Detailed information for compound 41434

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 472.489 | Formula: C27H24N2O6
  • H donors: 1 H acceptors: 4 LogP: 2.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@H](c2c1cc1nc3ccccc3nc1c2)O
  • InChi: 1S/C27H24N2O6/c1-32-21-8-13(9-22(33-2)26(21)34-3)23-14-10-19-20(29-18-7-5-4-6-17(18)28-19)11-15(14)25(30)16-12-35-27(31)24(16)23/h4-11,16,23-25,30H,12H2,1-3H3/t16-,23+,24-,25-/m0/s1
  • InChiKey: LIKPPSCJUJVBQG-RGWZMNCVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis orexin receptor type 2 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Schistosoma mansoni hypothetical protein 0.037 0.2675 0.2922
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0299 0.2146 0.2364
Leishmania major nucleobase transporter 0.0234 0.1658 0.1827
Trypanosoma brucei adenosine kinase, putative 0.1224 0.9076 1
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0808 0.0808
Onchocerca volvulus 0.0443 0.3225 0.3175
Brugia malayi hypothetical protein 0.0017 0.0036 0.0004
Brugia malayi sulfakinin receptor protein 0.0443 0.3225 0.3203
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0457 0.3328 0.5
Leishmania major putative PfkB family sugar kinase 0.014 0.095 0.1047
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0147 0.0162
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Schistosoma mansoni neuropeptide receptor 0.0443 0.3225 0.353
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.0921
Leishmania major adenosine kinase-like protein 0.014 0.095 0.1047
Schistosoma mansoni hypothetical protein 0.0037 0.018 0.0163
Brugia malayi putative neuropeptide receptor NPR1 0.0443 0.3225 0.3203
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0147 0.0115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0014
Echinococcus granulosus equilibrative nucleoside transporter 3 0.1348 1 1
Echinococcus multilocularis fmrfamide receptor 0.0443 0.3225 0.3203
Onchocerca volvulus 0.023 0.1626 0.1565
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0457 0.3328 0.3666
Onchocerca volvulus 0.0443 0.3225 0.3175
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0149 0.0149
Trypanosoma brucei adenosine transporter 2, putative 0.0234 0.1658 0.1827
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.014 0.095 0.095
Onchocerca volvulus 0.0443 0.3225 0.3175
Brugia malayi G-protein coupled receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0306 0.0275
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0443 0.3225 0.353
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.0808 0.0778
Echinococcus granulosus rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Toxoplasma gondii nucleoside transporter protein 0.0234 0.1658 0.1806
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0166 0.115 0.1122
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.0253 0.1802 0.1776
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0147 0.0734
Entamoeba histolytica hypothetical protein 0.0039 0.0195 0.0195
Trypanosoma brucei unspecified product 0.0234 0.1658 0.1827
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0443 0.3225 0.353
Loa Loa (eye worm) hypothetical protein 0.0029 0.0122 0.009
Echinococcus granulosus serotonin receptor 0.0443 0.3225 0.3203
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0108 0.0717 0.0687
Mycobacterium leprae Probable adenosine kinase adk 0.014 0.095 0.865
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0078 0.0493 0.0543
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0457 0.3328 0.3666
Echinococcus granulosus solute carrier family 28 0.0166 0.115 0.1122
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0166 0.115 0.1122
Echinococcus multilocularis neuropeptide Y receptor 0.0443 0.3225 0.3203
Brugia malayi Dopamine receptor protein 1 0.0443 0.3225 0.3203
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0082 0.0082
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0457 0.3328 1
Onchocerca volvulus 0.0443 0.3225 0.3175
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0457 0.3328 0.3666
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0253 0.1802 0.1957
Schistosoma mansoni myosin xvIII 0.0443 0.3225 0.353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0443 0.3225 0.353
Loa Loa (eye worm) G-protein coupled receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0443 0.3225 0.3203
Brugia malayi G-protein coupled receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0229 0.1617 0.159
Echinococcus granulosus allatostatin A receptor 0.0443 0.3225 0.3203
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0443 0.3225 0.3203
Echinococcus granulosus 7tm_1 domain containing protein 0.0443 0.3225 0.3203
Echinococcus multilocularis geminin 0.037 0.2675 0.2652
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0108 0.0251
Schistosoma mansoni neuropeptide F-like receptor 0.0443 0.3225 0.353
Brugia malayi hypothetical protein 0.1348 1 1
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0078 0.0493 0.0543
