Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.593 | 0.593 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.021 | 0.593 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.593 | 0.593 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.021 | 0.593 | 0.593 |
Echinococcus multilocularis | acetylcholinesterase | 0.021 | 0.593 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.021 | 0.593 | 1 |
Loa Loa (eye worm) | STAT protein | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.021 | 0.593 | 0.593 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.021 | 0.593 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.021 | 0.593 | 0.593 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.021 | 0.593 | 0.593 |
Echinococcus granulosus | acetylcholinesterase | 0.021 | 0.593 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.021 | 0.593 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.021 | 0.593 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0035 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 287 nM | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor | ChEMBL. | 16971117 |
Ki (binding) | > 10000 nM | Displacement of [3H]DPCPX from recombinant adenosine A1 receptor | ChEMBL. | 16971117 |
Ki (binding) | > 10000 nM | Displacement of [3H]DPCPX from recombinant adenosine A1 receptor | ChEMBL. | 16971117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.