Detailed information for compound 41455

Basic information

Technical information
  • TDR Targets ID: 41455
  • Name: 3-hydroxypropyl 4-(hexadecylamino)benzoate
  • MW: 419.64 | Formula: C26H45NO3
  • H donors: 2 H acceptors: 2 LogP: 9.18 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCCCNc1ccc(cc1)C(=O)OCCCO
  • InChi: 1S/C26H45NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21-27-25-19-17-24(18-20-25)26(29)30-23-16-22-28/h17-20,27-28H,2-16,21-23H2,1H3
  • InChiKey: KVZHCDUVRSCZFO-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-(hexadecylamino)benzoic acid 3-hydroxypropyl ester
  • 4-(cetylamino)benzoic acid 3-hydroxypropyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0052 0.0157
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0096 0.0289
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0098 0.0098
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.024 0.1612
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trypanosoma brucei DNA polymerase IV, putative 0.0092 0.02 0.1314
Trichomonas vaginalis histone deacetylase, putative 0.053 0.1261 0.9703
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0127 0.0383
Brugia malayi Protein kinase domain containing protein 0.0178 0.0409 0.2748
Echinococcus granulosus Protein patched homolog 1 0.0126 0.0283 0.0849
Schistosoma mansoni microtubule-associated protein tau 0.1376 0.331 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0148 0.0126
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0131 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0386 0.2938
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0013 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0092 0.0273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0216 0.1451
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0039 0.0226
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0027 0.0213
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0024 0.0019
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0016 0.0014 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0025 0.0159
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.024 0.1612
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0022 0.0175
Echinococcus granulosus flap endonuclease 1 0.0026 0.0039 0.0113
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0062 0.0181
Schistosoma mansoni hypothetical protein 0.0083 0.0177 0.0535
Giardia lamblia DNA damage repair protein 0.0022 0.0031 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0025 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0015
Echinococcus granulosus histone deacetylase 6 0.0622 0.1482 0.4476
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0148 0.1176
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.003 0.0049 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0092 0.0279
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0177 0.1183
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0031 0.005
Brugia malayi hypothetical protein 0.0018 0.002 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0216 0.1423
Loa Loa (eye worm) hypothetical protein 0.0053 0.0105 0.0701
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0106 0.0232 0.1558
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0024 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0005
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0027 0.0163
Schistosoma mansoni hypothetical protein 0.0047 0.0091 0.0274
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0027 0.0175
Echinococcus granulosus alkaline phosphatase 0.0163 0.037 0.1114
Mycobacterium tuberculosis Possible oxidoreductase 0.0064 0.0131 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0025 0.0165
Loa Loa (eye worm) hypothetical protein 0.0106 0.0232 0.1563
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0095 0.0605
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0252 0.0587 0.1
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0027 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0148 0.0989
Onchocerca volvulus 0.0021 0.0027 0.0348
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0027 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0052 0.0157
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0027 0.0005
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0024 0.0068
Entamoeba histolytica protein kinase domain containing protein 0.0178 0.0409 0.3242
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0049 0.0333
Brugia malayi glutaminase DH11.1 0.0546 0.1299 0.8761
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0052 0.0085
Leishmania major UDP-galactopyranose mutase 0.0064 0.0131 0.085
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0005
Brugia malayi Flap endonuclease-1 0.0026 0.0039 0.0252
Brugia malayi protein C24B5.3 0.0018 0.002 0.0121
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0015 0.0013 0.0007
Brugia malayi topoisomerase 0.003 0.0049 0.0318
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2426 0.5852 1
Schistosoma mansoni ran 0.0021 0.0028 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0223 0.1495
Schistosoma mansoni histone deacetylase hda2 0.0262 0.0611 0.1845
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Echinococcus granulosus phd:f box containing protein 0.0016 0.0014 0.0038
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0013 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0148 0.0989
Onchocerca volvulus 0.0015 0.0013 0.0114
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0264 0.0615 0.1858
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0027 0.0005
Schistosoma mansoni hypothetical protein 0.0047 0.0091 0.0274
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0148 0.0262
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.024 0.0724
Brugia malayi hypothetical protein 0.005 0.0098 0.065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0098 0.0159
Schistosoma mansoni vesicular amine transporter 0.0016 0.0014 0.0043
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0119 0.0359
Loa Loa (eye worm) hypothetical protein 0.007 0.0145 0.0972
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0163 0.037 0.063
Toxoplasma gondii histone deacetylase HDAC4 0.0262 0.0611 0.0611
Echinococcus multilocularis histone deacetylase 6 0.0622 0.1482 0.2531
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.06 0.4597
Loa Loa (eye worm) hypothetical protein 0.0071 0.0148 0.0994
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0027 0.0081
Schistosoma mansoni alkaline phosphatase 0.0163 0.037 0.1119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0025 0.0165
Echinococcus multilocularis nibrin 0.003 0.0049 0.0081
Entamoeba histolytica protein kinase, putative 0.0178 0.0409 0.3242
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0033 0.0215
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0177 0.03
Schistosoma mansoni hypothetical protein 0.0083 0.0177 0.0535
Loa Loa (eye worm) hypothetical protein 0.0151 0.0342 0.2306
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0043 0.0082 0.0241
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0091 0.0152
Mycobacterium ulcerans chorismate synthase 0.4138 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0025 0.0159
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0082 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0025 0.0159
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0027 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0092 0.0273
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0025 0.0077
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0015 0.0013 0.0103
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0299 0.0701 0.2118
Trypanosoma brucei unspecified product 0.005 0.0097 0.0618
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0178 0.0409 0.2752
Loa Loa (eye worm) hypothetical protein 0.0155 0.0351 0.2366
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0002 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0091 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0098 0.0159
Schistosoma mansoni thyroid hormone receptor 0.002 0.0025 0.0077
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0024 0.0144
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0283 0.214
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0031 0.0201
Echinococcus multilocularis Immunoglobulin 0.0016 0.0014 0.0021
Echinococcus granulosus Immunoglobulin 0.0016 0.0014 0.0037
Brugia malayi hypothetical protein 0.0018 0.002 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0216 0.1423
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0024 0.0153
Schistosoma mansoni hypothetical protein 0.0047 0.0091 0.0274
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0049 0.0333
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0028 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0027 0.0169