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0299 0.2148 0.2122
Echinococcus multilocularis neuropeptide FF receptor 2 0.0443 0.3225 0.3203
Onchocerca volvulus Putative pyridoxal kinase 0.014 0.095 0.0884
Brugia malayi 6-phosphofructokinase 0.012 0.0808 0.0778
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0443 0.3225 0.3203
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0457 0.3328 0.3306
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0443 0.3225 0.3203
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0147 0.0115
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0808 0.0808
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0808 0.089
Entamoeba histolytica nucleoside transporter, putative 0.1348 1 1
Onchocerca volvulus Netrin receptor homolog 0.003 0.0129 0.0057
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3666
Echinococcus granulosus rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Trypanosoma brucei nucleoside transporter 1, putative 0.0234 0.1658 0.1827
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0443 0.3225 0.3203
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0306 0.0275
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0457 0.3328 0.3644
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.0253 0.1802 0.1776
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0108 0.0144
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.018 0.0148
Loa Loa (eye worm) hypothetical protein 0.0054 0.0306 0.0275
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0147 0.0369
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0149 0.0149
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.0078 0.0493 0.1415
Echinococcus multilocularis g protein coupled receptor 0.0443 0.3225 0.3203
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0108 0.0119
Echinococcus granulosus peptide allatostatin:somatostatin 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0468 0.0515
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0231 0.0199
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0457 0.3328 0.3666
Trypanosoma cruzi hypothetical protein, conserved 0.0259 0.1847 0.2034
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0443 0.3225 0.3203
Schistosoma mansoni adenosine kinase 0.1224 0.9076 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0158 0.1085 0.1085
Brugia malayi Pax transcription factor protein 2 0.0259 0.1842 0.1815
Loa Loa (eye worm) hypothetical protein 0.0056 0.0327 0.0295
Schistosoma mansoni biogenic amine receptor 0.0443 0.3225 0.353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0443 0.3225 0.353
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0122 0.0109
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0698 0.5134 0.5118
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0147 0.0115
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0299 0.2148 0.2122
Brugia malayi G protein-coupled receptor 0.0443 0.3225 0.3203
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0443 0.3225 0.3203
Leishmania major ribokinase, putative 0.014 0.095 0.1047
Brugia malayi GnHR receptor homolog 0.0443 0.3225 0.3203
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0468 0.0468
Schistosoma mansoni amine GPCR 0.0443 0.3225 0.353
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0147 0.0136
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0149 0.0149
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0149 0.0149
Echinococcus granulosus fmrfamide receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0147 0.0115
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0457 0.3328 0.3666
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis G protein coupled receptor 139 0.0443 0.3225 0.3203
Trypanosoma brucei adenosine transporter 2 0.0234 0.1658 0.1827
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0299 0.2148 0.2148
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Brugia malayi Serotonin receptor 0.0443 0.3225 0.3203
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0122 0.0099
Schistosoma mansoni neuropeptide f receptor 76f 0.0443 0.3225 0.353
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.003 0.0129 0.0097
Echinococcus granulosus tm gpcr rhodopsin 0.0443 0.3225 0.3203
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0142 0.0966 0.1064
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0443 0.3225 0.3203
Leishmania major hypothetical protein, conserved 0.0259 0.1847 0.2034
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma brucei unspecified product 0.0234 0.1658 0.1827
Brugia malayi larval opioid receptor 0.0443 0.3225 0.3203
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0149 0.0375
Loa Loa (eye worm) RecQ helicase 0.0024 0.0082 0.005
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0147 0.0115
Onchocerca volvulus 0.0259 0.1842 0.1782
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3328
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0149 0.027
