Detailed information for compound 41405

Basic information

Technical information
  • TDR Targets ID: 41405
  • Name: 5-[(E)-2-cyclopropylethenyl]-3-ethyl-7-fluoro -5-(trifluoromethyl)-1H-4,1-benzoxazepin-2-on e
  • MW: 343.316 | Formula: C17H17F4NO2
  • H donors: 1 H acceptors: 1 LogP: 4.14 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1OC(/C=C/C2CC2)(c2c(NC1=O)ccc(c2)F)C(F)(F)F
  • InChi: 1S/C17H17F4NO2/c1-2-14-15(23)22-13-6-5-11(18)9-12(13)16(24-14,17(19,20)21)8-7-10-3-4-10/h5-10,14H,2-4H2,1H3,(H,22,23)/b8-7+
  • InChiKey: VUOSBBZWOPIIAE-BQYQJAHWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(E)-2-cyclopropylvinyl]-3-ethyl-7-fluoro-5-(trifluoromethyl)-1H-4,1-benzoxazepin-2-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1222 0.1789
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0459 0.5366 0.5366
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.023 0.033
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0496 0.0531
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0708 0.0758
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1312 0.1365
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0459 0.5366 0.5742
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0055 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0078
Echinococcus multilocularis neuropeptides capa receptor 0.0459 0.5366 0.5366
Brugia malayi hypothetical protein 0.0026 0.0169 0.0136
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0296 0.3417 0.3628
Trichomonas vaginalis ribokinase, putative 0.009 0.0943 0.138
Schistosoma mansoni alpha-1 adrenergic receptor 0.0459 0.5366 0.5742
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.023 0.0203
Leishmania major putative PfkB family sugar kinase 0.009 0.0943 0.1004
Loa Loa (eye worm) hypothetical protein 0.0079 0.081 0.0825
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1222 0.1789
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.061 0.061
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0579 0.6803 0.6803
Entamoeba histolytica ribokinase, putative 0.009 0.0943 0.138
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.1068 0.1138
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0791 0.9345 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0459 0.5366 0.5722
Trichomonas vaginalis ribokinase, putative 0.009 0.0943 0.138
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.1068 0.1138
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0148 0.1641 1
Toxoplasma gondii ribonuclease HI protein 0.0027 0.0183 0.0152
Schistosoma mansoni neuropeptide F-like receptor 0.0459 0.5366 0.5742
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0281 0.3234 0.3457
Trypanosoma brucei unspecified product 0.0029 0.021 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0062 0.061 0.0652
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0708 0.0708
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0459 0.5366 0.5722
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0215 0.2447 0.2585
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0055 0.0015
Schistosoma mansoni netrin receptor unc5 0.0015 0.0042 0.0045
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0708 0.0753
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1222 0.1789
Echinococcus granulosus equilibrative nucleoside transporter 0.0579 0.6803 0.728
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.009 0.0943 0.0943
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0459 0.5366 0.5742
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0115 0.0379
Brugia malayi RNA binding protein 0.0062 0.061 0.061
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1222 0.1302
Schistosoma mansoni adenosine kinase 0.0791 0.9345 1
Echinococcus granulosus ribonuclease H1 0.0027 0.0183 0.0195
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0783 0.0783
Echinococcus granulosus geminin 0.0348 0.4038 0.4321
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0042 0.0045
Echinococcus granulosus tm gpcr rhodopsin 0.0459 0.5366 0.5742
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0821 0.4626
Trypanosoma brucei adenosine transporter 2 0.01 0.1068 0.1138
Loa Loa (eye worm) hypothetical protein 0.009 0.0943 0.0968
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.01 0.1068 0.1138
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Brugia malayi hypothetical protein 0.0127 0.1384 0.1443
Brugia malayi G protein-coupled receptor F59B2.13 0.0459 0.5366 0.5722
Schistosoma mansoni neuropeptide receptor 0.0459 0.5366 0.5742
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0459 0.5366 0.5742
Schistosoma mansoni hypothetical protein 0.0459 0.5366 0.5742
Brugia malayi AKH receptor 0.0459 0.5366 0.5722
Brugia malayi Uncoordinated protein 44 0.0015 0.0042 0.000000011203
Brugia malayi hypothetical protein 0.009 0.0943 0.0968
Schistosoma mansoni biogenic amine receptor 0.0459 0.5366 0.5742
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.1222 0.1222
Echinococcus granulosus Ankyrin 0.0015 0.0044 0.0047
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.009 0.0943 0.56
Brugia malayi Ribokinase 0.009 0.0943 0.0968
Echinococcus multilocularis rhodopsin orphan GPCR 0.0459 0.5366 0.5366