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0046 0.0134
Loa Loa (eye worm) RNA binding protein 0.0125 0.028 0.1881
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0092 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0125 0.028 0.0845
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.0216 0.1423
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0324
Loa Loa (eye worm) hypothetical protein 0.0098 0.0213 0.1433
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0014 0.0044
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0025 0.004
Onchocerca volvulus 0.0106 0.0232 0.3747
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0013 0.0034
Onchocerca volvulus 0.0015 0.0013 0.0114
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0018 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0013 0.0013
Plasmodium vivax chorismate synthase 0.4138 1 1
Leishmania major hypothetical protein, conserved 0.0016 0.0014 0.0058
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0116
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0064 0.0131 0.0126
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0014 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0015
Brugia malayi nuclear hormone receptor 0.002 0.0025 0.0159
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0148 0.0248
Schistosoma mansoni chromosome transmission fidelity factor 0.003 0.0049 0.0148
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0025 0.0159
Loa Loa (eye worm) patched family protein 0.0018 0.002 0.0127
Echinococcus granulosus GPCR family 2 0.0047 0.0091 0.0268
Loa Loa (eye worm) patched family protein 0.0018 0.002 0.0127
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0105 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0049 0.0324
Brugia malayi jmjC domain containing protein 0.0016 0.0014 0.0085
Echinococcus multilocularis dnaJ subfamily B 0.0814 0.1949 0.3329
Brugia malayi Pax transcription activation domain interacting protein 0.003 0.0049 0.0318
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0165
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0039 0.0258
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0091 0.06
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0021 0.0132
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0014 0.0022
Mycobacterium ulcerans oxidoreductase 0.0064 0.0131 0.011
Plasmodium vivax JmjC domain containing protein 0.0016 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0095 0.0605
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0027 0.0014
Onchocerca volvulus 0.0151 0.0342 0.5567
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0178 0.0409 0.2728
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0024 0.0126
Plasmodium falciparum replication factor C subunit 1, putative 0.003 0.0049 0.0043
Echinococcus granulosus cyclin dependent kinase 0.0043 0.0082 0.0241
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.024 0.4905
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0027 0.0014
Loa Loa (eye worm) RecQ helicase 0.002 0.0024 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0025 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.0099 0.0216 0.1423
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0027 0.0169
Schistosoma mansoni alkaline phosphatase 0.0163 0.037 0.1119
Echinococcus granulosus lysine specific histone demethylase 1A 0.0064 0.0131 0.0392
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0484 0.3258
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0151 0.1016
Brugia malayi Pre-SET motif family protein 0.0031 0.0052 0.0337
Brugia malayi histone deacetylase 3 (HD3) 0.053 0.1261 0.8502
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0033 0.0208
Plasmodium vivax patched family protein, putative 0.0018 0.002 0.002
Schistosoma mansoni cell adhesion molecule 0.0016 0.0014 0.0043
Echinococcus multilocularis cyclin dependent kinase 0.0043 0.0082 0.0136
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0024 0.0153
Loa Loa (eye worm) hypothetical protein 0.0126 0.0283 0.1901
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0022 0.011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0126 0.0283 0.1901
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.2041 0.4919 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0028 0.0219
Echinococcus granulosus dna polymerase kappa 0.0099 0.0216 0.0647
Loa Loa (eye worm) hypothetical protein 0.0064 0.0131 0.088
Echinococcus multilocularis histone deacetylase 1 0.053 0.1261 0.2152
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.0082 0.0544
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0165
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Echinococcus granulosus cyclin dependent kinase 1 0.0043 0.0082 0.0241
Echinococcus granulosus dnaJ subfamily B 0.0814 0.1949 0.5887
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0148 0.0994
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0013 0.0034
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0175
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.024 0.1584
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0105 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0015
Trypanosoma brucei chrX additional, unordered contigs 0.0022 0.0031 0.0169
Echinococcus multilocularis 0.0064 0.0131 0.0221
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0072 0.0151 0.1016
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0266 0.1787
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0016 0.0014 0.0021
Leishmania major GTP-binding protein, putative 0.0021 0.0028 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0052 0.0157
Trichomonas vaginalis histone deacetylase, putative 0.053 0.1261 0.9703
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0015 0.0013 0.0007
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0346 0.0814 0.0794
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Giardia lamblia Replication factor C, subunit 1 0.003 0.0049 0.0288
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0148 0.0126
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0065 0.0461
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0048 0.0048
Echinococcus multilocularis histone deacetylase 0.0622 0.1482 0.2531
Echinococcus multilocularis histone deacetylase 6 0.0634 0.1512 0.2581
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.024 0.0218
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0151 0.1011
Giardia lamblia DINP protein human, muc B family 0.0079 0.0167 0.1238
Onchocerca volvulus 0.0018 0.002 0.0229
Schistosoma mansoni brca1-associated protein (brap2) 0.0012 0.0006 0.0018
Echinococcus multilocularis replication factor c subunit 1 0.003 0.0049 0.0081
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0135 0.0302 0.0577
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0027 0.0076
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0065 0.0421
Brugia malayi protein C24B5.3 0.0018 0.002 0.0121
Brugia malayi 6-phosphofructokinase 0.0109 0.024 0.1607
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0035
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0015 0.0013 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.024 0.1809
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0014 0.002
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0031 0.0169
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0082 0.0586
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0211 0.0488 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0167 0.1095
Echinococcus multilocularis sterol regulatory element binding protein 0.0126 0.0283 0.048
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0027 0.0043
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.008
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0028 0.0078
Loa Loa (eye worm) histone deacetylase 0.0622 0.1482 1
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.0409 0.1235
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0014 0.0044
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0091 0.06
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0092 0.0616
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.024 0.0724
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0002 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0216 0.1451
Schistosoma mansoni hypothetical protein 0.0122 0.0272 0.082
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0211 0.0488 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.025 0.025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0115 0.077
Echinococcus granulosus histone deacetylase 6 0.0634 0.1512 0.4565
Loa Loa (eye worm) hypothetical protein 0.0064 0.0131 0.088
Brugia malayi Muscleblind-like protein 0.0447 0.1059 0.7139
Loa Loa (eye worm) histone deacetylase 3 0.053 0.1261 0.8503
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0125