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0299 0.2146 0.2364
Onchocerca volvulus 0.0084 0.0533 0.0463
Chlamydia trachomatis endonuclease IV 0.0085 0.0542 0.1235
Echinococcus multilocularis neuropeptide receptor 0.0443 0.3225 0.3203
Brugia malayi Tachykinin-like peptides receptor 99D 0.0443 0.3225 0.3203
Trichomonas vaginalis conserved hypothetical protein 0.0259 0.1847 0.1847
Trichomonas vaginalis set domain proteins, putative 0.023 0.1625 0.1625
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0457 0.3328 0.3666
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1348 1 1
Brugia malayi AKH receptor 0.0443 0.3225 0.3203
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0808 0.0808
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0234 0.1658 0.1827
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0315 0.2267 0.2242
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0457 0.3328 0.3666
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0195 0.018
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0866 0.0836
Entamoeba histolytica fructokinase, putative 0.014 0.095 0.095
Brugia malayi phosphofructokinase 0.012 0.0808 0.0778
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.0078 0.0493 0.0543
Trypanosoma brucei adenosine transporter, putative 0.0234 0.1658 0.1827
Echinococcus multilocularis adenosine kinase 0.1224 0.9076 0.9073
Mycobacterium ulcerans fructokinase, PfkB 0.014 0.095 0.2697
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0234 0.1658 0.1827
Schistosoma mansoni hypothetical protein 0.0443 0.3225 0.353
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0149 0.027
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.0078 0.0493 0.1321
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0085 0.0542 0.1471
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0234 0.1658 0.1658
Onchocerca volvulus Neuropeptide F receptor homolog 0.0443 0.3225 0.3175
Echinococcus granulosus dro:myosuppressin receptor 0.0443 0.3225 0.3203
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0082 0.0082
Schistosoma mansoni ankyrin 23/unc44 0.003 0.0129 0.0107
Brugia malayi isocitrate dehydrogenase 0.0032 0.0147 0.0115
Schistosoma mansoni hypothetical protein 0.0443 0.3225 0.353
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Entamoeba histolytica ribokinase, putative 0.014 0.095 0.095
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0234 0.1658 0.1827
Schistosoma mansoni opsin-like receptor 0.0443 0.3225 0.353
Brugia malayi hypothetical protein 0.014 0.095 0.0921
Onchocerca volvulus 0.014 0.095 0.0884
Echinococcus granulosus neuropeptide receptor 0.0443 0.3225 0.3203
Echinococcus granulosus g-protein coupled receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) phosphofructokinase 0.012 0.0808 0.0778
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0108 0.0119
Echinococcus granulosus biogenic amine 5HT receptor 0.0443 0.3225 0.3203
Echinococcus granulosus geminin 0.037 0.2675 0.2652
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0808 0.0808
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0443 0.3225 0.353
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0232 0.1644 0.1583
Brugia malayi MH2 domain containing protein 0.0128 0.0866 0.0836
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0158 0.1087 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0234 0.1658 0.1827
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0457 0.3328 0.3644
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis allatostatin A receptor 0.0443 0.3225 0.3203
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0457 0.3328 1
Echinococcus multilocularis Ankyrin 0.003 0.0131 0.0099
Loa Loa (eye worm) hypothetical protein 0.0084 0.0533 0.0502
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0234 0.1658 0.1658
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1348 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0147 0.0115
Leishmania major ATP-dependent phosphofructokinase 0.012 0.0808 0.089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0122 0.009
Loa Loa (eye worm) hypothetical protein 0.0085 0.0542 0.0511
Leishmania major nucleoside transporter 1, putative 0.0234 0.1658 0.1827
Onchocerca volvulus 0.1085 0.8031 0.8017
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.014 0.095 0.865
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3328
Echinococcus multilocularis rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Echinococcus granulosus rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Echinococcus granulosus bloom syndrome protein 0.0024 0.0082 0.005
Echinococcus granulosus tachykinin peptides receptor 99D 0.0443 0.3225 0.3203
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0149 0.0139
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0299 0.2146 0.2027
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.1114 0.8247 0.8241
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0443 0.3225 0.3203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0443 0.3225 0.353