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0459 0.5366 0.5366
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0054 0.0054
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0821 0.1565
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Echinococcus granulosus g protein coupled receptor 0.0459 0.5366 0.5742
Brugia malayi Dopamine receptor protein 1 0.0459 0.5366 0.5722
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.5013 0.7366
Echinococcus granulosus orexin receptor type 2 0.0459 0.5366 0.5742
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Brugia malayi RE15519p 0.0459 0.5366 0.5722
Trypanosoma brucei purine nucleoside transporter 0.01 0.1068 0.1138
Echinococcus multilocularis bloom syndrome protein 0.0022 0.013 0.013
Echinococcus multilocularis ribokinase 0.009 0.0943 0.0943
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.5013 0.5362
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1222 0.1789
Schistosoma mansoni phosphoglucomutase 0.0027 0.0183 0.0195
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.5013 0.7366
Onchocerca volvulus 0.0459 0.5366 0.6474
Echinococcus multilocularis orexin receptor type 2 0.0459 0.5366 0.5366
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0459 0.5366 0.5742
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.1222 0.1307
Echinococcus multilocularis rhodopsin orphan GPCR 0.0459 0.5366 0.5366
Trypanosoma cruzi nucleoside transporter-like, putative 0.01 0.1068 0.1138
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0579 0.6803 0.728
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0097 0.0086
Brugia malayi RNase H family protein 0.0027 0.0183 0.0151
Echinococcus multilocularis somatostatin receptor 0.0459 0.5366 0.5366
Trypanosoma cruzi nucleobase transporter, putative 0.01 0.1068 0.1138
Onchocerca volvulus Putative pyridoxal kinase 0.009 0.0943 0.1096
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0459 0.5366 0.5742
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0459 0.5366 0.5722
Echinococcus multilocularis g protein coupled receptor 0.0459 0.5366 0.5366
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0133 0.1458 0.1522
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0459 0.5366 0.5366
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0459 0.5366 0.5366
Brugia malayi putative neuropeptide receptor NPR1 0.0459 0.5366 0.5722
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Echinococcus granulosus 7TM GPCR rhodopsin 0.0459 0.5366 0.5742
Echinococcus granulosus neuropeptide Y receptor 0.0459 0.5366 0.5742
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.023 0.0203
Echinococcus multilocularis Ankyrin 0.0015 0.0044 0.0044
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0281 0.3237 0.4754
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0429 0.5013 0.5343
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0579 0.6803 0.6803
Echinococcus granulosus rhodopsin orphan GPCR 0.0459 0.5366 0.5742
Brugia malayi neuropeptide F receptor 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0478 0.5598 0.5598
Echinococcus granulosus neuropeptide Y receptor 0.0459 0.5366 0.5742
Brugia malayi neuropeptide F receptor 0.0459 0.5366 0.5722
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0281 0.3234 0.3457
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0296 0.3417 0.3628
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0459 0.5366 0.5742
Echinococcus granulosus adenylate cyclase 9 0.0079 0.081 0.0867
Loa Loa (eye worm) RNA binding protein 0.0062 0.061 0.061
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.5013 0.5364
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.1068 0.1563
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Echinococcus multilocularis G protein coupled receptor 139 0.0459 0.5366 0.5366
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0708 0.1034
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0429 0.5013 0.5362
Entamoeba histolytica nucleoside transporter, putative 0.01 0.1068 0.1563
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.5013 0.7366
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0079 0.081 0.0933
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0459 0.5366 0.5366
Onchocerca volvulus 0.009 0.0943 0.1096
Brugia malayi MH2 domain containing protein 0.0121 0.1312 0.1365
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.023 0.033
Loa Loa (eye worm) TYRA-2 protein 0.0459 0.5366 0.5722
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0055 0.0053
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.6803 1
Trypanosoma cruzi adenosine kinase, putative 0.009 0.0943 0.1004
Schistosoma mansoni neuropeptide receptor 0.0459 0.5366 0.5742
Echinococcus granulosus rhodopsin orphan GPCR 0.0459 0.5366 0.5742
Trypanosoma brucei ribokinase, putative 0.009 0.0943 0.1004
Trichomonas vaginalis ribokinase, putative 0.009 0.0943 0.138
Onchocerca volvulus 0.0459 0.5366 0.6474
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0459 0.5366 0.5722
Schistosoma mansoni opsin-like receptor 0.0459 0.5366 0.5742
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.023 0.033
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0468 0.0457