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0024 0.0092
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0013 0.0056
Echinococcus granulosus nibrin 0.003 0.0049 0.0142
Loa Loa (eye worm) glutaminase 2 0.0546 0.1299 0.8762
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0015 0.0013 0.0103
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.008 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0025 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0002 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0008 0.0015
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0065 0.0436
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Echinococcus granulosus roundabout 2 0.0016 0.0014 0.0037
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0556 0.1323 0.3996
Echinococcus granulosus histone deacetylase 8 0.0262 0.0611 0.184
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0002 0.0006
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.0082 0.0544
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0165
Plasmodium falciparum protein kinase 5 0.0043 0.0082 0.0076
Mycobacterium ulcerans hypothetical protein 0.0022 0.0031 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0025 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0065 0.0461
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.053 0.1261 0.9703
Giardia lamblia Kinase, CMGC CDK 0.0043 0.0082 0.055
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0015 0.0013 0.0039
Trypanosoma cruzi UDP-galactopyranose mutase 0.0064 0.0131 0.088
Trypanosoma cruzi histone deacetylase, putative 0.0622 0.1482 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0016 0.0014 0.0043
Schistosoma mansoni hypothetical protein 0.0177 0.0405 0.1225
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.028 0.1881
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0015 0.0013 0.0007
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0025 0.004
Schistosoma mansoni hypothetical protein 0.0083 0.0177 0.0535
Schistosoma mansoni topbp1 0.003 0.0049 0.0148
Brugia malayi Patched related family protein 12 0.0018 0.002 0.0121
Mycobacterium tuberculosis Conserved hypothetical protein 0.0072 0.0151 0.0269
Onchocerca volvulus 0.0018 0.002 0.0229
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0024 0.0159
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0091
Brugia malayi RE40412p 0.0015 0.0013 0.0074
Onchocerca volvulus 0.0021 0.0027 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0015
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0064 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0002 0.0006
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0027 0.0005
Giardia lamblia Kinase, CMGC CDK 0.0043 0.0082 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0113 0.0727
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0135 0.0302 0.0563
Entamoeba histolytica deoxycytidyl transferase, putative 0.0072 0.0151 0.1202
Trypanosoma cruzi histone deacetylase 1, putative 0.053 0.1261 0.8503
Plasmodium falciparum histone deacetylase 2 0.0622 0.1482 0.1477
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0009
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0014 0.0091
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0014 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0324
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0048 0.0958
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0273 0.0825
Echinococcus granulosus lysine specific histone demethylase 1A 0.0064 0.0131 0.0392
Schistosoma mansoni DNA polymerase eta 0.0098 0.0213 0.0644
Onchocerca volvulus 0.0071 0.0148 0.2355
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Loa Loa (eye worm) histone deacetylase 1 0.053 0.1261 0.8503
Schistosoma mansoni hypothetical protein 0.0122 0.0272 0.082
Toxoplasma gondii patched family protein 0.0018 0.002 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0148 0.0262
Leishmania major DNA polymerase kappa, putative 0.0022 0.0031 0.0169
Echinococcus multilocularis expressed conserved protein 0.0277 0.0647 0.1102
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0324
Trichomonas vaginalis DNA polymerase eta, putative 0.0099 0.0216 0.1624
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0015
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0049 0.0333
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0065 0.0198
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0014 0.0009
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.0082 0.0136
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0015 0.0013 0.0019
Brugia malayi MH2 domain containing protein 0.0119 0.0266 0.1782
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0033 0.0208
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0323
Brugia malayi histone deacetylase 11 0.0262 0.0611 0.4112
Schistosoma mansoni histone deacetylase 4 5 0.0622 0.1482 0.4479
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0025 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0015
Schistosoma mansoni cpg binding protein 0.006 0.0123 0.0371
Echinococcus multilocularis muscleblind protein 1 0.0447 0.1059 0.1807
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0147
Brugia malayi Histone deacetylase family protein 0.0622 0.1482 1
Brugia malayi jmjC domain containing protein 0.0016 0.0014 0.0085
Brugia malayi Fli-1 protein 0.0219 0.0508 0.3415
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0025 0.0077
Plasmodium vivax replication factor C subunit 1, putative 0.003 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0062 0.0126 0.0844
Plasmodium vivax histone deacetylase, putative 0.0262 0.0611 0.0611
Entamoeba histolytica histone deacetylase, putative 0.053 0.1261 1
Loa Loa (eye worm) hypothetical protein 0.053 0.1261 0.8503
Schistosoma mansoni topbp1 0.003 0.0049 0.0148
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0025 0.0077
Trypanosoma brucei unspecified product 0.0092 0.02 0.1314
Schistosoma mansoni amine oxidase 0.0064 0.0131 0.0397
Schistosoma mansoni importin beta-1 0.0029 0.0046 0.0139
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0009
Trypanosoma brucei histone deacetylase 1 0.053 0.1261 0.8498
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0148 0.1176
Echinococcus multilocularis histone deacetylase 6 0.0622 0.1482 0.2531
Onchocerca volvulus 0.0057 0.0115 0.1805
Echinococcus granulosus conserved hypothetical protein 0.0015 0.0013 0.0033
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0163 0.037 0.063
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0006
Echinococcus granulosus FTZ F1 alpha 0.002 0.0025 0.0071
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0211 0.0488 0.0442
Schistosoma mansoni glutaminase 0.0546 0.1299 0.3925
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0324
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0027 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.06 0.4597
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0049 0.0333
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0024 0.0126
Loa Loa (eye worm) hypothetical protein 0.0064 0.0131 0.088
Onchocerca volvulus 0.0021 0.0027 0.0348
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0113 0.0727
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trypanosoma cruzi histone deacetylase, putative 0.0622 0.1482 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Brugia malayi histone deacetylase 1 (HD1) 0.053 0.1261 0.8502
Schistosoma mansoni hypothetical protein 0.0047 0.0091 0.0274
Loa Loa (eye worm) hypothetical protein 0.0053 0.0105 0.0701
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0022 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0098 0.0655
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0049 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0025 0.0159
Onchocerca volvulus 0.0238 0.0553 0.9052
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0216 0.1423
Loa Loa (eye worm) hypothetical protein 0.0064 0.0131 0.088
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0072 0.0151 0.0256
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0012 0.0006 0.0006
Loa Loa (eye worm) oxidoreductase 0.0021 0.0027 0.0175
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.003 0.0049 0.0388
Schistosoma mansoni hypothetical protein 0.0023 0.0031 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.06 0.4597
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0151 0.0256
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0006 0.0033
Leishmania major importin beta-1 subunit, putative 0.0023 0.0033 0.0182
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0177 0.1189
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0105 0.0105
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0049 0.0333
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0025 0.0077
Brugia malayi hypothetical protein 0.003 0.0049 0.0318
