Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 8 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.003 uM | Inhibition of Tpl2 kinase by ELISA | ChEMBL. | 16973359 |
IC50 (binding) | = 0.003 uM | Inhibition of Tpl2 kinase by ELISA | ChEMBL. | 16973359 |
Inhibition (functional) | = 0.4 uM | Inhibition of LPS-induced TNFalpha production in human monocytes by ELISA | ChEMBL. | 16973359 |
Inhibition (functional) | = 0.4 uM | Inhibition of LPS-induced TNFalpha production in human monocytes by ELISA | ChEMBL. | 16973359 |
Inhibition (functional) | = 15.8 uM | Inhibition of LPS-induced TNFalpha production in human whole blood by ELISA | ChEMBL. | 16973359 |
Inhibition (functional) | = 15.8 uM | Inhibition of LPS-induced TNFalpha production in human whole blood by ELISA | ChEMBL. | 16973359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.