Loa Loa (eye worm) hypothetical protein 0.008 0.0821 0.0837
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0042 0.0042
Echinococcus multilocularis GPCR, family 2 0.0016 0.0054 0.0054
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0459 0.5366 0.5366
Giardia lamblia Hypothetical protein 0.0579 0.6803 1
Brugia malayi 6-phosphofructokinase 0.0113 0.1222 0.1268
Schistosoma mansoni protein kinase 0.01 0.1068 0.1143
Onchocerca volvulus Ribonuclease H1 homolog 0.0027 0.0183 0.017
Trypanosoma cruzi nucleobase transporter, putative 0.01 0.1068 0.1138
Leishmania major adenosine kinase-like protein 0.009 0.0943 0.1004
Brugia malayi larval opioid receptor 0.0459 0.5366 0.5722
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.5013 0.5364
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Entamoeba histolytica hypothetical protein 0.0036 0.03 0.0433
Schistosoma mansoni biogenic amine (5HT) receptor 0.0459 0.5366 0.5742
Echinococcus granulosus ribokinase 0.009 0.0943 0.1009
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0459 0.5366 0.6474
Trypanosoma brucei unspecified product 0.01 0.1068 0.1138
Schistosoma mansoni neuropeptide receptor 0.0459 0.5366 0.5742
Echinococcus multilocularis sex peptide receptor 0.0459 0.5366 0.5366
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0029 0.021 0.0219
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0133 0.1458 0.1556
Leishmania major adenosine kinase-like protein 0.009 0.0943 0.1004
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0042 0.0045
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.5013 0.5364
Mycobacterium ulcerans fructokinase, PfkB 0.009 0.0943 0.1691
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0459 0.5366 0.5742
Leishmania major ribonuclease H1, putative 0.0027 0.0183 0.019
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.5013 0.5362
Echinococcus granulosus g protein coupled receptor 0.0459 0.5366 0.5742
Trypanosoma cruzi nucleoside transporter 1, putative 0.01 0.1068 0.1138
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.009 0.0943 0.1009
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.023 0.0354
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0429 0.5013 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0169 0.0175
Brugia malayi Death domain containing protein 0.0015 0.0042 0.000000011203
Onchocerca volvulus 0.07 0.8264 1
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.1068 0.1138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0459 0.5366 0.5742
Echinococcus granulosus g-protein coupled receptor 0.0459 0.5366 0.5742
Loa Loa (eye worm) neuropeptide F receptor 0.0459 0.5366 0.5722
Brugia malayi G-protein coupled receptor 0.0459 0.5366 0.5722
Schistosoma mansoni hypothetical protein 0.0348 0.4038 0.4321
Onchocerca volvulus 0.0459 0.5366 0.6474
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0281 0.3237 0.4754
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1222 0.1268
Loa Loa (eye worm) hypothetical protein 0.0579 0.6803 0.7268
Toxoplasma gondii endonuclease IV APN 0.008 0.0821 0.0838
Echinococcus multilocularis rhodopsin orphan GPCR 0.0459 0.5366 0.5366
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.5013 0.5364
Echinococcus multilocularis neuropeptide receptor 0.0459 0.5366 0.5366
Toxoplasma gondii nucleoside transporter protein 0.01 0.1068 0.1104
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0459 0.5366 0.5742
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0459 0.5366 0.5742
Echinococcus granulosus neuropeptides capa receptor 0.0459 0.5366 0.5742
Schistosoma mansoni hypothetical protein 0.0348 0.4038 0.4321
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0013
Schistosoma mansoni neuropeptide receptor 0.0459 0.5366 0.5742
Brugia malayi TAR-binding protein 0.0062 0.061 0.061
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0281 0.3234 0.3457
Echinococcus multilocularis adenosine kinase 0.0791 0.9345 0.9345
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0429 0.5013 0.7296
Leishmania major tagatose-6-phosphate kinase-like protein 0.009 0.0943 0.1004
Onchocerca volvulus 0.0076 0.0769 0.0884
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Schistosoma mansoni hypothetical protein 0.0015 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0459 0.5366 0.5742
Echinococcus multilocularis neuropeptide Y receptor 0.0459 0.5366 0.5366
Brugia malayi STAT protein, DNA binding domain containing protein 0.0137 0.1507 0.1574
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0459 0.5366 0.5742
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Echinococcus multilocularis neuropeptide receptor 0.0459 0.5366 0.5366
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0459 0.5366 0.5722
Trypanosoma cruzi adenosine kinase, putative 0.009 0.0943 0.1004
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0708 0.0753
Schistosoma mansoni tar DNA-binding protein 0.0062 0.061 0.0652
Schistosoma mansoni amine GPCR 0.0459 0.5366 0.5742
Leishmania major nucleobase transporter 0.01 0.1068 0.1138
Trypanosoma cruzi nucleobase transporter, putative 0.01 0.1068 0.1138
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Leishmania major nucleoside transporter 1, putative 0.01 0.1068 0.1138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0169 0.0136