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0027 0.0014
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0328 0.0557
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0079 0.0167 0.1095
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0151 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0025 0.0159
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0005
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0318 0.0955
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0001 0.0003
Plasmodium vivax importin-beta 2, putative 0.0029 0.0046 0.0046
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0072 0.0151 0.0458
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.002 0.0014
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0006
Onchocerca volvulus 0.002 0.0025 0.0323
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0346 0.0814 0.0814
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0025 0.0071
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0027 0.0175
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0071 0.0065
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0025 0.0071
Toxoplasma gondii patched family protein 0.0018 0.002 0.002
Brugia malayi cell division control protein 2 homolog 0.0043 0.0082 0.0539
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0343
Brugia malayi Histone deacetylase 1 0.053 0.1261 0.8502
Echinococcus multilocularis dna polymerase kappa 0.0099 0.0216 0.0366
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0024 0.0039
Onchocerca volvulus Histone deacetylase 10 homolog 0.0262 0.0611 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0013 0.0076
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0119 0.02
Echinococcus multilocularis tar DNA binding protein 0.0125 0.028 0.0475
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0249 0.0579 0.0986
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0006 0.0033
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0844 0.2021 0.4085
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0216 0.1423
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0009
Schistosoma mansoni hypothetical protein 0.0102 0.0223 0.0674
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0163 0.037 0.1114
Entamoeba histolytica cell division protein kinase 2, putative 0.0043 0.0082 0.0647
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.024 0.1809
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0337 0.227
Brugia malayi SWIRM domain containing protein 0.0064 0.0131 0.0875
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0025 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.00000000013362
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0025 0.0323
Brugia malayi hypothetical protein 0.003 0.0049 0.0318
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.024 0.0449
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0177 0.0535
Schistosoma mansoni cpg binding protein 0.0057 0.0115 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0386 0.2938
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.053 0.1261 0.9703
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0048 0.0323
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.024 0.1902
Onchocerca volvulus 0.0018 0.002 0.0229
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0024 0.0024
Loa Loa (eye worm) histone deacetylase 7A 0.0622 0.1482 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0064 0.0131 0.011
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0013 0.0013
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0015 0.0013 0.0013
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0294 0.069 0.5472
Brugia malayi jmjC domain containing protein 0.0016 0.0014 0.0085
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Mycobacterium ulcerans hypothetical protein 0.0071 0.0148 0.0126
Brugia malayi Importin beta-1 subunit 0.0029 0.0046 0.0298
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.0216 0.0194
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0024 0.0153
Echinococcus granulosus defective proboscis extension response 0.0016 0.0014 0.0037
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0027 0.0014
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0002 0.0009
Echinococcus granulosus dna polymerase eta 0.0098 0.0213 0.0639
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0553 0.4234
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0148 0.0126
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0131 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0025 0.0159
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.0082 0.0544
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0013 0.0019
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0249 0.0579 0.1744
Schistosoma mansoni hypothetical protein 0.0814 0.1949 0.589
Loa Loa (eye worm) hypothetical protein 0.0102 0.0223 0.15
Trypanosoma brucei histone deacetylase 2 0.0262 0.0611 0.4096
Mycobacterium ulcerans DNA polymerase IV 0.0099 0.0216 0.0194
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0031 0.0201
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0027 0.0014
Echinococcus multilocularis BRCA1 associated protein 0.0012 0.0006 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0015
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0024 0.0144
Plasmodium falciparum chorismate synthase 0.4138 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0062 0.049
Echinococcus multilocularis cyclin dependent kinase 5 0.0043 0.0082 0.0136
Trypanosoma cruzi histone deacetylase 1, putative 0.053 0.1261 0.8503
Echinococcus multilocularis neuroglian 0.0016 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0447 0.1059 0.7141
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.018
Loa Loa (eye worm) hypothetical protein 0.0262 0.0611 0.4115
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0071 0.0564
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0002 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0323
Loa Loa (eye worm) hypothetical protein 0.0294 0.069 0.465
Loa Loa (eye worm) hypothetical protein 0.0083 0.0177 0.1189
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0025 0.0071
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0092 0.061
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0148 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.009
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0065 0.0461
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0015 0.0013 0.0013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0025 0.0071
Brugia malayi hypothetical protein 0.0064 0.0131 0.0875
Brugia malayi hypothetical protein 0.0032 0.0055 0.0359
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0027 0.0014
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0016 0.0014 0.0037
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0027 0.0175
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0015 0.0013 0.0049
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0048 0.0378
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0048 0.0042
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0067
Echinococcus granulosus tumor protein p63 0.0336 0.079 0.2383
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.003 0.0049 0.0049
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0328 0.22
Trichomonas vaginalis histone deacetylase, putative 0.053 0.1261 0.9703
Trypanosoma brucei DNA polymerase eta, putative 0.0098 0.0213 0.1404
Onchocerca volvulus 0.0031 0.0052 0.076
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0386 0.2938
Schistosoma mansoni ran 0.0021 0.0028 0.0083
Brugia malayi ImpB/MucB/SamB family protein 0.0098 0.0213 0.1428
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0005
Leishmania major hypothetical protein, unknown function 0.0015 0.0013 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0125 0.028 0.0845
Echinococcus multilocularis histone deacetylase 3 0.053 0.1261 0.2152
Schistosoma mansoni nuclear hormone receptor 0.002 0.0025 0.0077
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0015 0.0013 0.0082
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0098 0.0092
Echinococcus granulosus twitchin 0.0017 0.0018 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trypanosoma brucei histone deacetylase 3 0.0622 0.1482 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0125
Leishmania major histone deacetylase, putative 0.053 0.1261 0.8498
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0091 0.0268
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0065 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0014 0.0091
Loa Loa (eye worm) TAR-binding protein 0.0125 0.028 0.1881
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0027 0.0143
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0014 0.0014
Trypanosoma cruzi FHA domain containing protein, putative 0.003 0.0049 0.0324
