	0.1077
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0034	0.0382	0.1077
Echinococcus granulosus	proteasome subunit alpha type 6	0.0023	0.0129	0.0365
Brugia malayi	Proteasome A-type and B-type family protein	0.0023	0.0129	0.0365
Brugia malayi	Proteasome subunit alpha type 7-1	0.0023	0.0129	0.0365
Brugia malayi	steroid hormone receptor	0.0034	0.0382	0.1077
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0023	0.0129	0.0129
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Brugia malayi	proteasome subunit alpha type 2	0.0023	0.0129	0.0365
Trypanosoma cruzi	20S proteasome subunit	0.0073	0.134	0.3546
Brugia malayi	Steroid receptor seven-up type 2	0.0034	0.0382	0.1077
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0034	0.0382	0.0382
Brugia malayi	proteasome subunit alpha type 3	0.0023	0.0129	0.0365
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0023	0.0129	0.0129
Brugia malayi	ecdysteroid receptor	0.0034	0.0382	0.1077
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0034	0.0382	0.1077
Echinococcus granulosus	proteasome subunit beta t family	0.0023	0.0129	0.0365
Leishmania major	proteasome beta 2 subunit, putative	0.0073	0.134	0.3546
Echinococcus granulosus	proteasome prosome macropain	0.0165	0.3544	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0034	0.0382	0.0382
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0034	0.0382	0.1077
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0023	0.0129	0.0365
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0023	0.0129	0.0365
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0023	0.0129	0.0365
Toxoplasma gondii	proteasome subunit beta type, putative	0.0165	0.3544	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0034	0.0382	0.1077
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0073	0.134	0.3546
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Loa Loa (eye worm)	tubulin beta-4 chain	0.0025	0.0167	0.0471
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0034	0.0382	0.1077
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0073	0.134	0.134
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0034	0.0382	0.1077
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0034	0.0382	0.1077
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0382	0.1077
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0034	0.0382	0.0382
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0023	0.0129	0.0365
Schistosoma mansoni	coup transcription factor	0.0034	0.0382	0.0382
Echinococcus granulosus	tubulin subunit beta	0.0025	0.0167	0.0471
Echinococcus granulosus	beta tubulin	0.0025	0.0167	0.0471
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0023	0.0129	0.0129
Brugia malayi	20S proteasome alpha5 subunit	0.0023	0.0129	0.0365
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0167	0.0167
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0382	0.1077
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0023	0.0129	0.0365
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Brugia malayi	proteasome subunit beta type 2	0.0073	0.134	0.3781
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0034	0.0382	0.1077
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0023	0.0129	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0382	0.1077
Echinococcus multilocularis	proteasome subunit beta type 6	0.0023	0.0129	0.0365
Loa Loa (eye worm)	BEN-1 protein	0.0025	0.0167	0.0471
Plasmodium falciparum	proteasome subunit beta type-5	0.0165	0.3544	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0025	0.0167	0.011
Schistosoma mansoni	RAR-like nuclear receptor	0.0034	0.0382	0.0382
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0023	0.0129	0.0129
Echinococcus granulosus	ecdysone induced protein 78C	0.0034	0.0382	0.1077
Trypanosoma brucei	beta tubulin	0.0025	0.0167	0.011
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0025	0.0167	0.011
Brugia malayi	proteasome subunit alpha type 4	0.0023	0.0129	0.0365
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0023	0.0129	0.0365
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0167	0.0167
Trypanosoma cruzi	beta tubulin, putative	0.0025	0.0167	0.011
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0023	0.0129	0.0365
Echinococcus granulosus	proteasome subunit beta type 7	0.0023	0.0129	0.0365
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0023	0.0129	0.0365
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0034	0.0382	0.1077
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0073	0.134	0.134
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0034	0.0382	0.1077
Loa Loa (eye worm)	tubulin beta-1 chain	0.0025	0.0167	0.0471
Echinococcus granulosus	beta tubulin	0.0025	0.0167	0.0471
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0023	0.0129	0.0365
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0073	0.134	0.3546
Brugia malayi	proteasome subunit beta type 3	0.0023	0.0129	0.0365
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0034	0.0382	0.1077
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0382	0.1077