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0148 0.1641 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.023 0.0354
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.1222 0.2151
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.5013 0.7366
Echinococcus granulosus rhodopsin orphan GPCR 0.0459 0.5366 0.5742
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0459 0.5366 0.5742
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0459 0.5366 0.5366
Echinococcus multilocularis rhodopsin orphan GPCR 0.0459 0.5366 0.5366
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0054 0.0013
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0579 0.6803 0.8223
Leishmania major hypothetical protein, conserved 0.0026 0.0169 0.0175
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0281 0.3237 0.3464
Brugia malayi Tachykinin-like peptides receptor 99D 0.0459 0.5366 0.5722
Leishmania major ribokinase, putative 0.009 0.0943 0.1004
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0459 0.5366 0.5366
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0054 0.0013
Echinococcus granulosus 7tm_1 domain containing protein 0.0459 0.5366 0.5742
Onchocerca volvulus 0.0459 0.5366 0.6474
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0276 0.0252
Loa Loa (eye worm) hypothetical protein 0.0053 0.0496 0.0488
Schistosoma mansoni neuropeptide f receptor 76f 0.0459 0.5366 0.5742
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0166 0.1859 0.199
Loa Loa (eye worm) hypothetical protein 0.0579 0.6803 0.7268
Echinococcus multilocularis dro:myosuppressin receptor 0.0459 0.5366 0.5366
Leishmania major nucleobase transporter 0.01 0.1068 0.1138
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0166 0.1859 0.1859
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.03 0.0321
Echinococcus granulosus fmrfamide receptor 0.0459 0.5366 0.5742
Schistosoma mansoni hypothetical protein 0.0459 0.5366 0.5742
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0148 0.1639 0.2403
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0055 0.0055
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0429 0.5013 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.023 0.033
Brugia malayi hypothetical protein 0.0036 0.03 0.0276
Brugia malayi ORL1-like opioid receptor 0.0459 0.5366 0.5722
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0169 0.0175
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.021 0.0219
Brugia malayi putative neuropeptide receptor 0.0459 0.5366 0.5722
Onchocerca volvulus 0.0053 0.0496 0.0552
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0459 0.5366 0.5742
Echinococcus granulosus neuropeptide receptor 0.0459 0.5366 0.5742
Trypanosoma brucei ribonuclease H1 0.0027 0.0183 0.019
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0943 0.138
Loa Loa (eye worm) adenylyl cyclase 3 0.0079 0.081 0.0825
Trypanosoma brucei adenosine kinase, putative 0.0791 0.9345 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0459 0.5366 0.5742
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0055 0.0013
Schistosoma mansoni opsin-like receptor 0.0459 0.5366 0.5742
Echinococcus multilocularis neuropeptides capa receptor 0.0459 0.5366 0.5366
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1222 0.1789
Echinococcus multilocularis g-protein coupled receptor 0.0459 0.5366 0.5366
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.5013 0.5013
Entamoeba histolytica hypothetical protein 0.0036 0.03 0.0433
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.013 0.0183
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0459 0.5366 0.5722
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.1068 0.1138
Schistosoma mansoni hypothetical protein 0.0459 0.5366 0.5742
Echinococcus granulosus solute carrier family 28 0.0166 0.1859 0.199
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.1222 0.7354
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.021 0.0219
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.5013 0.7366
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0055 0.0053
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0281 0.3237 0.3434
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.5013 1
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0429 0.5013 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0055 0.0053
Echinococcus granulosus serotonin receptor 0.0459 0.5366 0.5742
Brugia malayi Dopamine receptor protein 2 0.0459 0.5366 0.5722
Echinococcus granulosus allatostatin A receptor 0.0459 0.5366 0.5742
Onchocerca volvulus Neuropeptide F receptor homolog 0.0459 0.5366 0.6474
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0169 0.0137
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Onchocerca volvulus 0.0459 0.5366 0.6474
Echinococcus granulosus rhodopsin orphan GPCR 0.0459 0.5366 0.5742
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.1068 0.1138
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0468 0.0457
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Schistosoma mansoni histamine h1 receptor 0.0459 0.5366 0.5742
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0169 0.0253
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.5013 0.5362