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0015
Brugia malayi RNA binding protein 0.0125 0.028 0.1876
Loa Loa (eye worm) phosphofructokinase 0.0109 0.024 0.1612
Onchocerca volvulus 0.0018 0.002 0.0229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0025 0.0165
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0098 0.0092
Toxoplasma gondii histone deacetylase HDAC5 0.0262 0.0611 0.0611
Brugia malayi jmjC domain containing protein 0.0059 0.0119 0.0791
Brugia malayi Niemann-Pick C1 protein precursor 0.0294 0.069 0.4647
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0177 0.053
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0046 0.0271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0015
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0028 0.0028
Entamoeba histolytica recQ family DNA helicase 0.001 0.0001 0.0007
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Brugia malayi ecdysteroid receptor 0.002 0.0025 0.0159
Loa Loa (eye worm) hypothetical protein 0.0177 0.0405 0.273
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0018 0.0107
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0323
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0027 0.0143
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.018
Toxoplasma gondii patched family protein 0.0018 0.002 0.002
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.2041 0.4919 1
Trypanosoma cruzi histone deacetylase, putative 0.0262 0.0611 0.4115
Schistosoma mansoni tar DNA-binding protein 0.0125 0.028 0.0845
Echinococcus granulosus dual specificity 0.0178 0.0409 0.123
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0049 0.0333
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0025 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0005
Brugia malayi nuclear receptor NHR-88 0.002 0.0025 0.0159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.009
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0149 0.0337 0.227
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0025 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0125 0.028 0.0845
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0027 0.0014
Loa Loa (eye worm) hypothetical protein 0.005 0.0098 0.0655
Loa Loa (eye worm) hypothetical protein 0.0053 0.0105 0.0701
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0165
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0015 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0306 0.0718 0.2168
Echinococcus granulosus BRCA1 associated protein 0.0012 0.0006 0.0012
Echinococcus granulosus histone deacetylase 0.0622 0.1482 0.4476
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0014 0.0022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0131 0.0228
Leishmania major histone deacetylase, putative 0.0622 0.1482 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0046 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0408 0.3108
Brugia malayi hypothetical protein 0.0011 0.0002 0.0003
Brugia malayi hypothetical protein 0.0121 0.0269 0.1802
Onchocerca volvulus Protein patched homolog 0.0018 0.002 0.0229
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0065 0.0109
Plasmodium vivax histone deacetylase, putative 0.0622 0.1482 0.1482
Brugia malayi CHE-14 protein 0.0126 0.0283 0.1896
Brugia malayi Pre-SET motif family protein 0.0209 0.0484 0.3254
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0002 0.0007
Trichomonas vaginalis histone deacetylase, putative 0.053 0.1261 0.9703
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.0082 0.0544
Echinococcus multilocularis protein dispatched 1 0.0144 0.0326 0.0554
Echinococcus multilocularis histone deacetylase 7 0.0622 0.1482 0.2531
Echinococcus granulosus snurportin 1 0.0306 0.0718 0.2164
Brugia malayi Protein kinase domain containing protein 0.0043 0.0082 0.0539
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0064 0.0131 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0216 0.1451
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trypanosoma cruzi UDP-galactopyranose mutase 0.0064 0.0131 0.088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0022 0.0142
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.024 0.1584
Echinococcus multilocularis GPCR, family 2 0.0047 0.0091 0.0152
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0062 0.0187
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0025 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0159
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0048 0.0048
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0065 0.0109
Plasmodium vivax histone deacetylase 2, putative 0.0622 0.1482 0.1482
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.06 0.4597
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0022 0.0072
Loa Loa (eye worm) hypothetical protein 0.0071 0.0148 0.0994
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0025 0.0159
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.024 0.1809
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0064 0.0131 0.0131
Echinococcus granulosus muscleblind protein 0.0447 0.1059 0.3195
Brugia malayi Histone deacetylase family protein 0.0622 0.1482 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0013 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0165
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0043 0.0082 0.0513
Echinococcus multilocularis bloom syndrome protein 0.002 0.0024 0.0039
Echinococcus granulosus bloom syndrome protein 0.002 0.0024 0.0068
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0022 0.0004
Entamoeba histolytica hypothetical protein 0.0178 0.0409 0.3242
Plasmodium falciparum importin beta, putative 0.0029 0.0046 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0052 0.0157
Echinococcus multilocularis protoporphyrinogen oxidase 0.0064 0.0131 0.0221
Brugia malayi polk-prov protein 0.0049 0.0095 0.0631
Onchocerca volvulus Protein patched homolog 0.0018 0.002 0.0229
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0328 0.099
Echinococcus multilocularis geminin 0.0177 0.0405 0.069
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0098 0.0098
Schistosoma mansoni ets-related 0.0219 0.0508 0.1534
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0216 0.1423
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0005
Plasmodium falciparum flap endonuclease 1 0.0026 0.0039 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0014 0.0044
Toxoplasma gondii histone deacetylase HDAC2 0.053 0.1261 0.1261
Loa Loa (eye worm) hypothetical protein 0.0447 0.1059 0.7141
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0091
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0043 0.0082 0.0544
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0022
Entamoeba histolytica protein kinase, putative 0.0178 0.0409 0.3242
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0216 0.1423
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0014 0.0022
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.0082 0.0544
Echinococcus granulosus microtubule associated protein 2 0.1376 0.331 1
Trypanosoma brucei unspecified product 0.005 0.0097 0.0618
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0178 0.0409 0.2752
Echinococcus granulosus histone deacetylase 7 0.0622 0.1482 0.4476
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.003 0.0049 0.0318
Schistosoma mansoni hypothetical protein 0.0085 0.0181 0.0547
Echinococcus multilocularis alkaline phosphatase 0.0163 0.037 0.063
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.06 0.4042
Entamoeba histolytica cell division protein kinase 2, putative 0.0043 0.0082 0.0647
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0386 0.6282
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0323
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0048 0.0277
Echinococcus granulosus histone deacetylase 6 0.0622 0.1482 0.4476
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0022 0.0433
Echinococcus multilocularis Niemann Pick C1 protein 0.0294 0.069 0.1176
Schistosoma mansoni nephrin 0.0016 0.0014 0.0043
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.024 0.0719
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0148 0.1176
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0127 0.085
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.008 0.0571
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0098 0.0624
Brugia malayi hypothetical protein 0.0151 0.0342 0.2301
Trichomonas vaginalis helicase, putative 0.0013 0.0008 0.0015
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0013 0.0019
Echinococcus multilocularis muscleblind protein 0.0447 0.1059 0.1807
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Schistosoma mansoni histone deacetylase 1 2 3 0.0262 0.0611 0.1845
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0039 0.0258
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0027 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0082 0.0586