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0034	0.0382	0.1077
Loa Loa (eye worm)	beta-tubulin	0.0025	0.0167	0.0471
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Echinococcus multilocularis	beta tubulin	0.0025	0.0167	0.0471
Echinococcus granulosus	tubulin beta 4A class IVa	0.0025	0.0167	0.0471
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0023	0.0129	0.0129
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0165	0.3544	0.3544
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0382	0.0382
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0165	0.3544	1
Brugia malayi	beta-tubulin, identical	0.0025	0.0167	0.0471
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0165	0.3544	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0034	0.0382	0.1077
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0023	0.0129	0.0365
Loa Loa (eye worm)	BEN-1 protein	0.0025	0.0167	0.0471
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0023	0.0129	0.0129
Brugia malayi	photoreceptor-specific nuclear receptor	0.0034	0.0382	0.1077
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0382	0.1077
Brugia malayi	proteasome subunit beta type 1	0.0023	0.0129	0.0365
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0023	0.0129	0.0365
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0382	0.0382
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0023	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0382	0.1077
Leishmania major	proteasome beta 5 subunit, putative	0.0165	0.3544	1
Entamoeba histolytica	tubulin family protein	0.0025	0.0167	0.011
Trypanosoma brucei	beta tubulin	0.0025	0.0167	0.011
Trichomonas vaginalis	tubulin beta chain, putative	0.0025	0.0167	0.011
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0023	0.0129	0.0129
Trypanosoma brucei	beta tubulin	0.0025	0.0167	0.011
Echinococcus multilocularis	FTZ F1 alpha	0.0034	0.0382	0.1077
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0023	0.0129	0.5
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0073	0.134	0.3781
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0382	0.1077
Plasmodium vivax	tubulin beta chain, putative	0.0025	0.0167	0.011
Loa Loa (eye worm)	tubulin beta-2A chain	0.0025	0.0167	0.0471
Giardia lamblia	Beta tubulin	0.0025	0.0167	0.011
Brugia malayi	Proteasome A-type and B-type family protein	0.0023	0.0129	0.0365
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0023	0.0129	0.0129
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0165	0.3544	1
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0073	0.134	0.3546
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0023	0.0129	0.0365
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0073	0.134	0.3546
Brugia malayi	proteasome subunit alpha type 6	0.0023	0.0129	0.0365
Onchocerca volvulus		0.0034	0.0382	1
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0023	0.0129	0.0365
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0167	0.0167
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0023	0.0129	0.0365
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0034	0.0382	0.1077
Echinococcus multilocularis	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0034	0.0382	0.1077
Schistosoma mansoni	retinoic acid receptor RXR	0.0034	0.0382	0.0382
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0382	0.1077
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0165	0.3544	1
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0073	0.134	0.3546
Trypanosoma brucei	beta tubulin	0.0025	0.0167	0.011
Echinococcus multilocularis	proteasome subunit beta type 7	0.0023	0.0129	0.0365
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0034	0.0382	0.1077
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0034	0.0382	0.1077
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0023	0.0129	0.0129
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0023	0.0129	0.0129
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0165	0.3544	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0382	0.1077
Echinococcus granulosus	proteasome subunit beta type 6	0.0023	0.0129	0.0365
Brugia malayi	Proteasome subunit alpha type 1	0.0023	0.0129	0.0365
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0023	0.0129	0.0365
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0023	0.0129	0.0365
Trichomonas vaginalis	tubulin gamma chain, putative	0.0025	0.0167	0.011
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0382	0.1077
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0034	0.0382	0.1077
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0073	0.134	0.3546
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0023	0.0129	0.0365
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0382	0.1077
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0382	0.1077
Loa Loa (eye worm)	PAS-3 protein	0.0023	0.0129	0.0365
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0073	0.134	0.3546
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0025	0.0167	0.0471