Onchocerca volvulus 0.0443 0.3225 0.3175
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3328
Brugia malayi follicle stimulating hormone receptor 0.0698 0.5134 0.5118
Echinococcus granulosus g protein coupled receptor 0.0443 0.3225 0.3203
Brugia malayi Melatonin receptor type 1A 0.0443 0.3225 0.3203
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0299 0.2148 0.2122
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0315 0.2267 0.2242
Schistosoma mansoni amine GPCR 0.0443 0.3225 0.353
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0142 0.0966 0.1064
Schistosoma mansoni ribokinase 0.014 0.095 0.1015
Echinococcus granulosus neuropeptide receptor 0.0443 0.3225 0.3203
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0457 0.3328 0.3306
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0443 0.3225 0.3203
Trypanosoma brucei adenosine transporter 2, putative 0.0234 0.1658 0.1827
Echinococcus multilocularis somatostatin receptor 0.0443 0.3225 0.3203
Echinococcus granulosus neuropeptides capa receptor 0.0443 0.3225 0.3203
Schistosoma mansoni neuropeptide receptor 0.0443 0.3225 0.353
Brugia malayi Dopamine receptor protein 2 0.0443 0.3225 0.3203
Trypanosoma cruzi nucleobase transporter, putative 0.0234 0.1658 0.1827
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0147 0.0162
Echinococcus multilocularis neuropeptide receptor A26 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus neuropeptides capa receptor 0.0443 0.3225 0.3203
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0234 0.1658 0.1827
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0183 0.1274 0.1274
Loa Loa (eye worm) hypothetical protein 0.1224 0.9076 0.9073
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0099
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0147 0.0162
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus tm gpcr rhodopsin 0.0443 0.3225 0.3203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0443 0.3225 0.3203
Schistosoma mansoni neuropeptide F-like receptor 0.0443 0.3225 0.353
Schistosoma mansoni biogenic amine receptor 0.0443 0.3225 0.353
Echinococcus multilocularis fmrfamide receptor 0.0443 0.3225 0.3203
Echinococcus granulosus nuclear factor of activated T cells 5 0.0153 0.1051 0.1022
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.003 0.0131 0.0109
Brugia malayi Ribokinase 0.014 0.095 0.0921
Onchocerca volvulus 0.0443 0.3225 0.3175
Echinococcus multilocularis serotonin receptor 0.0443 0.3225 0.3203
Entamoeba histolytica hypothetical protein 0.0039 0.0195 0.0195
Echinococcus granulosus 7TM GPCR rhodopsin 0.0443 0.3225 0.3203
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0468 0.0515
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0808 0.0808
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0129 0.0097
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus adenosine kinase 0.1224 0.9076 0.9073
Trypanosoma cruzi nucleobase transporter, putative 0.0234 0.1658 0.1827
Schistosoma mansoni equilibrative nucleoside transporter 0.0234 0.1658 0.1798
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0147 0.0115
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.014 0.095 0.095
Trypanosoma brucei adenosine transporter 2 0.0234 0.1658 0.1827
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0195 0.0163
Brugia malayi Death domain containing protein 0.003 0.0129 0.0097
Trypanosoma cruzi adenosine kinase, putative 0.1224 0.9076 1
Echinococcus granulosus neuropeptide s receptor 0.0443 0.3225 0.3203
Mycobacterium tuberculosis Adenosine kinase 0.014 0.095 0.865
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0443 0.3225 0.3203
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.014 0.095 0.0921
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0866 0.0836
Brugia malayi RE15519p 0.0443 0.3225 0.3203
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0808 0.0808
Schistosoma mansoni opsin-like receptor 0.0443 0.3225 0.353
Trypanosoma cruzi adenosine kinase, putative 0.014 0.095 0.1047
Brugia malayi 6-phosphofructokinase 0.012 0.0808 0.0778
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0078 0.0493 0.0493
Echinococcus multilocularis rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3666
Onchocerca volvulus 0.0443 0.3225 0.3175
Trichomonas vaginalis ribokinase, putative 0.014 0.095 0.095
Echinococcus multilocularis g protein coupled receptor 0.0443 0.3225 0.3203
Toxoplasma gondii endonuclease IV APN 0.0085 0.0542 0.0572
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.014 0.095 0.0921
Brugia malayi Adenylyl cyclase protein 0.0084 0.0533 0.0502
Toxoplasma gondii nucleoside transporter protein 0.0234 0.1658 0.1806
Entamoeba histolytica nucleoside transporter, putative 0.0234 0.1658 0.1658
Echinococcus multilocularis rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Onchocerca volvulus 0.0443 0.3225 0.3175
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0147 0.0162
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0327 0.0325