Onchocerca volvulus 0.0021 0.0027 0.0348
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0027 0.0005
Schistosoma mansoni histone deacetylase 0.053 0.1261 0.3809
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0015 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.009
Echinococcus multilocularis cpg binding protein 0.006 0.0123 0.0207
Loa Loa (eye worm) hypothetical protein 0.0064 0.0131 0.088
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0049 0.0324
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0303
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0908 0.2176 0.2159
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0046 0.0075
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0065 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0113 0.0727
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.009
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0323
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0027 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0025 0.0159
Chlamydia trachomatis DNA ligase 0.003 0.0049 0.0001
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0015 0.0013 0.0007
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0027 0.0175
Brugia malayi nuclear receptor RXR 0.0011 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0025 0.0159
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0025 0.004
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0025 0.004
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0027 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Plasmodium vivax SET domain protein, putative 0.0031 0.0052 0.0052
Echinococcus granulosus Niemann Pick C1 protein 0.0294 0.069 0.208
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.003 0.0049 0.0578
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0024 0.0068
Toxoplasma gondii ATPase, AAA family protein 0.003 0.0049 0.0049
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.024 0.1902
Mycobacterium ulcerans glutaminase 0.0546 0.1299 0.128
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.024 0.0407
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0165
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0009
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0027 0.0027
Mycobacterium ulcerans dehydrogenase 0.0064 0.0131 0.011
Schistosoma mansoni DNA ligase IV 0.003 0.0049 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0025 0.0165
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.0718 0.4837
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0065 0.0436
Schistosoma mansoni histone deacetylase 4 5 0.0622 0.1482 0.4479
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Brugia malayi Ets-domain containing protein 0.0072 0.0151 0.101
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0065 0.052
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0015
Schistosoma mansoni cpg binding protein 0.006 0.0123 0.0371
Schistosoma mansoni ets-related 0.001 0.0002 0.0006
Schistosoma mansoni DNA helicase recq1 0.002 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.018
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0027 0.0005
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0027 0.0169
Plasmodium falciparum protoporphyrinogen oxidase 0.0064 0.0131 0.0126
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0002 0.0001
Plasmodium vivax protein kinase Crk2 0.0043 0.0082 0.0082
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0329 0.0773 0.5212
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0014 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0092 0.0154
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.024 0.1902
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0008 0.0015
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0025 0.0323
Loa Loa (eye worm) hypothetical protein 0.036 0.0848 0.572
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0092 0.0279
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0067
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0025 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0025 0.0159
Brugia malayi jmjC domain containing protein 0.0016 0.0014 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.06 0.4597
Toxoplasma gondii zinc finger cdgsh type protein 0.0015 0.0013 0.0013
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0046 0.0271
Chlamydia trachomatis dehyroquinate synthase 0.0135 0.0302 0.0256
Trypanosoma brucei histone deacetylase 4 0.0622 0.1482 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.008 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0015
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0043 0.0082 0.0082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0062 0.0102
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0065 0.043
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.028 0.1876
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0337 0.2266
Loa Loa (eye worm) hypothetical protein 0.0121 0.0269 0.1807
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0024 0.0159
Brugia malayi Ets-domain containing protein 0.0072 0.0151 0.101
Brugia malayi BRCA1-associated protein 2 containing protein 0.0012 0.0006 0.0027
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0211 0.0488 0.0467
Entamoeba histolytica hypothetical protein 0.0035 0.0062 0.049
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.024 0.0435
Onchocerca volvulus 0.0049 0.0096 0.1483
Schistosoma mansoni histone deacetylase hda2 0.0634 0.1512 0.4568
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0027 0.0163
Echinococcus granulosus cpg binding protein 0.006 0.0123 0.0366
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0091 0.0605
Loa Loa (eye worm) hypothetical protein 0.0252 0.0587 0.3955
Echinococcus multilocularis dna polymerase eta 0.0098 0.0213 0.0361
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0013 0.0082
Plasmodium falciparum histone deacetylase, putative 0.0622 0.1482 0.1477
Echinococcus multilocularis conserved hypothetical protein 0.0015 0.0013 0.0019
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0064 0.0131 0.0221
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0022 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0091
Loa Loa (eye worm) patched family protein 0.0018 0.002 0.0127
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0052 0.0085
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0065 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0025 0.0159
Plasmodium vivax histone deacetylase 1, putative 0.053 0.1261 0.1261
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.012 0.0267 0.0807
Brugia malayi CXXC zinc finger family protein 0.0057 0.0115 0.0764
Loa Loa (eye worm) acetyltransferase 0.0145 0.0328 0.2205
Schistosoma mansoni flap endonuclease-1 0.0023 0.0033 0.01
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0266 0.1787
Loa Loa (eye worm) hypothetical protein 0.0049 0.0095 0.0636
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0031 0.0169
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0908 0.2176 0.2159
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0216 0.1423
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.053 0.1261 0.9703
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0002 0.0006
Onchocerca volvulus 0.0064 0.0131 0.2076
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0039 0.0209
Schistosoma mansoni thyroid hormone receptor 0.002 0.0025 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0216 0.1423
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0015 0.0013 0.0013
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0252 0.0587 0.1769
Trypanosoma cruzi histone deacetylase, putative 0.0262 0.0611 0.4115
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0013 0.0056
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0064 0.0131 0.0126
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0025 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0324
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0022 0.0061
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0049 0.0324
Toxoplasma gondii histone deacetylase HDAC1 0.0622 0.1482 0.1482
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0165
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0022 0.0142
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0025 0.0323
Trypanosoma cruzi DNA polymerase eta, putative 0.0098 0.0213 0.1433
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0135 0.0302 0.0577
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0039 0.0064
Brugia malayi hypothetical protein 0.0035 0.0062 0.0405
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0135 0.0302 0.0281
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0105 0.0057
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0014 0.0035