Brugia malayi RNase H family protein 0.0027 0.0183 0.0151
Schistosoma mansoni phosphoglucomutase 0.0027 0.0183 0.0195
Onchocerca volvulus 0.0459 0.5366 0.6474
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Brugia malayi hypothetical protein 0.01 0.1068 0.1102
Loa Loa (eye worm) neuropeptide F receptor 0.0459 0.5366 0.5722
Trypanosoma cruzi nucleoside transporter-like, putative 0.01 0.1068 0.1138
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.009 0.0943 0.138
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1312 0.1365
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0055 0.0023
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0058
Echinococcus granulosus neuropeptide FF receptor 2 0.0459 0.5366 0.5742
Echinococcus granulosus rhodopsin orphan GPCR 0.0459 0.5366 0.5742
Mycobacterium tuberculosis Ribokinase RbsK 0.009 0.0943 0.56
Brugia malayi follicle stimulating hormone receptor 0.0699 0.8241 0.8814
Onchocerca volvulus 0.0459 0.5366 0.6474
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0055 0.0055
Schistosoma mansoni adenoreceptor 0.0459 0.5366 0.5742
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0459 0.5366 0.5722
Schistosoma mansoni biogenic amine receptor 0.0459 0.5366 0.5742
Echinococcus granulosus neuropeptide s receptor 0.0459 0.5366 0.5742
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0054 0.0013
Echinococcus granulosus GPCR family 2 0.0016 0.0054 0.0058
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Echinococcus granulosus adenosine kinase 0.0791 0.9345 1
Trypanosoma brucei nucleoside transporter 1, putative 0.01 0.1068 0.1138
Onchocerca volvulus 0.0459 0.5366 0.6474
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1222 0.1307
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0183 0.019
Schistosoma mansoni tar DNA-binding protein 0.0062 0.061 0.0652
Brugia malayi Serotonin receptor 0.0459 0.5366 0.5722
Brugia malayi G-protein coupled receptor 0.0459 0.5366 0.5722
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.03 0.03
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0281 0.3234 0.4609
Schistosoma mansoni growth hormone secretagogue receptor 0.0459 0.5366 0.5742
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0054 0.0058
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.023 0.0098
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0459 0.5366 0.5742
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.023 0.0203
Echinococcus multilocularis fmrfamide receptor 0.0459 0.5366 0.5366
Onchocerca volvulus 0.0459 0.5366 0.6474
Trypanosoma cruzi ribokinase, putative 0.009 0.0943 0.1004
Brugia malayi G protein-coupled receptor 0.0459 0.5366 0.5722
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0459 0.5366 0.5722
Echinococcus granulosus neuropeptides capa receptor 0.0459 0.5366 0.5742
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0281 0.3237 0.3237
Brugia malayi Protein kinase domain containing protein 0.0015 0.0042 0.000000011203
Brugia malayi Nucleoside transporter family protein 0.0579 0.6803 0.7268
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.01 0.1068 0.1138
Trichomonas vaginalis ribonuclease H1, putative 0.0027 0.0183 0.0261
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0708 0.0753
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0073 0.0079
Echinococcus granulosus bloom syndrome protein 0.0022 0.013 0.0139
Echinococcus granulosus biogenic amine 5HT receptor 0.0459 0.5366 0.5742
Echinococcus granulosus tumor protein p63 0.0361 0.419 0.4484
Loa Loa (eye worm) STAT protein 0.0137 0.1507 0.1574
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.5013 0.5362
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.1068 0.1138
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.1068 0.1138
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.1068 0.1138
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0115 0.0088
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0429 0.5013 0.5362
Onchocerca volvulus 0.0459 0.5366 0.6474
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Schistosoma mansoni neuropeptide F-like receptor 0.0459 0.5366 0.5742
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.1222 0.725
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0459 0.5366 0.5742
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Echinococcus granulosus peptide allatostatin:somatostatin 0.0459 0.5366 0.5742
Brugia malayi Dopamine receptor 0.0459 0.5366 0.5722
Schistosoma mansoni opsin-like receptor 0.0459 0.5366 0.5742
Echinococcus granulosus sex peptide receptor 0.0459 0.5366 0.5742
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0459 0.5366 0.5366
Loa Loa (eye worm) hypothetical protein 0.0018 0.0076 0.0036
Onchocerca volvulus 0.0079 0.081 0.0933
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0459 0.5366 0.5366
Loa Loa (eye worm) hypothetical protein 0.01 0.1068 0.1102
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0429 0.5013 1
Chlamydia trachomatis endonuclease IV 0.008 0.0821 0.1236
Echinococcus granulosus tm gpcr rhodopsin 0.0459 0.5366 0.5742
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Mycobacterium ulcerans endonuclease IV 0.008 0.0821 0.1442