Trypanosoma cruzi nucleoside transporter 1, putative 0.0234 0.1658 0.1827
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0195 0.0163
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0085 0.0542 0.1564
Trypanosoma cruzi hypothetical protein 0.0259 0.1847 0.2034
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0457 0.3328 1
Trypanosoma brucei adenosine transporter 2, putative 0.0234 0.1658 0.1827
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis adenylate cyclase 9 0.0084 0.0533 0.0502
Trypanosoma cruzi adenosine kinase, putative 0.1224 0.9076 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus equilibrative nucleoside transporter 0.1348 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma cruzi ribokinase, putative 0.014 0.095 0.1047
Trypanosoma cruzi nucleoside transporter 1, putative 0.0234 0.1658 0.1827
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0147 0.0127
Leishmania major ubiquitin activating enzyme, putative 0.0078 0.0493 0.0543
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.0253 0.1802 0.1965
Trypanosoma brucei ribokinase, putative 0.014 0.095 0.1047
Echinococcus granulosus adenylate cyclase 9 0.0084 0.0533 0.0502
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0166 0.115 0.1122
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0158 0.1085 0.1057
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0234 0.1658 0.1658
Brugia malayi Adenosine kinase-like 0.1224 0.9076 0.9073
Trypanosoma cruzi hypothetical protein, conserved 0.0259 0.1847 0.2034
Leishmania major hypothetical protein, conserved 0.0027 0.0108 0.0119
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0443 0.3225 0.3203
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3328
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0457 0.3328 0.3306
Trypanosoma cruzi nucleobase transporter, putative 0.0234 0.1658 0.1827
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0149 0.0149
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0082 0.005
Schistosoma mansoni growth hormone secretagogue receptor 0.0443 0.3225 0.353
Schistosoma mansoni biogenic amine receptor 0.0443 0.3225 0.353
Echinococcus multilocularis solute carrier family 28 0.0166 0.115 0.1122
Echinococcus granulosus G protein coupled receptor 139 0.0443 0.3225 0.3203
Onchocerca volvulus 0.0443 0.3225 0.3175
Schistosoma mansoni hypothetical protein 0.0443 0.3225 0.353
Entamoeba histolytica hypothetical protein 0.0039 0.0195 0.0195
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0129 0.0097
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0149 0.0149
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0443 0.3225 0.353
Brugia malayi hypothetical protein 0.0027 0.0108 0.0076
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3328
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0443 0.3225 0.3203
Echinococcus multilocularis G-protein coupled receptor, putative 0.0443 0.3225 0.3203
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0808 0.089
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0142 0.0966 0.0936
Echinococcus multilocularis serotonin receptor 0.0443 0.3225 0.3203
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0085 0.0542 0.0511
Entamoeba histolytica nucleoside transporter, putative 0.0234 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.1348 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0468 0.0515
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0457 0.3328 0.3306
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0253 0.1802 0.1802
Entamoeba histolytica hypothetical protein 0.0039 0.0195 0.0195
Trypanosoma brucei purine nucleoside transporter 0.0234 0.1658 0.1827
Brugia malayi Serotonin receptor 0.0443 0.3225 0.3203
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0142 0.0966 0.1064
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0443 0.3225 0.3203
Echinococcus multilocularis neuropeptide Y receptor 0.0443 0.3225 0.3203
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0108 0.0144
Echinococcus granulosus ribokinase 0.014 0.095 0.0921
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0114 0.0082
Echinococcus granulosus neuropeptide Y receptor 0.0443 0.3225 0.3203
Mycobacterium tuberculosis Ribokinase RbsK 0.014 0.095 0.865
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0443 0.3225 0.3175
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0468 0.0437
Schistosoma mansoni adenosine kinase 0.1224 0.9076 1
Loa Loa (eye worm) hypothetical protein 0.1348 1 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0146 0.0997 0.0968
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0299 0.2146 0.2364
Schistosoma mansoni amine GPCR 0.0443 0.3225 0.353
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0147 0.0136
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1416 0.1388
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.0808 0.7243
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0045 0.0014
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0457 0.3328 0.3306