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0023	0.0129	0.0365
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0034	0.0382	0.1077
Mycobacterium ulcerans	proteasome PrcB	0.0165	0.3544	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0382	0.1077
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0382	0.1077
Brugia malayi	nuclear hormone receptor	0.0034	0.0382	0.1077
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0382	0.0382
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0034	0.0382	0.1077
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0382	0.1077
Trichomonas vaginalis	tubulin alpha chain, putative	0.0025	0.0167	0.011
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Toxoplasma gondii	beta-tubulin, putative	0.0025	0.0167	0.011
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0023	0.0129	0.0365
Giardia lamblia	Beta tubulin	0.0025	0.0167	0.011
Echinococcus granulosus	Tubulin beta 2C chain	0.0025	0.0167	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0382	0.1077
Toxoplasma gondii	beta-1 tubulin, putative	0.0025	0.0167	0.011
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0034	0.0382	0.1077
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0382	0.0382
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Echinococcus multilocularis	beta tubulin	0.0025	0.0167	0.0471
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0023	0.0129	0.0365
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0165	0.3544	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0025	0.0167	0.0471
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0382	0.1077
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0023	0.0129	0.0129
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0165	0.3544	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0165	0.3544	1
Echinococcus granulosus	FTZ F1 alpha	0.0034	0.0382	0.1077
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0165	0.3544	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0034	0.0382	0.1077
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0034	0.0382	0.0382
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0023	0.0129	0.0129
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Brugia malayi	Proteasome A-type and B-type family protein	0.0023	0.0129	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0382	0.1077
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0034	0.0382	0.1077
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0034	0.0382	0.1077
Loa Loa (eye worm)	steroid hormone receptor	0.0034	0.0382	0.1077
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0023	0.0129	0.0365
Schistosoma mansoni	tubulin subunit beta	0.0025	0.0167	0.0167
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0165	0.3544	1
Toxoplasma gondii	beta tubulin	0.0025	0.0167	0.011
Echinococcus granulosus	Proteasome subunit alpha beta	0.0023	0.0129	0.0365
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0073	0.134	0.3781
Leishmania major	beta tubulin	0.0025	0.0167	0.011
Onchocerca volvulus	Bile acid receptor homolog	0.0034	0.0382	1
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0023	0.0129	0.0365
Giardia lamblia	Beta tubulin	0.0025	0.0167	0.011
Brugia malayi	proteasome subunit alpha type 1	0.0023	0.0129	0.0365
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0073	0.134	0.3781
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0382	0.1077
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0165	0.3544	1
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0073	0.134	0.3546
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0023	0.0129	0.0365
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0034	0.0382	0.0382

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 0.46239	Agonist activity at GST-tagged Homo sapiens (human) PPARdelta ligand binding domain after 2 hr by FRET assay	ChEMBL.	No reference
EC50 (binding)	= 2.44	Agonist activity at Homo sapiens (human) PPARgamma expressed in mouse 3T3-L1 cells incubated for 2 days followed by compound wash out measured after 4 days by insulin receptor binding assay	ChEMBL.	No reference
EC50 (binding)	= 3.0969	Agonist activity at GST-tagged Homo sapiens (human) PPARalpha ligand binding domain after 2 hr by FRET assay	ChEMBL.	No reference
EC50 (functional)	= 2.9 nM	Agonist activity at human PPAR delta by FRET assay	ChEMBL.	17274610
EC50 (functional)	= 2.9 nM	Agonist activity at human PPAR delta by FRET assay	ChEMBL.	17274610
EC50 (functional)	= 280 nM	Agonist activity at PPAR gamma in mouse 3T3L1 cells assessed as increase in insulin receptor by IRBA	ChEMBL.	17274610
EC50 (functional)	= 280 nM	Agonist activity at PPAR gamma in mouse 3T3L1 cells assessed as increase in insulin receptor by IRBA	ChEMBL.	17274610
EC50 (functional)	= 1250 nM	Agonist activity at human PPAR alpha by FRET assay	ChEMBL.	17274610
EC50 (functional)	= 1250 nM	Agonist activity at human PPAR alpha by FRET assay	ChEMBL.	17274610

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL220837
PubChem: 10003213

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 413523