Echinococcus multilocularis microtubule associated protein 2 0.1376 0.331 0.5654
Echinococcus granulosus intestinal type alkaline phosphatase 0.0163 0.037 0.1114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0025 0.004
Giardia lamblia Histone deacetylase 0.053 0.1261 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0065 0.0109
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0048 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0082 0.0247
Brugia malayi jmjC domain containing protein 0.0062 0.0127 0.0844
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0072 0.0151 0.0452
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Leishmania major histone deacetylase, putative 0.0622 0.1482 1
Trichomonas vaginalis histone deacetylase, putative 0.053 0.1261 0.9703
Entamoeba histolytica hypothetical protein 0.0035 0.0062 0.049
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0052 0.0151
Brugia malayi RNA, U transporter 1 0.0082 0.0174 0.1162
Echinococcus multilocularis histone deacetylase 8 0.0262 0.0611 0.1041
Echinococcus granulosus cyclin dependent kinase 5 0.0043 0.0082 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0092 0.0279
Trichomonas vaginalis glutaminase, putative 0.0546 0.1299 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0091 0.0268
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.06 0.4046
Echinococcus granulosus replication factor c subunit 1 0.003 0.0049 0.0142
Echinococcus granulosus Niemann Pick C1 protein 0.0421 0.0996 0.3005
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0025 0.0159
Toxoplasma gondii histone deacetylase HDAC3 0.053 0.1261 0.1261
Trypanosoma cruzi histone deacetylase, putative 0.0622 0.1482 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0012 0.0006 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.06 0.4597
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0022 0.0142
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0022 0.011
Leishmania major histone deacetylase, putative 0.053 0.1261 0.8498
Plasmodium vivax DNA repair protein REV1, putative 0.0022 0.0031 0.0031
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0022 0.0062
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0039 0.0039
Echinococcus multilocularis snurportin 1 0.0306 0.0718 0.1224
Schistosoma mansoni terminal deoxycytidyl transferase 0.0072 0.0151 0.0458
Entamoeba histolytica hypothetical protein 0.0035 0.0062 0.049
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0148 0.0964
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0027 0.0014
Schistosoma mansoni DNA polymerase IV / kappa 0.0022 0.0031 0.0093
Trichomonas vaginalis histone deacetylase, putative 0.053 0.1261 0.9703
Schistosoma mansoni histone deacetylase 0.053 0.1261 0.3809
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0025 0.0165
Brugia malayi Patched protein homolog 1 0.0018 0.002 0.0121
Schistosoma mansoni hypothetical protein 0.0035 0.0062 0.0187
Schistosoma mansoni 3-dehydroquinate synthase 0.0135 0.0302 0.0914
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0013 0.0056
Loa Loa (eye worm) hypothetical protein 0.0053 0.0105 0.0701
Schistosoma mansoni ets 0.001 0.0002 0.0006
Brugia malayi Fibronectin type III domain containing protein 0.0016 0.0014 0.0084
Brugia malayi phosphofructokinase 0.0109 0.024 0.1607
Leishmania major DNA polymerase eta, putative 0.0048 0.0092 0.0587
Echinococcus multilocularis Immunoglobulin 0.0016 0.0014 0.0021
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0048 0.0048
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0079 0.0167 0.0301
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0027 0.0175
Toxoplasma gondii exonuclease III APE 0.0019 0.0022 0.0022
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0139 0.0314 0.2112
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0014 0.002
Echinococcus multilocularis protein patched 0.0126 0.0283 0.048
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0177 0.053
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.008 0.008
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0014 0.0058
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0025 0.004
Echinococcus granulosus tar DNA binding protein 0.0125 0.028 0.084
Brugia malayi DKFZp564C0469 protein 0.003 0.0049 0.0318
Schistosoma mansoni patched 1 0.0126 0.0283 0.0854
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Brugia malayi steroid hormone receptor 0.002 0.0025 0.0159
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0031 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0015
Onchocerca volvulus 0.003 0.0049 0.0712
Toxoplasma gondii patched family protein 0.0018 0.002 0.002
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0024 0.0144
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Brugia malayi hypothetical protein 0.0011 0.0002 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0027 0.0169
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0065 0.0192
Echinococcus granulosus geminin 0.0177 0.0405 0.122
Toxoplasma gondii histone lysine-specific demethylase 0.0064 0.0131 0.0131
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0027 0.0143
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0015 0.0013 0.0013
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0048 0.0048
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0067 0.014 0.014
Echinococcus multilocularis roundabout 2 0.0016 0.0014 0.0021
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0163 0.037 0.063
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0031 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.0216 0.1423
Schistosoma mansoni elf1 0.001 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0105 0.0701
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0025 0.0077
Brugia malayi amine oxidase, flavin-containing family protein 0.0064 0.0131 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0015
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0178 0.0409 0.2752
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0264 0.0615 0.1858
Trypanosoma brucei histone deacetylase, putative 0.0622 0.1482 1
Brugia malayi Patched related family protein 4 0.0018 0.002 0.0121
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.026
Onchocerca volvulus 0.0018 0.002 0.0229
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0064 0.0131 0.0397
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0148 0.0989
Toxoplasma gondii chorismate synthase, putative 0.4138 1 1
Leishmania major DNA polymerase kappa, putative 0.0079 0.0167 0.1095
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.0061
Loa Loa (eye worm) fli-1 protein 0.0219 0.0508 0.3419
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0027 0.0021
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0105 0.0173
Brugia malayi 6-phosphofructokinase 0.0109 0.024 0.1608
Schistosoma mansoni tar DNA-binding protein 0.0125 0.028 0.0845
Brugia malayi RE40412p 0.0015 0.0013 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0005
Schistosoma mansoni hypothetical protein 0.0122 0.0272 0.082
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.024 0.1612
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0022 0.0136
Onchocerca volvulus 0.0018 0.002 0.0229
Echinococcus multilocularis dual specificity 0.0178 0.0409 0.0695
Echinococcus granulosus neuroglian 0.0016 0.0014 0.0037
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0014 0.0035
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0174
Leishmania major DNA polymerase eta, putative 0.0098 0.0213 0.1404
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0049 0.0333
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.024 0.1809
Entamoeba histolytica hypothetical protein 0.003 0.0049 0.0388
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0071 0.0466
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0177 0.03
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0177 0.0535
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.009
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0015 0.0013 0.0039
Trichomonas vaginalis ran, putative 0.0021 0.0028 0.0168
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0014 0.0038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.009
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0163 0.037 0.1114
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0033 0.0208
Brugia malayi hypothetical protein 0.0018 0.002 0.0121
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0014 0.0091
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0014 0.0084
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0252 0.0587 0.1773
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0121 0.0269 0.1807
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0082 0.0247
Echinococcus granulosus expressed conserved protein 0.0277 0.0647 0.1949
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0148 0.0126