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0443 0.3225 0.3203
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.003 0.0129 0.0097
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3666
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0234 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0148
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.1348 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0443 0.3225 0.3203
Plasmodium vivax SET domain protein, putative 0.0029 0.0122 0.0293
Brugia malayi ORL1-like opioid receptor 0.0443 0.3225 0.3203
Trypanosoma cruzi hypothetical protein 0.0259 0.1847 0.2034
Trypanosoma brucei adenosine transporter 2, putative 0.0234 0.1658 0.1827
Onchocerca volvulus 0.0443 0.3225 0.3175
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0108 0.0119
Schistosoma mansoni alpha-1 adrenergic receptor 0.0443 0.3225 0.353
Brugia malayi Pre-SET motif family protein 0.0029 0.0122 0.009
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0443 0.3225 0.3203
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0084 0.0533 0.0463
Brugia malayi hypothetical protein 0.0039 0.0195 0.0163
Loa Loa (eye worm) pax transcription factor protein 2 0.0259 0.1842 0.1815
Onchocerca volvulus 0.0443 0.3225 0.3175
Echinococcus multilocularis sex peptide receptor 0.0443 0.3225 0.3203
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0306 0.0275
Brugia malayi neuropeptide F receptor 0.0443 0.3225 0.3203
Echinococcus granulosus 6 phosphofructokinase 0.012 0.0808 0.0778
Schistosoma mansoni netrin receptor unc5 0.003 0.0129 0.0107
Giardia lamblia Ribokinase 0.014 0.095 0.0813
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0443 0.3225 0.353
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3666
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0443 0.3225 0.3203
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0149 0.0149
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0443 0.3225 0.3203
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3328
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0808 0.0808
Trypanosoma cruzi hypothetical protein, conserved 0.0259 0.1847 0.2034
Brugia malayi Ectopic membrane ruffles in embryo protein 1 0.0253 0.1802 0.1776
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0443 0.3225 0.353
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0231 0.0199
Trypanosoma brucei purine nucleoside transporter 0.0234 0.1658 0.1827
Loa Loa (eye worm) hypothetical protein 0.0352 0.2539 0.2515
Trypanosoma brucei nucleoside 2-deoxyribosyltransferase 0.0259 0.1847 0.2034
Trichomonas vaginalis ribokinase, putative 0.014 0.095 0.095
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0085 0.0542 0.4621
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0457 0.3328 0.365
Schistosoma mansoni neuropeptide receptor 0.0443 0.3225 0.353
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0299 0.2148 0.2148
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.0808 0.7243
Leishmania major adenosine kinase-like protein 0.014 0.095 0.1047
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0234 0.1658 0.1827
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3328
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0468 0.0515
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0149 0.0139
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Mycobacterium ulcerans endonuclease IV 0.0085 0.0542 0.1441
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0443 0.3225 0.353
Echinococcus granulosus biogenic amine 5HT receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0149 0.0139
Loa Loa (eye worm) TYRA-2 protein 0.0443 0.3225 0.3203
Onchocerca volvulus 0.0443 0.3225 0.3175
Trichomonas vaginalis ribokinase, putative 0.014 0.095 0.095
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0443 0.3225 0.3203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0457 0.3328 0.3227
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0299 0.2148 0.2122
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0073 0.0041
Toxoplasma gondii kinase, pfkB family protein 0.1224 0.9076 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0147 0.0162
Leishmania major nucleobase transporter 0.0234 0.1658 0.1827
Loa Loa (eye worm) adenylyl cyclase 3 0.0084 0.0533 0.0502
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0443 0.3225 0.353
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0468 0.0437
Schistosoma mansoni amine GPCR 0.0443 0.3225 0.353
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0299 0.2146 0.2364
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0443 0.3225 0.353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0122 0.0099
Schistosoma mansoni hypothetical protein 0.0039 0.0195 0.018
Echinococcus granulosus sex peptide receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0076
Echinococcus multilocularis dro:myosuppressin receptor 0.0443 0.3225 0.3203
Echinococcus multilocularis neuropeptides capa receptor 0.0443 0.3225 0.3203