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.5013 0.5362
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1222 0.1302
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0352 0.0377
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0042 0.0042
Brugia malayi isocitrate dehydrogenase 0.0016 0.0055 0.0013
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0459 0.5366 0.5742
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.1068 0.1563
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0058
Echinococcus granulosus G protein coupled receptor 139 0.0459 0.5366 0.5742
Trypanosoma brucei nucleoside transporter 1, putative 0.01 0.1068 0.1138
Echinococcus multilocularis serotonin receptor 0.0459 0.5366 0.5366
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0699 0.8241 0.8814
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Leishmania major adenosine kinase, putative 0.0791 0.9345 1
Brugia malayi Serotonin receptor 0.0459 0.5366 0.5722
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0459 0.5366 0.5366
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.009 0.0943 0.138
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0821 0.0837
Schistosoma mansoni amine GPCR 0.0459 0.5366 0.5742
Entamoeba histolytica nucleoside transporter, putative 0.0579 0.6803 1
Schistosoma mansoni adenosine kinase 0.0791 0.9345 1
Schistosoma mansoni hypothetical protein 0.01 0.1062 0.1137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0459 0.5366 0.5742
Echinococcus granulosus rhodopsin orphan GPCR 0.0459 0.5366 0.5742
Echinococcus granulosus g protein coupled receptor 0.0459 0.5366 0.5742
Loa Loa (eye worm) RecQ helicase 0.0022 0.013 0.0094
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0109 0.1165 0.1165
Echinococcus multilocularis geminin 0.0348 0.4038 0.4038
Entamoeba histolytica kinase, PfkB family 0.009 0.0943 0.138
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.5366 0.5366
Brugia malayi Adenosine kinase-like 0.0791 0.9345 1
Giardia lamblia Ribokinase 0.009 0.0943 0.1149
Schistosoma mansoni ribokinase 0.009 0.0943 0.1009
Echinococcus multilocularis g protein coupled receptor 0.0459 0.5366 0.5366
Brugia malayi 6-phosphofructokinase 0.0113 0.1222 0.1268
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0429 0.5013 0.5344
Echinococcus multilocularis serotonin receptor 0.0459 0.5366 0.5366
Schistosoma mansoni tar DNA-binding protein 0.0062 0.061 0.0652
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Echinococcus granulosus biogenic amine 5HT receptor 0.0459 0.5366 0.5742
Echinococcus multilocularis rhodopsin orphan GPCR 0.0459 0.5366 0.5366
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.1068 0.1138
Entamoeba histolytica hypothetical protein 0.0036 0.03 0.0433
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0169 0.023
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0058
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1222 0.1307
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.1458 0.1556
Echinococcus multilocularis ribonuclease H1 0.0027 0.0183 0.0183
Echinococcus granulosus alpha 1A adrenergic receptor 0.0459 0.5366 0.5742
Trypanosoma cruzi nucleoside transporter 1, putative 0.01 0.1068 0.1138
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0002
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0352 0.0352
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0459 0.5366 0.5742
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0459 0.5366 0.5742
Leishmania major tagatose-6-phosphate kinase-like protein 0.009 0.0943 0.1004
Echinococcus multilocularis G-protein coupled receptor, putative 0.0459 0.5366 0.5366
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0459 0.5366 0.5366
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Entamoeba histolytica fructokinase, putative 0.009 0.0943 0.138
Trypanosoma brucei ribokinase, putative 0.009 0.0943 0.1004
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.6803 1
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1222 0.1789
Echinococcus multilocularis rhodopsin orphan GPCR 0.0459 0.5366 0.5366
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.1068 0.1138
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Echinococcus multilocularis tumor protein p63 0.0361 0.419 0.419
Entamoeba histolytica hypothetical protein 0.0036 0.03 0.0433
Toxoplasma gondii kinase, pfkB family protein 0.0791 0.9345 1
Onchocerca volvulus 0.0459 0.5366 0.6474
Echinococcus granulosus tm gpcr rhodopsin 0.0459 0.5366 0.5742
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0429 0.5013 0.5362
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.021 0.0219
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.5013 0.5362
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.5013 0.5364
Echinococcus multilocularis allatostatin A receptor 0.0459 0.5366 0.5366
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0429 0.5013 0.5344
Brugia malayi sulfakinin receptor protein 0.0459 0.5366 0.5722
Schistosoma mansoni amine GPCR 0.0459 0.5366 0.5742
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0055 0.0053
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0281 0.3237 0.3434
Loa Loa (eye worm) hypothetical protein 0.0579 0.6803 0.7268