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0148 0.0964
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0001 0.0001
Brugia malayi Myosin head containing protein 0.0018 0.002 0.0121
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0022
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0027 0.0143
Loa Loa (eye worm) hypothetical protein 0.0064 0.0131 0.088
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0047 0.0047
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0148 0.0126
Schistosoma mansoni hypothetical protein 0.0122 0.0272 0.082
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0065 0.0198
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0013 0.0082
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0027 0.0005
Schistosoma mansoni brca1-associated protein (brap2) 0.0012 0.0006 0.0018
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0119 0.02
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0025 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0025 0.0159
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0324
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0039 0.0226
Trypanosoma cruzi DNA polymerase kappa, putative 0.0099 0.0216 0.1451
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0031 0.0088
Chlamydia trachomatis protoporphyrinogen oxidase 0.0064 0.0131 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0031 0.0201
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0025 0.004
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0039 0.0258
Echinococcus multilocularis Niemann Pick C1 protein 0.0421 0.0996 0.1699
Loa Loa (eye worm) hypothetical protein 0.0047 0.0091 0.0605
Treponema pallidum DNA ligase (lig) 0.003 0.0049 0.0986
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0002 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0008 0.0015
Echinococcus granulosus sterol regulatory element binding protein 0.0126 0.0283 0.0849
Mycobacterium ulcerans monoamine oxidase 0.0064 0.0131 0.011
Loa Loa (eye worm) glutaminase 0.0546 0.1299 0.8762
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0386 0.2938
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0015 0.0013 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0386 0.2938
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0346 0.0814 0.077
Loa Loa (eye worm) hypothetical protein 0.0177 0.0405 0.273
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0092 0.0618
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0046 0.0046
Schistosoma mansoni DNA helicase recq5 0.002 0.0024 0.0074
Schistosoma mansoni coup transcription factor 0.002 0.0025 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0386 0.2938
Brugia malayi hypothetical protein 0.0018 0.002 0.0121
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0049 0.0292
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0027 0.0175
Loa Loa (eye worm) patched family protein 0.0018 0.002 0.0127
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.0082 0.0544
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0012 0.0006 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0022 0.0031 0.0031
Schistosoma mansoni amine oxidase 0.0064 0.0131 0.0397
Plasmodium falciparum DNA repair protein REV1, putative 0.0022 0.0031 0.0025
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0027 0.0005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0052 0.0052
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0015 0.0013 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0098 0.0655
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0014 0.0091
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.003 0.0049 0.0045
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0064 0.0131 0.0397
Loa Loa (eye worm) histone deacetylase 11 0.0262 0.0611 0.4115
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.009
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Leishmania major hypothetical protein, conserved 0.005 0.0098 0.0624
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0014 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0165
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.0082 0.0136
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0127 0.0378
Echinococcus granulosus histone deacetylase 3 0.053 0.1261 0.3806
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.008 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0049 0.0333
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0013 0.0076
Toxoplasma gondii hypothetical protein 0.0018 0.002 0.002
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.008 0.008
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0099 0.0216 0.1624
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0408 0.3108
Echinococcus granulosus histone deacetylase 1 0.053 0.1261 0.3806
Leishmania major DNA damage repair protein, putative 0.0022 0.0031 0.0169
Loa Loa (eye worm) patched family protein 0.0018 0.002 0.0127
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0025 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0013 0.0056
Trypanosoma brucei cdc2-related kinase 3 0.0043 0.0082 0.0513
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0025 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0027 0.0169
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0148 0.0964
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0346 0.0814 0.1608
Schistosoma mansoni hypothetical protein 0.0177 0.0405 0.1225
Loa Loa (eye worm) hypothetical protein 0.0259 0.0604 0.4074
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0027 0.0169
Brugia malayi hypothetical protein 0.0016 0.0014 0.0084
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0065 0.0436
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0048 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0031 0.0201
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0006 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0127 0.0383
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0178 0.0409 0.2728
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0386 0.2938
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0098 0.0159
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0119 0.0354
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.009
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0043 0.0082 0.0513
Brugia malayi Patched family protein 0.0018 0.002 0.0121
Brugia malayi TAR-binding protein 0.0125 0.028 0.1876
Entamoeba histolytica recQ family helicase, putative 0.002 0.0024 0.0194
Loa Loa (eye worm) hypothetical protein 0.0049 0.0096 0.0639
Trichomonas vaginalis replication factor C large subunit, putative 0.003 0.0049 0.0333
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0039 0.0311
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0015 0.0013 0.0039
Echinococcus multilocularis tumor protein p63 0.0336 0.079 0.1347
Trypanosoma brucei cdc2-related kinase 1 0.0043 0.0082 0.0513
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0025 0.0159
Schistosoma mansoni gabp alpha 0.0072 0.0151 0.0457
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0148 0.0126
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0337 0.2266
Onchocerca volvulus 0.0018 0.002 0.0229
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0098 0.0159
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0148 0.0248
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0065 0.0404
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0014 0.0044
Plasmodium falciparum histone deacetylase 1 0.053 0.1261 0.1255
Loa Loa (eye worm) hypothetical protein 0.0372 0.0878 0.5918
Brugia malayi Patched related family protein 10 0.0018 0.002 0.0121
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0015 0.0013 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0127
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0522

Activities

Activity type Activity value Assay description Source Reference
Diet (functional) < 46 % In vivo triglyceride lowering activity dosed at 0.10 % of the diet. ChEMBL. 6604817
Diet (functional) < 67 % In vivo triglyceride lowering activity when dosed as 0.01 % of the diet ChEMBL. 6604817
Diet (functional) < 68 % In vivo sterol lowering activity at dose of 0.10 % of the diet ChEMBL. 6604817
Diet (functional) < 74 % In vivo triglyceride lowering activity when dosed at 0.03 % of the diet ChEMBL. 6604817
Diet (functional) < 82 % In vivo sterol lowering activity when dosed as 0.03 % of the diet ChEMBL. 6604817
Diet (functional) = 94 % In vivo sterol lowering activity when dosed as 0.01 % of the diet ChEMBL. 6604817
Inhibition (binding) = 14 % In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase ChEMBL. 6604817
Inhibition (binding) = 14 % In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase ChEMBL. 6604817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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