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0457 0.3328 0.3644
Echinococcus granulosus orexin receptor type 2 0.0443 0.3225 0.3203
Brugia malayi Uncoordinated protein 44 0.003 0.0129 0.0097
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.003 0.0129 0.0097
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0153 0.1051 0.1022
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.1348 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0443 0.3225 0.3203
Brugia malayi hypothetical protein 0.0234 0.1658 0.1631
Echinococcus multilocularis neuropeptide s receptor 0.0443 0.3225 0.3203
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0142 0.0966 0.1064
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Entamoeba histolytica kinase, PfkB family 0.014 0.095 0.095
Trypanosoma cruzi nucleoside transporter-like, putative 0.0234 0.1658 0.1827
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0122 0.0099
Brugia malayi Protein kinase domain containing protein 0.003 0.0129 0.0097
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0443 0.3225 0.3203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Echinococcus multilocularis ribokinase 0.014 0.095 0.0921
Giardia lamblia Hypothetical protein 0.1348 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.0808 0.2072
Brugia malayi G protein-coupled receptor F59B2.13 0.0443 0.3225 0.3203
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0457 0.3328 1
Schistosoma mansoni hypothetical protein 0.0443 0.3225 0.353
Leishmania major nucleoside transporter 1, putative 0.0234 0.1658 0.1827
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0468 0.0437
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0443 0.3225 0.353
Echinococcus granulosus tm gpcr rhodopsin 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus Ankyrin 0.003 0.0131 0.0099
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0808 0.0778
Onchocerca volvulus 0.0443 0.3225 0.3175
Schistosoma mansoni protein kinase 0.0234 0.1658 0.1798
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0808 0.0857
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0443 0.3225 0.353
Brugia malayi neuropeptide F receptor 0.0443 0.3225 0.3203
Trypanosoma brucei adenosine transporter 2, putative 0.0234 0.1658 0.1827
Brugia malayi Pre-SET motif family protein 0.0202 0.1416 0.1388
Echinococcus granulosus death domain containing protein 0.003 0.0129 0.0097
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Onchocerca volvulus 0.0443 0.3225 0.3175
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0443 0.3225 0.353
Trypanosoma cruzi nucleoside transporter-like, putative 0.0234 0.1658 0.1827
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0457 0.3328 0.3644
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0457 0.3328 0.365
Echinococcus multilocularis g protein coupled receptor 0.0443 0.3225 0.3203
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0142 0.0966 0.1064
Loa Loa (eye worm) neuropeptide F receptor 0.0443 0.3225 0.3203
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0149 0.0149
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0085 0.0542 0.4621
Echinococcus granulosus netrin receptor unc 5 0.003 0.0129 0.0097
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0443 0.3225 0.3203
Echinococcus multilocularis netrin receptor unc 5 0.003 0.0129 0.0097
Echinococcus granulosus tumor protein p63 0.0384 0.2783 0.276
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.0253 0.1802 0.1776
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Toxoplasma gondii nucleoside transporter protein 0.0234 0.1658 0.1806
Brugia malayi Dopamine receptor 0.0443 0.3225 0.3203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0457 0.3328 1
Echinococcus granulosus neuropeptide receptor A26 0.0443 0.3225 0.3203
Echinococcus granulosus rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Onchocerca volvulus 0.0443 0.3225 0.3175
Trypanosoma brucei adenosine transporter, putative 0.0234 0.1658 0.1827
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0468 0.0481
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0147 0.0264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0443 0.3225 0.353
Schistosoma mansoni hypothetical protein 0.003 0.0129 0.0107
Trypanosoma cruzi nucleoside transporter 1, putative 0.0234 0.1658 0.1827
Schistosoma mansoni hypothetical protein 0.037 0.2675 0.2922
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0808 0.0778
Schistosoma mansoni histamine h1 receptor 0.0443 0.3225 0.353
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.1348 1 1
Brugia malayi hypothetical protein 0.0135 0.0916 0.0886
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0443 0.3225 0.353
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.0808 0.2258
Loa Loa (eye worm) hypothetical protein 0.0234 0.1658 0.1631
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0443 0.3225 0.3203
Echinococcus multilocularis g-protein coupled receptor 0.0443 0.3225 0.3203