Onchocerca volvulus Ribokinase homolog 0.009 0.0943 0.1096
Trypanosoma brucei purine nucleoside transporter 0.01 0.1068 0.1138
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.5366 0.5742
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0459 0.5366 0.5742
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0055 0.0015
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0055 0.0058
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0429 0.5013 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0133 0.1458 0.1556
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0579 0.6803 0.8223
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0058
Loa Loa (eye worm) pax transcription factor protein 2 0.0244 0.2785 0.2948
Loa Loa (eye worm) melatonin receptor type 1A 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.1222 0.1302
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.023 0.0376
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Trypanosoma cruzi adenosine kinase, putative 0.0791 0.9345 1
Onchocerca volvulus 0.0459 0.5366 0.6474
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.009 0.0943 0.0968
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0169 0.023
Echinococcus granulosus tar DNA binding protein 0.0062 0.061 0.0652
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.1222 0.226
Toxoplasma gondii kinase, pfkB family protein 0.009 0.0943 0.097
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0133 0.1458 0.1556
Echinococcus multilocularis tar DNA binding protein 0.0062 0.061 0.061
Trypanosoma brucei adenosine transporter, putative 0.01 0.1068 0.1138
Trypanosoma brucei adenosine transporter, putative 0.01 0.1068 0.1138
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.5013 0.5013
Toxoplasma gondii nucleoside transporter protein 0.01 0.1068 0.1104
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.061 0.061
Brugia malayi hypothetical protein 0.0579 0.6803 0.7268
Echinococcus granulosus somatostatin receptor 0.0459 0.5366 0.5742
Onchocerca volvulus 0.0459 0.5366 0.6474
Schistosoma mansoni tar DNA-binding protein 0.0062 0.061 0.0652
Toxoplasma gondii nucleoside transporter protein 0.01 0.1068 0.1104
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.1068 0.1563
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.5366 0.5366
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.5013 0.7366
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0183 0.019
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.03 0.0321
Brugia malayi phosphofructokinase 0.0113 0.1222 0.1268
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.023 0.033
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0708 0.0758
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0219 0.2487 0.2973
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0429 0.5013 0.5362
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0044 0.0047
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.1068 0.1563
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0459 0.5366 0.5366
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0058
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.1068 0.1563
Onchocerca volvulus 0.0459 0.5366 0.6474
Trypanosoma brucei unspecified product 0.01 0.1068 0.1138
Schistosoma mansoni hypothetical protein 0.0036 0.03 0.0321
Trypanosoma cruzi adenosine kinase, putative 0.0791 0.9345 1
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0133 0.1458 0.1556
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.023 0.033
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1222 0.1268
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0459 0.5366 0.5366
Brugia malayi hypothetical protein 0.0016 0.006 0.0019
Schistosoma mansoni myosin xvIII 0.0459 0.5366 0.5742
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0783 0.0838
Echinococcus multilocularis fmrfamide receptor 0.0459 0.5366 0.5366
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Trypanosoma cruzi nucleoside transporter 1, putative 0.01 0.1068 0.1138
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0708 0.0716
Echinococcus granulosus dro:myosuppressin receptor 0.0459 0.5366 0.5742
Echinococcus granulosus hypothetical protein 0.0459 0.5366 0.5742
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0459 0.5366 0.5742
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.01 0.1068 0.1138
Onchocerca volvulus 0.0459 0.5366 0.6474
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.023 0.033
Echinococcus granulosus tachykinin peptides receptor 99D 0.0459 0.5366 0.5742
Echinococcus granulosus rhodopsin orphan GPCR 0.0459 0.5366 0.5742
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.013 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0459 0.5366 0.5366
Schistosoma mansoni phosphoglucomutase 0.0027 0.0183 0.0195
Loa Loa (eye worm) TAR-binding protein 0.0062 0.061 0.061
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.023 0.033
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0166 0.1859 0.199
Brugia malayi Melatonin receptor type 1A 0.0459 0.5366 0.5722
Brugia malayi GnHR receptor homolog 0.0459 0.5366 0.5722
Loa Loa (eye worm) hypothetical protein 0.0034 0.0276 0.0252
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.5013 0.5362
