Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0341 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0036 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.03 uM | Inhibition of nitric oxide production in IFNgamma stimulated RAW 264.7 cells | ChEMBL. | 16996735 |
IC50 (functional) | = 0.03 uM | Inhibition of nitric oxide production in IFNgamma stimulated RAW 264.7 cells | ChEMBL. | 16996735 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 16996735 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.