Onchocerca volvulus 0.008 0.0506 0.0437
Schistosoma mansoni adenoreceptor 0.0443 0.3225 0.353
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.1348 1 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0457 0.3328 0.3328
Schistosoma mansoni neuropeptide receptor 0.0443 0.3225 0.353
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1348 1 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma brucei ribokinase, putative 0.014 0.095 0.1047
Echinococcus granulosus g protein coupled receptor 0.0443 0.3225 0.3203
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0808 0.0857
Trypanosoma brucei adenosine kinase, putative 0.1224 0.9076 1
Leishmania major tagatose-6-phosphate kinase-like protein 0.014 0.095 0.1047
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1348 1 1
Echinococcus granulosus hypothetical protein 0.0443 0.3225 0.3203
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0443 0.3225 0.353
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0108 0.0093
Leishmania major tagatose-6-phosphate kinase-like protein 0.014 0.095 0.1047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0443 0.3225 0.353
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0122 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0443 0.3225 0.353
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0158 0.1087 1
Onchocerca volvulus 0.0443 0.3225 0.3175
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0122 0.0099
Loa Loa (eye worm) hypothetical protein 0.0299 0.2148 0.2122
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0899 0.6636 0.6626
Trypanosoma cruzi adenosine kinase, putative 0.014 0.095 0.1047
Loa Loa (eye worm) STAT protein 0.0146 0.0997 0.0968
Schistosoma mansoni amine GPCR 0.0443 0.3225 0.353
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0122 0.009
Echinococcus granulosus neuropeptide Y receptor 0.0443 0.3225 0.3203
Onchocerca volvulus 0.0029 0.0122 0.005
Brugia malayi putative neuropeptide receptor 0.0443 0.3225 0.3203
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0234 0.1658 0.1658
Onchocerca volvulus 0.0443 0.3225 0.3175
Echinococcus multilocularis tumor protein p63 0.0384 0.2783 0.276
Onchocerca volvulus 0.0056 0.0327 0.0256
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0443 0.3225 0.353
Loa Loa (eye worm) melatonin receptor type 1A 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.1348 1 1
Echinococcus multilocularis neuropeptide receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0149 0.0375
Loa Loa (eye worm) neuropeptide F receptor 0.0443 0.3225 0.3203
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0443 0.3225 0.3203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0443 0.3225 0.353
Brugia malayi hypothetical protein 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus granulosus somatostatin receptor 0.0443 0.3225 0.3203
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0468 0.0437
Echinococcus granulosus rhodopsin orphan GPCR 0.0443 0.3225 0.3203
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0041
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0457 0.3328 0.3666
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.014 0.095 0.095
Schistosoma mansoni biogenic amine (5HT) receptor 0.0443 0.3225 0.353
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0443 0.3225 0.3203
Mycobacterium ulcerans carbohydrate kinase CbhK 0.014 0.095 0.2697
Toxoplasma gondii kinase, pfkB family protein 0.014 0.095 0.1024
Leishmania major adenosine kinase, putative 0.1224 0.9076 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.3225 0.3203
Trypanosoma brucei nucleoside transporter 1, putative 0.0234 0.1658 0.1827
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0443 0.3225 0.3203
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0082 0.005
Echinococcus granulosus g protein coupled receptor 0.0443 0.3225 0.3203
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0234 0.1658 0.1827
Schistosoma mansoni biogenic amine (5HT) receptor 0.0443 0.3225 0.353
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0234 0.1658 0.1827
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0147 0.0115
Schistosoma mansoni opsin-like receptor 0.0443 0.3225 0.353
Onchocerca volvulus Ribokinase homolog 0.014 0.095 0.0884

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6.21 uM Growth inhibitory activity (antiproliferative) against KB/7d cell lines ChEMBL. 8691469
IC50 (functional) = 6.21 uM Growth inhibitory activity (antiproliferative) against KB/7d cell lines ChEMBL. 8691469
IC50 (functional) = 23.42 uM Growth inhibitory activity (antiproliferative) against KB cell lines ChEMBL. 8691469
IC50 (functional) = 23.42 uM Growth inhibitory activity (antiproliferative) against KB cell lines ChEMBL. 8691469
Ratio (functional) = 0 The differential toxicity ratio of the compound was defined as IC50(KB/7d)/IC50(KB) ChEMBL. 8691469

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 8691469

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.