Onchocerca volvulus 0.0244 0.2785 0.3335
Brugia malayi hypothetical protein 0.0459 0.5366 0.5722
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0459 0.5366 0.5742
Trypanosoma brucei RNA helicase, putative 0.01 0.1062 0.1132
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.5013 0.7366
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0459 0.5366 0.5742
Schistosoma mansoni equilibrative nucleoside transporter 0.01 0.1068 0.1143
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0169 0.0175
Brugia malayi Adenylyl cyclase protein 0.0079 0.081 0.0825
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0042 0.0045
Loa Loa (eye worm) G-protein coupled receptor 0.0459 0.5366 0.5722
Schistosoma mansoni hypothetical protein 0.0459 0.5366 0.5742
Loa Loa (eye worm) G-protein coupled receptor 0.0459 0.5366 0.5722
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0115 0.0078
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0459 0.5366 0.5742
Trypanosoma brucei adenosine transporter 2 0.01 0.1068 0.1138
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.023 0.0071
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.6803 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0459 0.5366 0.5366
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0054 0.0058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0054 0.0054
Schistosoma mansoni amine GPCR 0.0459 0.5366 0.5742
Leishmania major nucleoside transporter 1, putative 0.01 0.1068 0.1138
Onchocerca volvulus 0.0459 0.5366 0.6474
Loa Loa (eye worm) hypothetical protein 0.005 0.0468 0.0457
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.6803 1
Trypanosoma brucei adenosine kinase, putative 0.0791 0.9345 1
Entamoeba histolytica nucleoside transporter, putative 0.01 0.1068 0.1563
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0281 0.3234 0.3457
Mycobacterium tuberculosis Adenosine kinase 0.009 0.0943 0.56
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1222 0.1789
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0468 0.0457
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Onchocerca volvulus 0.0459 0.5366 0.6474
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.023 0.0376
Echinococcus granulosus death domain containing protein 0.0015 0.0042 0.0045
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0708 0.0753
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0459 0.5366 0.5742
Schistosoma mansoni biogenic amine (5HT) receptor 0.0459 0.5366 0.5742
Echinococcus multilocularis neuropeptide Y receptor 0.0459 0.5366 0.5366
Echinococcus multilocularis solute carrier family 28 0.0166 0.1859 0.1859
Mycobacterium ulcerans carbohydrate kinase CbhK 0.009 0.0943 0.1691
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.5013 0.5362
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0708 0.0716
Loa Loa (eye worm) hypothetical protein 0.0459 0.5366 0.5722
Schistosoma mansoni amine GPCR 0.0459 0.5366 0.5742
Loa Loa (eye worm) hypothetical protein 0.0281 0.3237 0.3434
Echinococcus multilocularis adenylate cyclase 9 0.0079 0.081 0.081
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.5013 0.5364
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0459 0.5366 0.5742
Brugia malayi Pax transcription factor protein 2 0.0244 0.2785 0.2948
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0821 0.4829
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0148 0.1639 0.1716
Echinococcus granulosus neuropeptide receptor 0.0459 0.5366 0.5742
Schistosoma mansoni hypothetical protein 0.0034 0.0276 0.0296
Loa Loa (eye worm) phosphofructokinase 0.0113 0.1222 0.1268
Loa Loa (eye worm) hypothetical protein 0.0331 0.3829 0.407
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.5013 0.7366
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0821 0.1546
Mycobacterium leprae Probable adenosine kinase adk 0.009 0.0943 0.5426
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.013 0.0183
Echinococcus multilocularis g protein coupled receptor 0.0459 0.5366 0.5366
Schistosoma mansoni biogenic amine receptor 0.0459 0.5366 0.5742
Echinococcus multilocularis neuropeptide FF receptor 2 0.0459 0.5366 0.5366
Brugia malayi RNase H family protein 0.0027 0.0183 0.0151

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 151 nM Compound was evaluated for its ability to inhibit HIV-1 Reverse Transcriptase in an in vitro enzyme assay ChEMBL. 11378361
IC50 (binding) = 151 nM Compound was evaluated for its ability to inhibit HIV-1 Reverse Transcriptase in an in vitro enzyme assay ChEMBL. 11378361
IC90 (functional) = 2.5 nM Compound was evaluated for its ability to inhibit the wild type RF strain of HIV-1 ChEMBL. 11378361
IC90 (functional) = 2.5 nM Compound was evaluated for its ability to inhibit the wild type RF strain of HIV-1 ChEMBL. 11378361
IC90 (functional) = 70 nM Compound was evaluated for its ability to inhibit a virus containing the clinically relevant K103N mutation ChEMBL. 11378361
IC90 (functional) = 70 nM Compound was evaluated for its ability to inhibit a virus containing the clinically relevant K103N mutation ChEMBL. 11378361

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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